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Protein

BTB/POZ domain-containing protein KCTD9

Gene

KCTD9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-30693-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD9
Gene namesi
Name:KCTD9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:22401. KCTD9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi54793.
OpenTargetsiENSG00000104756.
PharmGKBiPA134869993.

Polymorphism and mutation databases

BioMutaiKCTD9.
DMDMi50400921.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912931 – 389BTB/POZ domain-containing protein KCTD9Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7L273.
MaxQBiQ7L273.
PaxDbiQ7L273.
PeptideAtlasiQ7L273.
PRIDEiQ7L273.

PTM databases

iPTMnetiQ7L273.
PhosphoSitePlusiQ7L273.

Expressioni

Gene expression databases

BgeeiENSG00000104756.
CleanExiHS_KCTD9.
ExpressionAtlasiQ7L273. baseline and differential.
GenevisibleiQ7L273. HS.

Organism-specific databases

HPAiHPA042468.
HPA047902.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-4397613,EBI-4397613
AQP1P299723EBI-4397613,EBI-745213
CARD9Q9H2573EBI-4397613,EBI-751319
CBX8Q9HC525EBI-4397613,EBI-712912
CRADDP785603EBI-4397613,EBI-520375
CUL3Q136185EBI-4397613,EBI-456129
EHHADHQ084263EBI-4397613,EBI-2339219
FAM124BQ9H5Z63EBI-4397613,EBI-741626
FAM208BQ5VWN6-23EBI-4397613,EBI-10172380
GEMP550405EBI-4397613,EBI-744104
GORASP2Q9H8Y85EBI-4397613,EBI-739467
KRT40Q6A1623EBI-4397613,EBI-10171697
LONRF1Q17RB85EBI-4397613,EBI-2341787
MAD2L2Q9UI953EBI-4397613,EBI-77889
NUP35Q8NFH55EBI-4397613,EBI-9050429
PICK1Q9NRD54EBI-4397613,EBI-79165
PNKDQ8N4903EBI-4397613,EBI-746368
PPP1R16BQ96T493EBI-4397613,EBI-10293968
PPP1R18Q6NYC83EBI-4397613,EBI-2557469
PSMA1P257863EBI-4397613,EBI-359352
PSMB2P497213EBI-4397613,EBI-359335
RBPMSQ930623EBI-4397613,EBI-740322
SDCBPO005605EBI-4397613,EBI-727004
SKP1P632083EBI-4397613,EBI-307486
STX11O755583EBI-4397613,EBI-714135
SYT6Q5T7P8-25EBI-4397613,EBI-10246152
TRIM27P143735EBI-4397613,EBI-719493
TRIM32Q130495EBI-4397613,EBI-742790
TRIM42A1L4B63EBI-4397613,EBI-10172216

Protein-protein interaction databases

BioGridi120153. 36 interactors.
IntActiQ7L273. 61 interactors.
STRINGi9606.ENSP00000221200.

Structurei

Secondary structure

1389
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi90 – 95Combined sources6
Beta strandi98 – 103Combined sources6
Helixi104 – 108Combined sources5
Helixi115 – 119Combined sources5
Beta strandi136 – 138Combined sources3
Turni143 – 145Combined sources3
Helixi146 – 154Combined sources9
Helixi165 – 175Combined sources11
Helixi178 – 188Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5BXHX-ray2.76A/B/C/D/E89-191[»]
ProteinModelPortaliQ7L273.
SMRiQ7L273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 82KHAPROSITE-ProRule annotationAdd BLAST80
Domaini89 – 161BTBPROSITE-ProRule annotationAdd BLAST73
Domaini273 – 297Pentapeptide repeat 1Add BLAST25
Domaini303 – 342Pentapeptide repeat 2Add BLAST40
Domaini343 – 377Pentapeptide repeat 3Add BLAST35

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 1 KHA domain.PROSITE-ProRule annotation
Contains 3 pentapeptide repeat domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1665. Eukaryota.
COG1357. LUCA.
GeneTreeiENSGT00530000062980.
HOGENOMiHOG000010269.
HOVERGENiHBG052243.
InParanoidiQ7L273.
OMAiNDENFSE.
OrthoDBiEOG091G07KY.
PhylomeDBiQ7L273.
TreeFamiTF313754.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001646. 5peptide_repeat.
IPR000210. BTB/POZ_dom.
IPR021789. KHA_dom.
IPR032675. L_dom-like.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
PF11834. KHA. 1 hit.
PF00805. Pentapeptide. 3 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS51490. KHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7L273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRVTLFLNG SPKNGKVVAV YGTLSDLLSV ASSKLGIKAT SVYNGKGGLI
60 70 80 90 100
DDIALIRDDD VLFVCEGEPF IDPQTDSKPP EGLLGFHTDW LTLNVGGRYF
110 120 130 140 150
TTTRSTLVNK EPDSMLAHMF KDKGVWGNKQ DHRGAFLIDR SPEYFEPILN
160 170 180 190 200
YLRHGQLIVN DGINLLGVLE EARFFGIDSL IEHLEVAIKN SQPPEDHSPI
210 220 230 240 250
SRKEFVRFLL ATPTKSELRC QGLNFSGADL SRLDLRYINF KMANLSRCNL
260 270 280 290 300
AHANLCCANL ERADLSGSVL DCANLQGVKM LCSNAEGASL KLCNFEDPSG
310 320 330 340 350
LKANLEGANL KGVDMEGSQM TGINLRVATL KNAKLKNCNL RGATLAGTDL
360 370 380
ENCDLSGCDL QEANLRGSNV KGAIFEEMLT PLHMSQSVR
Length:389
Mass (Da):42,567
Last modified:July 5, 2004 - v1
Checksum:i43D4AE36F3B9618F
GO

Sequence cautioni

The sequence BAA90904 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12P → R in AAH68518 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021216 mRNA. Translation: AAH21216.2.
BC068518 mRNA. Translation: AAH68518.1.
AK000045 mRNA. Translation: BAA90904.1. Different initiation.
CCDSiCCDS6048.1.
RefSeqiNP_060104.2. NM_017634.3.
UniGeneiHs.188763.
Hs.72071.

Genome annotation databases

EnsembliENST00000221200; ENSP00000221200; ENSG00000104756.
GeneIDi54793.
KEGGihsa:54793.
UCSCiuc003xeo.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021216 mRNA. Translation: AAH21216.2.
BC068518 mRNA. Translation: AAH68518.1.
AK000045 mRNA. Translation: BAA90904.1. Different initiation.
CCDSiCCDS6048.1.
RefSeqiNP_060104.2. NM_017634.3.
UniGeneiHs.188763.
Hs.72071.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5BXHX-ray2.76A/B/C/D/E89-191[»]
ProteinModelPortaliQ7L273.
SMRiQ7L273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120153. 36 interactors.
IntActiQ7L273. 61 interactors.
STRINGi9606.ENSP00000221200.

PTM databases

iPTMnetiQ7L273.
PhosphoSitePlusiQ7L273.

Polymorphism and mutation databases

BioMutaiKCTD9.
DMDMi50400921.

Proteomic databases

EPDiQ7L273.
MaxQBiQ7L273.
PaxDbiQ7L273.
PeptideAtlasiQ7L273.
PRIDEiQ7L273.

Protocols and materials databases

DNASUi54793.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221200; ENSP00000221200; ENSG00000104756.
GeneIDi54793.
KEGGihsa:54793.
UCSCiuc003xeo.4. human.

Organism-specific databases

CTDi54793.
DisGeNETi54793.
GeneCardsiKCTD9.
HGNCiHGNC:22401. KCTD9.
HPAiHPA042468.
HPA047902.
neXtProtiNX_Q7L273.
OpenTargetsiENSG00000104756.
PharmGKBiPA134869993.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1665. Eukaryota.
COG1357. LUCA.
GeneTreeiENSGT00530000062980.
HOGENOMiHOG000010269.
HOVERGENiHBG052243.
InParanoidiQ7L273.
OMAiNDENFSE.
OrthoDBiEOG091G07KY.
PhylomeDBiQ7L273.
TreeFamiTF313754.

Enzyme and pathway databases

BioCyciZFISH:G66-30693-MONOMER.

Miscellaneous databases

GenomeRNAii54793.
PROiQ7L273.

Gene expression databases

BgeeiENSG00000104756.
CleanExiHS_KCTD9.
ExpressionAtlasiQ7L273. baseline and differential.
GenevisibleiQ7L273. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR001646. 5peptide_repeat.
IPR000210. BTB/POZ_dom.
IPR021789. KHA_dom.
IPR032675. L_dom-like.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
PF11834. KHA. 1 hit.
PF00805. Pentapeptide. 3 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS51490. KHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKCTD9_HUMAN
AccessioniPrimary (citable) accession number: Q7L273
Secondary accession number(s): Q6NUM8, Q9NXV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.