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Protein

RING finger protein 44

Gene

RNF44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri380 – 42142RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 44
Gene namesi
Name:RNF44
Synonyms:KIAA1100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:19180. RNF44.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38819.

Polymorphism and mutation databases

BioMutaiRNF44.
DMDMi74758994.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432RING finger protein 44PRO_0000273413Add
BLAST

Proteomic databases

PaxDbiQ7L0R7.
PRIDEiQ7L0R7.

PTM databases

iPTMnetiQ7L0R7.
PhosphoSiteiQ7L0R7.

Expressioni

Gene expression databases

BgeeiQ7L0R7.
CleanExiHS_RNF44.
ExpressionAtlasiQ7L0R7. baseline and differential.
GenevisibleiQ7L0R7. HS.

Organism-specific databases

HPAiHPA038981.

Interactioni

Protein-protein interaction databases

IntActiQ7L0R7. 1 interaction.
STRINGi9606.ENSP00000274811.

Structurei

3D structure databases

ProteinModelPortaliQ7L0R7.
SMRiQ7L0R7. Positions 357-426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi12 – 321310Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri380 – 42142RING-type; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00730000110459.
HOGENOMiHOG000231638.
HOVERGENiHBG059283.
InParanoidiQ7L0R7.
KOiK19041.
OMAiPLPTGQH.
OrthoDBiEOG74TWZV.
PhylomeDBiQ7L0R7.
TreeFamiTF325756.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7L0R7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPWALAVTR WPPSAPVGQR RFSAGPGSTP GQLWGSPGLE GPLASPPARD
60 70 80 90 100
ERLPSQQPPS RPPHLPVEER RASAPAGGSP RMLHPATQQS PFMVDLHEQV
110 120 130 140 150
HQGPVPLSYT VTTVTTQGFP LPTGQHIPGC SAQQLPACSV MFSGQHYPLC
160 170 180 190 200
CLPPPLIQAC TMQQLPVPYQ AYPHLISSDH YILHPPPPAP PPQPTHMAPL
210 220 230 240 250
GQFVSLQTQH PRMPLQRLDN DVDLRGDQPS LGSFTYSTSA PGPALSPSVP
260 270 280 290 300
LHYLPHDPLH QELSFGVPYS HMMPRRLSTQ RYRLQQPLPP PPPPPPPPPY
310 320 330 340 350
YPSFLPYFLS MLPMSPTAMG PTISLDLDVD DVEMENYEAL LNLAERLGDA
360 370 380 390 400
KPRGLTKADI EQLPSYRFNP DSHQSEQTLC VVCFSDFEAR QLLRVLPCNH
410 420 430
EFHTKCVDKW LKANRTCPIC RADASEVPRE AE
Length:432
Mass (Da):47,728
Last modified:July 5, 2004 - v1
Checksum:iD6C2938B18A66816
GO
Isoform 2 (identifier: Q7L0R7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Note: No experimental confirmation available.
Show »
Length:351
Mass (Da):39,184
Checksum:i8DE42CDC2AEEA003
GO

Sequence cautioni

The sequence BAA83052.2 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8181Missing in isoform 2. 1 PublicationVSP_055432Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029023 mRNA. Translation: BAA83052.2. Different initiation.
AK302385 mRNA. Translation: BAG63702.1.
AC010316 Genomic DNA. No translation available.
AC091934 Genomic DNA. No translation available.
BC039833 mRNA. Translation: AAH39833.1.
BC063297 mRNA. Translation: AAH63297.1.
AL834489 mRNA. Translation: CAD39147.2.
CCDSiCCDS4404.1. [Q7L0R7-1]
RefSeqiNP_055716.1. NM_014901.4. [Q7L0R7-1]
XP_005265897.1. XM_005265840.1. [Q7L0R7-1]
XP_005265898.1. XM_005265841.3. [Q7L0R7-1]
XP_005265899.1. XM_005265842.3. [Q7L0R7-2]
XP_005265900.1. XM_005265843.1. [Q7L0R7-2]
XP_005265901.1. XM_005265844.3. [Q7L0R7-2]
XP_005265902.1. XM_005265845.3. [Q7L0R7-2]
XP_011532768.1. XM_011534466.1. [Q7L0R7-1]
XP_011532769.1. XM_011534467.1. [Q7L0R7-2]
UniGeneiHs.434888.

Genome annotation databases

EnsembliENST00000274811; ENSP00000274811; ENSG00000146083. [Q7L0R7-1]
GeneIDi22838.
KEGGihsa:22838.
UCSCiuc003mek.2. human. [Q7L0R7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029023 mRNA. Translation: BAA83052.2. Different initiation.
AK302385 mRNA. Translation: BAG63702.1.
AC010316 Genomic DNA. No translation available.
AC091934 Genomic DNA. No translation available.
BC039833 mRNA. Translation: AAH39833.1.
BC063297 mRNA. Translation: AAH63297.1.
AL834489 mRNA. Translation: CAD39147.2.
CCDSiCCDS4404.1. [Q7L0R7-1]
RefSeqiNP_055716.1. NM_014901.4. [Q7L0R7-1]
XP_005265897.1. XM_005265840.1. [Q7L0R7-1]
XP_005265898.1. XM_005265841.3. [Q7L0R7-1]
XP_005265899.1. XM_005265842.3. [Q7L0R7-2]
XP_005265900.1. XM_005265843.1. [Q7L0R7-2]
XP_005265901.1. XM_005265844.3. [Q7L0R7-2]
XP_005265902.1. XM_005265845.3. [Q7L0R7-2]
XP_011532768.1. XM_011534466.1. [Q7L0R7-1]
XP_011532769.1. XM_011534467.1. [Q7L0R7-2]
UniGeneiHs.434888.

3D structure databases

ProteinModelPortaliQ7L0R7.
SMRiQ7L0R7. Positions 357-426.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7L0R7. 1 interaction.
STRINGi9606.ENSP00000274811.

PTM databases

iPTMnetiQ7L0R7.
PhosphoSiteiQ7L0R7.

Polymorphism and mutation databases

BioMutaiRNF44.
DMDMi74758994.

Proteomic databases

PaxDbiQ7L0R7.
PRIDEiQ7L0R7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274811; ENSP00000274811; ENSG00000146083. [Q7L0R7-1]
GeneIDi22838.
KEGGihsa:22838.
UCSCiuc003mek.2. human. [Q7L0R7-1]

Organism-specific databases

CTDi22838.
GeneCardsiRNF44.
HGNCiHGNC:19180. RNF44.
HPAiHPA038981.
neXtProtiNX_Q7L0R7.
PharmGKBiPA38819.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00730000110459.
HOGENOMiHOG000231638.
HOVERGENiHBG059283.
InParanoidiQ7L0R7.
KOiK19041.
OMAiPLPTGQH.
OrthoDBiEOG74TWZV.
PhylomeDBiQ7L0R7.
TreeFamiTF325756.

Miscellaneous databases

ChiTaRSiRNF44. human.
GenomeRNAii22838.
NextBioi35476191.
PROiQ7L0R7.

Gene expression databases

BgeeiQ7L0R7.
CleanExiHS_RNF44.
ExpressionAtlasiQ7L0R7. baseline and differential.
GenevisibleiQ7L0R7. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta and Uterus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-432 (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiRNF44_HUMAN
AccessioniPrimary (citable) accession number: Q7L0R7
Secondary accession number(s): B4DYE0, Q8ND05, Q9UPQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.