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Protein

Ferrochelatase

Gene

DKFZp686P18130

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

Pathwayi: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ferrochelatase (DKFZp686P18130), Ferrochelatase, Ferrochelatase, Ferrochelatase, Ferrochelatase (FECH), Ferrochelatase, mitochondrial (FECH)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processHeme biosynthesisUniRule annotation, Porphyrin biosynthesisUniRule annotation
LigandIronUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325

Names & Taxonomyi

Protein namesi
Recommended name:
FerrochelataseUniRule annotation (EC:4.99.1.1UniRule annotation)
Gene namesi
Name:DKFZp686P18130Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28087

Chemistry databases

DrugBankiDB02659 Cholic Acid

PTM / Processingi

Proteomic databases

PeptideAtlasiQ7KZA3
PRIDEiQ7KZA3

Expressioni

Gene expression databases

GenevisibleiQ7KZA3 HS

Structurei

Miscellaneous databases

EvolutionaryTraceiQ7KZA3

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1321 Eukaryota
COG0276 LUCA
HOVERGENiHBG051898
KOiK01772

Family and domain databases

CDDicd00419 Ferrochelatase_C, 1 hit
cd03411 Ferrochelatase_N, 1 hit
HAMAPiMF_00323 Ferrochelatase, 1 hit
InterProiView protein in InterPro
IPR001015 Ferrochelatase
IPR019772 Ferrochelatase_AS
IPR033644 Ferrochelatase_C
IPR033659 Ferrochelatase_N
PANTHERiPTHR11108 PTHR11108, 1 hit
PfamiView protein in Pfam
PF00762 Ferrochelatase, 1 hit
TIGRFAMsiTIGR00109 hemH, 1 hit
PROSITEiView protein in PROSITE
PS00534 FERROCHELATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q7KZA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAALRAAGV LLRDPLASSS WRVCQPWRWK SGAAAAAVTT ETAQHAQGAK
60 70 80 90 100
PQVQPQKRKP KTGILMLNMG GPETLGDVHD FLLRLFLDRD LMTLPIQNKL
110 120 130 140 150
APFIAKRRTP KIQEQYRRIG GGSPIKIWTS KQGEGMVKLL DELSPNTAPH
160 170 180 190 200
KYYIGFRYVH PLTEEAIEEM ERDGLERAIA FTQYPQYSCS TTGSSLNAIY
210 220 230 240 250
RYYNQVGRKP TMKWSTIDRW PTHHLLIQCF ADHILKELDH FPLEKRSEVV
260 270 280 290 300
ILFSAHSLPM SVVNRGDPYP QEVSATVQKV MERLEYCNPY RLVWQSKVGP
310 320 330 340 350
MPWLGPQTDE SIKGLCERGR KNILLVPIAF TSDHIETLYE LDIEYSQVLA
360 370 380 390 400
KECGVENIRR AESLNGNPLF SKALADLVHS HIQSNELCSK QLTLSCPLCV
410
NPVCRETKSF FTSQQL
Length:416
Mass (Da):47,132
Last modified:July 5, 2004 - v1
Checksum:i4CC6E64E061042D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571744 mRNA Translation: CAE11869.1
RefSeqiNP_000131.2, NM_000140.3
NP_001012533.1, NM_001012515.2
UniGeneiHs.365365

Genome annotation databases

GeneIDi2235
KEGGihsa:2235

Similar proteinsi

Entry informationi

Entry nameiQ7KZA3_HUMAN
AccessioniPrimary (citable) accession number: Q7KZA3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 31, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.