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Q7L1I2

- SV2B_HUMAN

UniProt

Q7L1I2 - SV2B_HUMAN

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Protein
Synaptic vesicle glycoprotein 2B
Gene
SV2B, KIAA0735
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably plays a role in the control of regulated secretion in neural and endocrine cells By similarity.

GO - Molecular functioni

  1. transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. neurotransmitter transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiREACT_200616. Toxicity of botulinum toxin type E (BoNT/E).
REACT_200617. Toxicity of botulinum toxin type D (BoNT/D).
REACT_200659. Toxicity of botulinum toxin type F (BoNT/F).
REACT_200737. Toxicity of botulinum toxin type A (BoNT/A).

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2B
Gene namesi
Name:SV2B
Synonyms:KIAA0735
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:16874. SV2B.

Subcellular locationi

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Multi-pass membrane protein By similarity. Cytoplasmic vesiclesecretory vesicleacrosome By similarity
Note: Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas. Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 108108Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei109 – 12921Helical; Reviewed prediction
Add
BLAST
Topological domaini130 – 14819Extracellular Reviewed prediction
Add
BLAST
Transmembranei149 – 16921Helical; Reviewed prediction
Add
BLAST
Topological domaini170 – 18213Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei183 – 20321Helical; Reviewed prediction
Add
BLAST
Topological domaini204 – 2052Extracellular Reviewed prediction
Transmembranei206 – 22621Helical; Reviewed prediction
Add
BLAST
Topological domaini227 – 23711Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei238 – 25821Helical; Reviewed prediction
Add
BLAST
Topological domaini259 – 27719Extracellular Reviewed prediction
Add
BLAST
Transmembranei278 – 29821Helical; Reviewed prediction
Add
BLAST
Topological domaini299 – 39092Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei391 – 41121Helical; Reviewed prediction
Add
BLAST
Topological domaini412 – 535124Extracellular Reviewed prediction
Add
BLAST
Transmembranei536 – 55621Helical; Reviewed prediction
Add
BLAST
Topological domaini557 – 5659Cytoplasmic Reviewed prediction
Transmembranei566 – 58621Helical; Reviewed prediction
Add
BLAST
Topological domaini587 – 5926Extracellular Reviewed prediction
Transmembranei593 – 61321Helical; Reviewed prediction
Add
BLAST
Topological domaini614 – 62613Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei627 – 64923Helical; Reviewed prediction
Add
BLAST
Topological domaini650 – 6534Extracellular Reviewed prediction
Transmembranei654 – 67219Helical; Reviewed prediction
Add
BLAST
Topological domaini673 – 68311Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. acrosomal vesicle Source: UniProtKB-SubCell
  2. cell junction Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
  4. synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134930999.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 683683Synaptic vesicle glycoprotein 2B
PRO_0000239768Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei423 – 4231Phosphotyrosine By similarity
Glycosylationi441 – 4411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi491 – 4911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi516 – 5161N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.
The N-terminal cytoplasmic domain is phosphorylated by CK1 By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ7L1I2.
PRIDEiQ7L1I2.

PTM databases

PhosphoSiteiQ7L1I2.

Expressioni

Gene expression databases

BgeeiQ7L1I2.
CleanExiHS_SV2B.
GenevestigatoriQ7L1I2.

Organism-specific databases

HPAiHPA046247.

Interactioni

Subunit structurei

Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25 By similarity.

Protein-protein interaction databases

BioGridi115228. 2 interactions.
STRINGi9606.ENSP00000332818.

Structurei

3D structure databases

ProteinModelPortaliQ7L1I2.
SMRiQ7L1I2. Positions 128-407, 439-520.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ7L1I2.
KOiK06258.
OMAiIGWQCLF.
OrthoDBiEOG74TWZ1.
PhylomeDBiQ7L1I2.
TreeFamiTF324824.

Family and domain databases

InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PANTHERiPTHR24065. PTHR24065. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7L1I2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDDYKYQDNY GGYAPSDGYY RGNESNPEED AQSDVTEGHD EEDEIYEGEY    50
QGIPHPDDVK AKQAKMAPSR MDSLRGQTDL MAERLEDEEQ LAHQYETIMD 100
ECGHGRFQWI LFFVLGLALM ADGVEVFVVS FALPSAEKDM CLSSSKKGML 150
GMIVYLGMMA GAFILGGLAD KLGRKRVLSM SLAVNASFAS LSSFVQGYGA 200
FLFCRLISGI GIGGALPIVF AYFSEFLSRE KRGEHLSWLG IFWMTGGLYA 250
SAMAWSIIPH YGWGFSMGTN YHFHSWRVFV IVCALPCTVS MVALKFMPES 300
PRFLLEMGKH DEAWMILKQV HDTNMRAKGT PEKVFTVSNI KTPKQMDEFI 350
EIQSSTGTWY QRWLVRFKTI FKQVWDNALY CVMGPYRMNT LILAVVWFAM 400
AFSYYGLTVW FPDMIRYFQD EEYKSKMKVF FGEHVYGATI NFTMENQIHQ 450
HGKLVNDKFT RMYFKHVLFE DTFFDECYFE DVTSTDTYFK NCTIESTIFY 500
NTDLYEHKFI NCRFINSTFL EQKEGCHMDL EQDNDFLIYL VSFLGSLSVL 550
PGNIISALLM DRIGRLKMIG GSMLISAVCC FFLFFGNSES AMIGWQCLFC 600
GTSIAAWNAL DVITVELYPT NQRATAFGIL NGLCKFGAIL GNTIFASFVG 650
ITKVVPILLA AASLVGGGLI ALRLPETREQ VLM 683
Length:683
Mass (Da):77,444
Last modified:July 5, 2004 - v1
Checksum:iB9818120898F09E2
GO
Isoform 2 (identifier: Q7L1I2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Note: No experimental confirmation available.

Show »
Length:532
Mass (Da):60,439
Checksum:i0079FA3304D1C038
GO

Sequence cautioni

The sequence BAA34455.2 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 151151Missing in isoform 2.
VSP_045194Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti683 – 6831M → I in CAG33367. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018278 mRNA. Translation: BAA34455.2. Different initiation.
CR457086 mRNA. Translation: CAG33367.1.
AK294902 mRNA. Translation: BAG57991.1.
FJ515843 Genomic DNA. Translation: ACS13737.1.
AC123784 Genomic DNA. No translation available.
AC127520 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02143.1.
BC030011 mRNA. Translation: AAH30011.1.
CCDSiCCDS10370.1. [Q7L1I2-1]
CCDS53972.1. [Q7L1I2-2]
RefSeqiNP_001161052.1. NM_001167580.1. [Q7L1I2-2]
NP_055663.1. NM_014848.4. [Q7L1I2-1]
XP_005255054.1. XM_005254997.2. [Q7L1I2-1]
XP_005255055.1. XM_005254998.2. [Q7L1I2-1]
UniGeneiHs.21754.

Genome annotation databases

EnsembliENST00000330276; ENSP00000332818; ENSG00000185518. [Q7L1I2-1]
ENST00000394232; ENSP00000377779; ENSG00000185518. [Q7L1I2-1]
ENST00000545111; ENSP00000443243; ENSG00000185518. [Q7L1I2-2]
ENST00000557410; ENSP00000450992; ENSG00000185518. [Q7L1I2-1]
GeneIDi9899.
KEGGihsa:9899.
UCSCiuc002bqt.3. human. [Q7L1I2-1]

Polymorphism databases

DMDMi74738530.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018278 mRNA. Translation: BAA34455.2 . Different initiation.
CR457086 mRNA. Translation: CAG33367.1 .
AK294902 mRNA. Translation: BAG57991.1 .
FJ515843 Genomic DNA. Translation: ACS13737.1 .
AC123784 Genomic DNA. No translation available.
AC127520 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02143.1 .
BC030011 mRNA. Translation: AAH30011.1 .
CCDSi CCDS10370.1. [Q7L1I2-1 ]
CCDS53972.1. [Q7L1I2-2 ]
RefSeqi NP_001161052.1. NM_001167580.1. [Q7L1I2-2 ]
NP_055663.1. NM_014848.4. [Q7L1I2-1 ]
XP_005255054.1. XM_005254997.2. [Q7L1I2-1 ]
XP_005255055.1. XM_005254998.2. [Q7L1I2-1 ]
UniGenei Hs.21754.

3D structure databases

ProteinModelPortali Q7L1I2.
SMRi Q7L1I2. Positions 128-407, 439-520.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115228. 2 interactions.
STRINGi 9606.ENSP00000332818.

PTM databases

PhosphoSitei Q7L1I2.

Polymorphism databases

DMDMi 74738530.

Proteomic databases

PaxDbi Q7L1I2.
PRIDEi Q7L1I2.

Protocols and materials databases

DNASUi 9899.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000330276 ; ENSP00000332818 ; ENSG00000185518 . [Q7L1I2-1 ]
ENST00000394232 ; ENSP00000377779 ; ENSG00000185518 . [Q7L1I2-1 ]
ENST00000545111 ; ENSP00000443243 ; ENSG00000185518 . [Q7L1I2-2 ]
ENST00000557410 ; ENSP00000450992 ; ENSG00000185518 . [Q7L1I2-1 ]
GeneIDi 9899.
KEGGi hsa:9899.
UCSCi uc002bqt.3. human. [Q7L1I2-1 ]

Organism-specific databases

CTDi 9899.
GeneCardsi GC15P091643.
HGNCi HGNC:16874. SV2B.
HPAi HPA046247.
MIMi 185861. gene.
neXtProti NX_Q7L1I2.
PharmGKBi PA134930999.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
HOGENOMi HOG000065727.
HOVERGENi HBG053967.
InParanoidi Q7L1I2.
KOi K06258.
OMAi IGWQCLF.
OrthoDBi EOG74TWZ1.
PhylomeDBi Q7L1I2.
TreeFami TF324824.

Enzyme and pathway databases

Reactomei REACT_200616. Toxicity of botulinum toxin type E (BoNT/E).
REACT_200617. Toxicity of botulinum toxin type D (BoNT/D).
REACT_200659. Toxicity of botulinum toxin type F (BoNT/F).
REACT_200737. Toxicity of botulinum toxin type A (BoNT/A).

Miscellaneous databases

ChiTaRSi SV2B. human.
GeneWikii SV2B.
GenomeRNAii 9899.
NextBioi 37323.
PROi Q7L1I2.
SOURCEi Search...

Gene expression databases

Bgeei Q7L1I2.
CleanExi HS_SV2B.
Genevestigatori Q7L1I2.

Family and domain databases

InterProi IPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view ]
PANTHERi PTHR24065. PTHR24065. 1 hit.
Pfami PF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
TIGRFAMsi TIGR01299. synapt_SV2. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. NHLBI resequencing and genotyping service (RS&G)
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiSV2B_HUMAN
AccessioniPrimary (citable) accession number: Q7L1I2
Secondary accession number(s): B4DH30
, C6G489, O94840, Q6IAR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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