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Protein

Protein ABHD13

Gene

ABHD13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei193Charge relay systemBy similarity1
Active sitei268Charge relay systemBy similarity1
Active sitei298Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERihuman-ABHD13. ABHD13-BEM46.
MEROPSiS09.051.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD13Curated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 13Curated
Short name:
Abhydrolase domain-containing protein 13Imported
Gene namesi
Name:ABHD13Imported
Synonyms:C13orf6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20293. ABHD13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 57Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139826.
PharmGKBiPA134862303.

Polymorphism and mutation databases

BioMutaiABHD13.
DMDMi74749881.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002810761 – 337Protein ABHD13Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ7L211.
MaxQBiQ7L211.
PaxDbiQ7L211.
PeptideAtlasiQ7L211.
PRIDEiQ7L211.

PTM databases

PhosphoSitePlusiQ7L211.

Expressioni

Gene expression databases

BgeeiENSG00000139826.
CleanExiHS_ABHD13.
ExpressionAtlasiQ7L211. baseline and differential.
GenevisibleiQ7L211. HS.

Organism-specific databases

HPAiHPA032143.
HPA032144.

Interactioni

Protein-protein interaction databases

IntActiQ7L211. 1 interactor.
STRINGi9606.ENSP00000365063.

Structurei

3D structure databases

ProteinModelPortaliQ7L211.
SMRiQ7L211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serine esterase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4391. Eukaryota.
COG1073. LUCA.
GeneTreeiENSGT00390000000948.
HOGENOMiHOG000007143.
HOVERGENiHBG080816.
InParanoidiQ7L211.
KOiK06889.
OMAiMGHRLQN.
OrthoDBiEOG091G0FPM.
PhylomeDBiQ7L211.
TreeFamiTF315122.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR022742. Hydrolase_4.
[Graphical view]
PfamiPF12146. Hydrolase_4. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7L211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKSWMLWNF VERWLIALAS WSWALCRISL LPLIVTFHLY GGIILLLLIF
60 70 80 90 100
ISIAGILYKF QDVLLYFPEQ PSSSRLYVPM PTGIPHENIF IRTKDGIRLN
110 120 130 140 150
LILIRYTGDN SPYSPTIIYF HGNAGNIGHR LPNALLMLVN LKVNLLLVDY
160 170 180 190 200
RGYGKSEGEA SEEGLYLDSE AVLDYVMTRP DLDKTKIFLF GRSLGGAVAI
210 220 230 240 250
HLASENSHRI SAIMVENTFL SIPHMASTLF SFFPMRYLPL WCYKNKFLSY
260 270 280 290 300
RKISQCRMPS LFISGLSDQL IPPVMMKQLY ELSPSRTKRL AIFPDGTHND
310 320 330
TWQCQGYFTA LEQFIKEVVK SHSPEEMAKT SSNVTII
Length:337
Mass (Da):38,548
Last modified:October 11, 2004 - v1
Checksum:iD8298BF81784827F
GO

Sequence cautioni

The sequence AAH70226 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK075195 differs from that shown. Reason: Erroneous termination at position 167. Translated as Leu.Curated
The sequence BAB55387 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43I → V in AK075195 (PubMed:16303743).Curated1
Sequence conflicti80M → I in AK075195 (PubMed:16303743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027812 mRNA. Translation: BAB55387.1. Different initiation.
AK124864 mRNA. Translation: BAG54109.1.
AK075195 mRNA. No translation available.
AL157762 Genomic DNA. Translation: CAH70630.1.
CH471085 Genomic DNA. Translation: EAX09097.1.
BC022566 mRNA. Translation: AAH22566.2.
BC070226 mRNA. Translation: AAH70226.1. Different initiation.
CCDSiCCDS32007.1.
RefSeqiNP_116248.2. NM_032859.2.
XP_011519430.1. XM_011521128.2.
UniGeneiHs.183528.

Genome annotation databases

EnsembliENST00000375898; ENSP00000365063; ENSG00000139826.
GeneIDi84945.
KEGGihsa:84945.
UCSCiuc001vqq.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027812 mRNA. Translation: BAB55387.1. Different initiation.
AK124864 mRNA. Translation: BAG54109.1.
AK075195 mRNA. No translation available.
AL157762 Genomic DNA. Translation: CAH70630.1.
CH471085 Genomic DNA. Translation: EAX09097.1.
BC022566 mRNA. Translation: AAH22566.2.
BC070226 mRNA. Translation: AAH70226.1. Different initiation.
CCDSiCCDS32007.1.
RefSeqiNP_116248.2. NM_032859.2.
XP_011519430.1. XM_011521128.2.
UniGeneiHs.183528.

3D structure databases

ProteinModelPortaliQ7L211.
SMRiQ7L211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7L211. 1 interactor.
STRINGi9606.ENSP00000365063.

Protein family/group databases

ESTHERihuman-ABHD13. ABHD13-BEM46.
MEROPSiS09.051.

PTM databases

PhosphoSitePlusiQ7L211.

Polymorphism and mutation databases

BioMutaiABHD13.
DMDMi74749881.

Proteomic databases

EPDiQ7L211.
MaxQBiQ7L211.
PaxDbiQ7L211.
PeptideAtlasiQ7L211.
PRIDEiQ7L211.

Protocols and materials databases

DNASUi84945.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375898; ENSP00000365063; ENSG00000139826.
GeneIDi84945.
KEGGihsa:84945.
UCSCiuc001vqq.4. human.

Organism-specific databases

CTDi84945.
GeneCardsiABHD13.
HGNCiHGNC:20293. ABHD13.
HPAiHPA032143.
HPA032144.
neXtProtiNX_Q7L211.
OpenTargetsiENSG00000139826.
PharmGKBiPA134862303.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4391. Eukaryota.
COG1073. LUCA.
GeneTreeiENSGT00390000000948.
HOGENOMiHOG000007143.
HOVERGENiHBG080816.
InParanoidiQ7L211.
KOiK06889.
OMAiMGHRLQN.
OrthoDBiEOG091G0FPM.
PhylomeDBiQ7L211.
TreeFamiTF315122.

Miscellaneous databases

GenomeRNAii84945.
PROiQ7L211.

Gene expression databases

BgeeiENSG00000139826.
CleanExiHS_ABHD13.
ExpressionAtlasiQ7L211. baseline and differential.
GenevisibleiQ7L211. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR022742. Hydrolase_4.
[Graphical view]
PfamiPF12146. Hydrolase_4. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiABHDD_HUMAN
AccessioniPrimary (citable) accession number: Q7L211
Secondary accession number(s): B3KWE7, Q8NBW1, Q96JX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.