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Protein

BTB/POZ domain-containing protein KCTD9

Gene

KCTD9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.Curated

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.Curated
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • cullin family protein binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • protein self-association Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD9
Gene namesi
Name:KCTD9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104756.15
HGNCiHGNC:22401 KCTD9
neXtProtiNX_Q7L273

Subcellular locationi

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi125V → A: Impaired interaction with CUL3. 1 Publication1

Organism-specific databases

DisGeNETi54793
OpenTargetsiENSG00000104756
PharmGKBiPA134869993

Polymorphism and mutation databases

BioMutaiKCTD9
DMDMi50400921

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912931 – 389BTB/POZ domain-containing protein KCTD9Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7L273
MaxQBiQ7L273
PaxDbiQ7L273
PeptideAtlasiQ7L273
PRIDEiQ7L273

PTM databases

iPTMnetiQ7L273
PhosphoSitePlusiQ7L273

Expressioni

Gene expression databases

BgeeiENSG00000104756
CleanExiHS_KCTD9
ExpressionAtlasiQ7L273 baseline and differential
GenevisibleiQ7L273 HS

Organism-specific databases

HPAiHPA042468
HPA047902

Interactioni

Subunit structurei

Forms pentamers. Component of a complex composed of 5 subunits of KCTD9 and 5 CUL3.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • cullin family protein binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • protein self-association Source: UniProtKB

Protein-protein interaction databases

BioGridi120153, 40 interactors
IntActiQ7L273, 85 interactors
MINTiQ7L273
STRINGi9606.ENSP00000221200

Structurei

Secondary structure

1389
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi90 – 95Combined sources6
Beta strandi98 – 103Combined sources6
Helixi104 – 108Combined sources5
Helixi115 – 119Combined sources5
Beta strandi136 – 138Combined sources3
Turni143 – 145Combined sources3
Helixi146 – 154Combined sources9
Helixi165 – 175Combined sources11
Helixi178 – 188Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5BXHX-ray2.76A/B/C/D/E89-191[»]
ProteinModelPortaliQ7L273
SMRiQ7L273
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 82KHAPROSITE-ProRule annotationAdd BLAST80
Domaini89 – 161BTBPROSITE-ProRule annotationAdd BLAST73
Domaini224 – 256Pentapeptide repeat 1Sequence analysisAdd BLAST33
Domaini258 – 297Pentapeptide repeat 2Sequence analysisAdd BLAST40
Domaini338 – 376Pentapeptide repeat 3Sequence analysisAdd BLAST39

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1665 Eukaryota
COG1357 LUCA
GeneTreeiENSGT00530000062980
HOGENOMiHOG000010269
HOVERGENiHBG052243
InParanoidiQ7L273
KOiK21919
OMAiSYACIKN
OrthoDBiEOG091G07KY
PhylomeDBiQ7L273
TreeFamiTF313754

Family and domain databases

InterProiView protein in InterPro
IPR001646 5peptide_repeat
IPR000210 BTB/POZ_dom
IPR036572 Doublecortin_dom_sf
IPR021789 KHA_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF11834 KHA, 1 hit
PF00805 Pentapeptide, 3 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
SSF89837 SSF89837, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS51490 KHA, 1 hit

Sequencei

Sequence statusi: Complete.

Q7L273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRVTLFLNG SPKNGKVVAV YGTLSDLLSV ASSKLGIKAT SVYNGKGGLI
60 70 80 90 100
DDIALIRDDD VLFVCEGEPF IDPQTDSKPP EGLLGFHTDW LTLNVGGRYF
110 120 130 140 150
TTTRSTLVNK EPDSMLAHMF KDKGVWGNKQ DHRGAFLIDR SPEYFEPILN
160 170 180 190 200
YLRHGQLIVN DGINLLGVLE EARFFGIDSL IEHLEVAIKN SQPPEDHSPI
210 220 230 240 250
SRKEFVRFLL ATPTKSELRC QGLNFSGADL SRLDLRYINF KMANLSRCNL
260 270 280 290 300
AHANLCCANL ERADLSGSVL DCANLQGVKM LCSNAEGASL KLCNFEDPSG
310 320 330 340 350
LKANLEGANL KGVDMEGSQM TGINLRVATL KNAKLKNCNL RGATLAGTDL
360 370 380
ENCDLSGCDL QEANLRGSNV KGAIFEEMLT PLHMSQSVR
Length:389
Mass (Da):42,567
Last modified:July 5, 2004 - v1
Checksum:i43D4AE36F3B9618F
GO

Sequence cautioni

The sequence BAA90904 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12P → R in AAH68518 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021216 mRNA Translation: AAH21216.2
BC068518 mRNA Translation: AAH68518.1
AK000045 mRNA Translation: BAA90904.1 Different initiation.
CCDSiCCDS6048.1
RefSeqiNP_060104.2, NM_017634.3
UniGeneiHs.188763
Hs.72071

Genome annotation databases

EnsembliENST00000221200; ENSP00000221200; ENSG00000104756
GeneIDi54793
KEGGihsa:54793
UCSCiuc003xeo.4 human

Similar proteinsi

Entry informationi

Entry nameiKCTD9_HUMAN
AccessioniPrimary (citable) accession number: Q7L273
Secondary accession number(s): Q6NUM8, Q9NXV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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