Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Synaptic vesicle glycoprotein 2B

Gene

SV2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably plays a role in the control of regulated secretion in neural and endocrine cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-33611-MONOMER.
ReactomeiR-HSA-5250955. Toxicity of botulinum toxin type D (BoNT/D).
R-HSA-5250968. Toxicity of botulinum toxin type A (BoNT/A).
R-HSA-5250981. Toxicity of botulinum toxin type F (BoNT/F).
R-HSA-5250992. Toxicity of botulinum toxin type E (BoNT/E).

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2B
Gene namesi
Name:SV2B
Synonyms:KIAA0735
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:16874. SV2B.

Subcellular locationi

  • Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Cytoplasmic vesiclesecretory vesicleacrosome By similarity

  • Note: Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas (By similarity). Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity).By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 108CytoplasmicSequence analysisAdd BLAST108
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 148ExtracellularSequence analysisAdd BLAST19
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 182CytoplasmicSequence analysisAdd BLAST13
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 205ExtracellularSequence analysis2
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 237CytoplasmicSequence analysisAdd BLAST11
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 277ExtracellularSequence analysisAdd BLAST19
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 390CytoplasmicSequence analysisAdd BLAST92
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Topological domaini412 – 535ExtracellularSequence analysisAdd BLAST124
Transmembranei536 – 556HelicalSequence analysisAdd BLAST21
Topological domaini557 – 565CytoplasmicSequence analysis9
Transmembranei566 – 586HelicalSequence analysisAdd BLAST21
Topological domaini587 – 592ExtracellularSequence analysis6
Transmembranei593 – 613HelicalSequence analysisAdd BLAST21
Topological domaini614 – 626CytoplasmicSequence analysisAdd BLAST13
Transmembranei627 – 649HelicalSequence analysisAdd BLAST23
Topological domaini650 – 653ExtracellularSequence analysis4
Transmembranei654 – 672HelicalSequence analysisAdd BLAST19
Topological domaini673 – 683CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi9899.
OpenTargetsiENSG00000185518.
PharmGKBiPA134930999.

Polymorphism and mutation databases

BioMutaiSV2B.
DMDMi74738530.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397681 – 683Synaptic vesicle glycoprotein 2BAdd BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineBy similarity1
Modified residuei36PhosphothreonineBy similarity1
Modified residuei423PhosphotyrosineBy similarity1
Glycosylationi441N-linked (GlcNAc...)Sequence analysis1
Glycosylationi491N-linked (GlcNAc...)Sequence analysis1
Glycosylationi516N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.By similarity
The N-terminal cytoplasmic domain is phosphorylated by CK1.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ7L1I2.
PeptideAtlasiQ7L1I2.
PRIDEiQ7L1I2.

PTM databases

iPTMnetiQ7L1I2.
PhosphoSitePlusiQ7L1I2.

Expressioni

Gene expression databases

BgeeiENSG00000185518.
CleanExiHS_SV2B.
GenevisibleiQ7L1I2. HS.

Organism-specific databases

HPAiHPA046247.

Interactioni

Subunit structurei

Interacts with SYT1 in a calcium-independent manner. Forms a complex with SYT1, syntaxin-1 and SNAP25 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
HSFY2Q96LI63EBI-10290607,EBI-3957665

Protein-protein interaction databases

BioGridi115228. 3 interactors.
IntActiQ7L1I2. 1 interactor.
STRINGi9606.ENSP00000332818.

Structurei

3D structure databases

ProteinModelPortaliQ7L1I2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ7L1I2.
KOiK06258.
OMAiKMYFKHV.
OrthoDBiEOG091G02NC.
PhylomeDBiQ7L1I2.
TreeFamiTF324824.

Family and domain databases

CDDicd06174. MFS. 2 hits.
InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7L1I2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDYKYQDNY GGYAPSDGYY RGNESNPEED AQSDVTEGHD EEDEIYEGEY
60 70 80 90 100
QGIPHPDDVK AKQAKMAPSR MDSLRGQTDL MAERLEDEEQ LAHQYETIMD
110 120 130 140 150
ECGHGRFQWI LFFVLGLALM ADGVEVFVVS FALPSAEKDM CLSSSKKGML
160 170 180 190 200
GMIVYLGMMA GAFILGGLAD KLGRKRVLSM SLAVNASFAS LSSFVQGYGA
210 220 230 240 250
FLFCRLISGI GIGGALPIVF AYFSEFLSRE KRGEHLSWLG IFWMTGGLYA
260 270 280 290 300
SAMAWSIIPH YGWGFSMGTN YHFHSWRVFV IVCALPCTVS MVALKFMPES
310 320 330 340 350
PRFLLEMGKH DEAWMILKQV HDTNMRAKGT PEKVFTVSNI KTPKQMDEFI
360 370 380 390 400
EIQSSTGTWY QRWLVRFKTI FKQVWDNALY CVMGPYRMNT LILAVVWFAM
410 420 430 440 450
AFSYYGLTVW FPDMIRYFQD EEYKSKMKVF FGEHVYGATI NFTMENQIHQ
460 470 480 490 500
HGKLVNDKFT RMYFKHVLFE DTFFDECYFE DVTSTDTYFK NCTIESTIFY
510 520 530 540 550
NTDLYEHKFI NCRFINSTFL EQKEGCHMDL EQDNDFLIYL VSFLGSLSVL
560 570 580 590 600
PGNIISALLM DRIGRLKMIG GSMLISAVCC FFLFFGNSES AMIGWQCLFC
610 620 630 640 650
GTSIAAWNAL DVITVELYPT NQRATAFGIL NGLCKFGAIL GNTIFASFVG
660 670 680
ITKVVPILLA AASLVGGGLI ALRLPETREQ VLM
Length:683
Mass (Da):77,444
Last modified:July 5, 2004 - v1
Checksum:iB9818120898F09E2
GO
Isoform 2 (identifier: Q7L1I2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Note: No experimental confirmation available.
Show »
Length:532
Mass (Da):60,439
Checksum:i0079FA3304D1C038
GO

Sequence cautioni

The sequence BAA34455 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti683M → I in CAG33367 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0451941 – 151Missing in isoform 2. 1 PublicationAdd BLAST151

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018278 mRNA. Translation: BAA34455.2. Different initiation.
CR457086 mRNA. Translation: CAG33367.1.
AK294902 mRNA. Translation: BAG57991.1.
FJ515843 Genomic DNA. Translation: ACS13737.1.
AC123784 Genomic DNA. No translation available.
AC127520 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02143.1.
BC030011 mRNA. Translation: AAH30011.1.
CCDSiCCDS10370.1. [Q7L1I2-1]
CCDS53972.1. [Q7L1I2-2]
RefSeqiNP_001161052.1. NM_001167580.2. [Q7L1I2-2]
NP_001309960.1. NM_001323031.2. [Q7L1I2-1]
NP_001309961.1. NM_001323032.2. [Q7L1I2-1]
NP_001309966.1. NM_001323037.2. [Q7L1I2-1]
NP_001309967.1. NM_001323038.2. [Q7L1I2-1]
NP_001309968.1. NM_001323039.2. [Q7L1I2-1]
NP_001309969.1. NM_001323040.2. [Q7L1I2-2]
NP_055663.1. NM_014848.6. [Q7L1I2-1]
XP_005255055.1. XM_005254998.3. [Q7L1I2-1]
XP_016878250.1. XM_017022761.1. [Q7L1I2-1]
XP_016878251.1. XM_017022762.1. [Q7L1I2-1]
UniGeneiHs.21754.

