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Protein

Zinc finger protein 765

Gene

ZNF765

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri215 – 23723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43222C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 11; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 765
Gene namesi
Name:ZNF765
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25092. ZNF765.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410312.

Polymorphism and mutation databases

BioMutaiZNF765.
DMDMi205639967.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Zinc finger protein 765PRO_0000344217Add
BLAST

Proteomic databases

EPDiQ7L2R6.
PaxDbiQ7L2R6.
PRIDEiQ7L2R6.
TopDownProteomicsiQ7L2R6-2. [Q7L2R6-2]

PTM databases

iPTMnetiQ7L2R6.
PhosphoSiteiQ7L2R6.

Expressioni

Gene expression databases

BgeeiQ7L2R6.
CleanExiHS_ZNF765.
ExpressionAtlasiQ7L2R6. baseline and differential.
GenevisibleiQ7L2R6. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DZIP3Q86Y133EBI-9676069,EBI-948630
RELQ048643EBI-9676069,EBI-307352
USHBP1Q8N6Y03EBI-9676069,EBI-739895

Protein-protein interaction databases

BioGridi124860. 3 interactions.
IntActiQ7L2R6. 4 interactions.
STRINGi9606.ENSP00000379689.

Structurei

3D structure databases

ProteinModelPortaliQ7L2R6.
SMRiQ7L2R6. Positions 166-516.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8174KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri215 – 23723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43222C2H2-type 8; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 11; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ7L2R6.
KOiK09228.
OMAiKSHFTCH.
PhylomeDBiQ7L2R6.
TreeFamiTF341892.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7L2R6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS
60 70 80 90 100
SKCMMKEFSS TAQGNREVFH AGTSQRHESH HNGDFCFQDI DKDIHDIEFQ
110 120 130 140 150
WQEDERNGHE ALMTKIKKLT GSTERYDQNY AGNKPVKYQL GFSFHSHLPE
160 170 180 190 200
LHIFHTEEKI DNQVVKSIHD ASLVSTAQRI SCRPETHISN DYGNNFLNSS
210 220 230 240 250
LFTQKQEVHM REKSFQCNDS GKAYNCSSLL RKHQLIHLGE KQYKCDICGK
260 270 280 290 300
VFNSKRYVAR HRRCHTGEKP YKCNECGKTF SQTYYLTCHR RLHTGEKPYK
310 320 330 340 350
CEECDKAFHF KSKLQIHRRI HTGEKPYKCN ECGKTFSQKS YLTCHRRLHT
360 370 380 390 400
GEKPYKCNEC GKTFSRKSHF TCHHRVHTGE KPYKCNECSK TFSHKSSLTY
410 420 430 440 450
HRRLHTEEKP YKCNECGKTF NQQLTLNICR LHSGEKPYKC EECDKAYSFK
460 470 480 490 500
SNLEIHQKIH TEENPYKCNE CGKTFSRTSS LTYHHRLHTG QKPYKCEDCD
510 520
EAFSFKSNLE RHRRIYTGEK LHV
Length:523
Mass (Da):61,633
Last modified:July 22, 2008 - v2
Checksum:iAF353F9210751258
GO
Isoform 2 (identifier: Q7L2R6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-60: DISSKCMMKEFSS → ELSGECPLAAPAS
     61-523: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Gene prediction based on EST data.
Show »
Length:60
Mass (Da):6,801
Checksum:i1A9DD9902280C334
GO
Isoform 3 (identifier: Q7L2R6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-127: DISSKCMMKE...KLTGSTERYD → EFWSVIPAKV...KSSHWRILFP
     128-523: Missing.

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):15,272
Checksum:i38AA41DD8D149944
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611T → A in BAG57279 (PubMed:14702039).Curated
Sequence conflicti100 – 1001Q → R in BAG57279 (PubMed:14702039).Curated
Sequence conflicti241 – 2411K → N in BAG57279 (PubMed:14702039).Curated
Sequence conflicti297 – 2971K → E in BAG57279 (PubMed:14702039).Curated
Sequence conflicti382 – 3821P → L in BAG57279 (PubMed:14702039).Curated
Sequence conflicti494 – 4941Y → N in BAH14671 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti389 – 3891S → G.2 Publications
Corresponds to variant rs10425136 [ dbSNP | Ensembl ].
VAR_045598

