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Q7L2E3

- DHX30_HUMAN

UniProt

Q7L2E3 - DHX30_HUMAN

Protein

Putative ATP-dependent RNA helicase DHX30

Gene

DHX30

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 By similarity. Associates with mitochondrial DNA.By similarity1 Publication

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi457 – 4648ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP-dependent helicase activity Source: InterPro
    3. chromatin binding Source: UniProtKB
    4. double-stranded RNA binding Source: MGI
    5. poly(A) RNA binding Source: UniProtKB
    6. protein binding Source: UniProtKB

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative ATP-dependent RNA helicase DHX30 (EC:3.6.4.13)
    Alternative name(s):
    DEAH box protein 30
    Gene namesi
    Name:DHX30
    Synonyms:DDX30, KIAA0890
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:16716. DHX30.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. mitochondrial nucleoid Source: BHF-UCL
    3. mitochondrion Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion, Mitochondrion nucleoid

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27217.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11941194Putative ATP-dependent RNA helicase DHX30PRO_0000245538Add
    BLAST

    Post-translational modificationi

    Isoform 2 is phosphorylated on Ser-15.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ7L2E3.
    PaxDbiQ7L2E3.
    PRIDEiQ7L2E3.

    PTM databases

    PhosphoSiteiQ7L2E3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7L2E3.
    BgeeiQ7L2E3.
    CleanExiHS_DHX30.
    GenevestigatoriQ7L2E3.

    Organism-specific databases

    HPAiHPA034805.
    HPA034806.

    Interactioni

    Subunit structurei

    Identified in a complex with TFAM and SSBP1. Interacts with AGO1 and AGO2. Interacts (via N-terminus) with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDK9P507505EBI-1211456,EBI-1383449
    DHX58Q96C102EBI-1211456,EBI-744193
    EIF2AK2P195253EBI-1211456,EBI-640775
    HDAC1Q135473EBI-1211456,EBI-301834
    HDAC3O153793EBI-1211456,EBI-607682
    MYBBP1AQ9BQG03EBI-1211456,EBI-676973
    NCOR1O753763EBI-1211456,EBI-347233
    NR2E3Q9Y5X45EBI-1211456,EBI-7216962
    OAS3Q9Y6K52EBI-1211456,EBI-6115729
    RBBP4Q090283EBI-1211456,EBI-620823
    RBBP7Q165764EBI-1211456,EBI-352227
    RBL1P287494EBI-1211456,EBI-971402
    SIN3AQ96ST33EBI-1211456,EBI-347218
    TBL3Q127885EBI-1211456,EBI-715766

    Protein-protein interaction databases

    BioGridi116571. 49 interactions.
    IntActiQ7L2E3. 40 interactions.
    MINTiMINT-1186537.
    STRINGi9606.ENSP00000392601.

    Structurei

    Secondary structure

    1
    1194
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni47 – 493
    Helixi53 – 6412
    Helixi67 – 737
    Beta strandi74 – 785
    Beta strandi81 – 9111
    Beta strandi93 – 953
    Beta strandi97 – 1059
    Helixi106 – 12419
    Helixi136 – 1449

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DB2NMR-A42-147[»]
    ProteinModelPortaliQ7L2E3.
    SMRiQ7L2E3. Positions 44-152, 239-336, 427-981.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7L2E3.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 12169DRBMAdd
    BLAST
    Domaini444 – 612169Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini654 – 827174Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi559 – 5624DEAH box

