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Q7L2J0

- MEPCE_HUMAN

UniProt

Q7L2J0 - MEPCE_HUMAN

Protein

7SK snRNA methylphosphate capping enzyme

Gene

MEPCE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei581 – 5811S-adenosyl-L-methionine; via carbonyl oxygen

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. RNA methyltransferase activity Source: UniProtKB
    3. S-adenosylmethionine-dependent methyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of chromatin binding Source: Ensembl
    2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
    4. RNA methylation Source: UniProtKB
    5. snRNA metabolic process Source: UniProtKB
    6. snRNA modification Source: UniProtKB

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    7SK snRNA methylphosphate capping enzyme (EC:2.1.1.-)
    Short name:
    MePCE
    Alternative name(s):
    Bicoid-interacting protein 3 homolog
    Short name:
    Bin3 homolog
    Gene namesi
    Name:MEPCE
    Synonyms:BCDIN3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:20247. MEPCE.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162395768.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6896897SK snRNA methylphosphate capping enzymePRO_0000289262Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei57 – 571Phosphoserine1 Publication
    Modified residuei60 – 601Phosphoserine2 Publications
    Modified residuei69 – 691Phosphoserine4 Publications
    Modified residuei101 – 1011Phosphoserine1 Publication
    Modified residuei152 – 1521Phosphoserine1 Publication
    Modified residuei175 – 1751Phosphoserine3 Publications
    Modified residuei179 – 1791Phosphoserine1 Publication
    Modified residuei213 – 2131Phosphothreonine4 Publications
    Modified residuei216 – 2161Phosphoserine2 Publications
    Modified residuei217 – 2171Phosphoserine3 Publications
    Modified residuei254 – 2541Phosphoserine4 Publications
    Modified residuei330 – 3301Phosphoserine1 Publication
    Modified residuei390 – 3901Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ7L2J0.
    PaxDbiQ7L2J0.
    PeptideAtlasiQ7L2J0.
    PRIDEiQ7L2J0.

    PTM databases

    PhosphoSiteiQ7L2J0.

    Expressioni

    Tissue specificityi

    Expressed in chronic myeloid leukemia cells, adrenal gland, brain, cerebellum, kidney, lung, mammary gland and testis. Weakly or not expressed in other tissues.1 Publication

    Gene expression databases

    BgeeiQ7L2J0.
    CleanExiHS_MEPCE.
    GenevestigatoriQ7L2J0.

    Organism-specific databases

    HPAiCAB026384.
    HPA042912.
    HPA051587.

    Interactioni

    Subunit structurei

    Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, MEPCE/BCDIN3, SART3 proteins and 7SK and U6 snRNAs.2 Publications

    Protein-protein interaction databases

    BioGridi121122. 179 interactions.
    IntActiQ7L2J0. 8 interactions.
    STRINGi9606.ENSP00000308546.

    Structurei

    Secondary structure

    1
    689
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi432 – 4354
    Helixi439 – 4413
    Turni442 – 4443
    Beta strandi445 – 4517
    Helixi456 – 4649
    Beta strandi468 – 4758
    Helixi477 – 4859
    Turni549 – 5524
    Beta strandi553 – 5575
    Helixi565 – 5684
    Beta strandi575 – 5828
    Helixi584 – 60623
    Beta strandi607 – 61610
    Helixi620 – 6245
    Turni625 – 6284
    Helixi631 – 6399
    Helixi644 – 6463
    Helixi647 – 6515
    Turni654 – 6563
    Beta strandi660 – 6645
    Beta strandi678 – 6825

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3G07X-ray2.65A/B/C/D/E/F400-689[»]
    ProteinModelPortaliQ7L2J0.
    SMRiQ7L2J0. Positions 431-685.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7L2J0.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini431 – 686256Bin3-type SAMPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni451 – 4533S-adenosyl-L-methionine binding
    Regioni474 – 4752S-adenosyl-L-methionine binding
    Regioni559 – 5602S-adenosyl-L-methionine binding

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi25 – 161137Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the methyltransferase superfamily.Curated
    Contains 1 Bin3-type SAM domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG322893.
    HOGENOMiHOG000113562.
    HOVERGENiHBG099856.
    InParanoidiQ7L2J0.
    KOiK15190.
    OMAiHRGQNRD.
    OrthoDBiEOG78M02C.
    PhylomeDBiQ7L2J0.
    TreeFamiTF324061.

