Q7L2E3 (DHX30_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative ATP-dependent RNA helicase DHX30
EC=3.6.4.13

Alternative name(s):
DEAH box protein 30

Gene names

Name:	DHX30
Synonyms:	DDX30, KIAA0890

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1194 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 By similarity. Associates with mitochondrial DNA. Ref.4
Catalytic activity	ATP + H2O = ADP + phosphate.
Subunit structure	Identified in a complex with TFAM and SSBP1. Interacts with EIF2C1 and EIF2C2. Interacts (via N-terminus) with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner By similarity. Ref.4 Ref.5
Subcellular location	Isoform 2: Cytoplasm Ref.4 Ref.6. Isoform 1: Cytoplasm Ref.4 Ref.6. Mitochondrion. Cytoplasm Potential. Mitochondrion matrix › mitochondrion nucleoid Ref.4 Ref.6.
Post-translational modification	Isoform 2 is phosphorylated on Ser-15.
Sequence similarities	Belongs to the DEAD box helicase family. DEAH subfamily. Contains 1 DRBM (double-stranded RNA-binding) domain. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.
Sequence caution	The sequence BAA74913.2 differs from that shown. Reason: Erroneous initiation. The sequence BAA92071.1 differs from that shown. Reason: Probable cloning artifact.

Ontologies

Keywords
Cellular component	Cytoplasm Mitochondrion Mitochondrion nucleoid
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Nucleotide-binding RNA-binding
Molecular function	Helicase Hydrolase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrial nucleoid Inferred from direct assay Ref.6. Source: BHF-UCL
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro RNA binding Inferred from electronic annotation. Source: UniProtKB-KW chromatin binding Inferred from direct assay Ref.6. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DHX58	Q96C10	2	EBI-1211456,EBI-744193
EIF2AK2	P19525	3	EBI-1211456,EBI-640775
OAS3	Q9Y6K5	2	EBI-1211456,EBI-6115729

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q7L2E3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7L2E3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MFSLDSFRKD...NPTPGGTISR → MAAARRLMAL...PGEGDGSLVN

Note: Contains a phosphoserine at position 15.

Isoform 3 (identifier: Q7L2E3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     40-41: SR → MA

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1194

1194

Putative ATP-dependent RNA helicase DHX30

PRO_0000245538

Regions

Domain

53 – 121

69

DRBM

Domain

444 – 612

169

Helicase ATP-binding

Domain

654 – 827

174

Helicase C-terminal

Nucleotide binding

457 – 464

8

ATP By similarity

Motif

559 – 562

4

DEAH box

Compositional bias

188 – 199

12

Poly-Glu

Natural variations

Alternative sequence

1 – 41

41

MFSLD…GTISR → MAAARRLMALAAGISPRLQP LGPRAAGRQGRSRGFSSSCA HPDHTKEAAEAESGMAPGGP GEGDGSLVN in isoform 2.

VSP_022118

Alternative sequence

1 – 39

39

Missing in isoform 3.

VSP_036891

Alternative sequence

40 – 41

2

SR → MA in isoform 3.

VSP_036892

Experimental info

Sequence conflict

557

1

I → T in BAF83955. Ref.2

Sequence conflict

781

1

G → D in BAF83955. Ref.2

Sequence conflict

1136

1

R → W in AAH14237. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1194

Helix Strand Turn

Details...

Turn

47 – 49

3

Helix

53 – 64

12

Helix

67 – 73

7

Beta strand

74 – 78

5

Beta strand

81 – 91

11

Beta strand

93 – 95

3

Beta strand

97 – 105

9

Helix

106 – 124

19

Helix

136 – 144

9

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 33D9A08799FE7A02	FASTA	1,194	133,938
	10 20 30 40 50 60 MFSLDSFRKD RAQHRQRQCK LPPPRLPPMC VNPTPGGTIS RASRDLLKEF PQPKNLLNSV 70 80 90 100 110 120 IGRALGISHA KDKLVYVHTN GPKKKKVTLH IKWPKSVEVE GYGSKKIDAE RQAAAAACQL 130 140 150 160 170 180 FKGWGLLGPR NELFDAAKYR VLADRFGSPA DSWWRPEPTM PPTSWRQLNP ESIRPGGPGG 190 200 210 220 230 240 LSRSLGREEE EDEEEELEEG TIDVTDFLSM TQQDSHAPLR DSRGSSFEMT DDDSAIRALT 250 260 270 280 290 300 QFPLPKNLLA KVIQIATSSS TAKNLMQFHT VGTKTKLSTL TLLWPCPMTF VAKGRRKAEA 310 320 330 340 350 360 ENKAAALACK KLKSLGLVDR NNEPLTHAMY NLASLRELGE TQRRPCTIQV PEPILRKIET 370 380 390 400 410 420 FLNHYPVESS WIAPELRLQS DDILPLGKDS GPLSDPITGK PYVPLLEAEE VRLSQSLLEL 430 440 450 460 470 480 WRRRGPVWQE APQLPVDPHR DTILNAIEQH PVVVISGDTG CGKTTRIPQL LLERYVTEGR 490 500 510 520 530 540 GARCNVIITQ PRRISAVSVA QRVSHELGPS LRRNVGFQVR LESKPPSRGG ALLFCTVGIL 550 560 570 580 590 600 LRKLQSNPSL EGVSHVIVDE VHERDVNTDF LLILLKGLQR LNPALRLVLM SATGDNERFS 610 620 630 640 650 660 RYFGGCPVIK VPGFMYPVKE HYLEDILAKL GKHQYLHRHR HHESEDECAL DLDLVTDLVL 670 680 690 700 710 720 HIDARGEPGG ILCFLPGWQE IKGVQQRLQE ALGMHESKYL ILPVHSNIPM MDQKAIFQQP 730 740 750 760 770 780 PVGVRKIVLA TNIAETSITI NDIVHVVDSG LHKEERYDLK TKVSCLETVW VSRANVIQRR 790 800 810 820 830 840 GRAGRCQSGF AYHLFPRSRL EKMVPFQVPE ILRTPLENLV LQAKIHMPEK TAVEFLSKAV 850 860 870 880 890 900 DSPNIKAVDE AVILLQEIGV LDQREYLTTL GQRLAHISTD PRLAKAIVLA AIFRCLHPLL 910 920 930 940 950 960 VVVSCLTRDP FSSSLQNRAE VDKVKALLSH DSGSDHLAFV RAVAGWEEVL RWQDRSSREN 970 980 990 1000 1010 1020 YLEENLLYAP SLRFIHGLIK QFSENIYEAF LVGKPSDCTL ASAQCNEYSE EEELVKGVLM 1030 1040 1050 1060 1070 1080 AGLYPNLIQV RQGKVTRQGK FKPNSVTYRT KSGNILLHKS TINREATRLR SRWLTYFMAV 1090 1100 1110 1120 1130 1140 KSNGSVFVRD SSQVHPLAVL LLTDGDVHIR DDGRRATISL SDSDLLRLEG DSRTVRLLKE 1150 1160 1170 1180 1190 LRRALGRMVE RSLRSELAAL PPSVQEEHGQ LLALLAELLR GPCGSFDVRK TADD
	Isoform 2 [UniParc]. Checksum: BEEE9D1C88DAFCA7	FASTA	1,222	136,115
	10 20 30 40 50 60 MAAARRLMAL AAGISPRLQP LGPRAAGRQG RSRGFSSSCA HPDHTKEAAE AESGMAPGGP 70 80 90 100 110 120 GEGDGSLVNA SRDLLKEFPQ PKNLLNSVIG RALGISHAKD KLVYVHTNGP KKKKVTLHIK 130 140 150 160 170 180 WPKSVEVEGY GSKKIDAERQ AAAAACQLFK GWGLLGPRNE LFDAAKYRVL ADRFGSPADS 190 200 210 220 230 240 WWRPEPTMPP TSWRQLNPES IRPGGPGGLS RSLGREEEED EEEELEEGTI DVTDFLSMTQ 250 260 270 280 290 300 QDSHAPLRDS RGSSFEMTDD DSAIRALTQF PLPKNLLAKV IQIATSSSTA KNLMQFHTVG 310 320 330 340 350 360 TKTKLSTLTL LWPCPMTFVA KGRRKAEAEN KAAALACKKL KSLGLVDRNN EPLTHAMYNL 370 380 390 400 410 420 ASLRELGETQ RRPCTIQVPE PILRKIETFL NHYPVESSWI APELRLQSDD ILPLGKDSGP 430 440 450 460 470 480 LSDPITGKPY VPLLEAEEVR LSQSLLELWR RRGPVWQEAP QLPVDPHRDT ILNAIEQHPV 490 500 510 520 530 540 VVISGDTGCG KTTRIPQLLL ERYVTEGRGA RCNVIITQPR RISAVSVAQR VSHELGPSLR 550 560 570 580 590 600 RNVGFQVRLE SKPPSRGGAL LFCTVGILLR KLQSNPSLEG VSHVIVDEVH ERDVNTDFLL 610 620 630 640 650 660 ILLKGLQRLN PALRLVLMSA TGDNERFSRY FGGCPVIKVP GFMYPVKEHY LEDILAKLGK 670 680 690 700 710 720 HQYLHRHRHH ESEDECALDL DLVTDLVLHI DARGEPGGIL CFLPGWQEIK GVQQRLQEAL 730 740 750 760 770 780 GMHESKYLIL PVHSNIPMMD QKAIFQQPPV GVRKIVLATN IAETSITIND IVHVVDSGLH 790 800 810 820 830 840 KEERYDLKTK VSCLETVWVS RANVIQRRGR AGRCQSGFAY HLFPRSRLEK MVPFQVPEIL 850 860 870 880 890 900 RTPLENLVLQ AKIHMPEKTA VEFLSKAVDS PNIKAVDEAV ILLQEIGVLD QREYLTTLGQ 910 920 930 940 950 960 RLAHISTDPR LAKAIVLAAI FRCLHPLLVV VSCLTRDPFS SSLQNRAEVD KVKALLSHDS 970 980 990 1000 1010 1020 GSDHLAFVRA VAGWEEVLRW QDRSSRENYL EENLLYAPSL RFIHGLIKQF SENIYEAFLV 1030 1040 1050 1060 1070 1080 GKPSDCTLAS AQCNEYSEEE ELVKGVLMAG LYPNLIQVRQ GKVTRQGKFK PNSVTYRTKS 1090 1100 1110 1120 1130 1140 GNILLHKSTI NREATRLRSR WLTYFMAVKS NGSVFVRDSS QVHPLAVLLL TDGDVHIRDD 1150 1160 1170 1180 1190 1200 GRRATISLSD SDLLRLEGDS RTVRLLKELR RALGRMVERS LRSELAALPP SVQEEHGQLL 1210 1220 ALLAELLRGP CGSFDVRKTA DD
	Isoform 3 [UniParc]. Checksum: D3417B4C609F6360	FASTA	1,155	129,438
	10 20 30 40 50 60 MAASRDLLKE FPQPKNLLNS VIGRALGISH AKDKLVYVHT NGPKKKKVTL HIKWPKSVEV 70 80 90 100 110 120 EGYGSKKIDA ERQAAAAACQ LFKGWGLLGP RNELFDAAKY RVLADRFGSP ADSWWRPEPT 130 140 150 160 170 180 MPPTSWRQLN PESIRPGGPG GLSRSLGREE EEDEEEELEE GTIDVTDFLS MTQQDSHAPL 190 200 210 220 230 240 RDSRGSSFEM TDDDSAIRAL TQFPLPKNLL AKVIQIATSS STAKNLMQFH TVGTKTKLST 250 260 270 280 290 300 LTLLWPCPMT FVAKGRRKAE AENKAAALAC KKLKSLGLVD RNNEPLTHAM YNLASLRELG 310 320 330 340 350 360 ETQRRPCTIQ VPEPILRKIE TFLNHYPVES SWIAPELRLQ SDDILPLGKD SGPLSDPITG 370 380 390 400 410 420 KPYVPLLEAE EVRLSQSLLE LWRRRGPVWQ EAPQLPVDPH RDTILNAIEQ HPVVVISGDT 430 440 450 460 470 480 GCGKTTRIPQ LLLERYVTEG RGARCNVIIT QPRRISAVSV AQRVSHELGP SLRRNVGFQV 490 500 510 520 530 540 RLESKPPSRG GALLFCTVGI LLRKLQSNPS LEGVSHVIVD EVHERDVNTD FLLILLKGLQ 550 560 570 580 590 600 RLNPALRLVL MSATGDNERF SRYFGGCPVI KVPGFMYPVK EHYLEDILAK LGKHQYLHRH 610 620 630 640 650 660 RHHESEDECA LDLDLVTDLV LHIDARGEPG GILCFLPGWQ EIKGVQQRLQ EALGMHESKY 670 680 690 700 710 720 LILPVHSNIP MMDQKAIFQQ PPVGVRKIVL ATNIAETSIT INDIVHVVDS GLHKEERYDL 730 740 750 760 770 780 KTKVSCLETV WVSRANVIQR RGRAGRCQSG FAYHLFPRSR LEKMVPFQVP EILRTPLENL 790 800 810 820 830 840 VLQAKIHMPE KTAVEFLSKA VDSPNIKAVD EAVILLQEIG VLDQREYLTT LGQRLAHIST 850 860 870 880 890 900 DPRLAKAIVL AAIFRCLHPL LVVVSCLTRD PFSSSLQNRA EVDKVKALLS HDSGSDHLAF 910 920 930 940 950 960 VRAVAGWEEV LRWQDRSSRE NYLEENLLYA PSLRFIHGLI KQFSENIYEA FLVGKPSDCT 970 980 990 1000 1010 1020 LASAQCNEYS EEEELVKGVL MAGLYPNLIQ VRQGKVTRQG KFKPNSVTYR TKSGNILLHK 1030 1040 1050 1060 1070 1080 STINREATRL RSRWLTYFMA VKSNGSVFVR DSSQVHPLAV LLLTDGDVHI RDDGRRATIS 1090 1100 1110 1120 1130 1140 LSDSDLLRLE GDSRTVRLLK ELRRALGRMV ERSLRSELAA LPPSVQEEHG QLLALLAELL 1150 RGPCGSFDVR KTADD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Placenta and Teratocarcinoma.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Brain, Lymph and Uterus.
[4]	"Human mitochondrial DNA nucleoids are linked to protein folding machinery and metabolic enzymes at the mitochondrial inner membrane." Wang Y., Bogenhagen D.F. J. Biol. Chem. 281:25791-25802(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBUNIT, MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[5]	"Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells." Hoeck J., Weinmann L., Ender C., Ruedel S., Kremmer E., Raabe M., Urlaub H., Meister G. EMBO Rep. 8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH EIF2C1 AND EIF2C2.
[6]	"The layered structure of human mitochondrial DNA nucleoids." Bogenhagen D.F., Rousseau D., Burke S. J. Biol. Chem. 283:3665-3675(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, ASSOCIATION WITH MITOCHONDRIAL DNA, IDENTIFICATION BY MASS SPECTROMETRY.
[7]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 (ISOFORM 2), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"Solution structure of the double-stranded RNA binding domain in KIAA0890 protein." RIKEN structural genomics initiative (RSGI) Submitted (JUN-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 42-148.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB020697 mRNA. Translation: BAA74913.2. Different initiation.
AK002076 mRNA. Translation: BAA92071.1. Sequence problems.
AK291266 mRNA. Translation: BAF83955.1.
BC014237 mRNA. Translation: AAH14237.1.
BC015029 mRNA. Translation: AAH15029.1.
BC020126 mRNA. Translation: AAH20126.1.
BC038417 mRNA. Translation: AAH38417.1.

IPI

IPI00411733.
IPI00926109.
IPI00927809.

PIR

E56236.

RefSeq

NP_055781.2. NM_014966.3.
NP_619520.1. NM_138615.2.

UniGene

Hs.517948.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DB2	NMR	-	A	42-148	[»]

ProteinModelPortal

Q7L2E3.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q7L2E3. 20 interactions.

MINT

MINT-1186537.

STRING

9606.ENSP00000392601.

PTM databases

PhosphoSite

Q7L2E3.

Polymorphism databases

DMDM

74758997.

Proteomic databases

PaxDb

Q7L2E3.

PRIDE

Q7L2E3.

Protocols and materials databases

DNASU

22907.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000445061; ENSP00000405620; ENSG00000132153.
ENST00000446256; ENSP00000392601; ENSG00000132153.
ENST00000457607; ENSP00000394682; ENSG00000132153.

GeneID

22907.

KEGG

hsa:22907.

UCSC

uc003crt.3. human.
uc003cru.3. human.

Organism-specific databases

CTD

22907.

GeneCards

GC03P047844.

HGNC

HGNC:16716. DHX30.

HPA

HPA034806.

neXtProt

NX_Q7L2E3.

PharmGKB

PA27217.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG1643.

HOGENOM

HOG000112212.

HOVERGEN

HBG081437.

InParanoid

Q7L2E3.

KO

K13185.

OMA

LHKEERY.

OrthoDB

EOG4VHK5M.

PhylomeDB

Q7L2E3.

Gene expression databases

ArrayExpress

Q7L2E3.

Bgee

Q7L2E3.

CleanEx

HS_DHX30.

Genevestigator

Q7L2E3.

Family and domain databases

InterPro

IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
[Graphical view]

Pfam

PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]

SMART

SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]

PROSITE

PS00690. DEAH_ATP_HELICASE. 1 hit.
PS50137. DS_RBD. False negative.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q7L2E3.

GenomeRNAi

22907.

NextBio

43571.

Entry information

Entry name

DHX30_HUMAN

Accession

Primary (citable) accession number: Q7L2E3
Secondary accession number(s): A8K5F1 , O94965, Q7Z753, Q96CH4, Q9NUQ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.