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Q7L0J3 (SV2A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptic vesicle glycoprotein 2A
Gene names
Name:SV2A
Synonyms:KIAA0736
ORF Names:PSEC0174
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length742 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles By similarity.

Subunit structure

Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2 By similarity.

Subcellular location

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Multi-pass membrane protein By similarity. Note: Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas By similarity.

Post-translational modification

Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1 By similarity.

N-glycosylated By similarity.

Miscellaneous

Identified as the brain binding-site for the antiepileptic drug levetiracetam/lev.

Sequence similarities

Belongs to the major facilitator superfamily.

Sequence caution

The sequence BAA34456.2 differs from that shown. Reason: Erroneous initiation.

The sequence CAI12573.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7L0J3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7L0J3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     683-742: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 742742Synaptic vesicle glycoprotein 2A
PRO_0000239764

Regions

Topological domain1 – 169169Cytoplasmic Potential
Transmembrane170 – 19021Helical; Potential
Topological domain191 – 20515Extracellular Potential
Transmembrane206 – 22621Helical; Potential
Topological domain227 – 2337Cytoplasmic Potential
Transmembrane234 – 25421Helical; Potential
Topological domain255 – 2628Extracellular Potential
Transmembrane263 – 28321Helical; Potential
Topological domain284 – 29411Cytoplasmic Potential
Transmembrane295 – 31521Helical; Potential
Topological domain316 – 33419Extracellular Potential
Transmembrane335 – 35521Helical; Potential
Topological domain356 – 44792Cytoplasmic Potential
Transmembrane448 – 46821Helical; Potential
Topological domain469 – 598130Extracellular Potential
Transmembrane599 – 61921Helical; Potential
Topological domain620 – 6267Cytoplasmic Potential
Transmembrane627 – 64721Helical; Potential
Topological domain648 – 6514Extracellular Potential
Transmembrane652 – 67221Helical; Potential
Topological domain673 – 68513Cytoplasmic Potential
Transmembrane686 – 70823Helical; Potential
Topological domain709 – 7124Extracellular Potential
Transmembrane713 – 73119Helical; Potential
Topological domain732 – 74211Cytoplasmic Potential
Region1 – 5757Interaction with SYT1 By similarity

Amino acid modifications

Modified residue801Phosphoserine Ref.9
Modified residue811Phosphoserine Ref.9
Modified residue841Phosphothreonine Ref.9
Modified residue4801Phosphotyrosine By similarity
Glycosylation4981N-linked (GlcNAc...) Potential
Glycosylation5481N-linked (GlcNAc...) Potential
Glycosylation5731N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence683 – 74260Missing in isoform 2.
VSP_019265

Experimental info

Sequence conflict1001G → D in CAD97824. Ref.4
Sequence conflict4041D → G in BAC11645. Ref.3
Sequence conflict4931E → G in CAD97824. Ref.4
Sequence conflict5241V → A in BAC11645. Ref.3
Sequence conflict5441T → A in BAC11645. Ref.3
Sequence conflict5821G → D in BAC11645. Ref.3
Sequence conflict6111G → R in BAC11645. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 913E216D5CFC2FB2

FASTA74282,695
        10         20         30         40         50         60 
MEEGFRDRAA FIRGAKDIAK EVKKHAAKKV VKGLDRVQDE YSRRSYSRFE EEDDDDDFPA 

        70         80         90        100        110        120 
PSDGYYRGEG TQDEEEGGAS SDATEGHDED DEIYEGEYQG IPRAESGGKG ERMADGAPLA 

       130        140        150        160        170        180 
GVRGGLSDGE GPPGGRGEAQ RRKEREELAQ QYEAILRECG HGRFQWTLYF VLGLALMADG 

       190        200        210        220        230        240 
VEVFVVGFVL PSAEKDMCLS DSNKGMLGLI VYLGMMVGAF LWGGLADRLG RRQCLLISLS 

       250        260        270        280        290        300 
VNSVFAFFSS FVQGYGTFLF CRLLSGVGIG GSIPIVFSYF SEFLAQEKRG EHLSWLCMFW 

       310        320        330        340        350        360 
MIGGVYAAAM AWAIIPHYGW SFQMGSAYQF HSWRVFVLVC AFPSVFAIGA LTTQPESPRF 

       370        380        390        400        410        420 
FLENGKHDEA WMVLKQVHDT NMRAKGHPER VFSVTHIKTI HQEDELIEIQ SDTGTWYQRW 

       430        440        450        460        470        480 
GVRALSLGGQ VWGNFLSCFG PEYRRITLMM MGVWFTMSFS YYGLTVWFPD MIRHLQAVDY 

       490        500        510        520        530        540 
ASRTKVFPGE RVEHVTFNFT LENQIHRGGQ YFNDKFIGLR LKSVSFEDSL FEECYFEDVT 

       550        560        570        580        590        600 
SSNTFFRNCT FINTVFYNTD LFEYKFVNSR LINSTFLHNK EGCPLDVTGT GEGAYMVYFV 

       610        620        630        640        650        660 
SFLGTLAVLP GNIVSALLMD KIGRLRMLAG SSVMSCVSCF FLSFGNSESA MIALLCLFGG 

       670        680        690        700        710        720 
VSIASWNALD VLTVELYPSD KRTTAFGFLN ALCKLAAVLG ISIFTSFVGI TKAAPILFAS 

       730        740 
AALALGSSLA LKLPETRGQV LQ 

« Hide

Isoform 2 [UniParc].

Checksum: 926FD8E2F5EAF88F
Show »

FASTA68276,619

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Teratocarcinoma.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Retina.
[5]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Ovary.
[8]"The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam."
Lynch B.A., Lambeng N., Nocka K., Kensel-Hammes P., Bajjalieh S.M., Matagne A., Fuks B.
Proc. Natl. Acad. Sci. U.S.A. 101:9861-9866(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION AS BINDING-SITE FOR ANTIEPILEPTIC DRUG LEVETIRACETAM.
[9]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80; SER-81 AND THR-84, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB018279 mRNA. Translation: BAA34456.2. Different initiation.
AK075480 mRNA. Translation: BAC11645.1.
BX537754 mRNA. Translation: CAD97824.1.
AL591493 Genomic DNA. Translation: CAI12572.1.
AL591493 Genomic DNA. Translation: CAI12573.1. Sequence problems.
CH471121 Genomic DNA. Translation: EAW53596.1.
CH471121 Genomic DNA. Translation: EAW53598.1.
BC000776 mRNA. Translation: AAH00776.2.
BC045111 mRNA. Translation: AAH45111.1.
CCDSCCDS940.1. [Q7L0J3-1]
RefSeqNP_001265648.1. NM_001278719.1.
NP_055664.3. NM_014849.4. [Q7L0J3-1]
UniGeneHs.516153.

3D structure databases

ProteinModelPortalQ7L0J3.
SMRQ7L0J3. Positions 168-396, 497-577.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115229. 4 interactions.
IntActQ7L0J3. 3 interactions.
MINTMINT-4722799.
STRING9606.ENSP00000358142.

Chemistry

ChEMBLCHEMBL1998.
DrugBankDB01202. Levetiracetam.

PTM databases

PhosphoSiteQ7L0J3.

Polymorphism databases

DMDM74749878.

Proteomic databases

MaxQBQ7L0J3.
PaxDbQ7L0J3.
PeptideAtlasQ7L0J3.
PRIDEQ7L0J3.

Protocols and materials databases

DNASU9900.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369145; ENSP00000358141; ENSG00000159164. [Q7L0J3-2]
ENST00000369146; ENSP00000358142; ENSG00000159164. [Q7L0J3-1]
ENST00000581609; ENSP00000463016; ENSG00000265307. [Q7L0J3-1]
ENST00000584087; ENSP00000462467; ENSG00000265307. [Q7L0J3-2]
GeneID9900.
KEGGhsa:9900.
UCSCuc001etg.3. human. [Q7L0J3-1]

Organism-specific databases

CTD9900.
GeneCardsGC01M149874.
HGNCHGNC:20566. SV2A.
HPACAB002226.
HPA007863.
MIM185860. gene.
neXtProtNX_Q7L0J3.
PharmGKBPA128394564.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOVERGENHBG053967.
InParanoidQ7L0J3.
KOK06258.
OMALTTMPES.
OrthoDBEOG74TWZ1.
PhylomeDBQ7L0J3.
TreeFamTF324824.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.

Gene expression databases

BgeeQ7L0J3.
CleanExHS_SV2A.
GenevestigatorQ7L0J3.

Family and domain databases

InterProIPR001646. 5peptide_repeat.
IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
IPR022308. SV2.
[Graphical view]
PANTHERPTHR24065. PTHR24065. 1 hit.
PfamPF07690. MFS_1. 1 hit.
PF13599. Pentapeptide_4. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 3 hits.
TIGRFAMsTIGR01299. synapt_SV2. 1 hit.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSV2A. human.
GeneWikiSV2A.
GenomeRNAi9900.
NextBio37327.
PROQ7L0J3.
SOURCESearch...

Entry information

Entry nameSV2A_HUMAN
AccessionPrimary (citable) accession number: Q7L0J3
Secondary accession number(s): D3DUZ7 expand/collapse secondary AC list , O94841, Q5QNX8, Q7Z3L6, Q8NBJ6, Q9BVZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM