Reviewed, UniProtKB/Swiss-Prot Q7L1Q6 (BZW1_HUMAN)

Names and origin

Protein names

Recommended name:
    Basic leucine zipper and W2 domain-containing protein 1
Alternative name(s):
    Protein Orf

Gene names

Name:	BZW1
Synonyms:	BZAP45, KIAA0005

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Enhances histone H4 gene transcription but does not seem to bind DNA directly. Ref.5
Developmental stage	Expressed in day 3 embryo. Ref.5
Sequence similarities	Belongs to the BZW family. Contains 1 W2 domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Coding sequence diversity	Alternative splicing
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from direct assay. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BZW2	Q9Y6E2	1	EBI-1046727,EBI-1051021
CMYA5	Q8N3K9	1	EBI-1046727,EBI-2323272
DCTN1	Q14203	1	EBI-1046727,EBI-724352
EDEM1	Q92611	1	EBI-1046727,EBI-1056336
KDELR1	P24390	1	EBI-1046727,EBI-1043076
MAGI1	Q96QZ7	1	EBI-1046727,EBI-924464
PREX1	Q8TCU6	1	EBI-1046727,EBI-1046542
PSTPIP1	O43586	1	EBI-1046727,EBI-1050964

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7L1Q6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7L1Q6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     286-351: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	Basic leucine zipper and W2 domain-containing protein 1		PRO_0000254609
Regions
	Domain	247 – 414	168	W2
Amino acid modifications
	Modified residue	411	1	Phosphoserine Ref.6 Ref.7 Ref.8 Ref.9
	Modified residue	413	1	Phosphoserine Ref.6 Ref.8 Ref.9
Natural variations
	Alternative sequence	286 – 351	66	Missing in isoform 2.		VSP_021266

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 9E952D52F5796F60	FASTA	419	48,043
	10 20 30 40 50 60 MNNQKQQKPT LSGQRFKTRK RDEKERFDPT QFQDCIIQGL TETGTDLEAV AKFLDASGAK 70 80 90 100 110 120 LDYRRYAETL FDILVAGGML APGGTLADDM MRTDVCVFAA QEDLETMQAF AQVFNKLIRR 130 140 150 160 170 180 YKYLEKGFED EVKKLLLFLK GFSESERNKL AMLTGVLLAN GTLNASILNS LYNENLVKEG 190 200 210 220 230 240 VSAAFAVKLF KSWINEKDIN AVAASLRKVS MDNRLMELFP ANKQSVEHFT KYFTEAGLKE 250 260 270 280 290 300 LSEYVRNQQT IGARKELQKE LQEQMSRGDP FKDIILYVKE EMKKNNIPEP VVIGIVWSSV 310 320 330 340 350 360 MSTVEWNKKE ELVAEQAIKH LKQYSPLLAA FTTQGQSELT LLLKIQEYCY DNIHFMKAFQ 370 380 390 400 410 KIVVLFYKAE VLSEEPILKW YKDAHVAKGK SVFLEQMKKF VEWLKNAEEE SESEAEEGD
	Isoform 2. Checksum: 1BD26FB298F41F56	FASTA	353	40,539
	10 20 30 40 50 60 MNNQKQQKPT LSGQRFKTRK RDEKERFDPT QFQDCIIQGL TETGTDLEAV AKFLDASGAK 70 80 90 100 110 120 LDYRRYAETL FDILVAGGML APGGTLADDM MRTDVCVFAA QEDLETMQAF AQVFNKLIRR 130 140 150 160 170 180 YKYLEKGFED EVKKLLLFLK GFSESERNKL AMLTGVLLAN GTLNASILNS LYNENLVKEG 190 200 210 220 230 240 VSAAFAVKLF KSWINEKDIN AVAASLRKVS MDNRLMELFP ANKQSVEHFT KYFTEAGLKE 250 260 270 280 290 300 LSEYVRNQQT IGARKELQKE LQEQMSRGDP FKDIILYVKE EMKKNNIHFM KAFQKIVVLF 310 320 330 340 350 YKAEVLSEEP ILKWYKDAHV AKGKSVFLEQ MKKFVEWLKN AEEESESEAE EGD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1." Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S. DNA Res. 1:27-35(1994) [PubMed: 7584026] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Eye.
[4]	"Characterization of different mRNA types expressed in human brain." Dmitrenko V.V., Garifulin O.M., Kavsan V.M. Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-74. Tissue: Fetal brain.
[5]	"Purification and functional analysis of a novel leucine-zipper/nucleotide-fold protein, BZAP45, stimulating cell cycle regulated histone H4 gene transcription." Mitra P., Vaughan P.S., Stein J.L., Stein G.S., van Wijnen A.J. Biochemistry 40:10693-10699(2001) [PubMed: 11524015] [Abstract] Cited for: PROTEIN SEQUENCE OF 6-15, DEVELOPMENTAL STAGE, FUNCTION.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411 AND SER-413, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411, MASS SPECTROMETRY. Tissue: Epithelium.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411 AND SER-413, MASS SPECTROMETRY.
[9]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411 AND SER-413, MASS SPECTROMETRY. Tissue: Liver.
[10]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411 AND SER-413, MASS SPECTROMETRY. Tissue: T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D13630 mRNA. Translation: BAA02795.2. Different initiation. AC007163 Genomic DNA. Translation: AAX93286.1. BC001804 mRNA. Translation: AAH01804.1. BC026303 mRNA. Translation: AAH26303.1. Z70221 mRNA. Translation: CAA94180.1.
IPI	IPI00180128. IPI00785096.
RefSeq	NP_055485.2.
UniGene	Hs.355983
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7L1Q6. 8 interactions.
STRING	Q7L1Q6.
PTM databases
PhosphoSite	Q7L1Q6.
Proteomic databases
PRIDE	Q7L1Q6.
Genome annotation databases
Ensembl	ENST00000409226; ENSP00000386837; ENSG00000082153; Homo sapiens. [Genome view] ENST00000409600; ENSP00000386474; ENSG00000082153; Homo sapiens. [Genome view] ENST00000431249; ENSP00000391867; ENSG00000082153; Homo sapiens. [Genome view] ENST00000452790; ENSP00000394316; ENSG00000082153; Homo sapiens. [Genome view]
GeneID	9689.
KEGG	hsa:9689.
UCSC	uc002uwc.1. human.
Organism-specific databases
CTD	9689.
GeneCards	GC02P201384.
HGNC	HGNC:18380. BZW1.
PharmGKB	PA38535.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q7L1Q6.
OrthoDB	EOG973S9J
Gene expression databases
ArrayExpress	Q7L1Q6.
Bgee	Q7L1Q6.
CleanEx	HS_BZW1.
Genevestigator	Q7L1Q6.
GermOnline	ENSG00000082153. Homo sapiens.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. IPR003307. eIF5C. [Graphical view]
Gene3D	G3DSA:1.25.40.230. eIF5C. 1 hit.
Pfam	PF02020. W2. 1 hit. [Graphical view]
SMART	SM00515. eIF5C. 1 hit. [Graphical view]
PROSITE	PS51363. W2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	36391.

Entry information

Entry name

BZW1_HUMAN

Accession

Primary (citable) accession number: Q7L1Q6
Secondary accession number(s): Q14281, Q15394, Q9BUY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 5, 2004
Last modified:	November 24, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.