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Protein

Developmental pluripotency-associated protein 4

Gene

DPPA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
SIGNORiQ7L190

Names & Taxonomyi

Protein namesi
Recommended name:
Developmental pluripotency-associated protein 4
Gene namesi
Name:DPPA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000121570.12
HGNCiHGNC:19200 DPPA4
MIMi614125 gene
neXtProtiNX_Q7L190

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55211
OpenTargetsiENSG00000121570
PharmGKBiPA134958838

Polymorphism and mutation databases

BioMutaiDPPA4
DMDMi296434484

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002392681 – 304Developmental pluripotency-associated protein 4Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei215PhosphothreonineCombined sources1
Modified residuei221PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7L190
PaxDbiQ7L190
PeptideAtlasiQ7L190
PRIDEiQ7L190

PTM databases

iPTMnetiQ7L190
PhosphoSitePlusiQ7L190

Expressioni

Gene expression databases

BgeeiENSG00000121570
CleanExiHS_DPPA4
ExpressionAtlasiQ7L190 baseline and differential
GenevisibleiQ7L190 HS

Organism-specific databases

HPAiCAB020678
HPA035249
HPA035250

Interactioni

Subunit structurei

Interacts with DPPA2 (By similarity). Interacts with PCGF1 (PubMed:26687479).By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120507, 106 interactors
IntActiQ7L190, 35 interactors
MINTiQ7L190
STRINGi9606.ENSP00000335306

Structurei

3D structure databases

ProteinModelPortaliQ7L190
SMRiQ7L190
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IG5K Eukaryota
ENOG41118PS LUCA
GeneTreeiENSGT00390000004871
HOGENOMiHOG000060113
HOVERGENiHBG066898
InParanoidiQ7L190
OMAiRAWCHQL
OrthoDBiEOG091G0QL3
PhylomeDBiQ7L190
TreeFamiTF338129

Family and domain databases

InterProiView protein in InterPro
IPR025891 Dppa2/4_C_dom
IPR025892 Dppa2/4_central_dom
PfamiView protein in Pfam
PF14047 DCR, 1 hit
PF14049 Dppa2_A, 2 hits

Sequencei

Sequence statusi: Complete.

Q7L190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGSASSTS MEKAKGKEWT STEKSREEDQ QASNQPNSIA LPGTSAKRTK
60 70 80 90 100
EKMSIKGSKV LCPKKKAEHT DNPRPQKKIP IPPLPSKLPP VNLIHRDILR
110 120 130 140 150
AWCQQLKLSS KGQKLDAYKR LCAFAYPNQK DFPSTAKEAK IRKSLQKKLK
160 170 180 190 200
VEKGETSLQS SETHPPEVAL PPVGEPPALE NSTALLEGVN TVVVTTSAPE
210 220 230 240 250
ALLASWARIS ARARTPEAVE SPQEASGVRW CVVHGKSLPA DTDGWVHLQF
260 270 280 290 300
HAGQAWVPEK QEGRVSALFL LPASNFPPPH LEDNMLCPKC VHRNKVLIKS

LQWE
Length:304
Mass (Da):33,541
Last modified:May 18, 2010 - v2
Checksum:iEF7C64D23CF2604F
GO

Sequence cautioni

The sequence BAA91765 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14188 differs from that shown. Reason: Frameshift at position 148.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06037255I → V2 PublicationsCorresponds to variant dbSNP:rs3762648Ensembl.1
Natural variantiVAR_060373226S → F. Corresponds to variant dbSNP:rs3905734Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001575 mRNA Translation: BAA91765.1 Different initiation.
AK022698 mRNA Translation: BAB14188.1 Frameshift.
AK290992 mRNA Translation: BAF83681.1
AC076971 Genomic DNA No translation available.
BC032846 mRNA Translation: AAH32846.2
CCDSiCCDS33814.1
RefSeqiNP_060659.3, NM_018189.3
UniGeneiHs.317659

Genome annotation databases

EnsembliENST00000335658; ENSP00000335306; ENSG00000121570
GeneIDi55211
KEGGihsa:55211
UCSCiuc003dxq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDPPA4_HUMAN
AccessioniPrimary (citable) accession number: Q7L190
Secondary accession number(s): A8K4M7, Q9H9N5, Q9NVI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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