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Protein

Synaptic vesicle glycoprotein 2B

Gene

SV2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably plays a role in the control of regulated secretion in neural and endocrine cells.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-5250955 Toxicity of botulinum toxin type D (BoNT/D)
R-HSA-5250968 Toxicity of botulinum toxin type A (BoNT/A)
R-HSA-5250981 Toxicity of botulinum toxin type F (BoNT/F)
R-HSA-5250992 Toxicity of botulinum toxin type E (BoNT/E)

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2B
Gene namesi
Name:SV2B
Synonyms:KIAA0735
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000185518.11
HGNCiHGNC:16874 SV2B
MIMi185861 gene
neXtProtiNX_Q7L1I2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 108CytoplasmicSequence analysisAdd BLAST108
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 148ExtracellularSequence analysisAdd BLAST19
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 182CytoplasmicSequence analysisAdd BLAST13
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 205ExtracellularSequence analysis2
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 237CytoplasmicSequence analysisAdd BLAST11
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 277ExtracellularSequence analysisAdd BLAST19
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 390CytoplasmicSequence analysisAdd BLAST92
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Topological domaini412 – 535ExtracellularSequence analysisAdd BLAST124
Transmembranei536 – 556HelicalSequence analysisAdd BLAST21
Topological domaini557 – 565CytoplasmicSequence analysis9
Transmembranei566 – 586HelicalSequence analysisAdd BLAST21
Topological domaini587 – 592ExtracellularSequence analysis6
Transmembranei593 – 613HelicalSequence analysisAdd BLAST21
Topological domaini614 – 626CytoplasmicSequence analysisAdd BLAST13
Transmembranei627 – 649HelicalSequence analysisAdd BLAST23
Topological domaini650 – 653ExtracellularSequence analysis4
Transmembranei654 – 672HelicalSequence analysisAdd BLAST19
Topological domaini673 – 683CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi9899
OpenTargetsiENSG00000185518
PharmGKBiPA134930999

Polymorphism and mutation databases

BioMutaiSV2B
DMDMi74738530

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397681 – 683Synaptic vesicle glycoprotein 2BAdd BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineBy similarity1
Modified residuei36PhosphothreonineBy similarity1
Modified residuei423PhosphotyrosineBy similarity1
Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi516N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity
The N-terminal cytoplasmic domain is phosphorylated by CK1.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ7L1I2
PeptideAtlasiQ7L1I2
PRIDEiQ7L1I2

PTM databases

iPTMnetiQ7L1I2
PhosphoSitePlusiQ7L1I2

Expressioni

Gene expression databases

BgeeiENSG00000185518
CleanExiHS_SV2B
GenevisibleiQ7L1I2 HS

Organism-specific databases

HPAiHPA046247

Interactioni

Subunit structurei

Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
HSFY2Q96LI63EBI-10290607,EBI-3957665

Protein-protein interaction databases

BioGridi115228, 4 interactors
IntActiQ7L1I2, 1 interactor
STRINGi9606.ENSP00000332818

Structurei

3D structure databases

ProteinModelPortaliQ7L1I2
SMRiQ7L1I2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00550000074384
HOGENOMiHOG000065727
HOVERGENiHBG053967
InParanoidiQ7L1I2
KOiK06258
OMAiKMYFKHV
OrthoDBiEOG091G02NC
PhylomeDBiQ7L1I2
TreeFamiTF324824

Family and domain databases

CDDicd06174 MFS, 2 hits
InterProiView protein in InterPro
IPR001646 5peptide_repeat
IPR011701 MFS
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
IPR022308 SV2
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PF13599 Pentapeptide_4, 1 hit
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 3 hits
TIGRFAMsiTIGR01299 synapt_SV2, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7L1I2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDYKYQDNY GGYAPSDGYY RGNESNPEED AQSDVTEGHD EEDEIYEGEY
60 70 80 90 100
QGIPHPDDVK AKQAKMAPSR MDSLRGQTDL MAERLEDEEQ LAHQYETIMD
110 120 130 140 150
ECGHGRFQWI LFFVLGLALM ADGVEVFVVS FALPSAEKDM CLSSSKKGML
160 170 180 190 200
GMIVYLGMMA GAFILGGLAD KLGRKRVLSM SLAVNASFAS LSSFVQGYGA
210 220 230 240 250
FLFCRLISGI GIGGALPIVF AYFSEFLSRE KRGEHLSWLG IFWMTGGLYA
260 270 280 290 300
SAMAWSIIPH YGWGFSMGTN YHFHSWRVFV IVCALPCTVS MVALKFMPES
310 320 330 340 350
PRFLLEMGKH DEAWMILKQV HDTNMRAKGT PEKVFTVSNI KTPKQMDEFI
360 370 380 390 400
EIQSSTGTWY QRWLVRFKTI FKQVWDNALY CVMGPYRMNT LILAVVWFAM
410 420 430 440 450
AFSYYGLTVW FPDMIRYFQD EEYKSKMKVF FGEHVYGATI NFTMENQIHQ
460 470 480 490 500
HGKLVNDKFT RMYFKHVLFE DTFFDECYFE DVTSTDTYFK NCTIESTIFY
510 520 530 540 550
NTDLYEHKFI NCRFINSTFL EQKEGCHMDL EQDNDFLIYL VSFLGSLSVL
560 570 580 590 600
PGNIISALLM DRIGRLKMIG GSMLISAVCC FFLFFGNSES AMIGWQCLFC
610 620 630 640 650
GTSIAAWNAL DVITVELYPT NQRATAFGIL NGLCKFGAIL GNTIFASFVG
660 670 680
ITKVVPILLA AASLVGGGLI ALRLPETREQ VLM
Length:683
Mass (Da):77,444
Last modified:July 5, 2004 - v1
Checksum:iB9818120898F09E2
GO
Isoform 2 (identifier: Q7L1I2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Note: No experimental confirmation available.
Show »
Length:532
Mass (Da):60,439
Checksum:i0079FA3304D1C038
GO

Sequence cautioni

The sequence BAA34455 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti683M → I in CAG33367 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0451941 – 151Missing in isoform 2. 1 PublicationAdd BLAST151

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018278 mRNA Translation: BAA34455.2 Different initiation.
CR457086 mRNA Translation: CAG33367.1
AK294902 mRNA Translation: BAG57991.1
FJ515843 Genomic DNA Translation: ACS13737.1
AC123784 Genomic DNA No translation available.
AC127520 Genomic DNA No translation available.
CH471101 Genomic DNA Translation: EAX02143.1
BC030011 mRNA Translation: AAH30011.1
CCDSiCCDS10370.1 [Q7L1I2-1]
CCDS53972.1 [Q7L1I2-2]
RefSeqiNP_001161052.1, NM_001167580.2 [Q7L1I2-2]
NP_001309960.1, NM_001323031.2 [Q7L1I2-1]
NP_001309961.1, NM_001323032.2 [Q7L1I2-1]
NP_001309966.1, NM_001323037.2 [Q7L1I2-1]
NP_001309967.1, NM_001323038.2 [Q7L1I2-1]
NP_001309968.1, NM_001323039.2 [Q7L1I2-1]
NP_001309969.1, NM_001323040.2 [Q7L1I2-2]
NP_055663.1, NM_014848.6 [Q7L1I2-1]
XP_005255055.1, XM_005254998.3 [Q7L1I2-1]
XP_016878250.1, XM_017022761.1 [Q7L1I2-1]
XP_016878251.1, XM_017022762.1 [Q7L1I2-1]
UniGeneiHs.21754

Genome annotation databases

EnsembliENST00000330276; ENSP00000332818; ENSG00000185518 [Q7L1I2-1]
ENST00000394232; ENSP00000377779; ENSG00000185518 [Q7L1I2-1]
ENST00000545111; ENSP00000443243; ENSG00000185518 [Q7L1I2-2]
ENST00000557410; ENSP00000450992; ENSG00000185518 [Q7L1I2-1]
GeneIDi9899
KEGGihsa:9899
UCSCiuc010uqv.3 human [Q7L1I2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSV2B_HUMAN
AccessioniPrimary (citable) accession number: Q7L1I2
Secondary accession number(s): B4DH30
, C6G489, O94840, Q6IAR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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