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Q7L211

- ABHDD_HUMAN

UniProt

Q7L211 - ABHDD_HUMAN

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Protein

Alpha/beta hydrolase domain-containing protein 13

Gene
ABHD13, C13orf6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei193 – 1931Charge relay system By similarity
Active sitei268 – 2681Charge relay system By similarity
Active sitei298 – 2981Charge relay system By similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

MEROPSiS09.051.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha/beta hydrolase domain-containing protein 13 (EC:3.-.-.-)
Short name:
Abhydrolase domain-containing protein 13
Gene namesi
Name:ABHD13
Synonyms:C13orf6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:20293. ABHD13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134862303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Alpha/beta hydrolase domain-containing protein 13PRO_0000281076Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi299 – 2991N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ7L211.
PaxDbiQ7L211.
PeptideAtlasiQ7L211.
PRIDEiQ7L211.

PTM databases

PhosphoSiteiQ7L211.

Expressioni

Gene expression databases

BgeeiQ7L211.
CleanExiHS_ABHD13.
GenevestigatoriQ7L211.

Organism-specific databases

HPAiHPA032144.

Interactioni

Protein-protein interaction databases

IntActiQ7L211. 1 interaction.
STRINGi9606.ENSP00000365063.

Structurei

3D structure databases

ProteinModelPortaliQ7L211.
SMRiQ7L211. Positions 81-298.

Family & Domainsi

Sequence similaritiesi

Belongs to the serine esterase family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1073.
HOGENOMiHOG000007143.
HOVERGENiHBG080816.
InParanoidiQ7L211.
KOiK06889.
OMAiPEGTHND.
OrthoDBiEOG789CBW.
PhylomeDBiQ7L211.
TreeFamiTF315122.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR029059. AB_hydrolase_5.
[Graphical view]
PfamiPF12695. Abhydrolase_5. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7L211-1 [UniParc]FASTAAdd to Basket

« Hide

MEKSWMLWNF VERWLIALAS WSWALCRISL LPLIVTFHLY GGIILLLLIF    50
ISIAGILYKF QDVLLYFPEQ PSSSRLYVPM PTGIPHENIF IRTKDGIRLN 100
LILIRYTGDN SPYSPTIIYF HGNAGNIGHR LPNALLMLVN LKVNLLLVDY 150
RGYGKSEGEA SEEGLYLDSE AVLDYVMTRP DLDKTKIFLF GRSLGGAVAI 200
HLASENSHRI SAIMVENTFL SIPHMASTLF SFFPMRYLPL WCYKNKFLSY 250
RKISQCRMPS LFISGLSDQL IPPVMMKQLY ELSPSRTKRL AIFPDGTHND 300
TWQCQGYFTA LEQFIKEVVK SHSPEEMAKT SSNVTII 337
Length:337
Mass (Da):38,548
Last modified:October 11, 2004 - v1
Checksum:iD8298BF81784827F
GO

Sequence cautioni

The sequence AAH70226.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB55387.1 differs from that shown. Reason: Erroneous initiation.
The sequence AK075195 differs from that shown. Reason: Erroneous termination at position 167. Translated as Leu.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431I → V in AK075195. 1 Publication
Sequence conflicti80 – 801M → I in AK075195. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027812 mRNA. Translation: BAB55387.1. Different initiation.
AK124864 mRNA. Translation: BAG54109.1.
AK075195 mRNA. No translation available.
AL157762 Genomic DNA. Translation: CAH70630.1.
CH471085 Genomic DNA. Translation: EAX09097.1.
BC022566 mRNA. Translation: AAH22566.2.
BC070226 mRNA. Translation: AAH70226.1. Different initiation.
CCDSiCCDS32007.1.
RefSeqiNP_116248.2. NM_032859.2.
UniGeneiHs.183528.

Genome annotation databases

EnsembliENST00000375898; ENSP00000365063; ENSG00000139826.
GeneIDi84945.
KEGGihsa:84945.
UCSCiuc001vqq.3. human.

Polymorphism databases

DMDMi74749881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027812 mRNA. Translation: BAB55387.1 . Different initiation.
AK124864 mRNA. Translation: BAG54109.1 .
AK075195 mRNA. No translation available.
AL157762 Genomic DNA. Translation: CAH70630.1 .
CH471085 Genomic DNA. Translation: EAX09097.1 .
BC022566 mRNA. Translation: AAH22566.2 .
BC070226 mRNA. Translation: AAH70226.1 . Different initiation.
CCDSi CCDS32007.1.
RefSeqi NP_116248.2. NM_032859.2.
UniGenei Hs.183528.

3D structure databases

ProteinModelPortali Q7L211.
SMRi Q7L211. Positions 81-298.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q7L211. 1 interaction.
STRINGi 9606.ENSP00000365063.

Protein family/group databases

MEROPSi S09.051.

PTM databases

PhosphoSitei Q7L211.

Polymorphism databases

DMDMi 74749881.

Proteomic databases

MaxQBi Q7L211.
PaxDbi Q7L211.
PeptideAtlasi Q7L211.
PRIDEi Q7L211.

Protocols and materials databases

DNASUi 84945.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375898 ; ENSP00000365063 ; ENSG00000139826 .
GeneIDi 84945.
KEGGi hsa:84945.
UCSCi uc001vqq.3. human.

Organism-specific databases

CTDi 84945.
GeneCardsi GC13P108870.
HGNCi HGNC:20293. ABHD13.
HPAi HPA032144.
neXtProti NX_Q7L211.
PharmGKBi PA134862303.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1073.
HOGENOMi HOG000007143.
HOVERGENi HBG080816.
InParanoidi Q7L211.
KOi K06889.
OMAi PEGTHND.
OrthoDBi EOG789CBW.
PhylomeDBi Q7L211.
TreeFami TF315122.

Miscellaneous databases

GenomeRNAii 84945.
NextBioi 75418.
PROi Q7L211.

Gene expression databases

Bgeei Q7L211.
CleanExi HS_ABHD13.
Genevestigatori Q7L211.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR029059. AB_hydrolase_5.
[Graphical view ]
Pfami PF12695. Abhydrolase_5. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus and Placenta.
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiABHDD_HUMAN
AccessioniPrimary (citable) accession number: Q7L211
Secondary accession number(s): B3KWE7, Q8NBW1, Q96JX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi