UBE2I

Functionⁱ

Catalytic activityⁱ

SUMOyl-[E2 SUMO-conjugating enzyme]-L-cysteine + [acceptor-protein]-L-lysine = [E2 SUMO-conjugating enzyme]-L-cysteine + N₆-SUMOyl-[acceptor protein]-L-lysine.UniRule annotation

Pathwayⁱ: protein sumoylation

This protein is involved in the pathway protein sumoylation, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	93	Glycyl thioester intermediatePROSITE-ProRule annotation		1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-UniRule
SUMO transferase activity Source: InterPro

Complete GO annotation...

Keywordsⁱ

Biological process	Ubl conjugation pathwayUniRule annotationSAAS annotation
Ligand	ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayⁱ	UPA00886.

UniPathwayⁱ

UPA00886.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SUMO-conjugating enzymeUniRule annotation (EC:2.3.2.-UniRule annotation)
Gene namesⁱ	Name:UBE2IImported ORF Names:hCG_42687Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
	G2XKQ0	3	EBI-10180829,EBI-10175576
BEND5	Q7L4P6	3	EBI-10180829,EBI-724373
CBS	P35520	3	EBI-10180829,EBI-740135
CLK2	P49760	3	EBI-10180829,EBI-750020
DES	P17661	3	EBI-10180829,EBI-1055572
FHL3	Q96C98	3	EBI-10180829,EBI-10229248
GMCL1P1	Q8NEA9	3	EBI-10180829,EBI-745707
HNRNPC	P07910	3	EBI-10180829,EBI-357966
HNRNPLL	Q8WVV9	3	EBI-10180829,EBI-535849
IKZF1	Q13422	3	EBI-10180829,EBI-745305
KCTD1	Q719H9	3	EBI-10180829,EBI-9027502
KLHL12	Q53G59	3	EBI-10180829,EBI-740929
KRT19	P08727	3	EBI-10180829,EBI-742756
LMO2	P25791	3	EBI-10180829,EBI-739696
MAPK1IP1L	Q8NDC0	3	EBI-10180829,EBI-741424
PIAS2	O75928	3	EBI-10180829,EBI-348555
PUF60	Q9UHX1	3	EBI-10180829,EBI-1053259
RCBTB2	O95199	3	EBI-10180829,EBI-742404
RFPL3	O75679	3	EBI-10180829,EBI-10188956
RNF40	O75150	3	EBI-10180829,EBI-744408
SETBP1	Q9Y6X0	3	EBI-10180829,EBI-2548259
SUMO1	P63165	3	EBI-10180829,EBI-80140
TRIM21	P19474	3	EBI-10180829,EBI-81290
TRIM23	P36406	3	EBI-10180829,EBI-740098
TRIM38	O00635	3	EBI-10180829,EBI-2130415
UBXN1	Q04323	3	EBI-10180829,EBI-1058647
ZBED1	O96006	3	EBI-10180829,EBI-740037
ZBTB2	Q8N680	4	EBI-10180829,EBI-2515601
ZBTB8A	Q96BR9	3	EBI-10180829,EBI-742740

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Protein-protein interaction databases

IntActⁱ	Q7KZS0. 32 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-5003295.

Structureⁱ

3D structure databases

SMRⁱ	Q7KZS0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	7 – 137	UBIQUITIN_CONJUGAT_2InterPro annotationAdd BLAST		131