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi188 – 19912Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1643.
    HOGENOMiHOG000112212.
    HOVERGENiHBG081437.
    InParanoidiQ7L2E3.
    KOiK13185.
    OMAiHKEERYD.
    OrthoDBiEOG7JX33D.
    PhylomeDBiQ7L2E3.
    TreeFamiTF352030.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR002464. DNA/RNA_helicase_DEAH_CS.
    IPR011709. DUF1605.
    IPR007502. Helicase-assoc_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00270. DEAD. 1 hit.
    PF04408. HA2. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF07717. OB_NTP_bind. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00847. HA2. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00690. DEAH_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q7L2E3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFSLDSFRKD RAQHRQRQCK LPPPRLPPMC VNPTPGGTIS RASRDLLKEF     50
    PQPKNLLNSV IGRALGISHA KDKLVYVHTN GPKKKKVTLH IKWPKSVEVE 100
    GYGSKKIDAE RQAAAAACQL FKGWGLLGPR NELFDAAKYR VLADRFGSPA 150
    DSWWRPEPTM PPTSWRQLNP ESIRPGGPGG LSRSLGREEE EDEEEELEEG 200
    TIDVTDFLSM TQQDSHAPLR DSRGSSFEMT DDDSAIRALT QFPLPKNLLA 250
    KVIQIATSSS TAKNLMQFHT VGTKTKLSTL TLLWPCPMTF VAKGRRKAEA 300
    ENKAAALACK KLKSLGLVDR NNEPLTHAMY NLASLRELGE TQRRPCTIQV 350
    PEPILRKIET FLNHYPVESS WIAPELRLQS DDILPLGKDS GPLSDPITGK 400
    PYVPLLEAEE VRLSQSLLEL WRRRGPVWQE APQLPVDPHR DTILNAIEQH 450
    PVVVISGDTG CGKTTRIPQL LLERYVTEGR GARCNVIITQ PRRISAVSVA 500
    QRVSHELGPS LRRNVGFQVR LESKPPSRGG ALLFCTVGIL LRKLQSNPSL 550
    EGVSHVIVDE VHERDVNTDF LLILLKGLQR LNPALRLVLM SATGDNERFS 600
    RYFGGCPVIK VPGFMYPVKE HYLEDILAKL GKHQYLHRHR HHESEDECAL 650
    DLDLVTDLVL HIDARGEPGG ILCFLPGWQE IKGVQQRLQE ALGMHESKYL 700
    ILPVHSNIPM MDQKAIFQQP PVGVRKIVLA TNIAETSITI NDIVHVVDSG 750
    LHKEERYDLK TKVSCLETVW VSRANVIQRR GRAGRCQSGF AYHLFPRSRL 800
    EKMVPFQVPE ILRTPLENLV LQAKIHMPEK TAVEFLSKAV DSPNIKAVDE 850
    AVILLQEIGV LDQREYLTTL GQRLAHISTD PRLAKAIVLA AIFRCLHPLL 900
    VVVSCLTRDP FSSSLQNRAE VDKVKALLSH DSGSDHLAFV RAVAGWEEVL 950
    RWQDRSSREN YLEENLLYAP SLRFIHGLIK QFSENIYEAF LVGKPSDCTL 1000
    ASAQCNEYSE EEELVKGVLM AGLYPNLIQV RQGKVTRQGK FKPNSVTYRT 1050
    KSGNILLHKS TINREATRLR SRWLTYFMAV KSNGSVFVRD SSQVHPLAVL 1100
    LLTDGDVHIR DDGRRATISL SDSDLLRLEG DSRTVRLLKE LRRALGRMVE 1150
    RSLRSELAAL PPSVQEEHGQ LLALLAELLR GPCGSFDVRK TADD 1194
    Length:1,194
    Mass (Da):133,938
    Last modified:July 5, 2004 - v1
    Checksum:i33D9A08799FE7A02
    GO
    Isoform 2 (identifier: Q7L2E3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-41: MFSLDSFRKD...NPTPGGTISR → MAAARRLMAL...PGEGDGSLVN

    Note: Contains a phosphoserine at position 15.

    Show »
    Length:1,222
    Mass (Da):136,115
    Checksum:iBEEE9D1C88DAFCA7
    GO
    Isoform 3 (identifier: Q7L2E3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-39: Missing.
         40-41: SR → MA

    Show »
    Length:1,155
    Mass (Da):129,438
    Checksum:iD3417B4C609F6360
    GO

    Sequence cautioni

    The sequence BAA92071.1 differs from that shown. Reason: Probable cloning artifact.
    The sequence BAA74913.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti557 – 5571I → T in BAF83955. (PubMed:14702039)Curated
    Sequence conflicti781 – 7811G → D in BAF83955. (PubMed:14702039)Curated
    Sequence conflicti1136 – 11361R → W in AAH14237. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4141MFSLD…GTISR → MAAARRLMALAAGISPRLQP LGPRAAGRQGRSRGFSSSCA HPDHTKEAAEAESGMAPGGP GEGDGSLVN in isoform 2. 1 PublicationVSP_022118Add
    BLAST
    Alternative sequencei1 – 3939Missing in isoform 3. 2 PublicationsVSP_036891Add
    BLAST
    Alternative sequencei40 – 412SR → MA in isoform 3. 2 PublicationsVSP_036892

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020697 mRNA. Translation: BAA74913.2. Different initiation.
    AK002076 mRNA. Translation: BAA92071.1. Sequence problems.
    AK291266 mRNA. Translation: BAF83955.1.
    BC014237 mRNA. Translation: AAH14237.1.
    BC015029 mRNA. Translation: AAH15029.1.
    BC020126 mRNA. Translation: AAH20126.1.
    BC038417 mRNA. Translation: AAH38417.1.
    CCDSiCCDS2759.1. [Q7L2E3-1]
    PIRiE56236.
    RefSeqiNP_055781.2. NM_014966.3. [Q7L2E3-3]
    NP_619520.1. NM_138615.2. [Q7L2E3-1]
    XP_006713095.1. XM_006713032.1. [Q7L2E3-2]
    UniGeneiHs.517948.

    Genome annotation databases

    EnsembliENST00000445061; ENSP00000405620; ENSG00000132153. [Q7L2E3-1]
    ENST00000446256; ENSP00000392601; ENSG00000132153. [Q7L2E3-3]
    ENST00000457607; ENSP00000394682; ENSG00000132153. [Q7L2E3-2]
    GeneIDi22907.
    KEGGihsa:22907.
    UCSCiuc003crt.3. human. [Q7L2E3-3]
    uc003cru.3. human. [Q7L2E3-1]

    Polymorphism databases

    DMDMi74758997.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020697 mRNA. Translation: BAA74913.2 . Different initiation.
    AK002076 mRNA. Translation: BAA92071.1 . Sequence problems.
    AK291266 mRNA. Translation: BAF83955.1 .
    BC014237 mRNA. Translation: AAH14237.1 .
    BC015029 mRNA. Translation: AAH15029.1 .
    BC020126 mRNA. Translation: AAH20126.1 .
    BC038417 mRNA. Translation: AAH38417.1 .
    CCDSi CCDS2759.1. [Q7L2E3-1 ]
    PIRi E56236.
    RefSeqi NP_055781.2. NM_014966.3. [Q7L2E3-3 ]
    NP_619520.1. NM_138615.2. [Q7L2E3-1 ]
    XP_006713095.1. XM_006713032.1. [Q7L2E3-2 ]
    UniGenei Hs.517948.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DB2 NMR - A 42-147 [» ]
    ProteinModelPortali Q7L2E3.
    SMRi Q7L2E3. Positions 44-152, 239-336, 427-981.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116571. 49 interactions.
    IntActi Q7L2E3. 40 interactions.
    MINTi MINT-1186537.
    STRINGi 9606.ENSP00000392601.

    PTM databases

    PhosphoSitei Q7L2E3.

    Polymorphism databases

    DMDMi 74758997.

    Proteomic databases

    MaxQBi Q7L2E3.
    PaxDbi Q7L2E3.
    PRIDEi Q7L2E3.

    Protocols and materials databases

    DNASUi 22907.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000445061 ; ENSP00000405620 ; ENSG00000132153 . [Q7L2E3-1 ]
    ENST00000446256 ; ENSP00000392601 ; ENSG00000132153 . [Q7L2E3-3 ]
    ENST00000457607 ; ENSP00000394682 ; ENSG00000132153 . [Q7L2E3-2 ]
    GeneIDi 22907.
    KEGGi hsa:22907.
    UCSCi uc003crt.3. human. [Q7L2E3-3 ]
    uc003cru.3. human. [Q7L2E3-1 ]

    Organism-specific databases

    CTDi 22907.
    GeneCardsi GC03P047844.
    HGNCi HGNC:16716. DHX30.
    HPAi HPA034805.
    HPA034806.
    neXtProti NX_Q7L2E3.
    PharmGKBi PA27217.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1643.
    HOGENOMi HOG000112212.
    HOVERGENi HBG081437.
    InParanoidi Q7L2E3.
    KOi K13185.
    OMAi HKEERYD.
    OrthoDBi EOG7JX33D.
    PhylomeDBi Q7L2E3.
    TreeFami TF352030.

    Miscellaneous databases

    EvolutionaryTracei Q7L2E3.
    GenomeRNAii 22907.
    NextBioi 43571.
    PROi Q7L2E3.

    Gene expression databases

    ArrayExpressi Q7L2E3.
    Bgeei Q7L2E3.
    CleanExi HS_DHX30.
    Genevestigatori Q7L2E3.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR002464. DNA/RNA_helicase_DEAH_CS.
    IPR011709. DUF1605.
    IPR007502. Helicase-assoc_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00270. DEAD. 1 hit.
    PF04408. HA2. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF07717. OB_NTP_bind. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00847. HA2. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00690. DEAH_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Placenta and Teratocarcinoma.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Brain, Lymph and Uterus.
    4. "Human mitochondrial DNA nucleoids are linked to protein folding machinery and metabolic enzymes at the mitochondrial inner membrane."
      Wang Y., Bogenhagen D.F.
      J. Biol. Chem. 281:25791-25802(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    5. "Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells."
      Hoeck J., Weinmann L., Ender C., Ruedel S., Kremmer E., Raabe M., Urlaub H., Meister G.
      EMBO Rep. 8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AGO1 AND AGO2.
    6. "The layered structure of human mitochondrial DNA nucleoids."
      Bogenhagen D.F., Rousseau D., Burke S.
      J. Biol. Chem. 283:3665-3675(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, ASSOCIATION WITH MITOCHONDRIAL DNA, IDENTIFICATION BY MASS SPECTROMETRY.
    7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Solution structure of the double-stranded RNA binding domain in KIAA0890 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 42-148.

    Entry informationi

    Entry nameiDHX30_HUMAN
    AccessioniPrimary (citable) accession number: Q7L2E3
    Secondary accession number(s): A8K5F1
    , O94965, Q7Z753, Q96CH4, Q9NUQ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3