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei48 – 12780DISSK…TERYD → EFWSVIPAKVQWCHLRSLQP PLPRFKQFSCLSLPSTWDYR YLFQMHVEDVVVNRARQYRS DPHRDIAQTSKSSHWRILFP in isoform 3. CuratedVSP_055629Add
BLAST
Alternative sequencei48 – 6013DISSK…KEFSS → ELSGECPLAAPAS in isoform 2. 1 PublicationVSP_034746Add
BLAST
Alternative sequencei61 – 523463Missing in isoform 2. 1 PublicationVSP_034747Add
BLAST
Alternative sequencei128 – 523396Missing in isoform 3. CuratedVSP_055630Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293890 mRNA. Translation: BAG57279.1.
AK316300 mRNA. Translation: BAH14671.1.
AC022137 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72134.1.
BC001610 mRNA. No translation available.
BC017357 mRNA. No translation available.
BC140724 mRNA. Translation: AAI40725.1.
CCDSiCCDS46171.1. [Q7L2R6-1]
RefSeqiNP_001035275.1. NM_001040185.1. [Q7L2R6-1]
XP_006723529.1. XM_006723466.2. [Q7L2R6-1]
UniGeneiHs.685640.

Genome annotation databases

EnsembliENST00000396408; ENSP00000379689; ENSG00000196417. [Q7L2R6-1]
ENST00000504235; ENSP00000424395; ENSG00000196417. [Q7L2R6-2]
ENST00000594030; ENSP00000470468; ENSG00000196417. [Q7L2R6-2]
GeneIDi91661.
KEGGihsa:91661.
UCSCiuc002qbm.4. human. [Q7L2R6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293890 mRNA. Translation: BAG57279.1.
AK316300 mRNA. Translation: BAH14671.1.
AC022137 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72134.1.
BC001610 mRNA. No translation available.
BC017357 mRNA. No translation available.
BC140724 mRNA. Translation: AAI40725.1.
CCDSiCCDS46171.1. [Q7L2R6-1]
RefSeqiNP_001035275.1. NM_001040185.1. [Q7L2R6-1]
XP_006723529.1. XM_006723466.2. [Q7L2R6-1]
UniGeneiHs.685640.

3D structure databases

ProteinModelPortaliQ7L2R6.
SMRiQ7L2R6. Positions 166-516.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124860. 3 interactions.
IntActiQ7L2R6. 4 interactions.
STRINGi9606.ENSP00000379689.

PTM databases

iPTMnetiQ7L2R6.
PhosphoSiteiQ7L2R6.

Polymorphism and mutation databases

BioMutaiZNF765.
DMDMi205639967.

Proteomic databases

EPDiQ7L2R6.
PaxDbiQ7L2R6.
PRIDEiQ7L2R6.
TopDownProteomicsiQ7L2R6-2. [Q7L2R6-2]

Protocols and materials databases

DNASUi91661.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396408; ENSP00000379689; ENSG00000196417. [Q7L2R6-1]
ENST00000504235; ENSP00000424395; ENSG00000196417. [Q7L2R6-2]
ENST00000594030; ENSP00000470468; ENSG00000196417. [Q7L2R6-2]
GeneIDi91661.
KEGGihsa:91661.
UCSCiuc002qbm.4. human. [Q7L2R6-1]

Organism-specific databases

CTDi91661.
GeneCardsiZNF765.
HGNCiHGNC:25092. ZNF765.
neXtProtiNX_Q7L2R6.
PharmGKBiPA162410312.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ7L2R6.
KOiK09228.
OMAiKSHFTCH.
PhylomeDBiQ7L2R6.
TreeFamiTF341892.

Miscellaneous databases

GenomeRNAii91661.
PROiQ7L2R6.

Gene expression databases

BgeeiQ7L2R6.
CleanExiHS_ZNF765.
ExpressionAtlasiQ7L2R6. baseline and differential.
GenevisibleiQ7L2R6. HS.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-389.
    Tissue: Cerebellum and Placenta.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLY-389.
    Tissue: Lymph.

Entry informationi

Entry nameiZN765_HUMAN
AccessioniPrimary (citable) accession number: Q7L2R6
Secondary accession number(s): A8MYG0
, B4DF18, B7ZAI5, B9EIL1, Q9BV49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: June 8, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.