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Q7L0Y3

- MRRP1_HUMAN

UniProt

Q7L0Y3 - MRRP1_HUMAN

Protein

Mitochondrial ribonuclease P protein 1

Gene

TRMT10C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (20 Jan 2009)
      Previous versions | rss
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    Functioni

    Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends.2 Publications

    GO - Molecular functioni

    1. methyltransferase activity Source: UniProtKB-KW
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. mitochondrial RNA 5'-end processing Source: UniProtKB
    2. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial ribonuclease P protein 1 (EC:2.1.1.-)
    Short name:
    Mitochondrial RNase P protein 1
    Alternative name(s):
    HBV pre-S2 trans-regulated protein 2
    RNA (guanine-9-)-methyltransferase domain-containing protein 1
    Renal carcinoma antigen NY-REN-49
    tRNA methyltransferase 10 homolog C
    Gene namesi
    Name:TRMT10C
    Synonyms:MRPP1, RG9MTD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:26022. TRMT10C.

    Subcellular locationi

    Mitochondrion matrixmitochondrion nucleoid 2 Publications

    GO - Cellular componenti

    1. mitochondrial nucleoid Source: UniProtKB-SubCell
    2. mitochondrion Source: HPA
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Mitochondrion, Mitochondrion nucleoid

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134988378.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
    BLAST
    Chaini40 – 403364Mitochondrial ribonuclease P protein 1PRO_0000311309Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei84 – 841PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ7L0Y3.
    PaxDbiQ7L0Y3.
    PeptideAtlasiQ7L0Y3.
    PRIDEiQ7L0Y3.

    PTM databases

    PhosphoSiteiQ7L0Y3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7L0Y3.
    BgeeiQ7L0Y3.
    CleanExiHS_RG9MTD1.
    GenevestigatoriQ7L0Y3.

    Organism-specific databases

    HPAiHPA036671.

    Interactioni

    Subunit structurei

    Interacts with MRPP2/HSD17B10 and MRPP3/KIAA0391. Interacts with GRSF1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HSD17B10Q997144EBI-2107046,EBI-79964

    Protein-protein interaction databases

    BioGridi120271. 7 interactions.
    IntActiQ7L0Y3. 20 interactions.
    MINTiMINT-4992496.
    STRINGi9606.ENSP00000312356.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7L0Y3.
    SMRiQ7L0Y3. Positions 205-379.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini191 – 383193SAM-dependent MTase TRM10-typePROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili138 – 16932Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.PROSITE-ProRule annotation
    Contains 1 SAM-dependent MTase TRM10-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transit peptide

    Phylogenomic databases

    eggNOGiNOG270094.
    HOGENOMiHOG000088648.
    HOVERGENiHBG108146.
    InParanoidiQ7L0Y3.
    KOiK17654.
    OMAiNVDPFHI.
    OrthoDBiEOG71RXK2.
    PhylomeDBiQ7L0Y3.
    TreeFamiTF319795.

    Family and domain databases

    InterProiIPR025812. Mt_RNase_P_1.
    IPR028564. MT_TRM10-typ.
    IPR007356. tRNA_m1G_MeTrfase_euk.
    IPR016009. tRNA_MeTrfase_TRMD/TRM10.
    [Graphical view]
    PANTHERiPTHR13563. PTHR13563. 1 hit.
    PTHR13563:SF5. PTHR13563:SF5. 1 hit.
    PfamiPF01746. tRNA_m1G_MT. 1 hit.
    [Graphical view]
    PROSITEiPS51675. SAM_MT_TRM10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7L0Y3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAFLKMSVS VNFFRPFTRF LVPFTLHRKR NNLTILQRYM SSKIPAVTYP    50
    KNESTPPSEE LELDKWKTTM KSSVQEECVS TISSSKDEDP LAATREFIEM 100
    WRLLGREVPE HITEEELKTL MECVSNTAKK KYLKYLYTKE KVKKARQIKK 150
    EMKAAAREEA KNIKLLETTE EDKQKNFLFL RLWDRNMDIA MGWKGAQAMQ 200
    FGQPLVFDMA YENYMKRKEL QNTVSQLLES EGWNRRNVDP FHIYFCNLKI 250
    DGALHRELVK RYQEKWDKLL LTSTEKSHVD LFPKDSIIYL TADSPNVMTT 300
    FRHDKVYVIG SFVDKSMQPG TSLAKAKRLN LATECLPLDK YLQWEIGNKN 350
    LTLDQMIRIL LCLKNNGNWQ EALQFVPKRK HTGFLEISQH SQEFINRLKK 400
    AKT 403
    Length:403
    Mass (Da):47,347
    Last modified:January 20, 2009 - v2
    Checksum:i28CBD97B4114819F
    GO

    Sequence cautioni

    The sequence BAA91166.1 differs from that shown. Reason: Frameshift at position 128.
    The sequence AAD42877.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAH35967.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti56 – 561P → R.1 Publication
    Corresponds to variant rs3762735 [ dbSNP | Ensembl ].
    VAR_057355
    Natural varianti164 – 1641K → N.
    Corresponds to variant rs16844031 [ dbSNP | Ensembl ].
    VAR_057356

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF226052 mRNA. Translation: AAF86952.1.
    AK000439 mRNA. Translation: BAA91166.1. Frameshift.
    CH471052 Genomic DNA. Translation: EAW79795.1.
    BC035967 mRNA. Translation: AAH35967.2. Different initiation.
    AF155111 mRNA. Translation: AAD42877.1. Different initiation.
    AY561707 mRNA. Translation: AAS66980.1.
    CCDSiCCDS43122.1.
    RefSeqiNP_060289.2. NM_017819.3.
    UniGeneiHs.594839.
    Hs.740864.
    Hs.744223.

