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Q7L0J3

- SV2A_HUMAN

UniProt

Q7L0J3 - SV2A_HUMAN

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Protein
Synaptic vesicle glycoprotein 2A
Gene
SV2A, KIAA0736, PSEC0174
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles By similarity.

GO - Molecular functioni

  1. protein kinase binding Source: ParkinsonsUK-UCL
  2. receptor activity Source: Ensembl
  3. transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. cellular calcium ion homeostasis Source: Ensembl
  2. neurotransmitter transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiREACT_200616. Toxicity of botulinum toxin type E (BoNT/E).
REACT_200617. Toxicity of botulinum toxin type D (BoNT/D).
REACT_200659. Toxicity of botulinum toxin type F (BoNT/F).
REACT_200737. Toxicity of botulinum toxin type A (BoNT/A).

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2A
Gene namesi
Name:SV2A
Synonyms:KIAA0736
ORF Names:PSEC0174
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:20566. SV2A.

Subcellular locationi

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Multi-pass membrane protein By similarity
Note: Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 169169Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei170 – 19021Helical; Reviewed prediction
Add
BLAST
Topological domaini191 – 20515Extracellular Reviewed prediction
Add
BLAST
Transmembranei206 – 22621Helical; Reviewed prediction
Add
BLAST
Topological domaini227 – 2337Cytoplasmic Reviewed prediction
Transmembranei234 – 25421Helical; Reviewed prediction
Add
BLAST
Topological domaini255 – 2628Extracellular Reviewed prediction
Transmembranei263 – 28321Helical; Reviewed prediction
Add
BLAST
Topological domaini284 – 29411Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei295 – 31521Helical; Reviewed prediction
Add
BLAST
Topological domaini316 – 33419Extracellular Reviewed prediction
Add
BLAST
Transmembranei335 – 35521Helical; Reviewed prediction
Add
BLAST
Topological domaini356 – 44792Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei448 – 46821Helical; Reviewed prediction
Add
BLAST
Topological domaini469 – 598130Extracellular Reviewed prediction
Add
BLAST
Transmembranei599 – 61921Helical; Reviewed prediction
Add
BLAST
Topological domaini620 – 6267Cytoplasmic Reviewed prediction
Transmembranei627 – 64721Helical; Reviewed prediction
Add
BLAST
Topological domaini648 – 6514Extracellular Reviewed prediction
Transmembranei652 – 67221Helical; Reviewed prediction
Add
BLAST
Topological domaini673 – 68513Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei686 – 70823Helical; Reviewed prediction
Add
BLAST
Topological domaini709 – 7124Extracellular Reviewed prediction
Transmembranei713 – 73119Helical; Reviewed prediction
Add
BLAST
Topological domaini732 – 74211Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell-cell junction Source: Ensembl
  2. cytoplasm Source: HPA
  3. endoplasmic reticulum Source: LIFEdb
  4. integral component of membrane Source: UniProtKB-KW
  5. neuromuscular junction Source: Ensembl
  6. neuron projection Source: Ensembl
  7. presynaptic active zone Source: Ensembl
  8. synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 742742Synaptic vesicle glycoprotein 2A
PRO_0000239764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei80 – 801Phosphoserine1 Publication
Modified residuei81 – 811Phosphoserine1 Publication
Modified residuei84 – 841Phosphothreonine1 Publication
Modified residuei480 – 4801Phosphotyrosine By similarity
Glycosylationi498 – 4981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi548 – 5481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi573 – 5731N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1 By similarity.
N-glycosylated By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ7L0J3.
PaxDbiQ7L0J3.
PeptideAtlasiQ7L0J3.
PRIDEiQ7L0J3.

PTM databases

PhosphoSiteiQ7L0J3.

Expressioni

Gene expression databases

BgeeiQ7L0J3.
CleanExiHS_SV2A.
GenevestigatoriQ7L0J3.

Organism-specific databases

HPAiCAB002226.
HPA007863.

Interactioni

Subunit structurei

Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2 By similarity.

Protein-protein interaction databases

BioGridi115229. 3 interactions.
IntActiQ7L0J3. 3 interactions.
MINTiMINT-4722799.
STRINGi9606.ENSP00000358142.

Structurei

3D structure databases

ProteinModelPortaliQ7L0J3.
SMRiQ7L0J3. Positions 168-396, 497-577.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5757Interaction with SYT1 By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
HOVERGENiHBG053967.
InParanoidiQ7L0J3.
KOiK06258.
OMAiLTTMPES.
OrthoDBiEOG74TWZ1.
PhylomeDBiQ7L0J3.
TreeFamiTF324824.

Family and domain databases

InterProiIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PANTHERiPTHR24065. PTHR24065. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR01299. synapt_SV2. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7L0J3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEEGFRDRAA FIRGAKDIAK EVKKHAAKKV VKGLDRVQDE YSRRSYSRFE    50
EEDDDDDFPA PSDGYYRGEG TQDEEEGGAS SDATEGHDED DEIYEGEYQG 100
IPRAESGGKG ERMADGAPLA GVRGGLSDGE GPPGGRGEAQ RRKEREELAQ 150
QYEAILRECG HGRFQWTLYF VLGLALMADG VEVFVVGFVL PSAEKDMCLS 200
DSNKGMLGLI VYLGMMVGAF LWGGLADRLG RRQCLLISLS VNSVFAFFSS 250
FVQGYGTFLF CRLLSGVGIG GSIPIVFSYF SEFLAQEKRG EHLSWLCMFW 300
MIGGVYAAAM AWAIIPHYGW SFQMGSAYQF HSWRVFVLVC AFPSVFAIGA 350
LTTQPESPRF FLENGKHDEA WMVLKQVHDT NMRAKGHPER VFSVTHIKTI 400
HQEDELIEIQ SDTGTWYQRW GVRALSLGGQ VWGNFLSCFG PEYRRITLMM 450
MGVWFTMSFS YYGLTVWFPD MIRHLQAVDY ASRTKVFPGE RVEHVTFNFT 500
LENQIHRGGQ YFNDKFIGLR LKSVSFEDSL FEECYFEDVT SSNTFFRNCT 550
FINTVFYNTD LFEYKFVNSR LINSTFLHNK EGCPLDVTGT GEGAYMVYFV 600
SFLGTLAVLP GNIVSALLMD KIGRLRMLAG SSVMSCVSCF FLSFGNSESA 650
MIALLCLFGG VSIASWNALD VLTVELYPSD KRTTAFGFLN ALCKLAAVLG 700
ISIFTSFVGI TKAAPILFAS AALALGSSLA LKLPETRGQV LQ 742
Length:742
Mass (Da):82,695
Last modified:July 5, 2004 - v1
Checksum:i913E216D5CFC2FB2
GO
Isoform 2 (identifier: Q7L0J3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     683-742: Missing.

Note: No experimental confirmation available.

Show »
Length:682
Mass (Da):76,619
Checksum:i926FD8E2F5EAF88F
GO

Sequence cautioni

The sequence BAA34456.2 differs from that shown. Reason: Erroneous initiation.
The sequence CAI12573.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei683 – 74260Missing in isoform 2.
VSP_019265Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001G → D in CAD97824. 1 Publication
Sequence conflicti404 – 4041D → G in BAC11645. 1 Publication
Sequence conflicti493 – 4931E → G in CAD97824. 1 Publication
Sequence conflicti524 – 5241V → A in BAC11645. 1 Publication
Sequence conflicti544 – 5441T → A in BAC11645. 1 Publication
Sequence conflicti582 – 5821G → D in BAC11645. 1 Publication
Sequence conflicti611 – 6111G → R in BAC11645. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018279 mRNA. Translation: BAA34456.2. Different initiation.
AK075480 mRNA. Translation: BAC11645.1.
BX537754 mRNA. Translation: CAD97824.1.
AL591493 Genomic DNA. Translation: CAI12572.1.
AL591493 Genomic DNA. Translation: CAI12573.1. Sequence problems.
CH471121 Genomic DNA. Translation: EAW53596.1.
CH471121 Genomic DNA. Translation: EAW53598.1.
BC000776 mRNA. Translation: AAH00776.2.
BC045111 mRNA. Translation: AAH45111.1.
CCDSiCCDS940.1. [Q7L0J3-1]
RefSeqiNP_001265648.1. NM_001278719.1.
NP_055664.3. NM_014849.4. [Q7L0J3-1]
UniGeneiHs.516153.

Genome annotation databases

EnsembliENST00000369145; ENSP00000358141; ENSG00000159164. [Q7L0J3-2]
ENST00000369146; ENSP00000358142; ENSG00000159164. [Q7L0J3-1]
ENST00000581609; ENSP00000463016; ENSG00000265307. [Q7L0J3-1]
ENST00000584087; ENSP00000462467; ENSG00000265307. [Q7L0J3-2]
GeneIDi9900.
KEGGihsa:9900.
UCSCiuc001etg.3. human. [Q7L0J3-1]

Polymorphism databases

DMDMi74749878.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018279 mRNA. Translation: BAA34456.2 . Different initiation.
AK075480 mRNA. Translation: BAC11645.1 .
BX537754 mRNA. Translation: CAD97824.1 .
AL591493 Genomic DNA. Translation: CAI12572.1 .
AL591493 Genomic DNA. Translation: CAI12573.1 . Sequence problems.
CH471121 Genomic DNA. Translation: EAW53596.1 .
CH471121 Genomic DNA. Translation: EAW53598.1 .
BC000776 mRNA. Translation: AAH00776.2 .
BC045111 mRNA. Translation: AAH45111.1 .
CCDSi CCDS940.1. [Q7L0J3-1 ]
RefSeqi NP_001265648.1. NM_001278719.1.
NP_055664.3. NM_014849.4. [Q7L0J3-1 ]
UniGenei Hs.516153.

3D structure databases

ProteinModelPortali Q7L0J3.
SMRi Q7L0J3. Positions 168-396, 497-577.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115229. 3 interactions.
IntActi Q7L0J3. 3 interactions.
MINTi MINT-4722799.
STRINGi 9606.ENSP00000358142.

Chemistry

ChEMBLi CHEMBL1998.
DrugBanki DB01202. Levetiracetam.

PTM databases

PhosphoSitei Q7L0J3.

Polymorphism databases

DMDMi 74749878.

Proteomic databases

MaxQBi Q7L0J3.
PaxDbi Q7L0J3.
PeptideAtlasi Q7L0J3.
PRIDEi Q7L0J3.

Protocols and materials databases

DNASUi 9900.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369145 ; ENSP00000358141 ; ENSG00000159164 . [Q7L0J3-2 ]
ENST00000369146 ; ENSP00000358142 ; ENSG00000159164 . [Q7L0J3-1 ]
ENST00000581609 ; ENSP00000463016 ; ENSG00000265307 . [Q7L0J3-1 ]
ENST00000584087 ; ENSP00000462467 ; ENSG00000265307 . [Q7L0J3-2 ]
GeneIDi 9900.
KEGGi hsa:9900.
UCSCi uc001etg.3. human. [Q7L0J3-1 ]

Organism-specific databases

CTDi 9900.
GeneCardsi GC01M149874.
HGNCi HGNC:20566. SV2A.
HPAi CAB002226.
HPA007863.
MIMi 185860. gene.
neXtProti NX_Q7L0J3.
PharmGKBi PA128394564.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
HOVERGENi HBG053967.
InParanoidi Q7L0J3.
KOi K06258.
OMAi LTTMPES.
OrthoDBi EOG74TWZ1.
PhylomeDBi Q7L0J3.
TreeFami TF324824.

Enzyme and pathway databases

Reactomei REACT_200616. Toxicity of botulinum toxin type E (BoNT/E).
REACT_200617. Toxicity of botulinum toxin type D (BoNT/D).
REACT_200659. Toxicity of botulinum toxin type F (BoNT/F).
REACT_200737. Toxicity of botulinum toxin type A (BoNT/A).

Miscellaneous databases

ChiTaRSi SV2A. human.
GeneWikii SV2A.
GenomeRNAii 9900.
NextBioi 37327.
PROi Q7L0J3.
SOURCEi Search...

Gene expression databases

Bgeei Q7L0J3.
CleanExi HS_SV2A.
Genevestigatori Q7L0J3.

Family and domain databases

InterProi IPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view ]
PANTHERi PTHR24065. PTHR24065. 1 hit.
Pfami PF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
TIGRFAMsi TIGR01299. synapt_SV2. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Teratocarcinoma.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Retina.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Ovary.
  8. "The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam."
    Lynch B.A., Lambeng N., Nocka K., Kensel-Hammes P., Bajjalieh S.M., Matagne A., Fuks B.
    Proc. Natl. Acad. Sci. U.S.A. 101:9861-9866(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION AS BINDING-SITE FOR ANTIEPILEPTIC DRUG LEVETIRACETAM.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80; SER-81 AND THR-84, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiSV2A_HUMAN
AccessioniPrimary (citable) accession number: Q7L0J3
Secondary accession number(s): D3DUZ7
, O94841, Q5QNX8, Q7Z3L6, Q8NBJ6, Q9BVZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Identified as the brain binding-site for the antiepileptic drug levetiracetam/lev.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi