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Protein
Submitted name:

PFKL protein

Gene

PFKL

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
PFKL proteinImported
Gene namesi
Name:PFKLImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33215.

PTM / Processingi

Proteomic databases

PaxDbiQ7L2M7.
PRIDEiQ7L2M7.

Expressioni

Gene expression databases

BgeeiQ7L2M7.
GenevisibleiQ7L2M7. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000269848.

Structurei

3D structure databases

ProteinModelPortaliQ7L2M7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 111111PFKInterPro annotationAdd
BLAST
Domaini190 – 473284PFKInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG2440. Eukaryota.
COG0205. LUCA.
HOGENOMiHOG000200154.
HOVERGENiHBG000976.
KOiK00850.

Family and domain databases

InterProiIPR009161. 6-Pfructokinase_euk.
IPR022953. ATP_PFK.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 2 hits.
[Graphical view]
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 2 hits.
TIGRFAMsiTIGR02478. 6PF1K_euk. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q7L2M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GYLALVSALA SGADWLFIPE APPEDGWENF MCERLGETRS RGSRLNIIII
60 70 80 90 100
AEGAIDRNGK PISSSYVKDL VVQRLGFDTR VTVLGHVQRG GTPSAFDRIL
110 120 130 140 150
SSKMGMEAVM ALLEATPDTP ACVVTLSGNQ SVRLPLMECV QMTKEVQKAM
160 170 180 190 200
DDKRFDEATQ LRGGSFENNW NIYKLLAHQK PPKEKSNFSL AILNVGAPAA
210 220 230 240 250
GMNAAVRSAV RTGISHGHTV YVVHDGFEGL AKGQVQEVGW HDVAGWLGRG
260 270 280 290 300
GSMLGTKRTL PKGQLESIVE NIRIYGIHAL LVVGGFEAYE GVLQLVEARG
310 320 330 340 350
RYEELCIVMC VIPATISNNV PGTDFSLGSD TAVNAAMESC DRIKQSASGT
360 370 380 390 400
KRRVFIVETM GGYCGYLATV TGIAVGADAA YVFEDPFNIH DLKVNVEHMT
410 420 430 440 450
EKMKTDIQRG LVLRNEKCHD YYTTEFLYNL YSSEGKGVFD CRTNVLGHLQ
460 470 480 490 500
QGGAPTPFDR NYGTKLGVKA MLWLSEKLRE VYRKGRVFAN APDSACVIGL
510 520 530 540 550
KKKAVAFSPV TELKKDTDFE HRMPREQWWL SLRLMLKMLA QYRISMAAYV
560
SGELEHVTRR TLSMDKGF
Length:568
Mass (Da):62,640
Last modified:March 29, 2005 - v2
Checksum:i299BE2321A79AE7F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018295 mRNA. Translation: AAH18295.2.
RefSeqiNP_001002021.2. NM_001002021.2.
NP_002617.3. NM_002626.5.
UniGeneiHs.255093.

Genome annotation databases

GeneIDi5211.
KEGGihsa:5211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018295 mRNA. Translation: AAH18295.2.
RefSeqiNP_001002021.2. NM_001002021.2.
NP_002617.3. NM_002626.5.
UniGeneiHs.255093.

3D structure databases

ProteinModelPortaliQ7L2M7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000269848.

Proteomic databases

PaxDbiQ7L2M7.
PRIDEiQ7L2M7.

Protocols and materials databases

DNASUi5211.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5211.
KEGGihsa:5211.

Organism-specific databases

CTDi5211.
PharmGKBiPA33215.

Phylogenomic databases

eggNOGiKOG2440. Eukaryota.
COG0205. LUCA.
HOGENOMiHOG000200154.
HOVERGENiHBG000976.
KOiK00850.

Miscellaneous databases

ChiTaRSiPFKL. human.
GenomeRNAii5211.

Gene expression databases

BgeeiQ7L2M7.
GenevisibleiQ7L2M7. HS.

Family and domain databases

InterProiIPR009161. 6-Pfructokinase_euk.
IPR022953. ATP_PFK.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 2 hits.
[Graphical view]
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 2 hits.
TIGRFAMsiTIGR02478. 6PF1K_euk. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: CervixImported.

Entry informationi

Entry nameiQ7L2M7_HUMAN
AccessioniPrimary (citable) accession number: Q7L2M7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: March 29, 2005
Last modified: June 8, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.