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Protein

Vacuolar fusion protein MON1 homolog B

Gene

MON1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • early viral transcription Source: UniProtKB
  • late viral transcription Source: UniProtKB
  • vesicle-mediated transport Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar fusion protein MON1 homolog B
Alternative name(s):
HSV-1 stimulation-related gene 1 protein
HSV-I stimulating-related protein
Gene namesi
Name:MON1B
Synonyms:HSRG1, KIAA0872, SAND2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25020. MON1B.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • endomembrane system Source: GO_Central
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671341.

Polymorphism and mutation databases

DMDMi74738536.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Vacuolar fusion protein MON1 homolog BPRO_0000285765Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei59 – 591PhosphoserineCombined sources
Modified residuei61 – 611PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ7L1V2.
MaxQBiQ7L1V2.
PaxDbiQ7L1V2.
PeptideAtlasiQ7L1V2.
PRIDEiQ7L1V2.
TopDownProteomicsiQ7L1V2-1. [Q7L1V2-1]

PTM databases

iPTMnetiQ7L1V2.
PhosphoSiteiQ7L1V2.

Expressioni

Inductioni

Induced in fibroblast KMB17 cells by HSV-1.1 Publication

Gene expression databases

BgeeiENSG00000103111.
CleanExiHS_MON1B.
ExpressionAtlasiQ7L1V2. baseline and differential.
GenevisibleiQ7L1V2. HS.

Organism-specific databases

HPAiHPA046285.

Interactioni

Subunit structurei

Interacts with CCNT2; downregulates CCNT2-mediated activation of viral promoters during herpes simplex virus 1/HHV-1 infection.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
VPS18Q9P2532EBI-2655311,EBI-1053363

Protein-protein interaction databases

BioGridi116546. 9 interactions.
IntActiQ7L1V2. 9 interactions.
MINTiMINT-4657863.
STRINGi9606.ENSP00000248248.

Structurei

3D structure databases

ProteinModelPortaliQ7L1V2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MON1/SAND family.Curated

Phylogenomic databases

eggNOGiKOG0997. Eukaryota.
ENOG410XR29. LUCA.
GeneTreeiENSGT00390000006665.
HOGENOMiHOG000031337.
HOVERGENiHBG064381.
InParanoidiQ7L1V2.
KOiK20195.
OMAiDEEWRSQ.
OrthoDBiEOG091G066A.
PhylomeDBiQ7L1V2.

Family and domain databases

InterProiIPR004353. Vacuolar_fusion_protein_MON1.
[Graphical view]
PANTHERiPTHR13027. PTHR13027. 1 hit.
PfamiPF03164. Mon1. 1 hit.
[Graphical view]
PRINTSiPR01546. YEAST73DUF.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7L1V2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVGGDTAAP APGGAEDLED TQFPSEEARE GGGVHAVPPD PEDEGLEETG
60 70 80 90 100
SKDKDQPPSP SPPPQSEALS STSRLWSPAA PENSPTCSPE SSSGGQGGDP
110 120 130 140 150
SDEEWRSQRK HVFVLSEAGK PIYSRYGSVE ALSATMGVMT ALVSFVQSAG
160 170 180 190 200
DAIRAIYAED HKLVFLQQGP LLLVAMSRTS QSAAQLRGEL LAVHAQIVST
210 220 230 240 250
LTRASVARIF AHKQNYDLRR LLAGSERTLD RLLDSMEQDP GALLLGAVRC
260 270 280 290 300
VPLARPLRDA LGALLRRCTA PGLALSVLAV GGRLITAAQE RNVLAECRLD
310 320 330 340 350
PADLQLLLDW VGAPAFAAGE AWAPVCLPRF NPDGFFYAYV ARLDAMPVCL
360 370 380 390 400
LLLGTQREAF HAMAACRRLV EDGMHALGAM RALGEAASFS NASSASAPAY
410 420 430 440 450
SVQAVGAPGL RHFLYKPLDI PDHHRQLPQF TSPELEAPYS REEERQRLSD
460 470 480 490 500
LYHRLHARLH STSRPLRLIY HVAEKETLLA WVTSKFELYT CLSPLVTKAG
510 520 530 540
AILVVTKLLR WVKKEEDRLF IRYPPKYSTP PATSTDQAAH NGLFTGL
Length:547
Mass (Da):59,217
Last modified:July 5, 2004 - v1
Checksum:i06ED0B7C42AA2D17
GO
Isoform 2 (identifier: Q7L1V2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MEVGGDTAAPAP → MVSGQLRFGVKT
     13-158: Missing.

Note: No experimental confirmation available.
Show »
Length:401
Mass (Da):44,195
Checksum:iE53A035B772EE75B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1212MEVGG…AAPAP → MVSGQLRFGVKT in isoform 2. 1 PublicationVSP_054664Add
BLAST
Alternative sequencei13 – 158146Missing in isoform 2. 1 PublicationVSP_054665Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF442486 mRNA. Translation: AAL35292.1.
AB020679 mRNA. Translation: BAA74895.2.
AK293392 mRNA. Translation: BAG56901.1.
AC009139 Genomic DNA. No translation available.
BC024277 mRNA. Translation: AAH24277.1.
CCDSiCCDS10925.1. [Q7L1V2-1]
CCDS67082.1. [Q7L1V2-2]
RefSeqiNP_001273568.1. NM_001286639.1.
NP_001273569.1. NM_001286640.1. [Q7L1V2-2]
NP_055755.1. NM_014940.3. [Q7L1V2-1]
UniGeneiHs.513743.

Genome annotation databases

EnsembliENST00000248248; ENSP00000248248; ENSG00000103111. [Q7L1V2-1]
ENST00000545553; ENSP00000444881; ENSG00000103111. [Q7L1V2-2]
GeneIDi22879.
KEGGihsa:22879.
UCSCiuc002fez.5. human. [Q7L1V2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF442486 mRNA. Translation: AAL35292.1.
AB020679 mRNA. Translation: BAA74895.2.
AK293392 mRNA. Translation: BAG56901.1.
AC009139 Genomic DNA. No translation available.
BC024277 mRNA. Translation: AAH24277.1.
CCDSiCCDS10925.1. [Q7L1V2-1]
CCDS67082.1. [Q7L1V2-2]
RefSeqiNP_001273568.1. NM_001286639.1.
NP_001273569.1. NM_001286640.1. [Q7L1V2-2]
NP_055755.1. NM_014940.3. [Q7L1V2-1]
UniGeneiHs.513743.

3D structure databases

ProteinModelPortaliQ7L1V2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116546. 9 interactions.
IntActiQ7L1V2. 9 interactions.
MINTiMINT-4657863.
STRINGi9606.ENSP00000248248.

PTM databases

iPTMnetiQ7L1V2.
PhosphoSiteiQ7L1V2.

Polymorphism and mutation databases

DMDMi74738536.

Proteomic databases

EPDiQ7L1V2.
MaxQBiQ7L1V2.
PaxDbiQ7L1V2.
PeptideAtlasiQ7L1V2.
PRIDEiQ7L1V2.
TopDownProteomicsiQ7L1V2-1. [Q7L1V2-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248248; ENSP00000248248; ENSG00000103111. [Q7L1V2-1]
ENST00000545553; ENSP00000444881; ENSG00000103111. [Q7L1V2-2]
GeneIDi22879.
KEGGihsa:22879.
UCSCiuc002fez.5. human. [Q7L1V2-1]

Organism-specific databases

CTDi22879.
GeneCardsiMON1B.
HGNCiHGNC:25020. MON1B.
HPAiHPA046285.
MIMi608954. gene.
neXtProtiNX_Q7L1V2.
PharmGKBiPA142671341.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0997. Eukaryota.
ENOG410XR29. LUCA.
GeneTreeiENSGT00390000006665.
HOGENOMiHOG000031337.
HOVERGENiHBG064381.
InParanoidiQ7L1V2.
KOiK20195.
OMAiDEEWRSQ.
OrthoDBiEOG091G066A.
PhylomeDBiQ7L1V2.

Miscellaneous databases

GenomeRNAii22879.
PROiQ7L1V2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103111.
CleanExiHS_MON1B.
ExpressionAtlasiQ7L1V2. baseline and differential.
GenevisibleiQ7L1V2. HS.

Family and domain databases

InterProiIPR004353. Vacuolar_fusion_protein_MON1.
[Graphical view]
PANTHERiPTHR13027. PTHR13027. 1 hit.
PfamiPF03164. Mon1. 1 hit.
[Graphical view]
PRINTSiPR01546. YEAST73DUF.
ProtoNetiSearch...

Entry informationi

Entry nameiMON1B_HUMAN
AccessioniPrimary (citable) accession number: Q7L1V2
Secondary accession number(s): B4DDZ0, O94949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.