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Protein

Uncharacterized protein C16orf59

Gene

C16orf59

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C16orf59
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25849. C16orf59.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485396.

Polymorphism and mutation databases

BioMutaiC16orf59.
DMDMi121944421.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Uncharacterized protein C16orf59PRO_0000286557Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei159 – 1591PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7L2K0.
MaxQBiQ7L2K0.
PaxDbiQ7L2K0.
PeptideAtlasiQ7L2K0.
PRIDEiQ7L2K0.

PTM databases

iPTMnetiQ7L2K0.
PhosphoSiteiQ7L2K0.

Expressioni

Gene expression databases

BgeeiENSG00000162062.
CleanExiHS_C16orf59.
ExpressionAtlasiQ7L2K0. baseline and differential.
GenevisibleiQ7L2K0. HS.

Organism-specific databases

HPAiHPA051394.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-8465456,EBI-10172290
KRTAP10-9P604113EBI-8465456,EBI-10172052
NOTCH2NLQ7Z3S93EBI-8465456,EBI-945833

Protein-protein interaction databases

BioGridi123160. 11 interactions.
IntActiQ7L2K0. 4 interactions.
MINTiMINT-8417619.
STRINGi9606.ENSP00000355022.

Structurei

3D structure databases

ProteinModelPortaliQ7L2K0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IVDJ. Eukaryota.
ENOG410YP0K. LUCA.
GeneTreeiENSGT00390000011149.
HOGENOMiHOG000057283.
HOVERGENiHBG107747.
InParanoidiQ7L2K0.
OMAiDCSRRLV.
OrthoDBiEOG091G0BFP.
PhylomeDBiQ7L2K0.
TreeFamiTF337397.

Family and domain databases

InterProiIPR031518. DUF4693.
[Graphical view]
PfamiPF15764. DUF4693. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7L2K0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPAGCSRRL VAELQGALDA CAQRQLQLEQ SLRVCRRLLH AWEPTGTRAL
60 70 80 90 100
KPPPGPETNG EDPLPACTPS PQDLKELEFL TQALEKAVRV RRGITKAGER
110 120 130 140 150
DKAPSLKSRS IVTSSGTTAS APPHSPGQAG GHASDTRPTK GLRQTTVPAK
160 170 180 190 200
GHPERRLLSV GDGTRVGMGA RTPRPGAGLR DQQMAPSAAP QAPEAFTLKE
210 220 230 240 250
KGHLLRLPAA FRKAASQNSS LWAQLSSTQT SDSTDAAAAK TQFLQNMQTA
260 270 280 290 300
SGGPQPRLSA VEVEAEAGRL RKACSLLRLR MREELSAAPM DWMQEYRCLL
310 320 330 340 350
TLEGLQAMVG QCLHRLQELR AAVAEQPPRP CPVGRPPGAS PSCGGRAEPA
360 370 380 390 400
WSPQLLVYSS TQELQTLAAL KLRVAVLDQQ IHLEKVLMAE LLPLVSAAQP
410 420 430
QGPPWLALCR AVHSLLCEGG ARVLTILRDE PAV
Length:433
Mass (Da):46,402
Last modified:October 17, 2006 - v1
Checksum:i2B3C8B18D497D728
GO
Isoform 2 (identifier: Q7L2K0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-167: Missing.

Show »
Length:266
Mass (Da):28,645
Checksum:i204F4C994BFAC84E
GO
Isoform 3 (identifier: Q7L2K0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-167: Missing.
     323-362: VAEQPPRPCP...PQLLVYSSTQ → PRSCRPWRPS...RWGCNRGPQP
     363-433: Missing.

Note: No experimental confirmation available.
Show »
Length:195
Mass (Da):21,869
Checksum:i38D31C22146EEDC8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti346 – 3461R → K.
Corresponds to variant rs34948268 [ dbSNP | Ensembl ].
VAR_032115

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 167167Missing in isoform 2 and isoform 3. 3 PublicationsVSP_025086Add
BLAST
Alternative sequencei323 – 36240VAEQP…YSSTQ → PRSCRPWRPSSCEWLCWTSR STWKRCFWKRRWGCNRGPQP in isoform 3. 1 PublicationVSP_025087Add
BLAST
Alternative sequencei363 – 43371Missing in isoform 3. 1 PublicationVSP_025088Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023971 mRNA. Translation: BAB14745.1.
AK301929 mRNA. Translation: BAG63349.1.
CR457319 mRNA. Translation: CAG33600.1.
CH471112 Genomic DNA. Translation: EAW85507.1.
BC008882 mRNA. Translation: AAH08882.1.
BC018719 mRNA. Translation: AAH18719.2.
CCDSiCCDS10468.2. [Q7L2K0-1]
RefSeqiNP_079384.2. NM_025108.2. [Q7L2K0-1]
UniGeneiHs.534491.

Genome annotation databases

EnsembliENST00000361837; ENSP00000355022; ENSG00000162062. [Q7L2K0-1]
ENST00000483320; ENSP00000456478; ENSG00000162062. [Q7L2K0-2]
GeneIDi80178.
KEGGihsa:80178.
UCSCiuc002cqh.4. human. [Q7L2K0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023971 mRNA. Translation: BAB14745.1.
AK301929 mRNA. Translation: BAG63349.1.
CR457319 mRNA. Translation: CAG33600.1.
CH471112 Genomic DNA. Translation: EAW85507.1.
BC008882 mRNA. Translation: AAH08882.1.
BC018719 mRNA. Translation: AAH18719.2.
CCDSiCCDS10468.2. [Q7L2K0-1]
RefSeqiNP_079384.2. NM_025108.2. [Q7L2K0-1]
UniGeneiHs.534491.

3D structure databases

ProteinModelPortaliQ7L2K0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123160. 11 interactions.
IntActiQ7L2K0. 4 interactions.
MINTiMINT-8417619.
STRINGi9606.ENSP00000355022.

PTM databases

iPTMnetiQ7L2K0.
PhosphoSiteiQ7L2K0.

Polymorphism and mutation databases

BioMutaiC16orf59.
DMDMi121944421.

Proteomic databases

EPDiQ7L2K0.
MaxQBiQ7L2K0.
PaxDbiQ7L2K0.
PeptideAtlasiQ7L2K0.
PRIDEiQ7L2K0.

Protocols and materials databases

DNASUi80178.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361837; ENSP00000355022; ENSG00000162062. [Q7L2K0-1]
ENST00000483320; ENSP00000456478; ENSG00000162062. [Q7L2K0-2]
GeneIDi80178.
KEGGihsa:80178.
UCSCiuc002cqh.4. human. [Q7L2K0-1]

Organism-specific databases

CTDi80178.
GeneCardsiC16orf59.
HGNCiHGNC:25849. C16orf59.
HPAiHPA051394.
neXtProtiNX_Q7L2K0.
PharmGKBiPA143485396.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVDJ. Eukaryota.
ENOG410YP0K. LUCA.
GeneTreeiENSGT00390000011149.
HOGENOMiHOG000057283.
HOVERGENiHBG107747.
InParanoidiQ7L2K0.
OMAiDCSRRLV.
OrthoDBiEOG091G0BFP.
PhylomeDBiQ7L2K0.
TreeFamiTF337397.

Miscellaneous databases

GenomeRNAii80178.
PROiQ7L2K0.

Gene expression databases

BgeeiENSG00000162062.
CleanExiHS_C16orf59.
ExpressionAtlasiQ7L2K0. baseline and differential.
GenevisibleiQ7L2K0. HS.

Family and domain databases

InterProiIPR031518. DUF4693.
[Graphical view]
PfamiPF15764. DUF4693. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP059_HUMAN
AccessioniPrimary (citable) accession number: Q7L2K0
Secondary accession number(s): B4DXD7, Q96H61, Q9H872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.