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Protein

TLR4 interactor with leucine rich repeats

Gene

TRIL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the TLR4 signaling complex. Mediate the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion.1 Publication

GO - Molecular functioni

  • lipopolysaccharide binding Source: UniProtKB

GO - Biological processi

  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • regulation of cytokine production involved in immune response Source: UniProtKB
  • toll-like receptor 4 signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
TLR4 interactor with leucine rich repeats
Alternative name(s):
Leucine-rich repeat-containing protein KIAA0644
Gene namesi
Name:TRIL
Synonyms:KIAA0644
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22200. TRIL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 696671ExtracellularSequence analysisAdd
BLAST
Transmembranei697 – 71721HelicalSequence analysisAdd
BLAST
Topological domaini718 – 81194CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • lipopolysaccharide receptor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiTRIL.
DMDMi311033514.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 811786TLR4 interactor with leucine rich repeatsPRO_0000349255Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence analysis
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence analysis
Glycosylationi589 – 5891N-linked (GlcNAc...)Sequence analysis
Modified residuei798 – 7981PhosphoserineBy similarity

Post-translational modificationi

N-glycolysaled.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ7L0X0.

PTM databases

iPTMnetiQ7L0X0.

Expressioni

Tissue specificityi

Highly expressed in the brain, ovary, small intestine and spleen.1 Publication

Inductioni

By bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

GenevisibleiQ7L0X0. HS.

Interactioni

Subunit structurei

Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4. Interacts with TLR4; this interaction is greatly enhanced by LPS stimulation. Interacts with LPS.1 Publication

Protein-protein interaction databases

IntActiQ7L0X0. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ7L0X0.
SMRiQ7L0X0. Positions 36-438, 589-662.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 5732LRRNTAdd
BLAST
Repeati61 – 8121LRR 1Add
BLAST
Repeati84 – 10522LRR 2Add
BLAST
Repeati108 – 12922LRR 3Add
BLAST
Repeati132 – 15322LRR 4Add
BLAST
Repeati156 – 17722LRR 5Add
BLAST
Repeati180 – 20122LRR 6Add
BLAST
Repeati204 – 22320LRR 7Add
BLAST
Repeati230 – 25122LRR 8Add
BLAST
Repeati254 – 27522LRR 9Add
BLAST
Repeati278 – 29922LRR 10Add
BLAST
Repeati302 – 32322LRR 11Add
BLAST
Repeati326 – 34722LRR 12Add
BLAST
Domaini359 – 41658LRRCTAdd
BLAST

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118777.
HOVERGENiHBG066060.
InParanoidiQ7L0X0.
OMAiEFPCDRF.
PhylomeDBiQ7L0X0.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
PF01463. LRRCT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7L0X0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAARALRLL LVVCGCLALP PLAEPVCPER CDCQHPQHLL CTNRGLRVVP
60 70 80 90 100
KTSSLPSPHD VLTYSLGGNF ITNITAFDFH RLGQLRRLDL QYNQIRSLHP
110 120 130 140 150
KTFEKLSRLE ELYLGNNLLQ ALAPGTLAPL RKLRILYANG NEISRLSRGS
160 170 180 190 200
FEGLESLVKL RLDGNALGAL PDAVFAPLGN LLYLHLESNR IRFLGKNAFA
210 220 230 240 250
QLGKLRFLNL SANELQPSLR HAATFAPLRS LSSLILSANN LQHLGPRIFQ
260 270 280 290 300
HLPRLGLLSL RGNQLTHLAP EAFWGLEALR ELRLEGNRLS QLPTALLEPL
310 320 330 340 350
HSLEALDLSG NELSALHPAT FGHLGRLREL SLRNNALSAL SGDIFAASPA
360 370 380 390 400
LYRLDLDGNG WTCDCRLRGL KRWMGDWHSQ GRLLTVFVQC RHPPALRGKY
410 420 430 440 450
LDYLDDQQLQ NGSCADPSPS ASLTADRRRQ PLPTAAGEEM TPPAGLAEEL
460 470 480 490 500
PPQPQLQQQG RFLAGVAWDG AARELVGNRS ALRLSRRGPG LQQPSPSVAA
510 520 530 540 550
AAGPAPQSLD LHKKPQRGRP TRADPALAEP TPTASPGSAP SPAGDPWQRA
560 570 580 590 600
TKHRLGTEHQ ERAAQSDGGA GLPPLVSDPC DFNKFILCNL TVEAVGADSA
610 620 630 640 650
SVRWAVREHR SPRPLGGARF RLLFDRFGQQ PKFHRFVYLP ESSDSATLRE
660 670 680 690 700
LRGDTPYLVC VEGVLGGRVC PVAPRDHCAG LVTLPEAGSR GGVDYQLLTL
710 720 730 740 750
ALLTVNALLV LLALAAWASR WLRRKLRARR KGGAPVHVRH MYSTRRPLRS
760 770 780 790 800
MGTGVSADFS GFQSHRPRTT VCALSEADLI EFPCDRFMDS AGGGAGGSLR
810
REDRLLQRFA D
Length:811
Mass (Da):88,723
Last modified:November 2, 2010 - v2
Checksum:i5272376356F1A686
GO

