ID   Q7KZ52_HUMAN            Unreviewed;        88 AA.
AC   Q7KZ52;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   RecName: Full=Prothymosin alpha {ECO:0000256|ARBA:ARBA00040447};
DE   Flags: Fragment;
GN   Name=PTMA {ECO:0000313|EMBL:AAA61184.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAA61184.1};
RN   [1] {ECO:0000313|EMBL:AAA61184.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=3467312; DOI=10.1073/pnas.83.24.9403;
RA   Eschenfeldt W.H., Berger S.L.;
RT   "The human prothymosin alpha gene is polymorphic and induced upon growth
RT   stimulation: evidence using a cloned cDNA.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:9403-9407(1986).
RN   [2] {ECO:0000313|EMBL:AAA61184.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Eschenfeldt W.H., Berger S.L.;
RL   Submitted (JUN-1987) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Prothymosin alpha may mediate immune function by conferring
CC       resistance to certain opportunistic infections.
CC       {ECO:0000256|ARBA:ARBA00037621}.
CC   -!- SUBUNIT: Interacts with NUPR1; regulates apoptotic process.
CC       {ECO:0000256|ARBA:ARBA00038744}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the pro/parathymosin family.
CC       {ECO:0000256|ARBA:ARBA00008032}.
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DR   EMBL; M14794; AAA61184.1; -; mRNA.
DR   AlphaFoldDB; Q7KZ52; -.
DR   PeptideAtlas; Q7KZ52; -.
DR   ChiTaRS; PTMA; human.
DR   InterPro; IPR004931; Pro/parathymosin.
DR   PANTHER; PTHR22745; PROTHYMOSIN ALPHA; 1.
DR   PANTHER; PTHR22745:SF0; PROTHYMOSIN ALPHA; 1.
DR   Pfam; PF03247; Prothymosin; 1.
PE   2: Evidence at transcript level;
FT   REGION          1..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..82
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         88
FT                   /evidence="ECO:0000313|EMBL:AAA61184.1"
SQ   SEQUENCE   88 AA;  9538 MW;  374938F679C1C5DF CRC64;
     MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAN EENGEQEADN EVDEEEEEGG
     EEEEEEEEGD GEEEDGDEDE EAESATGK
//