Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BTB/POZ domain-containing protein KCTD9

Gene

KCTD9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD9
Gene namesi
Name:KCTD9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:22401. KCTD9.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134869993.

Polymorphism and mutation databases

BioMutaiKCTD9.
DMDMi50400921.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389BTB/POZ domain-containing protein KCTD9PRO_0000191293Add
BLAST

Proteomic databases

MaxQBiQ7L273.
PaxDbiQ7L273.
PRIDEiQ7L273.

PTM databases

PhosphoSiteiQ7L273.

Expressioni

Gene expression databases

BgeeiQ7L273.
CleanExiHS_KCTD9.
ExpressionAtlasiQ7L273. baseline and differential.
GenevisibleiQ7L273. HS.

Organism-specific databases

HPAiHPA042468.
HPA047902.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AQP1P299723EBI-4397613,EBI-745213
CARD9Q9H2573EBI-4397613,EBI-751319
CBX8Q9HC523EBI-4397613,EBI-712912
CRADDP785603EBI-4397613,EBI-520375
CUL3Q136183EBI-4397613,EBI-456129
EHHADHQ084263EBI-4397613,EBI-2339219
FAM124BQ9H5Z63EBI-4397613,EBI-741626
FAM208BQ5VWN6-23EBI-4397613,EBI-10172380
GEMP550403EBI-4397613,EBI-744104
GORASP2Q9H8Y83EBI-4397613,EBI-739467
KRT40Q6A1623EBI-4397613,EBI-10171697
LONRF1Q17RB83EBI-4397613,EBI-2341787
MAD2L2Q9UI953EBI-4397613,EBI-77889
NUP35Q8NFH53EBI-4397613,EBI-9050429
PNKDQ8N4903EBI-4397613,EBI-746368
PPP1R16BQ96T493EBI-4397613,EBI-10293968
PPP1R18Q6NYC83EBI-4397613,EBI-2557469
PSMA1P257863EBI-4397613,EBI-359352
PSMB2P497213EBI-4397613,EBI-359335
RBPMSQ930623EBI-4397613,EBI-740322
SDCBPO005603EBI-4397613,EBI-727004
SKP1P632083EBI-4397613,EBI-307486
STX11O755583EBI-4397613,EBI-714135
SYT6Q5T7P8-23EBI-4397613,EBI-10246152
TRIM27P143733EBI-4397613,EBI-719493
TRIM32Q130493EBI-4397613,EBI-742790
TRIM42A1L4B63EBI-4397613,EBI-10172216

Protein-protein interaction databases

BioGridi120153. 31 interactions.
IntActiQ7L273. 29 interactions.
STRINGi9606.ENSP00000221200.

Structurei

3D structure databases

ProteinModelPortaliQ7L273.
SMRiQ7L273. Positions 90-189, 217-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8280KHAPROSITE-ProRule annotationAdd
BLAST
Domaini89 – 16173BTBPROSITE-ProRule annotationAdd
BLAST
Domaini273 – 29725Pentapeptide repeat 1Add
BLAST
Domaini303 – 34240Pentapeptide repeat 2Add
BLAST
Domaini343 – 37735Pentapeptide repeat 3Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 1 KHA domain.PROSITE-ProRule annotation
Contains 3 pentapeptide repeat domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1357.
GeneTreeiENSGT00530000062980.
HOGENOMiHOG000010269.
HOVERGENiHBG052243.
InParanoidiQ7L273.
OMAiNSQPAED.
OrthoDBiEOG7FNC7P.
PhylomeDBiQ7L273.
TreeFamiTF313754.

Family and domain databases

InterProiIPR001646. 5peptide_repeat.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR021789. K_channel_plant.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
PF11834. DUF3354. 1 hit.
PF00805. Pentapeptide. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS51490. KHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7L273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRVTLFLNG SPKNGKVVAV YGTLSDLLSV ASSKLGIKAT SVYNGKGGLI
60 70 80 90 100
DDIALIRDDD VLFVCEGEPF IDPQTDSKPP EGLLGFHTDW LTLNVGGRYF
110 120 130 140 150
TTTRSTLVNK EPDSMLAHMF KDKGVWGNKQ DHRGAFLIDR SPEYFEPILN
160 170 180 190 200
YLRHGQLIVN DGINLLGVLE EARFFGIDSL IEHLEVAIKN SQPPEDHSPI
210 220 230 240 250
SRKEFVRFLL ATPTKSELRC QGLNFSGADL SRLDLRYINF KMANLSRCNL
260 270 280 290 300
AHANLCCANL ERADLSGSVL DCANLQGVKM LCSNAEGASL KLCNFEDPSG
310 320 330 340 350
LKANLEGANL KGVDMEGSQM TGINLRVATL KNAKLKNCNL RGATLAGTDL
360 370 380
ENCDLSGCDL QEANLRGSNV KGAIFEEMLT PLHMSQSVR
Length:389
Mass (Da):42,567
Last modified:July 5, 2004 - v1
Checksum:i43D4AE36F3B9618F
GO

Sequence cautioni

The sequence BAA90904.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121P → R in AAH68518 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021216 mRNA. Translation: AAH21216.2.
BC068518 mRNA. Translation: AAH68518.1.
AK000045 mRNA. Translation: BAA90904.1. Different initiation.
CCDSiCCDS6048.1.
RefSeqiNP_060104.2. NM_017634.3.
UniGeneiHs.188763.
Hs.72071.

Genome annotation databases

EnsembliENST00000221200; ENSP00000221200; ENSG00000104756.
GeneIDi54793.
KEGGihsa:54793.
UCSCiuc003xeo.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021216 mRNA. Translation: AAH21216.2.
BC068518 mRNA. Translation: AAH68518.1.
AK000045 mRNA. Translation: BAA90904.1. Different initiation.
CCDSiCCDS6048.1.
RefSeqiNP_060104.2. NM_017634.3.
UniGeneiHs.188763.
Hs.72071.

3D structure databases

ProteinModelPortaliQ7L273.
SMRiQ7L273. Positions 90-189, 217-377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120153. 31 interactions.
IntActiQ7L273. 29 interactions.
STRINGi9606.ENSP00000221200.

PTM databases

PhosphoSiteiQ7L273.

Polymorphism and mutation databases

BioMutaiKCTD9.
DMDMi50400921.

Proteomic databases

MaxQBiQ7L273.
PaxDbiQ7L273.
PRIDEiQ7L273.

Protocols and materials databases

DNASUi54793.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221200; ENSP00000221200; ENSG00000104756.
GeneIDi54793.
KEGGihsa:54793.
UCSCiuc003xeo.3. human.

Organism-specific databases

CTDi54793.
GeneCardsiGC08M025285.
HGNCiHGNC:22401. KCTD9.
HPAiHPA042468.
HPA047902.
neXtProtiNX_Q7L273.
PharmGKBiPA134869993.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1357.
GeneTreeiENSGT00530000062980.
HOGENOMiHOG000010269.
HOVERGENiHBG052243.
InParanoidiQ7L273.
OMAiNSQPAED.
OrthoDBiEOG7FNC7P.
PhylomeDBiQ7L273.
TreeFamiTF313754.

Miscellaneous databases

GenomeRNAii54793.
NextBioi57467.
PROiQ7L273.

Gene expression databases

BgeeiQ7L273.
CleanExiHS_KCTD9.
ExpressionAtlasiQ7L273. baseline and differential.
GenevisibleiQ7L273. HS.

Family and domain databases

InterProiIPR001646. 5peptide_repeat.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR021789. K_channel_plant.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
PF11834. DUF3354. 1 hit.
PF00805. Pentapeptide. 2 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS51490. KHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis and Uterus.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 151-389.
    Tissue: Colon.

Entry informationi

Entry nameiKCTD9_HUMAN
AccessioniPrimary (citable) accession number: Q7L273
Secondary accession number(s): Q6NUM8, Q9NXV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.