Q7L2R6 (ZN765_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 765

Gene names

Name:

ZNF765

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	523 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 11 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7L2R6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7L2R6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     48-60: DISSKCMMKEFSS → ELSGECPLAAPAS
     61-523: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 523	523	Zinc finger protein 765		PRO_0000344217
Regions
	Domain	8 – 81	74	KRAB
	Zinc finger	215 – 237	23	C2H2-type 1; degenerate
	Zinc finger	243 – 265	23	C2H2-type 2
	Zinc finger	271 – 293	23	C2H2-type 3
	Zinc finger	299 – 321	23	C2H2-type 4
	Zinc finger	327 – 349	23	C2H2-type 5
	Zinc finger	355 – 377	23	C2H2-type 6
	Zinc finger	383 – 405	23	C2H2-type 7
	Zinc finger	411 – 432	22	C2H2-type 8; atypical
	Zinc finger	438 – 460	23	C2H2-type 9
	Zinc finger	466 – 488	23	C2H2-type 10
	Zinc finger	494 – 516	23	C2H2-type 11; degenerate
Natural variations
	Alternative sequence	48 – 60	13	DISSK…KEFSS → ELSGECPLAAPAS in isoform 2.		VSP_034746
	Alternative sequence	61 – 523	463	Missing in isoform 2.		VSP_034747
	Natural variant	389	1	S → G. Ref.1 Ref.4 Corresponds to variant rs10425136 [ dbSNP | Ensembl ].		VAR_045598
Experimental info
	Sequence conflict	61	1	T → A in BAG57279. Ref.1
	Sequence conflict	100	1	Q → R in BAG57279. Ref.1
	Sequence conflict	241	1	K → N in BAG57279. Ref.1
	Sequence conflict	297	1	K → E in BAG57279. Ref.1
	Sequence conflict	382	1	P → L in BAG57279. Ref.1
	Sequence conflict	494	1	Y → N in BAH14671. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 22, 2008. Version 2. Checksum: AF353F9210751258	FASTA	523	61,633
	10 20 30 40 50 60 MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMMKEFSS 70 80 90 100 110 120 TAQGNREVFH AGTSQRHESH HNGDFCFQDI DKDIHDIEFQ WQEDERNGHE ALMTKIKKLT 130 140 150 160 170 180 GSTERYDQNY AGNKPVKYQL GFSFHSHLPE LHIFHTEEKI DNQVVKSIHD ASLVSTAQRI 190 200 210 220 230 240 SCRPETHISN DYGNNFLNSS LFTQKQEVHM REKSFQCNDS GKAYNCSSLL RKHQLIHLGE 250 260 270 280 290 300 KQYKCDICGK VFNSKRYVAR HRRCHTGEKP YKCNECGKTF SQTYYLTCHR RLHTGEKPYK 310 320 330 340 350 360 CEECDKAFHF KSKLQIHRRI HTGEKPYKCN ECGKTFSQKS YLTCHRRLHT GEKPYKCNEC 370 380 390 400 410 420 GKTFSRKSHF TCHHRVHTGE KPYKCNECSK TFSHKSSLTY HRRLHTEEKP YKCNECGKTF 430 440 450 460 470 480 NQQLTLNICR LHSGEKPYKC EECDKAYSFK SNLEIHQKIH TEENPYKCNE CGKTFSRTSS 490 500 510 520 LTYHHRLHTG QKPYKCEDCD EAFSFKSNLE RHRRIYTGEK LHV
	Isoform 2 [UniParc]. Checksum: 1A9DD9902280C334	FASTA	60	6,801
	10 20 30 40 50 60 MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLELS GECPLAAPAS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-389. Tissue: Cerebellum and Placenta.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLY-389. Tissue: Lymph.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK293890 mRNA. Translation: BAG57279.1. AK316300 mRNA. Translation: BAH14671.1. AC022137 Genomic DNA. No translation available. CH471135 Genomic DNA. Translation: EAW72134.1. BC001610 mRNA. No translation available. BC017357 mRNA. No translation available. BC140724 mRNA. Translation: AAI40725.1.
IPI	IPI00419458. IPI01013883.
RefSeq	NP_001035275.1. NM_001040185.1.
UniGene	Hs.685640.
3D structure databases
ProteinModelPortal	Q7L2R6.
ModBase	Search...
PTM databases
PhosphoSite	Q7L2R6.
Polymorphism databases
DMDM	205639967.
Proteomic databases
PaxDb	Q7L2R6.
PRIDE	Q7L2R6.
Protocols and materials databases
DNASU	91661.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000396408; ENSP00000379689; ENSG00000196417. ENST00000504235; ENSP00000424395; ENSG00000196417. ENST00000594030; ENSP00000470468; ENSG00000196417.
GeneID	91661.
KEGG	hsa:91661.
UCSC	uc002qbm.3. human.
Organism-specific databases
CTD	91661.
GeneCards	GC19P053898.
HGNC	HGNC:25092. ZNF765.
neXtProt	NX_Q7L2R6.
PharmGKB	PA162410312.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q7L2R6.
KO	K09228.
OMA	RHRRIYT.
Gene expression databases
ArrayExpress	Q7L2R6.
Bgee	Q7L2R6.
CleanEx	HS_ZNF765.
Genevestigator	Q7L2R6.
Family and domain databases
Gene3D	3.30.160.60. 11 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 11 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 8 hits. PS50157. ZINC_FINGER_C2H2_2. 11 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	91661.
NextBio	77364.

Entry information

Entry name

ZN765_HUMAN

Accession

Primary (citable) accession number: Q7L2R6
Secondary accession number(s): A8MYG0 , B4DF18, B7ZAI5, B9EIL1, Q9BV49

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	July 22, 2008
Last modified:	May 1, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.