Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7L1I2 (SV2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptic vesicle glycoprotein 2B
Gene names
Name:SV2B
Synonyms:KIAA0735
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length683 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably plays a role in the control of regulated secretion in neural and endocrine cells By similarity.

Subunit structure

Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25 By similarity.

Subcellular location

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Multi-pass membrane protein By similarity. Cytoplasmic vesiclesecretory vesicleacrosome By similarity. Note: Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas. Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids By similarity.

Post-translational modification

N-glycosylated By similarity.

The N-terminal cytoplasmic domain is phosphorylated by CK1 By similarity.

Sequence similarities

Belongs to the major facilitator superfamily.

Sequence caution

The sequence BAA34455.2 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7L1I2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7L1I2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 683683Synaptic vesicle glycoprotein 2B
PRO_0000239768

Regions

Topological domain1 – 108108Cytoplasmic Potential
Transmembrane109 – 12921Helical; Potential
Topological domain130 – 14819Extracellular Potential
Transmembrane149 – 16921Helical; Potential
Topological domain170 – 18213Cytoplasmic Potential
Transmembrane183 – 20321Helical; Potential
Topological domain204 – 2052Extracellular Potential
Transmembrane206 – 22621Helical; Potential
Topological domain227 – 23711Cytoplasmic Potential
Transmembrane238 – 25821Helical; Potential
Topological domain259 – 27719Extracellular Potential
Transmembrane278 – 29821Helical; Potential
Topological domain299 – 39092Cytoplasmic Potential
Transmembrane391 – 41121Helical; Potential
Topological domain412 – 535124Extracellular Potential
Transmembrane536 – 55621Helical; Potential
Topological domain557 – 5659Cytoplasmic Potential
Transmembrane566 – 58621Helical; Potential
Topological domain587 – 5926Extracellular Potential
Transmembrane593 – 61321Helical; Potential
Topological domain614 – 62613Cytoplasmic Potential
Transmembrane627 – 64923Helical; Potential
Topological domain650 – 6534Extracellular Potential
Transmembrane654 – 67219Helical; Potential
Topological domain673 – 68311Cytoplasmic Potential

Amino acid modifications

Modified residue4231Phosphotyrosine By similarity
Glycosylation4411N-linked (GlcNAc...) Potential
Glycosylation4911N-linked (GlcNAc...) Potential
Glycosylation5161N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 151151Missing in isoform 2.
VSP_045194

Experimental info

Sequence conflict6831M → I in CAG33367. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B9818120898F09E2

FASTA68377,444
        10         20         30         40         50         60 
MDDYKYQDNY GGYAPSDGYY RGNESNPEED AQSDVTEGHD EEDEIYEGEY QGIPHPDDVK 

        70         80         90        100        110        120 
AKQAKMAPSR MDSLRGQTDL MAERLEDEEQ LAHQYETIMD ECGHGRFQWI LFFVLGLALM 

       130        140        150        160        170        180 
ADGVEVFVVS FALPSAEKDM CLSSSKKGML GMIVYLGMMA GAFILGGLAD KLGRKRVLSM 

       190        200        210        220        230        240 
SLAVNASFAS LSSFVQGYGA FLFCRLISGI GIGGALPIVF AYFSEFLSRE KRGEHLSWLG 

       250        260        270        280        290        300 
IFWMTGGLYA SAMAWSIIPH YGWGFSMGTN YHFHSWRVFV IVCALPCTVS MVALKFMPES 

       310        320        330        340        350        360 
PRFLLEMGKH DEAWMILKQV HDTNMRAKGT PEKVFTVSNI KTPKQMDEFI EIQSSTGTWY 

       370        380        390        400        410        420 
QRWLVRFKTI FKQVWDNALY CVMGPYRMNT LILAVVWFAM AFSYYGLTVW FPDMIRYFQD 

