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Q7L1T6

- NB5R4_HUMAN

UniProt

Q7L1T6 - NB5R4_HUMAN

Protein

Cytochrome b5 reductase 4

Gene

CYB5R4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.

    Catalytic activityi

    NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5.

    Cofactori

    FAD.1 Publication

    Redox potential

    E0 is -108 mV.

    Kineticsi

    1. KM=25 mM for O2

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi89 – 891Iron (heme axial ligand)
    Metal bindingi112 – 1121Iron (heme axial ligand)

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi365 – 38016FADBy similarityAdd
    BLAST
    Nucleotide bindingi392 – 42433FADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. cytochrome-b5 reductase activity, acting on NAD(P)H Source: UniProtKB
    2. flavin adenine dinucleotide binding Source: Ensembl
    3. heme binding Source: Ensembl
    4. metal ion binding Source: UniProtKB-KW
    5. NAD(P)H oxidase activity Source: UniProtKB
    6. NADPH-hemoprotein reductase activity Source: Ensembl
    7. oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor Source: UniProtKB

    GO - Biological processi

    1. cell development Source: UniProtKB
    2. detection of oxygen Source: UniProtKB
    3. generation of precursor metabolites and energy Source: UniProtKB
    4. glucose homeostasis Source: UniProtKB
    5. insulin secretion Source: UniProtKB
    6. NADP metabolic process Source: Ensembl
    7. oxidation-reduction process Source: UniProtKB
    8. response to antibiotic Source: UniProtKB
    9. superoxide metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, Heme, Iron, Metal-binding, NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b5 reductase 4 (EC:1.6.2.2)
    Alternative name(s):
    Flavohemoprotein b5/b5R
    Short name:
    b5+b5R
    N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein
    cb5/cb5R
    Gene namesi
    Name:CYB5R4
    Synonyms:NCB5OR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:20147. CYB5R4.

    Subcellular locationi

    Endoplasmic reticulum 2 Publications
    Note: Soluble protein.

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134904907.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Cytochrome b5 reductase 4PRO_0000287556Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ7L1T6.
    PaxDbiQ7L1T6.
    PRIDEiQ7L1T6.

    PTM databases

    PhosphoSiteiQ7L1T6.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ7L1T6.
    BgeeiQ7L1T6.
    CleanExiHS_CYB5R4.
    GenevestigatoriQ7L1T6.

    Organism-specific databases

    HPAiHPA018992.

    Interactioni

    Protein-protein interaction databases

    BioGridi119347. 2 interactions.
    IntActiQ7L1T6. 1 interaction.
    MINTiMINT-4714403.
    STRINGi9606.ENSP00000358695.

    Structurei

    Secondary structure

    1
    521
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi53 – 575
    Helixi59 – 646
    Beta strandi70 – 756
    Beta strandi78 – 814
    Helixi83 – 853
    Turni86 – 883
    Helixi93 – 975
    Turni98 – 1014
    Helixi105 – 1128
    Helixi117 – 1204
    Helixi122 – 1243
    Beta strandi125 – 1295
    Helixi133 – 1364

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3LF5X-ray1.25A/B51-137[»]
    ProteinModelPortaliQ7L1T6.
    SMRiQ7L1T6. Positions 51-137, 275-495.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7L1T6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 13077Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini165 – 25692CSPROSITE-ProRule annotationAdd
    BLAST
    Domaini273 – 385113FAD-binding FR-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CS domain.PROSITE-ProRule annotation
    Contains 1 cytochrome b5 heme-binding domain.PROSITE-ProRule annotation
    Contains 1 FAD-binding FR-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0543.
    HOGENOMiHOG000230826.
    HOVERGENiHBG108174.
    InParanoidiQ7L1T6.
    OMAiKDYHEEK.
    OrthoDBiEOG718KBZ.
    PhylomeDBiQ7L1T6.
    TreeFamiTF313874.

    Family and domain databases

    Gene3Di2.60.40.790. 1 hit.
    3.10.120.10. 1 hit.
    InterProiIPR007052. CS_dom.
    IPR001199. Cyt_B5-like_heme/steroid-bd.
    IPR018506. Cyt_B5_heme-BS.
    IPR017927. Fd_Rdtase_FAD-bd.
    IPR008978. HSP20-like_chaperone.
    IPR001834. NADH-Cyt_B5_reductase.
    IPR008333. OxRdtase_FAD-bd_dom.
    IPR001433. OxRdtase_FAD/NAD-bd.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view]
    PfamiPF04969. CS. 1 hit.
    PF00173. Cyt-b5. 1 hit.
    PF00970. FAD_binding_6. 1 hit.
    PF00175. NAD_binding_1. 1 hit.
    [Graphical view]
    PRINTSiPR00406. CYTB5RDTASE.
    PR00363. CYTOCHROMEB5.
    SUPFAMiSSF49764. SSF49764. 1 hit.
    SSF55856. SSF55856. 1 hit.
    SSF63380. SSF63380. 1 hit.
    PROSITEiPS51203. CS. 1 hit.
    PS00191. CYTOCHROME_B5_1. 1 hit.
    PS50255. CYTOCHROME_B5_2. 1 hit.
    PS51384. FAD_FR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7L1T6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNVPSQSFP APRSQQRVAS GGRSKVPLKQ GRSLMDWIRL TKSGKDLTGL    50
    KGRLIEVTEE ELKKHNKKDD CWICIRGFVY NVSPYMEYHP GGEDELMRAA 100
    GSDGTELFDQ VHRWVNYESM LKECLVGRMA IKPAVLKDYR EEEKKVLNGM 150
    LPKSQVTDTL AKEGPSYPSY DWFQTDSLVT IAIYTKQKDI NLDSIIVDHQ 200
    NDSFRAETII KDCLYLIHIG LSHEVQEDFS VRVVESVGKI EIVLQKKENT 250
    SWDFLGHPLK NHNSLIPRKD TGLYYRKCQL ISKEDVTHDT RLFCLMLPPS 300
    THLQVPIGQH VYLKLPITGT EIVKPYTPVS GSLLSEFKEP VLPNNKYIYF 350
    LIKIYPTGLF TPELDRLQIG DFVSVSSPEG NFKISKFQEL EDLFLLAAGT 400
    GFTPMVKILN YALTDIPSLR KVKLMFFNKT EDDIIWRSQL EKLAFKDKRL 450
    DVEFVLSAPI SEWNGKQGHI SPALLSEFLK RNLDKSKVLV CICGPVPFTE 500
    QGVRLLHDLN FSKNEIHSFT A 521
    Length:521
    Mass (Da):59,474
    Last modified:August 30, 2005 - v1
    Checksum:i9D83BAB387E3B0F4
    GO

    Sequence cautioni

    The sequence AAF04812.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI19905.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI22326.1 differs from that shown. Reason: Erroneous gene model prediction.

    Polymorphismi

    Variants Arg-187 and Arg-223 do not influence the pathogenesis of non-autoimmune diabetes.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti140 – 1401R → H.1 Publication
    Corresponds to variant rs61762820 [ dbSNP | Ensembl ].
    VAR_047967
    Natural varianti187 – 1871Q → R.1 Publication
    VAR_032323
    Natural varianti223 – 2231H → R.1 Publication
    Corresponds to variant rs141290525 [ dbSNP | Ensembl ].
    VAR_032324
    Natural varianti267 – 2671P → A.1 Publication
    Corresponds to variant rs61382555 [ dbSNP | Ensembl ].
    VAR_047968
    Natural varianti282 – 2821S → P.
    Corresponds to variant rs10080628 [ dbSNP | Ensembl ].
    VAR_032325
    Natural varianti316 – 3161P → S.1 Publication
    Corresponds to variant rs10080628 [ dbSNP | Ensembl ].
    VAR_047969
    Natural varianti371 – 3711D → Y in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036240
    Natural varianti390 – 3901L → M in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036241

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU448291 Genomic DNA. Translation: ACA06109.1.
    AL139232, AL034347 Genomic DNA. Translation: CAI19904.2.
    AL034347, AL139232 Genomic DNA. Translation: CAI22325.2.
    AL034347, AL139232 Genomic DNA. Translation: CAI22326.1. Sequence problems.
    AL139232, AL034347 Genomic DNA. Translation: CAI19905.1. Sequence problems.
    BC025380 mRNA. Translation: AAH25380.2.
    AF169803 mRNA. Translation: AAF04812.1. Different initiation.
    CCDSiCCDS5000.2.
    RefSeqiNP_057314.2. NM_016230.3.
    UniGeneiHs.5741.

    Genome annotation databases

    EnsembliENST00000369681; ENSP00000358695; ENSG00000065615.
    GeneIDi51167.
    KEGGihsa:51167.
    UCSCiuc003pkf.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU448291 Genomic DNA. Translation: ACA06109.1 .
    AL139232 , AL034347 Genomic DNA. Translation: CAI19904.2 .
    AL034347 , AL139232 Genomic DNA. Translation: CAI22325.2 .
    AL034347 , AL139232 Genomic DNA. Translation: CAI22326.1 . Sequence problems.
    AL139232 , AL034347 Genomic DNA. Translation: CAI19905.1 . Sequence problems.
    BC025380 mRNA. Translation: AAH25380.2 .
    AF169803 mRNA. Translation: AAF04812.1 . Different initiation.
    CCDSi CCDS5000.2.
    RefSeqi NP_057314.2. NM_016230.3.
    UniGenei Hs.5741.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3LF5 X-ray 1.25 A/B 51-137 [» ]
    ProteinModelPortali Q7L1T6.
    SMRi Q7L1T6. Positions 51-137, 275-495.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119347. 2 interactions.
    IntActi Q7L1T6. 1 interaction.
    MINTi MINT-4714403.
    STRINGi 9606.ENSP00000358695.

    PTM databases

    PhosphoSitei Q7L1T6.

    Proteomic databases

    MaxQBi Q7L1T6.
    PaxDbi Q7L1T6.
    PRIDEi Q7L1T6.

    Protocols and materials databases

    DNASUi 51167.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369681 ; ENSP00000358695 ; ENSG00000065615 .
    GeneIDi 51167.
    KEGGi hsa:51167.
    UCSCi uc003pkf.3. human.

    Organism-specific databases

    CTDi 51167.
    GeneCardsi GC06P084569.
    HGNCi HGNC:20147. CYB5R4.
    HPAi HPA018992.
    MIMi 608343. gene.
    neXtProti NX_Q7L1T6.
    PharmGKBi PA134904907.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0543.
    HOGENOMi HOG000230826.
    HOVERGENi HBG108174.
    InParanoidi Q7L1T6.
    OMAi KDYHEEK.
    OrthoDBi EOG718KBZ.
    PhylomeDBi Q7L1T6.
    TreeFami TF313874.

    Miscellaneous databases

    EvolutionaryTracei Q7L1T6.
    GeneWikii CYB5R4.
    GenomeRNAii 51167.
    NextBioi 54103.
    PROi Q7L1T6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7L1T6.
    Bgeei Q7L1T6.
    CleanExi HS_CYB5R4.
    Genevestigatori Q7L1T6.

    Family and domain databases

    Gene3Di 2.60.40.790. 1 hit.
    3.10.120.10. 1 hit.
    InterProi IPR007052. CS_dom.
    IPR001199. Cyt_B5-like_heme/steroid-bd.
    IPR018506. Cyt_B5_heme-BS.
    IPR017927. Fd_Rdtase_FAD-bd.
    IPR008978. HSP20-like_chaperone.
    IPR001834. NADH-Cyt_B5_reductase.
    IPR008333. OxRdtase_FAD-bd_dom.
    IPR001433. OxRdtase_FAD/NAD-bd.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view ]
    Pfami PF04969. CS. 1 hit.
    PF00173. Cyt-b5. 1 hit.
    PF00970. FAD_binding_6. 1 hit.
    PF00175. NAD_binding_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00406. CYTB5RDTASE.
    PR00363. CYTOCHROMEB5.
    SUPFAMi SSF49764. SSF49764. 1 hit.
    SSF55856. SSF55856. 1 hit.
    SSF63380. SSF63380. 1 hit.
    PROSITEi PS51203. CS. 1 hit.
    PS00191. CYTOCHROME_B5_1. 1 hit.
    PS50255. CYTOCHROME_B5_2. 1 hit.
    PS51384. FAD_FR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. SeattleSNPs variation discovery resource
      Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-140; ALA-267 AND SER-316.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells."
      Zhu H., Qiu H., Yoon H.-W., Huang S., Bunn H.F.
      Proc. Natl. Acad. Sci. U.S.A. 96:14742-14747(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-521, SUBCELLULAR LOCATION, HEME-BINDING, FAD-BINDING, TISSUE SPECIFICITY.
    5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain."
      Deng B., Parthasarathy S., Wang W., Gibney B.R., Battaile K.P., Lovell S., Benson D.R., Zhu H.
      J. Biol. Chem. 285:30181-30191(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 51-137, HEME-BINDING SITES.
    7. "Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus."
      Andersen G., Wegner L., Rose C.S., Xie J., Zhu H., Larade K., Johansen A., Ek J., Lauenborg J., Drivsholm T., Borch-Johnsen K., Damm P., Hansen T., Bunn H.F., Pedersen O.
      Diabetes 53:2992-2997(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ARG-187 AND ARG-223.
    8. Cited for: SUBCELLULAR LOCATION.
    9. Cited for: VARIANTS [LARGE SCALE ANALYSIS] TYR-371 AND MET-390.

    Entry informationi

    Entry nameiNB5R4_HUMAN
    AccessioniPrimary (citable) accession number: Q7L1T6
    Secondary accession number(s): B1AEM2
    , Q5TGI9, Q9NUE4, Q9UHI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3