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Q7L0Y3 (MRRP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial ribonuclease P protein 1

Short name=Mitochondrial RNase P protein 1
EC=2.1.1.-
Alternative name(s):
HBV pre-S2 trans-regulated protein 2
RNA (guanine-9-)-methyltransferase domain-containing protein 1
Renal carcinoma antigen NY-REN-49
tRNA methyltransferase 10 homolog C
Gene names
Name:TRMT10C
Synonyms:MRPP1, RG9MTD1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Ref.7 Ref.9

Subunit structure

Interacts with MRPP2/HSD17B10 and MRPP3/KIAA0391. Interacts with GRSF1. Ref.7 Ref.10

Subcellular location

Mitochondrion matrixmitochondrion nucleoid Ref.7 Ref.10.

Sequence similarities

Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.

Contains 1 SAM-dependent MTase TRM10-type domain.

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.

Sequence caution

The sequence AAD42877.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAH35967.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAA91166.1 differs from that shown. Reason: Frameshift at position 128.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HSD17B10Q997144EBI-2107046,EBI-79964

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3939Mitochondrion Potential
Chain40 – 403364Mitochondrial ribonuclease P protein 1
PRO_0000311309

Regions

Domain191 – 383193SAM-dependent MTase TRM10-type
Coiled coil138 – 16932 Potential

Amino acid modifications

Modified residue841Phosphoserine By similarity

Natural variations

Natural variant561P → R. Ref.5
Corresponds to variant rs3762735 [ dbSNP | Ensembl ].
VAR_057355
Natural variant1641K → N.
Corresponds to variant rs16844031 [ dbSNP | Ensembl ].
VAR_057356

Sequences

Sequence LengthMass (Da)Tools
Q7L0Y3 [UniParc].

Last modified January 20, 2009. Version 2.
Checksum: 28CBD97B4114819F

FASTA40347,347
        10         20         30         40         50         60 
MAAFLKMSVS VNFFRPFTRF LVPFTLHRKR NNLTILQRYM SSKIPAVTYP KNESTPPSEE 

        70         80         90        100        110        120 
LELDKWKTTM KSSVQEECVS TISSSKDEDP LAATREFIEM WRLLGREVPE HITEEELKTL 

       130        140        150        160        170        180 
MECVSNTAKK KYLKYLYTKE KVKKARQIKK EMKAAAREEA KNIKLLETTE EDKQKNFLFL 

       190        200        210        220        230        240 
RLWDRNMDIA MGWKGAQAMQ FGQPLVFDMA YENYMKRKEL QNTVSQLLES EGWNRRNVDP 

       250        260        270        280        290        300 
FHIYFCNLKI DGALHRELVK RYQEKWDKLL LTSTEKSHVD LFPKDSIIYL TADSPNVMTT 

       310        320        330        340        350        360 
FRHDKVYVIG SFVDKSMQPG TSLAKAKRLN LATECLPLDK YLQWEIGNKN LTLDQMIRIL 

       370        380        390        400 
LCLKNNGNWQ EALQFVPKRK HTGFLEISQH SQEFINRLKK AKT 

« Hide

References

« Hide 'large scale' references
[1]"A novel gene expressed in human liver cancer tissue."
Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Signet-ring cell carcinoma.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[5]"Antigens recognized by autologous antibody in patients with renal-cell carcinoma."
Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H., Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T., Old L.J.
Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-129, IDENTIFICATION AS A RENAL CANCER ANTIGEN, VARIANT ARG-56.
Tissue: Renal cell carcinoma.
[6]"Screening of the genes of hepatitis B virus preS2 interacting proteins."
Lu Y.Y., Li K., Wang L., Liu Y., Wang Y.D., Cheng J., Zhang L.X.
Zhonghua Gan Zang Bing Za Zhi 11:8-10(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-403.
[7]"RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme."
Holzmann J., Frank P., Loeffler E., Bennett K.L., Gerner C., Rossmanith W.
Cell 135:462-474(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH HSD17B10 AND KIAA0391, SUBCELLULAR LOCATION.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs."
Brzezniak L.K., Bijata M., Szczesny R.J., Stepien P.P.
RNA Biol. 8:616-626(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[10]"GRSF1 regulates RNA processing in mitochondrial RNA granules."
Jourdain A.A., Koppen M., Wydro M., Rodley C.D., Lightowlers R.N., Chrzanowska-Lightowlers Z.M., Martinou J.C.
Cell Metab. 17:399-410(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH GRSF1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF226052 mRNA. Translation: AAF86952.1.
AK000439 mRNA. Translation: BAA91166.1. Frameshift.
CH471052 Genomic DNA. Translation: EAW79795.1.
BC035967 mRNA. Translation: AAH35967.2. Different initiation.
AF155111 mRNA. Translation: AAD42877.1. Different initiation.
AY561707 mRNA. Translation: AAS66980.1.
CCDSCCDS43122.1.
RefSeqNP_060289.2. NM_017819.3.
UniGeneHs.594839.
Hs.740864.
Hs.744223.

3D structure databases

ProteinModelPortalQ7L0Y3.
SMRQ7L0Y3. Positions 205-379.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120271. 7 interactions.
IntActQ7L0Y3. 20 interactions.
MINTMINT-4992496.
STRING9606.ENSP00000312356.

PTM databases

PhosphoSiteQ7L0Y3.

Polymorphism databases

DMDM221222465.

Proteomic databases

MaxQBQ7L0Y3.
PaxDbQ7L0Y3.
PeptideAtlasQ7L0Y3.
PRIDEQ7L0Y3.

Protocols and materials databases

DNASU54931.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309922; ENSP00000312356; ENSG00000174173.
GeneID54931.
KEGGhsa:54931.
UCSCuc003duz.4. human.

Organism-specific databases

CTD54931.
GeneCardsGC03P101281.
HGNCHGNC:26022. TRMT10C.
HPAHPA036671.
MIM615423. gene.
neXtProtNX_Q7L0Y3.
PharmGKBPA134988378.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG270094.
HOGENOMHOG000088648.
HOVERGENHBG108146.
InParanoidQ7L0Y3.
KOK17654.
OMANVDPFHI.
OrthoDBEOG71RXK2.
PhylomeDBQ7L0Y3.
TreeFamTF319795.

Gene expression databases

ArrayExpressQ7L0Y3.
BgeeQ7L0Y3.
CleanExHS_RG9MTD1.
GenevestigatorQ7L0Y3.

Family and domain databases

InterProIPR025812. Mt_RNase_P_1.
IPR028564. MT_TRM10-typ.
IPR007356. tRNA_m1G_MeTrfase_euk.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
[Graphical view]
PANTHERPTHR13563. PTHR13563. 1 hit.
PTHR13563:SF5. PTHR13563:SF5. 1 hit.
PfamPF01746. tRNA_m1G_MT. 1 hit.
[Graphical view]
PROSITEPS51675. SAM_MT_TRM10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi54931.
NextBio58035.
PROQ7L0Y3.
SOURCESearch...

Entry information

Entry nameMRRP1_HUMAN
AccessionPrimary (citable) accession number: Q7L0Y3
Secondary accession number(s): Q9NRG5, Q9NX54, Q9Y596
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 20, 2009
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM