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Protein

Developmental pluripotency-associated protein 4

Gene

DPPA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-2892247. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

Names & Taxonomyi

Protein namesi
Recommended name:
Developmental pluripotency-associated protein 4
Gene namesi
Name:DPPA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:19200. DPPA4.

Subcellular locationi

  • Nucleus By similarity

  • Note: Associated with transcriptionally active chromatin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958838.

Polymorphism and mutation databases

BioMutaiDPPA4.
DMDMi296434484.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Developmental pluripotency-associated protein 4PRO_0000239268Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei215 – 2151PhosphothreonineCombined sources
Modified residuei221 – 2211PhosphoserineCombined sources
Modified residuei226 – 2261PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7L190.
PRIDEiQ7L190.

PTM databases

iPTMnetiQ7L190.
PhosphoSiteiQ7L190.

Expressioni

Gene expression databases

BgeeiQ7L190.
CleanExiHS_DPPA4.
ExpressionAtlasiQ7L190. baseline and differential.
GenevisibleiQ7L190. HS.

Organism-specific databases

HPAiCAB020678.
HPA035249.
HPA035250.

Interactioni

Subunit structurei

Interacts with DPPA2 (By similarity). Interacts with PCGF1 (PubMed:26687479).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF4A2Q142403EBI-710457,EBI-73473
EIF4A2Q14240-23EBI-710457,EBI-10232522
GRB2P629933EBI-710457,EBI-401755
LDOC1O957514EBI-710457,EBI-740738
RPGRIP1Q96KN73EBI-710457,EBI-1050213
SH3GL1Q6FGM05EBI-710457,EBI-10173690
SH3GL1Q999615EBI-710457,EBI-697911

Protein-protein interaction databases

BioGridi120507. 34 interactions.
IntActiQ7L190. 19 interactions.
MINTiMINT-1398359.
STRINGi9606.ENSP00000335306.

Structurei

3D structure databases

ProteinModelPortaliQ7L190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IG5K. Eukaryota.
ENOG41118PS. LUCA.
GeneTreeiENSGT00390000004871.
HOGENOMiHOG000060113.
HOVERGENiHBG066898.
InParanoidiQ7L190.
OMAiEHTDNPR.
OrthoDBiEOG7SN8D1.
PhylomeDBiQ7L190.
TreeFamiTF338129.

Family and domain databases

InterProiIPR025891. Dppa2/4_C_dom.
IPR025892. Dppa2/4_central_dom.
[Graphical view]
PfamiPF14047. DCR. 1 hit.
PF14049. Dppa2_A. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7L190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGSASSTS MEKAKGKEWT STEKSREEDQ QASNQPNSIA LPGTSAKRTK
60 70 80 90 100
EKMSIKGSKV LCPKKKAEHT DNPRPQKKIP IPPLPSKLPP VNLIHRDILR
110 120 130 140 150
AWCQQLKLSS KGQKLDAYKR LCAFAYPNQK DFPSTAKEAK IRKSLQKKLK
160 170 180 190 200
VEKGETSLQS SETHPPEVAL PPVGEPPALE NSTALLEGVN TVVVTTSAPE
210 220 230 240 250
ALLASWARIS ARARTPEAVE SPQEASGVRW CVVHGKSLPA DTDGWVHLQF
260 270 280 290 300
HAGQAWVPEK QEGRVSALFL LPASNFPPPH LEDNMLCPKC VHRNKVLIKS

LQWE
Length:304
Mass (Da):33,541
Last modified:May 18, 2010 - v2
Checksum:iEF7C64D23CF2604F
GO

Sequence cautioni

The sequence BAA91765.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14188.1 differs from that shown. Reason: Frameshift at position 148. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551I → V.2 Publications
Corresponds to variant rs3762648 [ dbSNP | Ensembl ].
VAR_060372
Natural varianti226 – 2261S → F.
Corresponds to variant rs3905734 [ dbSNP | Ensembl ].
VAR_060373

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001575 mRNA. Translation: BAA91765.1. Different initiation.
AK022698 mRNA. Translation: BAB14188.1. Frameshift.
AK290992 mRNA. Translation: BAF83681.1.
AC076971 Genomic DNA. No translation available.
BC032846 mRNA. Translation: AAH32846.2.
CCDSiCCDS33814.1.
RefSeqiNP_060659.3. NM_018189.3.
UniGeneiHs.317659.

Genome annotation databases

EnsembliENST00000335658; ENSP00000335306; ENSG00000121570.
GeneIDi55211.
KEGGihsa:55211.
UCSCiuc003dxq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001575 mRNA. Translation: BAA91765.1. Different initiation.
AK022698 mRNA. Translation: BAB14188.1. Frameshift.
AK290992 mRNA. Translation: BAF83681.1.
AC076971 Genomic DNA. No translation available.
BC032846 mRNA. Translation: AAH32846.2.
CCDSiCCDS33814.1.
RefSeqiNP_060659.3. NM_018189.3.
UniGeneiHs.317659.

3D structure databases

ProteinModelPortaliQ7L190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120507. 34 interactions.
IntActiQ7L190. 19 interactions.
MINTiMINT-1398359.
STRINGi9606.ENSP00000335306.

PTM databases

iPTMnetiQ7L190.
PhosphoSiteiQ7L190.

Polymorphism and mutation databases

BioMutaiDPPA4.
DMDMi296434484.

Proteomic databases

PaxDbiQ7L190.
PRIDEiQ7L190.

Protocols and materials databases

DNASUi55211.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335658; ENSP00000335306; ENSG00000121570.
GeneIDi55211.
KEGGihsa:55211.
UCSCiuc003dxq.4. human.

Organism-specific databases

CTDi55211.
GeneCardsiDPPA4.
HGNCiHGNC:19200. DPPA4.
HPAiCAB020678.
HPA035249.
HPA035250.
MIMi614125. gene.
neXtProtiNX_Q7L190.
PharmGKBiPA134958838.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG5K. Eukaryota.
ENOG41118PS. LUCA.
GeneTreeiENSGT00390000004871.
HOGENOMiHOG000060113.
HOVERGENiHBG066898.
InParanoidiQ7L190.
OMAiEHTDNPR.
OrthoDBiEOG7SN8D1.
PhylomeDBiQ7L190.
TreeFamiTF338129.

Enzyme and pathway databases

ReactomeiR-HSA-2892247. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.

Miscellaneous databases

ChiTaRSiDPPA4. human.
GenomeRNAii55211.
PROiQ7L190.
SOURCEiSearch...

Gene expression databases

BgeeiQ7L190.
CleanExiHS_DPPA4.
ExpressionAtlasiQ7L190. baseline and differential.
GenevisibleiQ7L190. HS.

Family and domain databases

InterProiIPR025891. Dppa2/4_C_dom.
IPR025892. Dppa2/4_central_dom.
[Graphical view]
PfamiPF14047. DCR. 1 hit.
PF14049. Dppa2_A. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-55.
    Tissue: Teratocarcinoma.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-55.
    Tissue: Testis.
  4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-215; SER-221 AND SER-226, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis."
    Oliviero G., Munawar N., Watson A., Streubel G., Manning G., Bardwell V., Bracken A.P., Cagney G.
    Sci. Rep. 5:18388-18388(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH PCGF1.

Entry informationi

Entry nameiDPPA4_HUMAN
AccessioniPrimary (citable) accession number: Q7L190
Secondary accession number(s): A8K4M7, Q9H9N5, Q9NVI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.