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Protein

Ferrochelatase

Gene

DKFZp686P18130

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

Pathwayi: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ferrochelatase (DKFZp686P18130), Ferrochelatase, Ferrochelatase, Ferrochelatase, Ferrochelatase (FECH), Ferrochelatase, mitochondrial (FECH)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation

Keywords - Biological processi

Heme biosynthesisUniRule annotation, Porphyrin biosynthesisUniRule annotation

Keywords - Ligandi

IronUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
FerrochelataseUniRule annotation (EC:4.99.1.1UniRule annotation)
Gene namesi
Name:DKFZp686P18130Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28087.

Chemistry databases

DrugBankiDB02659. Cholic Acid.

PTM / Processingi

Proteomic databases

PaxDbiQ7KZA3.
PeptideAtlasiQ7KZA3.
PRIDEiQ7KZA3.

Expressioni

Gene expression databases

BgeeiENSG00000066926.
GenevisibleiQ7KZA3. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000372326.

Structurei

Miscellaneous databases

EvolutionaryTraceiQ7KZA3.

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1321. Eukaryota.
COG0276. LUCA.
HOVERGENiHBG051898.
KOiK01772.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7KZA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAALRAAGV LLRDPLASSS WRVCQPWRWK SGAAAAAVTT ETAQHAQGAK
60 70 80 90 100
PQVQPQKRKP KTGILMLNMG GPETLGDVHD FLLRLFLDRD LMTLPIQNKL
110 120 130 140 150
APFIAKRRTP KIQEQYRRIG GGSPIKIWTS KQGEGMVKLL DELSPNTAPH
160 170 180 190 200
KYYIGFRYVH PLTEEAIEEM ERDGLERAIA FTQYPQYSCS TTGSSLNAIY
210 220 230 240 250
RYYNQVGRKP TMKWSTIDRW PTHHLLIQCF ADHILKELDH FPLEKRSEVV
260 270 280 290 300
ILFSAHSLPM SVVNRGDPYP QEVSATVQKV MERLEYCNPY RLVWQSKVGP
310 320 330 340 350
MPWLGPQTDE SIKGLCERGR KNILLVPIAF TSDHIETLYE LDIEYSQVLA
360 370 380 390 400
KECGVENIRR AESLNGNPLF SKALADLVHS HIQSNELCSK QLTLSCPLCV
410
NPVCRETKSF FTSQQL
Length:416
Mass (Da):47,132
Last modified:July 5, 2004 - v1
Checksum:i4CC6E64E061042D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571744 mRNA. Translation: CAE11869.1.
RefSeqiNP_000131.2. NM_000140.3.
NP_001012533.1. NM_001012515.2.
UniGeneiHs.365365.

Genome annotation databases

GeneIDi2235.
KEGGihsa:2235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571744 mRNA. Translation: CAE11869.1.
RefSeqiNP_000131.2. NM_000140.3.
NP_001012533.1. NM_001012515.2.
UniGeneiHs.365365.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000372326.

Chemistry databases

DrugBankiDB02659. Cholic Acid.

Proteomic databases

PaxDbiQ7KZA3.
PeptideAtlasiQ7KZA3.
PRIDEiQ7KZA3.

Protocols and materials databases

DNASUi2235.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2235.
KEGGihsa:2235.

Organism-specific databases

CTDi2235.
PharmGKBiPA28087.

Phylogenomic databases

eggNOGiKOG1321. Eukaryota.
COG0276. LUCA.
HOVERGENiHBG051898.
KOiK01772.

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Miscellaneous databases

EvolutionaryTraceiQ7KZA3.
GenomeRNAii2235.

Gene expression databases

BgeeiENSG00000066926.
GenevisibleiQ7KZA3. HS.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7KZA3_HUMAN
AccessioniPrimary (citable) accession number: Q7KZA3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.