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Q7L211

- ABHDD_HUMAN

UniProt

Q7L211 - ABHDD_HUMAN

Protein

Alpha/beta hydrolase domain-containing protein 13

Gene

ABHD13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei193 – 1931Charge relay systemBy similarity
    Active sitei268 – 2681Charge relay systemBy similarity
    Active sitei298 – 2981Charge relay systemBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Protein family/group databases

    MEROPSiS09.051.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha/beta hydrolase domain-containing protein 13 (EC:3.-.-.-)
    Short name:
    Abhydrolase domain-containing protein 13
    Gene namesi
    Name:ABHD13
    Synonyms:C13orf6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:20293. ABHD13.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134862303.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337Alpha/beta hydrolase domain-containing protein 13PRO_0000281076Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ7L211.
    PaxDbiQ7L211.
    PeptideAtlasiQ7L211.
    PRIDEiQ7L211.

    PTM databases

    PhosphoSiteiQ7L211.

    Expressioni

    Gene expression databases

    BgeeiQ7L211.
    CleanExiHS_ABHD13.
    GenevestigatoriQ7L211.

    Organism-specific databases

    HPAiHPA032144.

    Interactioni

    Protein-protein interaction databases

    IntActiQ7L211. 1 interaction.
    STRINGi9606.ENSP00000365063.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7L211.
    SMRiQ7L211. Positions 81-298.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serine esterase family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1073.
    HOGENOMiHOG000007143.
    HOVERGENiHBG080816.
    InParanoidiQ7L211.
    KOiK06889.
    OMAiPEGTHND.
    OrthoDBiEOG789CBW.
    PhylomeDBiQ7L211.
    TreeFamiTF315122.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR029059. AB_hydrolase_5.
    [Graphical view]
    PfamiPF12695. Abhydrolase_5. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7L211-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKSWMLWNF VERWLIALAS WSWALCRISL LPLIVTFHLY GGIILLLLIF    50
    ISIAGILYKF QDVLLYFPEQ PSSSRLYVPM PTGIPHENIF IRTKDGIRLN 100
    LILIRYTGDN SPYSPTIIYF HGNAGNIGHR LPNALLMLVN LKVNLLLVDY 150
    RGYGKSEGEA SEEGLYLDSE AVLDYVMTRP DLDKTKIFLF GRSLGGAVAI 200
    HLASENSHRI SAIMVENTFL SIPHMASTLF SFFPMRYLPL WCYKNKFLSY 250
    RKISQCRMPS LFISGLSDQL IPPVMMKQLY ELSPSRTKRL AIFPDGTHND 300
    TWQCQGYFTA LEQFIKEVVK SHSPEEMAKT SSNVTII 337
    Length:337
    Mass (Da):38,548
    Last modified:October 11, 2004 - v1
    Checksum:iD8298BF81784827F
    GO

    Sequence cautioni

    The sequence AAH70226.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB55387.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AK075195 differs from that shown. Reason: Erroneous termination at position 167. Translated as Leu.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti43 – 431I → V in AK075195. (PubMed:16303743)Curated
    Sequence conflicti80 – 801M → I in AK075195. (PubMed:16303743)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027812 mRNA. Translation: BAB55387.1. Different initiation.
    AK124864 mRNA. Translation: BAG54109.1.
    AK075195 mRNA. No translation available.
    AL157762 Genomic DNA. Translation: CAH70630.1.
    CH471085 Genomic DNA. Translation: EAX09097.1.
    BC022566 mRNA. Translation: AAH22566.2.
    BC070226 mRNA. Translation: AAH70226.1. Different initiation.
    CCDSiCCDS32007.1.
    RefSeqiNP_116248.2. NM_032859.2.
    UniGeneiHs.183528.

    Genome annotation databases

    EnsembliENST00000375898; ENSP00000365063; ENSG00000139826.
    GeneIDi84945.
    KEGGihsa:84945.
    UCSCiuc001vqq.3. human.

    Polymorphism databases

    DMDMi74749881.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027812 mRNA. Translation: BAB55387.1 . Different initiation.
    AK124864 mRNA. Translation: BAG54109.1 .
    AK075195 mRNA. No translation available.
    AL157762 Genomic DNA. Translation: CAH70630.1 .
    CH471085 Genomic DNA. Translation: EAX09097.1 .
    BC022566 mRNA. Translation: AAH22566.2 .
    BC070226 mRNA. Translation: AAH70226.1 . Different initiation.
    CCDSi CCDS32007.1.
    RefSeqi NP_116248.2. NM_032859.2.
    UniGenei Hs.183528.

    3D structure databases

    ProteinModelPortali Q7L211.
    SMRi Q7L211. Positions 81-298.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q7L211. 1 interaction.
    STRINGi 9606.ENSP00000365063.

    Protein family/group databases

    MEROPSi S09.051.

    PTM databases

    PhosphoSitei Q7L211.

    Polymorphism databases

    DMDMi 74749881.

    Proteomic databases

    MaxQBi Q7L211.
    PaxDbi Q7L211.
    PeptideAtlasi Q7L211.
    PRIDEi Q7L211.

    Protocols and materials databases

    DNASUi 84945.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375898 ; ENSP00000365063 ; ENSG00000139826 .
    GeneIDi 84945.
    KEGGi hsa:84945.
    UCSCi uc001vqq.3. human.

    Organism-specific databases

    CTDi 84945.
    GeneCardsi GC13P108870.
    HGNCi HGNC:20293. ABHD13.
    HPAi HPA032144.
    neXtProti NX_Q7L211.
    PharmGKBi PA134862303.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1073.
    HOGENOMi HOG000007143.
    HOVERGENi HBG080816.
    InParanoidi Q7L211.
    KOi K06889.
    OMAi PEGTHND.
    OrthoDBi EOG789CBW.
    PhylomeDBi Q7L211.
    TreeFami TF315122.

    Miscellaneous databases

    GenomeRNAii 84945.
    NextBioi 75418.
    PROi Q7L211.

    Gene expression databases

    Bgeei Q7L211.
    CleanExi HS_ABHD13.
    Genevestigatori Q7L211.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR029059. AB_hydrolase_5.
    [Graphical view ]
    Pfami PF12695. Abhydrolase_5. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hippocampus and Placenta.
    2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    3. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiABHDD_HUMAN
    AccessioniPrimary (citable) accession number: Q7L211
    Secondary accession number(s): B3KWE7, Q8NBW1, Q96JX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3