       430        440        450        460        470        480 
EEYKSKMKVF FGEHVYGATI NFTMENQIHQ HGKLVNDKFT RMYFKHVLFE DTFFDECYFE 

       490        500        510        520        530        540 
DVTSTDTYFK NCTIESTIFY NTDLYEHKFI NCRFINSTFL EQKEGCHMDL EQDNDFLIYL 

       550        560        570        580        590        600 
VSFLGSLSVL PGNIISALLM DRIGRLKMIG GSMLISAVCC FFLFFGNSES AMIGWQCLFC 

       610        620        630        640        650        660 
GTSIAAWNAL DVITVELYPT NQRATAFGIL NGLCKFGAIL GNTIFASFVG ITKVVPILLA 

       670        680 
AASLVGGGLI ALRLPETREQ VLM 

« Hide

Isoform 2 [UniParc].

Checksum: 0079FA3304D1C038
Show »

FASTA53260,439

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[5]NHLBI resequencing and genotyping service (RS&G)
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB018278 mRNA. Translation: BAA34455.2. Different initiation.
CR457086 mRNA. Translation: CAG33367.1.
AK294902 mRNA. Translation: BAG57991.1.
FJ515843 Genomic DNA. Translation: ACS13737.1.
AC123784 Genomic DNA. No translation available.
AC127520 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02143.1.
BC030011 mRNA. Translation: AAH30011.1.
CCDSCCDS10370.1. [Q7L1I2-1]
CCDS53972.1. [Q7L1I2-2]
RefSeqNP_001161052.1. NM_001167580.1. [Q7L1I2-2]
NP_055663.1. NM_014848.4. [Q7L1I2-1]
XP_005255054.1. XM_005254997.2. [Q7L1I2-1]
XP_005255055.1. XM_005254998.2. [Q7L1I2-1]
UniGeneHs.21754.

3D structure databases

ProteinModelPortalQ7L1I2.
SMRQ7L1I2. Positions 128-407, 439-520.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115228. 2 interactions.
STRING9606.ENSP00000332818.

PTM databases

PhosphoSiteQ7L1I2.

Polymorphism databases

DMDM74738530.

Proteomic databases

PaxDbQ7L1I2.
PRIDEQ7L1I2.

Protocols and materials databases

DNASU9899.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000330276; ENSP00000332818; ENSG00000185518. [Q7L1I2-1]
ENST00000394232; ENSP00000377779; ENSG00000185518. [Q7L1I2-1]
ENST00000545111; ENSP00000443243; ENSG00000185518. [Q7L1I2-2]
ENST00000557410; ENSP00000450992; ENSG00000185518. [Q7L1I2-1]
GeneID9899.
KEGGhsa:9899.
UCSCuc002bqt.3. human. [Q7L1I2-1]

Organism-specific databases

CTD9899.
GeneCardsGC15P091643.
HGNCHGNC:16874. SV2B.
HPAHPA046247.
MIM185861. gene.
neXtProtNX_Q7L1I2.
PharmGKBPA134930999.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000065727.
HOVERGENHBG053967.
InParanoidQ7L1I2.
KOK06258.
OMAIGWQCLF.
OrthoDBEOG74TWZ1.
PhylomeDBQ7L1I2.
TreeFamTF324824.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.

Gene expression databases

BgeeQ7L1I2.
CleanExHS_SV2B.
GenevestigatorQ7L1I2.

Family and domain databases

InterProIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PANTHERPTHR24065. PTHR24065. 1 hit.
PfamPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 3 hits.
TIGRFAMsTIGR01299. synapt_SV2. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSV2B. human.
GeneWikiSV2B.
GenomeRNAi9899.
NextBio37323.
PROQ7L1I2.
SOURCESearch...

Entry information

Entry nameSV2B_HUMAN
AccessionPrimary (citable) accession number: Q7L1I2
Secondary accession number(s): B4DH30 expand/collapse secondary AC list , C6G489, O94840, Q6IAR8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM