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Q7L0Y3

- MRRP1_HUMAN

UniProt

Q7L0Y3 - MRRP1_HUMAN

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Protein

Mitochondrial ribonuclease P protein 1

Gene

TRMT10C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends.2 Publications

GO - Molecular functioni

  1. methyltransferase activity Source: UniProtKB-KW
  2. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. mitochondrial RNA 5'-end processing Source: UniProtKB
  2. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial ribonuclease P protein 1 (EC:2.1.1.-)
Short name:
Mitochondrial RNase P protein 1
Alternative name(s):
HBV pre-S2 trans-regulated protein 2
RNA (guanine-9-)-methyltransferase domain-containing protein 1
Renal carcinoma antigen NY-REN-49
tRNA methyltransferase 10 homolog C
Gene namesi
Name:TRMT10C
Synonyms:MRPP1, RG9MTD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:26022. TRMT10C.

Subcellular locationi

Mitochondrion matrixmitochondrion nucleoid 2 Publications

GO - Cellular componenti

  1. mitochondrial nucleoid Source: UniProtKB-KW
  2. mitochondrion Source: HPA
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134988378.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
BLAST
Chaini40 – 403364Mitochondrial ribonuclease P protein 1PRO_0000311309Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei84 – 841PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7L0Y3.
PaxDbiQ7L0Y3.
PeptideAtlasiQ7L0Y3.
PRIDEiQ7L0Y3.

PTM databases

PhosphoSiteiQ7L0Y3.

Expressioni

Gene expression databases

BgeeiQ7L0Y3.
CleanExiHS_RG9MTD1.
ExpressionAtlasiQ7L0Y3. baseline and differential.
GenevestigatoriQ7L0Y3.

Organism-specific databases

HPAiHPA036671.

Interactioni

Subunit structurei

Interacts with MRPP2/HSD17B10 and MRPP3/KIAA0391. Interacts with GRSF1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HSD17B10Q997144EBI-2107046,EBI-79964

Protein-protein interaction databases

BioGridi120271. 15 interactions.
IntActiQ7L0Y3. 20 interactions.
MINTiMINT-4992496.
STRINGi9606.ENSP00000312356.

Structurei

3D structure databases

ProteinModelPortaliQ7L0Y3.
SMRiQ7L0Y3. Positions 205-379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 383193SAM-dependent MTase TRM10-typePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili138 – 16932Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase TRM10-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiNOG270094.
GeneTreeiENSGT00530000063169.
HOGENOMiHOG000088648.
HOVERGENiHBG108146.
InParanoidiQ7L0Y3.
KOiK17654.
OMAiNVDPFHI.
OrthoDBiEOG71RXK2.
PhylomeDBiQ7L0Y3.
TreeFamiTF319795.

Family and domain databases

InterProiIPR025812. Mt_RNase_P_1.
IPR028564. MT_TRM10-typ.
IPR007356. tRNA_m1G_MeTrfase_euk.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
[Graphical view]
PANTHERiPTHR13563. PTHR13563. 1 hit.
PTHR13563:SF5. PTHR13563:SF5. 1 hit.
PfamiPF01746. tRNA_m1G_MT. 1 hit.
[Graphical view]
PROSITEiPS51675. SAM_MT_TRM10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7L0Y3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAFLKMSVS VNFFRPFTRF LVPFTLHRKR NNLTILQRYM SSKIPAVTYP
60 70 80 90 100
KNESTPPSEE LELDKWKTTM KSSVQEECVS TISSSKDEDP LAATREFIEM
110 120 130 140 150
WRLLGREVPE HITEEELKTL MECVSNTAKK KYLKYLYTKE KVKKARQIKK
160 170 180 190 200
EMKAAAREEA KNIKLLETTE EDKQKNFLFL RLWDRNMDIA MGWKGAQAMQ
210 220 230 240 250
FGQPLVFDMA YENYMKRKEL QNTVSQLLES EGWNRRNVDP FHIYFCNLKI
260 270 280 290 300
DGALHRELVK RYQEKWDKLL LTSTEKSHVD LFPKDSIIYL TADSPNVMTT
310 320 330 340 350
FRHDKVYVIG SFVDKSMQPG TSLAKAKRLN LATECLPLDK YLQWEIGNKN
360 370 380 390 400
LTLDQMIRIL LCLKNNGNWQ EALQFVPKRK HTGFLEISQH SQEFINRLKK

AKT
Length:403
Mass (Da):47,347
Last modified:January 20, 2009 - v2
Checksum:i28CBD97B4114819F
GO

Sequence cautioni

The sequence BAA91166.1 differs from that shown. Reason: Frameshift at position 128.
The sequence AAD42877.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAH35967.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561P → R.1 Publication
Corresponds to variant rs3762735 [ dbSNP | Ensembl ].
VAR_057355
Natural varianti164 – 1641K → N.
Corresponds to variant rs16844031 [ dbSNP | Ensembl ].
VAR_057356

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF226052 mRNA. Translation: AAF86952.1.
AK000439 mRNA. Translation: BAA91166.1. Frameshift.
CH471052 Genomic DNA. Translation: EAW79795.1.
BC035967 mRNA. Translation: AAH35967.2. Different initiation.
AF155111 mRNA. Translation: AAD42877.1. Different initiation.
AY561707 mRNA. Translation: AAS66980.1.
CCDSiCCDS43122.1.
RefSeqiNP_060289.2. NM_017819.3.
UniGeneiHs.594839.
Hs.740864.
Hs.744223.

Genome annotation databases

EnsembliENST00000309922; ENSP00000312356; ENSG00000174173.
GeneIDi54931.
KEGGihsa:54931.
UCSCiuc003duz.4. human.

Polymorphism databases

DMDMi221222465.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF226052 mRNA. Translation: AAF86952.1 .
AK000439 mRNA. Translation: BAA91166.1 . Frameshift.
CH471052 Genomic DNA. Translation: EAW79795.1 .
BC035967 mRNA. Translation: AAH35967.2 . Different initiation.
AF155111 mRNA. Translation: AAD42877.1 . Different initiation.
AY561707 mRNA. Translation: AAS66980.1 .
CCDSi CCDS43122.1.
RefSeqi NP_060289.2. NM_017819.3.
UniGenei Hs.594839.
Hs.740864.
Hs.744223.

3D structure databases

ProteinModelPortali Q7L0Y3.
SMRi Q7L0Y3. Positions 205-379.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120271. 15 interactions.
IntActi Q7L0Y3. 20 interactions.
MINTi MINT-4992496.
STRINGi 9606.ENSP00000312356.

PTM databases

PhosphoSitei Q7L0Y3.

Polymorphism databases

DMDMi 221222465.

Proteomic databases

MaxQBi Q7L0Y3.
PaxDbi Q7L0Y3.
PeptideAtlasi Q7L0Y3.
PRIDEi Q7L0Y3.

Protocols and materials databases

DNASUi 54931.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309922 ; ENSP00000312356 ; ENSG00000174173 .
GeneIDi 54931.
KEGGi hsa:54931.
UCSCi uc003duz.4. human.

Organism-specific databases

CTDi 54931.
GeneCardsi GC03P101281.
HGNCi HGNC:26022. TRMT10C.
HPAi HPA036671.
MIMi 615423. gene.
neXtProti NX_Q7L0Y3.
PharmGKBi PA134988378.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG270094.
GeneTreei ENSGT00530000063169.
HOGENOMi HOG000088648.
HOVERGENi HBG108146.
InParanoidi Q7L0Y3.
KOi K17654.
OMAi NVDPFHI.
OrthoDBi EOG71RXK2.
PhylomeDBi Q7L0Y3.
TreeFami TF319795.

Miscellaneous databases

GenomeRNAii 54931.
NextBioi 58035.
PROi Q7L0Y3.
SOURCEi Search...

Gene expression databases

Bgeei Q7L0Y3.
CleanExi HS_RG9MTD1.
ExpressionAtlasi Q7L0Y3. baseline and differential.
Genevestigatori Q7L0Y3.

Family and domain databases

InterProi IPR025812. Mt_RNase_P_1.
IPR028564. MT_TRM10-typ.
IPR007356. tRNA_m1G_MeTrfase_euk.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
[Graphical view ]
PANTHERi PTHR13563. PTHR13563. 1 hit.
PTHR13563:SF5. PTHR13563:SF5. 1 hit.
Pfami PF01746. tRNA_m1G_MT. 1 hit.
[Graphical view ]
PROSITEi PS51675. SAM_MT_TRM10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene expressed in human liver cancer tissue."
    Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Signet-ring cell carcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-129, IDENTIFICATION AS A RENAL CANCER ANTIGEN, VARIANT ARG-56.
    Tissue: Renal cell carcinoma.
  6. "Screening of the genes of hepatitis B virus preS2 interacting proteins."
    Lu Y.Y., Li K., Wang L., Liu Y., Wang Y.D., Cheng J., Zhang L.X.
    Zhonghua Gan Zang Bing Za Zhi 11:8-10(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-403.
  7. "RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme."
    Holzmann J., Frank P., Loeffler E., Bennett K.L., Gerner C., Rossmanith W.
    Cell 135:462-474(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH HSD17B10 AND KIAA0391, SUBCELLULAR LOCATION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs."
    Brzezniak L.K., Bijata M., Szczesny R.J., Stepien P.P.
    RNA Biol. 8:616-626(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. Cited for: SUBCELLULAR LOCATION, INTERACTION WITH GRSF1.

Entry informationi

Entry nameiMRRP1_HUMAN
AccessioniPrimary (citable) accession number: Q7L0Y3
Secondary accession number(s): Q9NRG5, Q9NX54, Q9Y596
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 20, 2009
Last modified: October 29, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3