    Genome annotation databases

    EnsembliENST00000309922; ENSP00000312356; ENSG00000174173.
    GeneIDi54931.
    KEGGihsa:54931.
    UCSCiuc003duz.4. human.

    Polymorphism databases

    DMDMi221222465.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF226052 mRNA. Translation: AAF86952.1 .
    AK000439 mRNA. Translation: BAA91166.1 . Frameshift.
    CH471052 Genomic DNA. Translation: EAW79795.1 .
    BC035967 mRNA. Translation: AAH35967.2 . Different initiation.
    AF155111 mRNA. Translation: AAD42877.1 . Different initiation.
    AY561707 mRNA. Translation: AAS66980.1 .
    CCDSi CCDS43122.1.
    RefSeqi NP_060289.2. NM_017819.3.
    UniGenei Hs.594839.
    Hs.740864.
    Hs.744223.

    3D structure databases

    ProteinModelPortali Q7L0Y3.
    SMRi Q7L0Y3. Positions 205-379.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120271. 7 interactions.
    IntActi Q7L0Y3. 20 interactions.
    MINTi MINT-4992496.
    STRINGi 9606.ENSP00000312356.

    PTM databases

    PhosphoSitei Q7L0Y3.

    Polymorphism databases

    DMDMi 221222465.

    Proteomic databases

    MaxQBi Q7L0Y3.
    PaxDbi Q7L0Y3.
    PeptideAtlasi Q7L0Y3.
    PRIDEi Q7L0Y3.

    Protocols and materials databases

    DNASUi 54931.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309922 ; ENSP00000312356 ; ENSG00000174173 .
    GeneIDi 54931.
    KEGGi hsa:54931.
    UCSCi uc003duz.4. human.

    Organism-specific databases

    CTDi 54931.
    GeneCardsi GC03P101281.
    HGNCi HGNC:26022. TRMT10C.
    HPAi HPA036671.
    MIMi 615423. gene.
    neXtProti NX_Q7L0Y3.
    PharmGKBi PA134988378.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG270094.
    HOGENOMi HOG000088648.
    HOVERGENi HBG108146.
    InParanoidi Q7L0Y3.
    KOi K17654.
    OMAi NVDPFHI.
    OrthoDBi EOG71RXK2.
    PhylomeDBi Q7L0Y3.
    TreeFami TF319795.

    Miscellaneous databases

    GenomeRNAii 54931.
    NextBioi 58035.
    PROi Q7L0Y3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7L0Y3.
    Bgeei Q7L0Y3.
    CleanExi HS_RG9MTD1.
    Genevestigatori Q7L0Y3.

    Family and domain databases

    InterProi IPR025812. Mt_RNase_P_1.
    IPR028564. MT_TRM10-typ.
    IPR007356. tRNA_m1G_MeTrfase_euk.
    IPR016009. tRNA_MeTrfase_TRMD/TRM10.
    [Graphical view ]
    PANTHERi PTHR13563. PTHR13563. 1 hit.
    PTHR13563:SF5. PTHR13563:SF5. 1 hit.
    Pfami PF01746. tRNA_m1G_MT. 1 hit.
    [Graphical view ]
    PROSITEi PS51675. SAM_MT_TRM10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene expressed in human liver cancer tissue."
      Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Signet-ring cell carcinoma.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-129, IDENTIFICATION AS A RENAL CANCER ANTIGEN, VARIANT ARG-56.
      Tissue: Renal cell carcinoma.
    6. "Screening of the genes of hepatitis B virus preS2 interacting proteins."
      Lu Y.Y., Li K., Wang L., Liu Y., Wang Y.D., Cheng J., Zhang L.X.
      Zhonghua Gan Zang Bing Za Zhi 11:8-10(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-403.
    7. "RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme."
      Holzmann J., Frank P., Loeffler E., Bennett K.L., Gerner C., Rossmanith W.
      Cell 135:462-474(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH HSD17B10 AND KIAA0391, SUBCELLULAR LOCATION.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs."
      Brzezniak L.K., Bijata M., Szczesny R.J., Stepien P.P.
      RNA Biol. 8:616-626(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. Cited for: SUBCELLULAR LOCATION, INTERACTION WITH GRSF1.

    Entry informationi

    Entry nameiMRRP1_HUMAN
    AccessioniPrimary (citable) accession number: Q7L0Y3
    Secondary accession number(s): Q9NRG5, Q9NX54, Q9Y596
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: January 20, 2009
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-7 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3