Sequence similaritiesⁱ

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG0424. Eukaryota. COG5078. LUCA.
HOVERGENⁱ	HBG063308.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00195. UBCc. 1 hit.
Gene3Dⁱ	3.10.110.10. 1 hit.
InterProⁱ	View protein in InterPro IPR027230. Ubc9. IPR000608. UBQ-conjugat_E2. IPR023313. UBQ-conjugating_AS. IPR016135. UBQ-conjugating_enzyme/RWD.
PANTHERⁱ	PTHR24067:SF164. PTHR24067:SF164. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00179. UQ_con. 1 hit.
SUPFAMⁱ	SSF54495. SSF54495. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q7KZS0-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MSGIALSRLA QERKAWRKDH PFGFVAVPTK NPDGTMNLMN WECAIPGKKG 
        60         70         80         90        100
TPWEGGLFKL RMLFKDDYPS SPPKCKFEPP LFHPNVYPSG TVCLSILEED 
       110        120        130        140        150
KDWRPAITIK QILLGIQELL NEPNIQDPAQ AEAYTIYWLV AALAPLVAAP 
       160        170        180 
PRPSQGRLAG REWSTQAHPR DSQGPRLCGE GRGA

Length:184

Mass (Da):20,444

Last modified:July 5, 2004 - v1

Checksum:ⁱAD786FF442074DB8

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	184	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT007010 mRNA. Translation: AAP35656.1. CH471112 Genomic DNA. Translation: EAW85674.1.
UniGeneⁱ	Hs.302903.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q7KZS0	B0QYN7 UPI00004E720B UPI0004F0A45B UPI0008F52A39 G7Q046	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Pan paniscus (Pygmy chimpanzee) (Bonobo) Gorilla gorilla gorilla (Western lowland gorilla) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	184	UniRef90_Q7KZS0	Cluster: SUMO-conjugating enzyme	6

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q7KZS0	Q9W6H5 A0A0R4IMC2 K7CSG8 UPI0008FA964D A0A1A8Q372 A0A1A8V6U5 A0A1A8F131 A0A1A7YD90 A0A1A8ECL1 A0A1A8M4R4 +234	Danio rerio (Zebrafish) (Brachydanio rerio) Pan troglodytes (Chimpanzee) Cyprinus carpio (Common carp) Nothobranchius rachovii (bluefin notho) Nothobranchius furzeri (Turquoise killifish) Nothobranchius korthausae Aphyosemion striatum Nothobranchius kadleci Nothobranchius pienaari Nothobranchius kuhntae (Beira killifish) And more	158	UniRef50_Q9W6H5	Cluster: SUMO-conjugating enzyme UBC9-A	245

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT007010 mRNA. Translation: AAP35656.1. CH471112 Genomic DNA. Translation: EAW85674.1.
UniGeneⁱ	Hs.302903.

3D structure databases

SMRⁱ	Q7KZS0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q7KZS0. 32 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-5003295.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	KOG0424. Eukaryota. COG5078. LUCA.
HOVERGENⁱ	HBG063308.

Enzyme and pathway databases

UniPathwayⁱ	UPA00886.

UniPathwayⁱ

UPA00886.

Miscellaneous databases

ChiTaRSⁱ	UBE2I. human.

ChiTaRSⁱ

UBE2I. human.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00195. UBCc. 1 hit.
Gene3Dⁱ	3.10.110.10. 1 hit.
InterProⁱ	View protein in InterPro IPR027230. Ubc9. IPR000608. UBQ-conjugat_E2. IPR023313. UBQ-conjugating_AS. IPR016135. UBQ-conjugating_enzyme/RWD.
PANTHERⁱ	PTHR24067:SF164. PTHR24067:SF164. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00179. UQ_con. 1 hit.
SUPFAMⁱ	SSF54495. SSF54495. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q7KZS0_HUMAN
Accessionⁱ	Q7KZS0Primary (citable) accession number: Q7KZS0
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 5, 2004
	Last sequence update:	July 5, 2004
	Last modified:	August 30, 2017
	This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - Q7KZS0 (Q7KZS0_HUMAN)

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SUMO-conjugating enzyme

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: protein sumoylation

Sites

GO - Molecular functionⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Interactionⁱ

Binary interactionsⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Experimental Info

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q7KZS0 (Q7KZS0_HUMAN)

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SUMO-conjugating enzyme

UBE2I

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein sumoylation

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

Pathwayⁱ: protein sumoylation

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