Q7L0Y3 (MRRP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial ribonuclease P protein 1
Short name=Mitochondrial RNase P protein 1
EC=2.1.1.-

Alternative name(s):
HBV pre-S2 trans-regulated protein 2
RNA (guanine-9-)-methyltransferase domain-containing protein 1
Renal carcinoma antigen NY-REN-49
tRNA methyltransferase 10 homolog C

Gene names

Name:	TRMT10C
Synonyms:	MRPP1, RG9MTD1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	403 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Ref.7
Subunit structure	Interacts with MRPP2/HSD17B10 and MRPP3/KIAA0391. Ref.7
Subcellular location	Mitochondrion Ref.7.
Sequence similarities	Belongs to the RNA methyltransferase TrmD family. TRM10 subfamily.
Caution	It is uncertain whether Met-1 or Met-7 is the initiator.
Sequence caution	The sequence AAD42877.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH35967.2 differs from that shown. Reason: Erroneous initiation. The sequence BAA91166.1 differs from that shown. Reason: Frameshift at position 128.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Domain	Coiled coil Transit peptide
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular_function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HSD17B10	Q99714	4	EBI-2107046,EBI-79964

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 39	39	Mitochondrion Potential
	Chain	40 – 403	364	Mitochondrial ribonuclease P protein 1		PRO_0000311309
Regions
	Coiled coil	138 – 169	32	Potential
Natural variations
	Natural variant	56	1	P → R. Ref.5 Corresponds to variant rs3762735 [ dbSNP | Ensembl ].		VAR_057355
	Natural variant	164	1	K → N. Corresponds to variant rs16844031 [ dbSNP | Ensembl ].		VAR_057356

Sequences

	Sequence		Length	Mass (Da)
	Q7L0Y3 [UniParc]. Last modified January 20, 2009. Version 2. Checksum: 28CBD97B4114819F	FASTA	403	47,347
	10 20 30 40 50 60 MAAFLKMSVS VNFFRPFTRF LVPFTLHRKR NNLTILQRYM SSKIPAVTYP KNESTPPSEE 70 80 90 100 110 120 LELDKWKTTM KSSVQEECVS TISSSKDEDP LAATREFIEM WRLLGREVPE HITEEELKTL 130 140 150 160 170 180 MECVSNTAKK KYLKYLYTKE KVKKARQIKK EMKAAAREEA KNIKLLETTE EDKQKNFLFL 190 200 210 220 230 240 RLWDRNMDIA MGWKGAQAMQ FGQPLVFDMA YENYMKRKEL QNTVSQLLES EGWNRRNVDP 250 260 270 280 290 300 FHIYFCNLKI DGALHRELVK RYQEKWDKLL LTSTEKSHVD LFPKDSIIYL TADSPNVMTT 310 320 330 340 350 360 FRHDKVYVIG SFVDKSMQPG TSLAKAKRLN LATECLPLDK YLQWEIGNKN LTLDQMIRIL 370 380 390 400 LCLKNNGNWQ EALQFVPKRK HTGFLEISQH SQEFINRLKK AKT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel gene expressed in human liver cancer tissue." Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Signet-ring cell carcinoma.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[5]	"Antigens recognized by autologous antibody in patients with renal-cell carcinoma." Scanlan M.J., Gordan J.D., Williamson B., Stockert E., Bander N.H., Jongeneel C.V., Gure A.O., Jaeger D., Jaeger E., Knuth A., Chen Y.-T., Old L.J. Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-129, IDENTIFICATION AS A RENAL CANCER ANTIGEN, VARIANT ARG-56. Tissue: Renal cell carcinoma.
[6]	"Screening of the genes of hepatitis B virus preS2 interacting proteins." Lu Y.Y., Li K., Wang L., Liu Y., Wang Y.D., Cheng J., Zhang L.X. Zhonghua Gan Zang Bing Za Zhi 11:8-10(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-403.
[7]	"RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme." Holzmann J., Frank P., Loeffler E., Bennett K.L., Gerner C., Rossmanith W. Cell 135:462-474(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH HSD17B10 AND KIAA0391, SUBCELLULAR LOCATION.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF226052 mRNA. Translation: AAF86952.1. AK000439 mRNA. Translation: BAA91166.1. Frameshift. CH471052 Genomic DNA. Translation: EAW79795.1. BC035967 mRNA. Translation: AAH35967.2. Different initiation. AF155111 mRNA. Translation: AAD42877.1. Different initiation. AY561707 mRNA. Translation: AAS66980.1.
IPI	IPI00099996.
RefSeq	NP_060289.2. NM_017819.3.
UniGene	Hs.727878.
3D structure databases
ProteinModelPortal	Q7L0Y3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7L0Y3. 19 interactions.
STRING	9606.ENSP00000312356.
PTM databases
PhosphoSite	Q7L0Y3.
Polymorphism databases
DMDM	221222465.
Proteomic databases
PaxDb	Q7L0Y3.
PeptideAtlas	Q7L0Y3.
PRIDE	Q7L0Y3.
Protocols and materials databases
DNASU	54931.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309922; ENSP00000312356; ENSG00000174173.
GeneID	54931.
KEGG	hsa:54931.
UCSC	uc003duz.3. human.
Organism-specific databases
CTD	54931.
GeneCards	GC03P101281.
HGNC	HGNC:26022. TRMT10C.
HPA	HPA036671.
neXtProt	NX_Q7L0Y3.
PharmGKB	PA134988378.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG270094.
HOGENOM	HOG000088648.
HOVERGEN	HBG108146.
InParanoid	Q7L0Y3.
OMA	NVDPFHI.
OrthoDB	EOG4ZS93C.
PhylomeDB	Q7L0Y3.
Gene expression databases
ArrayExpress	Q7L0Y3.
Bgee	Q7L0Y3.
CleanEx	HS_RG9MTD1.
Genevestigator	Q7L0Y3.
Family and domain databases
InterPro	IPR025812. Mt_RNase_P_1. IPR016009. tRNA_m1G_MeTrfase. IPR007356. tRNA_m1G_MeTrfase_euk. [Graphical view]
PANTHER	PTHR13563. PTHR13563. 1 hit. PTHR13563:SF5. PTHR13563:SF5. 1 hit.
Pfam	PF01746. tRNA_m1G_MT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	54931.
NextBio	58035.

Entry information

Entry name

MRRP1_HUMAN

Accession

Primary (citable) accession number: Q7L0Y3
Secondary accession number(s): Q9NRG5, Q9NX54, Q9Y596

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	January 20, 2009
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.