Sequence cautioni

The sequence BAA31619.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAL24209.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti240 – 2401N → S.3 Publications
Corresponds to variant rs740250 [ dbSNP | Ensembl ].
VAR_046307
Natural varianti347 – 3471A → T.
Corresponds to variant rs3735561 [ dbSNP | Ensembl ].
VAR_046308
Natural varianti369 – 3691G → D.
Corresponds to variant rs3735562 [ dbSNP | Ensembl ].
VAR_046309
Natural varianti666 – 6661G → R Found in a patient with Joubert syndrome; unknown pathological significance. 1 Publication
VAR_075695

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014544 mRNA. Translation: BAA31619.2. Different initiation.
AC005013 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24208.1.
CH236948 Genomic DNA. Translation: EAL24209.1. Sequence problems.
CH471073 Genomic DNA. Translation: EAW93913.1.
BC036337 mRNA. Translation: AAH36337.1.
CCDSiCCDS75573.1.
RefSeqiNP_055632.2. NM_014817.3.
UniGeneiHs.744120.

Genome annotation databases

EnsembliENST00000539664; ENSP00000479256; ENSG00000255690.
GeneIDi9865.
KEGGihsa:9865.
UCSCiuc032zip.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014544 mRNA. Translation: BAA31619.2. Different initiation.
AC005013 Genomic DNA. No translation available.
CH236948 Genomic DNA. Translation: EAL24208.1.
CH236948 Genomic DNA. Translation: EAL24209.1. Sequence problems.
CH471073 Genomic DNA. Translation: EAW93913.1.
BC036337 mRNA. Translation: AAH36337.1.
CCDSiCCDS75573.1.
RefSeqiNP_055632.2. NM_014817.3.
UniGeneiHs.744120.

3D structure databases

ProteinModelPortaliQ7L0X0.
SMRiQ7L0X0. Positions 36-438, 589-662.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7L0X0. 1 interaction.

PTM databases

iPTMnetiQ7L0X0.

Polymorphism and mutation databases

BioMutaiTRIL.
DMDMi311033514.

Proteomic databases

PRIDEiQ7L0X0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000539664; ENSP00000479256; ENSG00000255690.
GeneIDi9865.
KEGGihsa:9865.
UCSCiuc032zip.2. human.

Organism-specific databases

CTDi9865.
GeneCardsiTRIL.
HGNCiHGNC:22200. TRIL.
MIMi613356. gene.
neXtProtiNX_Q7L0X0.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118777.
HOVERGENiHBG066060.
InParanoidiQ7L0X0.
OMAiEFPCDRF.
PhylomeDBiQ7L0X0.

Miscellaneous databases

GeneWikiiKIAA0644.
GenomeRNAii9865.
NextBioi37186.
PROiQ7L0X0.
SOURCEiSearch...

Gene expression databases

GenevisibleiQ7L0X0. HS.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
PF01463. LRRCT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-240.
    Tissue: Brain.
  2. Ohara O., Suyama M., Nagase T., Ishikawa K.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-240.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-240.
    Tissue: Brain.
  7. Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION BY LPS IN COMPLEX WITH TLR4, INTERACTION WITH LPS, GLYCOSYLATION.
  8. Cited for: VARIANT ARG-666.

Entry informationi

Entry nameiTRIL_HUMAN
AccessioniPrimary (citable) accession number: Q7L0X0
Secondary accession number(s): A4D1A6, O75139
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: November 2, 2010
Last modified: May 11, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.