Genome annotation databases

EnsembliENST00000330276; ENSP00000332818; ENSG00000185518. [Q7L1I2-1]
ENST00000394232; ENSP00000377779; ENSG00000185518. [Q7L1I2-1]
ENST00000545111; ENSP00000443243; ENSG00000185518. [Q7L1I2-2]
ENST00000557410; ENSP00000450992; ENSG00000185518. [Q7L1I2-1]
GeneIDi9899.
KEGGihsa:9899.
UCSCiuc010uqv.3. human. [Q7L1I2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018278 mRNA. Translation: BAA34455.2. Different initiation.
CR457086 mRNA. Translation: CAG33367.1.
AK294902 mRNA. Translation: BAG57991.1.
FJ515843 Genomic DNA. Translation: ACS13737.1.
AC123784 Genomic DNA. No translation available.
AC127520 Genomic DNA. No translation available.
CH471101 Genomic DNA. Translation: EAX02143.1.
BC030011 mRNA. Translation: AAH30011.1.
CCDSiCCDS10370.1. [Q7L1I2-1]
CCDS53972.1. [Q7L1I2-2]
RefSeqiNP_001161052.1. NM_001167580.2. [Q7L1I2-2]
NP_001309960.1. NM_001323031.2. [Q7L1I2-1]
NP_001309961.1. NM_001323032.2. [Q7L1I2-1]
NP_001309966.1. NM_001323037.2. [Q7L1I2-1]
NP_001309967.1. NM_001323038.2. [Q7L1I2-1]
NP_001309968.1. NM_001323039.2. [Q7L1I2-1]
NP_001309969.1. NM_001323040.2. [Q7L1I2-2]
NP_055663.1. NM_014848.6. [Q7L1I2-1]
XP_005255055.1. XM_005254998.3. [Q7L1I2-1]
XP_016878250.1. XM_017022761.1. [Q7L1I2-1]
XP_016878251.1. XM_017022762.1. [Q7L1I2-1]
UniGeneiHs.21754.

3D structure databases

ProteinModelPortaliQ7L1I2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115228. 3 interactors.
IntActiQ7L1I2. 1 interactor.
STRINGi9606.ENSP00000332818.

PTM databases

iPTMnetiQ7L1I2.
PhosphoSitePlusiQ7L1I2.

Polymorphism and mutation databases

BioMutaiSV2B.
DMDMi74738530.

Proteomic databases

PaxDbiQ7L1I2.
PeptideAtlasiQ7L1I2.
PRIDEiQ7L1I2.

Protocols and materials databases

DNASUi9899.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330276; ENSP00000332818; ENSG00000185518. [Q7L1I2-1]
ENST00000394232; ENSP00000377779; ENSG00000185518. [Q7L1I2-1]
ENST00000545111; ENSP00000443243; ENSG00000185518. [Q7L1I2-2]
ENST00000557410; ENSP00000450992; ENSG00000185518. [Q7L1I2-1]
GeneIDi9899.
KEGGihsa:9899.
UCSCiuc010uqv.3. human. [Q7L1I2-1]

Organism-specific databases

CTDi9899.
DisGeNETi9899.
GeneCardsiSV2B.
HGNCiHGNC:16874. SV2B.
HPAiHPA046247.
MIMi185861. gene.
neXtProtiNX_Q7L1I2.
OpenTargetsiENSG00000185518.
PharmGKBiPA134930999.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0255. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00550000074384.
HOGENOMiHOG000065727.
HOVERGENiHBG053967.
InParanoidiQ7L1I2.
KOiK06258.
OMAiKMYFKHV.
OrthoDBiEOG091G02NC.
PhylomeDBiQ7L1I2.
TreeFamiTF324824.

Enzyme and pathway databases

BioCyciZFISH:G66-33611-MONOMER.
ReactomeiR-HSA-5250955. Toxicity of botulinum toxin type D (BoNT/D).
R-HSA-5250968. Toxicity of botulinum toxin type A (BoNT/A).
R-HSA-5250981. Toxicity of botulinum toxin type F (BoNT/F).
R-HSA-5250992. Toxicity of botulinum toxin type E (BoNT/E).

Miscellaneous databases

ChiTaRSiSV2B. human.
GeneWikiiSV2B.
GenomeRNAii9899.
PROiQ7L1I2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185518.
CleanExiHS_SV2B.
GenevisibleiQ7L1I2. HS.

Family and domain databases

CDDicd06174. MFS. 2 hits.
InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSV2B_HUMAN
AccessioniPrimary (citable) accession number: Q7L1I2
Secondary accession number(s): B4DH30
, C6G489, O94840, Q6IAR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.