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Protein

BTB/POZ domain-containing protein KCTD9

Gene

KCTD9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.Curated

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.Curated
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • cullin family protein binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • protein self-association Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD9
Gene namesi
Name:KCTD9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:22401. KCTD9.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi125V → A: Impaired interaction with CUL3. 1 Publication1

Organism-specific databases

DisGeNETi54793.
OpenTargetsiENSG00000104756.
PharmGKBiPA134869993.

Polymorphism and mutation databases

BioMutaiKCTD9.
DMDMi50400921.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912931 – 389BTB/POZ domain-containing protein KCTD9Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7L273.
MaxQBiQ7L273.
PaxDbiQ7L273.
PeptideAtlasiQ7L273.
PRIDEiQ7L273.

PTM databases

iPTMnetiQ7L273.
PhosphoSitePlusiQ7L273.

Expressioni

Gene expression databases

BgeeiENSG00000104756.
CleanExiHS_KCTD9.
ExpressionAtlasiQ7L273. baseline and differential.
GenevisibleiQ7L273. HS.

Organism-specific databases

HPAiHPA042468.
HPA047902.

Interactioni

Subunit structurei

Forms pentamers. Component of a complex composed of 5 subunits of KCTD9 and 5 CUL3.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • cullin family protein binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • protein self-association Source: UniProtKB

Protein-protein interaction databases

BioGridi120153. 39 interactors.
IntActiQ7L273. 85 interactors.
STRINGi9606.ENSP00000221200.

Structurei

Secondary structure

1389
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi90 – 95Combined sources6
Beta strandi98 – 103Combined sources6
Helixi104 – 108Combined sources5
Helixi115 – 119Combined sources5
Beta strandi136 – 138Combined sources3
Turni143 – 145Combined sources3
Helixi146 – 154Combined sources9
Helixi165 – 175Combined sources11
Helixi178 – 188Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5BXHX-ray2.76A/B/C/D/E89-191[»]
ProteinModelPortaliQ7L273.
SMRiQ7L273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 82KHAPROSITE-ProRule annotationAdd BLAST80
Domaini89 – 161BTBPROSITE-ProRule annotationAdd BLAST73
Domaini224 – 256Pentapeptide repeat 1Sequence analysisAdd BLAST33
Domaini258 – 297Pentapeptide repeat 2Sequence analysisAdd BLAST40
Domaini338 – 376Pentapeptide repeat 3Sequence analysisAdd BLAST39

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1665. Eukaryota.
COG1357. LUCA.
GeneTreeiENSGT00530000062980.
HOGENOMiHOG000010269.
HOVERGENiHBG052243.
InParanoidiQ7L273.
OMAiSYACIKN.
OrthoDBiEOG091G07KY.
PhylomeDBiQ7L273.
TreeFamiTF313754.

Family and domain databases

Gene3Di3.10.20.230. 1 hit.
InterProiView protein in InterPro
IPR001646. 5peptide_repeat.
IPR000210. BTB/POZ_dom.
IPR003533. Doublecortin_dom.
IPR021789. KHA_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
PfamiView protein in Pfam
PF02214. BTB_2. 1 hit.
PF11834. KHA. 1 hit.
PF00805. Pentapeptide. 3 hits.
SMARTiView protein in SMART
SM00225. BTB. 1 hit.
SUPFAMiSSF54695. SSF54695. 1 hit.
SSF89837. SSF89837. 1 hit.
PROSITEiView protein in PROSITE
PS50097. BTB. 1 hit.
PS51490. KHA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7L273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRVTLFLNG SPKNGKVVAV YGTLSDLLSV ASSKLGIKAT SVYNGKGGLI
60 70 80 90 100
DDIALIRDDD VLFVCEGEPF IDPQTDSKPP EGLLGFHTDW LTLNVGGRYF
110 120 130 140 150
TTTRSTLVNK EPDSMLAHMF KDKGVWGNKQ DHRGAFLIDR SPEYFEPILN
160 170 180 190 200
YLRHGQLIVN DGINLLGVLE EARFFGIDSL IEHLEVAIKN SQPPEDHSPI
210 220 230 240 250
SRKEFVRFLL ATPTKSELRC QGLNFSGADL SRLDLRYINF KMANLSRCNL
260 270 280 290 300
AHANLCCANL ERADLSGSVL DCANLQGVKM LCSNAEGASL KLCNFEDPSG
310 320 330 340 350
LKANLEGANL KGVDMEGSQM TGINLRVATL KNAKLKNCNL RGATLAGTDL
360 370 380
ENCDLSGCDL QEANLRGSNV KGAIFEEMLT PLHMSQSVR
Length:389
Mass (Da):42,567
Last modified:July 5, 2004 - v1
Checksum:i43D4AE36F3B9618F
GO

Sequence cautioni

The sequence BAA90904 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12P → R in AAH68518 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021216 mRNA. Translation: AAH21216.2.
BC068518 mRNA. Translation: AAH68518.1.
AK000045 mRNA. Translation: BAA90904.1. Different initiation.
CCDSiCCDS6048.1.
RefSeqiNP_060104.2. NM_017634.3.
UniGeneiHs.188763.
Hs.72071.

Genome annotation databases

EnsembliENST00000221200; ENSP00000221200; ENSG00000104756.
GeneIDi54793.
KEGGihsa:54793.
UCSCiuc003xeo.4. human.

Similar proteinsi

Entry informationi

Entry nameiKCTD9_HUMAN
AccessioniPrimary (citable) accession number: Q7L273
Secondary accession number(s): Q6NUM8, Q9NXV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references