Q7L1I2 (SV2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synaptic vesicle glycoprotein 2B

Gene names

Name:	SV2B
Synonyms:	KIAA0735

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	683 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probably plays a role in the control of regulated secretion in neural and endocrine cells By similarity.
Subunit structure	Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25 By similarity.
Subcellular location	Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Multi-pass membrane protein By similarity. Cytoplasmic vesicle › secretory vesicle › acrosome By similarity. Note: Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas. Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids By similarity.
Post-translational modification	N-glycosylated By similarity. The N-terminal cytoplasmic domain is phosphorylated by CK1 By similarity.
Sequence similarities	Belongs to the major facilitator superfamily.
Sequence caution	The sequence BAA34455.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Neurotransmitter transport Transport
Cellular component	Cell junction Cytoplasmic vesicle Membrane Synapse
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neurotransmitter transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	acrosomal vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW synaptic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7L1I2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7L1I2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 683	683	Synaptic vesicle glycoprotein 2B		PRO_0000239768
Regions
	Topological domain	1 – 108	108	Cytoplasmic Potential
	Transmembrane	109 – 129	21	Helical; Potential
	Topological domain	130 – 148	19	Extracellular Potential
	Transmembrane	149 – 169	21	Helical; Potential
	Topological domain	170 – 182	13	Cytoplasmic Potential
	Transmembrane	183 – 203	21	Helical; Potential
	Topological domain	204 – 205	2	Extracellular Potential
	Transmembrane	206 – 226	21	Helical; Potential
	Topological domain	227 – 237	11	Cytoplasmic Potential
	Transmembrane	238 – 258	21	Helical; Potential
	Topological domain	259 – 277	19	Extracellular Potential
	Transmembrane	278 – 298	21	Helical; Potential
	Topological domain	299 – 390	92	Cytoplasmic Potential
	Transmembrane	391 – 411	21	Helical; Potential
	Topological domain	412 – 535	124	Extracellular Potential
	Transmembrane	536 – 556	21	Helical; Potential
	Topological domain	557 – 565	9	Cytoplasmic Potential
	Transmembrane	566 – 586	21	Helical; Potential
	Topological domain	587 – 592	6	Extracellular Potential
	Transmembrane	593 – 613	21	Helical; Potential
	Topological domain	614 – 626	13	Cytoplasmic Potential
	Transmembrane	627 – 649	23	Helical; Potential
	Topological domain	650 – 653	4	Extracellular Potential
	Transmembrane	654 – 672	19	Helical; Potential
	Topological domain	673 – 683	11	Cytoplasmic Potential
Amino acid modifications
	Modified residue	423	1	Phosphotyrosine By similarity
	Glycosylation	441	1	N-linked (GlcNAc...) Potential
	Glycosylation	491	1	N-linked (GlcNAc...) Potential
	Glycosylation	516	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 151	151	Missing in isoform 2.		VSP_045194
Experimental info
	Sequence conflict	683	1	M → I in CAG33367. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B9818120898F09E2	FASTA	683	77,444
	10 20 30 40 50 60 MDDYKYQDNY GGYAPSDGYY RGNESNPEED AQSDVTEGHD EEDEIYEGEY QGIPHPDDVK 70 80 90 100 110 120 AKQAKMAPSR MDSLRGQTDL MAERLEDEEQ LAHQYETIMD ECGHGRFQWI LFFVLGLALM 130 140 150 160 170 180 ADGVEVFVVS FALPSAEKDM CLSSSKKGML GMIVYLGMMA GAFILGGLAD KLGRKRVLSM 190 200 210 220 230 240 SLAVNASFAS LSSFVQGYGA FLFCRLISGI GIGGALPIVF AYFSEFLSRE KRGEHLSWLG 250 260 270 280 290 300 IFWMTGGLYA SAMAWSIIPH YGWGFSMGTN YHFHSWRVFV IVCALPCTVS MVALKFMPES 310 320 330 340 350 360 PRFLLEMGKH DEAWMILKQV HDTNMRAKGT PEKVFTVSNI KTPKQMDEFI EIQSSTGTWY 370 380 390 400 410 420 QRWLVRFKTI FKQVWDNALY CVMGPYRMNT LILAVVWFAM AFSYYGLTVW FPDMIRYFQD 430 440 450 460 470 480 EEYKSKMKVF FGEHVYGATI NFTMENQIHQ HGKLVNDKFT RMYFKHVLFE DTFFDECYFE 490 500 510 520 530 540 DVTSTDTYFK NCTIESTIFY NTDLYEHKFI NCRFINSTFL EQKEGCHMDL EQDNDFLIYL 550 560 570 580 590 600 VSFLGSLSVL PGNIISALLM DRIGRLKMIG GSMLISAVCC FFLFFGNSES AMIGWQCLFC 610 620 630 640 650 660 GTSIAAWNAL DVITVELYPT NQRATAFGIL NGLCKFGAIL GNTIFASFVG ITKVVPILLA 670 680 AASLVGGGLI ALRLPETREQ VLM
	Isoform 2 [UniParc]. Checksum: 0079FA3304D1C038	FASTA	532	60,439
	10 20 30 40 50 60 MIVYLGMMAG AFILGGLADK LGRKRVLSMS LAVNASFASL SSFVQGYGAF LFCRLISGIG 70 80 90 100 110 120 IGGALPIVFA YFSEFLSREK RGEHLSWLGI FWMTGGLYAS AMAWSIIPHY GWGFSMGTNY 130 140 150 160 170 180 HFHSWRVFVI VCALPCTVSM VALKFMPESP RFLLEMGKHD EAWMILKQVH DTNMRAKGTP 190 200 210 220 230 240 EKVFTVSNIK TPKQMDEFIE IQSSTGTWYQ RWLVRFKTIF KQVWDNALYC VMGPYRMNTL 250 260 270 280 290 300 ILAVVWFAMA FSYYGLTVWF PDMIRYFQDE EYKSKMKVFF GEHVYGATIN FTMENQIHQH 310 320 330 340 350 360 GKLVNDKFTR MYFKHVLFED TFFDECYFED VTSTDTYFKN CTIESTIFYN TDLYEHKFIN 370 380 390 400 410 420 CRFINSTFLE QKEGCHMDLE QDNDFLIYLV SFLGSLSVLP GNIISALLMD RIGRLKMIGG 430 440 450 460 470 480 SMLISAVCCF FLFFGNSESA MIGWQCLFCG TSIAAWNALD VITVELYPTN QRATAFGILN 490 500 510 520 530 GLCKFGAILG NTIFASFVGI TKVVPILLAA ASLVGGGLIA LRLPETREQV LM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[5]	NHLBI resequencing and genotyping service (RS&G) Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB018278 mRNA. Translation: BAA34455.2. Different initiation. CR457086 mRNA. Translation: CAG33367.1. AK294902 mRNA. Translation: BAG57991.1. FJ515843 Genomic DNA. Translation: ACS13737.1. AC123784 Genomic DNA. No translation available. AC127520 Genomic DNA. No translation available. CH471101 Genomic DNA. Translation: EAX02143.1. BC030011 mRNA. Translation: AAH30011.1.
IPI	IPI00006631. IPI00954030.
RefSeq	NP_001161052.1. NM_001167580.1. NP_055663.1. NM_014848.4.
UniGene	Hs.21754.
3D structure databases
ProteinModelPortal	Q7L1I2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000332818.
PTM databases
PhosphoSite	Q7L1I2.
Polymorphism databases
DMDM	74738530.
Proteomic databases
PaxDb	Q7L1I2.
PRIDE	Q7L1I2.
Protocols and materials databases
DNASU	9899.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330276; ENSP00000332818; ENSG00000185518. ENST00000394232; ENSP00000377779; ENSG00000185518. ENST00000545111; ENSP00000443243; ENSG00000185518. ENST00000557410; ENSP00000450992; ENSG00000185518.
GeneID	9899.
KEGG	hsa:9899.
UCSC	uc002bqt.3. human.
Organism-specific databases
CTD	9899.
GeneCards	GC15P091643.
HGNC	HGNC:16874. SV2B.
HPA	HPA046247.
MIM	185861. gene.
neXtProt	NX_Q7L1I2.
PharmGKB	PA134930999.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0477.
HOGENOM	HOG000065727.
HOVERGEN	HBG053967.
InParanoid	Q7L1I2.
KO	K06258.
OMA	TNQRATA.
OrthoDB	EOG4K0QMZ.
PhylomeDB	Q7L1I2.
Gene expression databases
ArrayExpress	Q7L1I2.
Bgee	Q7L1I2.
CleanEx	HS_SV2B.
Genevestigator	Q7L1I2.
GermOnline	ENSG00000185518. Homo sapiens.
Family and domain databases
InterPro	IPR001646. 5peptide_repeat. IPR011701. MFS. IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005828. Sub_transporter. IPR005829. Sugar_transporter_CS. IPR022308. SV2. [Graphical view]
PANTHER	PTHR24065. PTHR24065. 1 hit.
Pfam	PF07690. MFS_1. 1 hit. PF13599. Pentapeptide_4. 1 hit. PF00083. Sugar_tr. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR01299. synapt_SV2. 1 hit.
PROSITE	PS50850. MFS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1999.
ChiTaRS	SV2B. human.
GenomeRNAi	9899.
NextBio	37323.
SOURCE	Search...

Entry information

Entry name

SV2B_HUMAN

Accession

Primary (citable) accession number: Q7L1I2
Secondary accession number(s): B4DH30 , C6G489, O94840, Q6IAR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.