    Family and domain databases

    Gene3Di3.40.50.150. 2 hits.
    InterProiIPR010675. Bin3.
    IPR024160. BIN3_SAM-bd_dom.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF06859. Bin3. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS51515. BIN3_SAM. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7L2J0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIEMAAEKEP FLVPAPPPPL KDESGGGGGP TVPPHQEAAS GELRGGTERG    50
    PGRCAPSAGS PAAAVGRESP GAAATSSSGP QAQQHRGGGP QAQSHGEARL 100
    SDPPGRAAPP DVGEERRGGG GTELGPPAPP RPRNGYQPHR PPGGGGGKRR 150
    NSCNVGGGGG GFKHPAFKRR RRVNSDCDSV LPSNFLLGGN IFDPLNLNSL 200
    LDEEVSRTLN AETPKSSPLP AKGRDPVEIL IPKDITDPLS LNTCTDEGHV 250
    VLASPLKTGR KRHRHRGQHH QQQQAAGGSE SHPVPPTAPL TPLLHGEGAS 300
    QQPRHRGQNR DAPQPYELNT AINCRDEVVS PLPSALQGPS GSLSAPPAAS 350
    VISAPPSSSS RHRKRRRTSS KSEAGARGGG QGSKEKGRGS WGGRHHHHHP 400
    LPAAGFKKQQ RKFQYGNYCK YYGYRNPSCE DGRLRVLKPE WFRGRDVLDL 450
    GCNVGHLTLS IACKWGPSRM VGLDIDSRLI HSARQNIRHY LSEELRLPPQ 500
    TLEGDPGAEG EEGTTTVRKR SCFPASLTAS RGPIAAPQVP LDGADTSVFP 550
    NNVVFVTGNY VLDRDDLVEA QTPEYDVVLC LSLTKWVHLN WGDEGLKRMF 600
    RRIYRHLRPG GILVLEPQPW SSYGKRKTLT ETIYKNYYRI QLKPEQFSSY 650
    LTSPDVGFSS YELVATPHNT SKGFQRPVYL FHKARSPSH 689
    Length:689
    Mass (Da):74,355
    Last modified:July 5, 2004 - v1
    Checksum:iCBB1D6BF144C923A
    GO
    Isoform 2 (identifier: Q7L2J0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-469: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:220
    Mass (Da):24,950
    Checksum:i799B7EB8BDF56524
    GO

    Sequence cautioni

    The sequence AAF74767.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH16396.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA91040.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti661 – 6611Y → N in BAG51598. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 469469Missing in isoform 2. 1 PublicationVSP_044512Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055964 mRNA. Translation: BAG51598.1.
    AC092849 Genomic DNA. No translation available.
    CH471091 Genomic DNA. Translation: EAW76534.1.
    CH471091 Genomic DNA. Translation: EAW76535.1.
    CH471091 Genomic DNA. Translation: EAW76536.1.
    CH236956 Genomic DNA. Translation: EAL23834.1.
    BC000556 mRNA. Translation: AAH00556.2.
    BC016396 mRNA. Translation: AAH16396.1. Different initiation.
    BC018935 mRNA. Translation: AAH18935.2.
    AF264752 Genomic DNA. Translation: AAF74767.1. Different initiation.
    AK000264 mRNA. Translation: BAA91040.1. Different initiation.
    CCDSiCCDS55136.1. [Q7L2J0-2]
    CCDS5693.1. [Q7L2J0-1]
    RefSeqiNP_001181919.1. NM_001194990.1. [Q7L2J0-2]
    NP_001181920.1. NM_001194991.1. [Q7L2J0-2]
    NP_001181921.1. NM_001194992.1. [Q7L2J0-2]
    NP_062552.2. NM_019606.5. [Q7L2J0-1]
    UniGeneiHs.178011.

    Genome annotation databases

    EnsembliENST00000310512; ENSP00000308546; ENSG00000146834. [Q7L2J0-1]
    ENST00000414441; ENSP00000400875; ENSG00000146834. [Q7L2J0-2]
    GeneIDi56257.
    KEGGihsa:56257.
    UCSCiuc003uuv.3. human. [Q7L2J0-2]
    uc003uuw.3. human. [Q7L2J0-1]

    Polymorphism databases

    DMDMi74758999.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK055964 mRNA. Translation: BAG51598.1 .
    AC092849 Genomic DNA. No translation available.
    CH471091 Genomic DNA. Translation: EAW76534.1 .
    CH471091 Genomic DNA. Translation: EAW76535.1 .
    CH471091 Genomic DNA. Translation: EAW76536.1 .
    CH236956 Genomic DNA. Translation: EAL23834.1 .
    BC000556 mRNA. Translation: AAH00556.2 .
    BC016396 mRNA. Translation: AAH16396.1 . Different initiation.
    BC018935 mRNA. Translation: AAH18935.2 .
    AF264752 Genomic DNA. Translation: AAF74767.1 . Different initiation.
    AK000264 mRNA. Translation: BAA91040.1 . Different initiation.
    CCDSi CCDS55136.1. [Q7L2J0-2 ]
    CCDS5693.1. [Q7L2J0-1 ]
    RefSeqi NP_001181919.1. NM_001194990.1. [Q7L2J0-2 ]
    NP_001181920.1. NM_001194991.1. [Q7L2J0-2 ]
    NP_001181921.1. NM_001194992.1. [Q7L2J0-2 ]
    NP_062552.2. NM_019606.5. [Q7L2J0-1 ]
    UniGenei Hs.178011.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3G07 X-ray 2.65 A/B/C/D/E/F 400-689 [» ]
    ProteinModelPortali Q7L2J0.
    SMRi Q7L2J0. Positions 431-685.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121122. 179 interactions.
    IntActi Q7L2J0. 8 interactions.
    STRINGi 9606.ENSP00000308546.

    PTM databases

    PhosphoSitei Q7L2J0.

    Polymorphism databases

    DMDMi 74758999.

    Proteomic databases

    MaxQBi Q7L2J0.
    PaxDbi Q7L2J0.
    PeptideAtlasi Q7L2J0.
    PRIDEi Q7L2J0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310512 ; ENSP00000308546 ; ENSG00000146834 . [Q7L2J0-1 ]
    ENST00000414441 ; ENSP00000400875 ; ENSG00000146834 . [Q7L2J0-2 ]
    GeneIDi 56257.
    KEGGi hsa:56257.
    UCSCi uc003uuv.3. human. [Q7L2J0-2 ]
    uc003uuw.3. human. [Q7L2J0-1 ]

    Organism-specific databases

    CTDi 56257.
    GeneCardsi GC07P100026.
    HGNCi HGNC:20247. MEPCE.
    HPAi CAB026384.
    HPA042912.
    HPA051587.
    MIMi 611478. gene.
    neXtProti NX_Q7L2J0.
    PharmGKBi PA162395768.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322893.
    HOGENOMi HOG000113562.
    HOVERGENi HBG099856.
    InParanoidi Q7L2J0.
    KOi K15190.
    OMAi HRGQNRD.
    OrthoDBi EOG78M02C.
    PhylomeDBi Q7L2J0.
    TreeFami TF324061.

    Miscellaneous databases

    ChiTaRSi MEPCE. human.
    EvolutionaryTracei Q7L2J0.
    GenomeRNAii 56257.
    NextBioi 61905.
    PROi Q7L2J0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7L2J0.
    CleanExi HS_MEPCE.
    Genevestigatori Q7L2J0.

    Family and domain databases

    Gene3Di 3.40.50.150. 2 hits.
    InterProi IPR010675. Bin3.
    IPR024160. BIN3_SAM-bd_dom.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF06859. Bin3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS51515. BIN3_SAM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 320-689 (ISOFORM 1).
      Tissue: Colon mucosa.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Identification and characterization of a novel gene encoding a SEREX antigen in chronic myeloid leukaemia."
      Rogers S.A., Bowen D.J., Ling M., Thomson P., Wang Z., Lim S.H.
      Br. J. Haematol. 119:112-114(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 73-689, TISSUE SPECIFICITY.
    6. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69 AND SER-175, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-217, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme."
      Jeronimo C., Forget D., Bouchard A., Li Q., Chua G., Poitras C., Therien C., Bergeron D., Bourassa S., Greenblatt J., Chabot B., Poirier G.G., Hughes T.R., Blanchette M., Price D.H., Coulombe B.
      Mol. Cell 27:262-274(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE 7SK SNRNP COMPLEX, CATALYTIC ACTIVITY.
    10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175 AND SER-179, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57; SER-60; SER-69; SER-152; SER-175; SER-254 AND SER-330, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; SER-69; THR-213; SER-216; SER-217 AND SER-254, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-213, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69; SER-101; THR-213; SER-216; SER-217; SER-254 AND SER-390, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-213, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "Methyltransferase domain of human bicoid-interacting protein 3 homolog (drosophila)."
      Structural genomics consortium (SGC)
      Submitted (MAY-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 400-689 IN COMPLEX WITH SUBSTRATE.

    Entry informationi

    Entry nameiMEPCE_HUMAN
    AccessioniPrimary (citable) accession number: Q7L2J0
    Secondary accession number(s): B3KP86, D6W5V7, Q9NPD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3