K-RAS protein - Homo sapiens (Human)

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Unreviewed, UniProtKB/TrEMBL Q7KZ06 (Q7KZ06_HUMAN)

Last modified February 9, 2010. Version 36. History...

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Names and origin · Protein attributes · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

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Names and origin

Protein names

Submitted name:
K-RAS protein EMBL AAD13953.1

Gene names

Name:

K-RAS EMBL AAD13953.1

Organism

Homo sapiens (Human) EMBL AAD13953.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	37 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

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Ontologies

Keywords
Ligand	GTP-binding RuleBase RU003312V0 Spearmint SPM015592 Nucleotide-binding
Gene Ontology (GO)
Biological process	Ras protein signal transduction Inferred from electronic annotation. Source: Compara actin cytoskeleton organization Inferred from electronic annotation. Source: Compara apoptosis Inferred from electronic annotation. Source: Compara cell aging Inferred from electronic annotation. Source: Compara cytokine-mediated signaling pathway Inferred from electronic annotation. Source: Compara endocytosis Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptosis Inferred from electronic annotation. Source: Compara positive regulation of DNA replication Inferred from electronic annotation. Source: Compara positive regulation of MAP kinase activity Inferred from electronic annotation. Source: Compara positive regulation of NF-kappaB transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of Rac protein signal transduction Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of nitric-oxide synthase activity Inferred from electronic annotation. Source: Compara protein heterooligomerization Inferred from electronic annotation. Source: Compara regulation of long-term neuronal synaptic plasticity Inferred from electronic annotation. Source: Compara regulation of synaptic transmission, GABAergic Inferred from electronic annotation. Source: Compara response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara response to mineralocorticoid stimulus Inferred from electronic annotation. Source: Compara striated muscle cell differentiation Inferred from electronic annotation. Source: Compara visual learning Inferred from electronic annotation. Source: Compara
Cellular component	membrane fraction Inferred from electronic annotation. Source: Compara membrane raft Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara
Molecular function	GDP binding Inferred from electronic annotation. Source: Compara GMP binding Inferred from electronic annotation. Source: Compara GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro LRR domain binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Experimental info

Non-terminal residue

EMBL AAD13953.1

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Sequences

Sequence

Length

Mass (Da)

Tools

Q7KZ06-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: AAA2C411D73D69DA
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FASTA

4,023

        10         20         30 
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD DYDPTLE

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References

[1]	"Detection of high incidence of H-RAS oncogene point mutations in acute myelogenous leukemia." Imamura N., Kuramoto A., Ishihara H., Shimizu S. Am. J. Hematol. 43:151-153(1993) [PubMed: 7916576] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	S64261 Genomic DNA. Translation: AAD13953.1.
IPI	IPI00791238.
UniGene	Hs.505033
3D structure databases
SMR	Q7KZ06. Positions 1-37.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7KZ06.
Genome annotation databases
Ensembl	ENST00000256078; ENSP00000256078; ENSG00000133703; Homo sapiens. [Genome view] ENST00000311175; ENSP00000312305; ENSG00000174775; Homo sapiens. [Genome view] ENST00000311189; ENSP00000309845; ENSG00000174775; Homo sapiens. [Genome view] ENST00000311936; ENSP00000308495; ENSG00000133703; Homo sapiens. [Genome view] ENST00000369535; ENSP00000358548; ENSG00000213281; Homo sapiens. [Genome view] ENST00000388730; ENSP00000373382; ENSG00000174775; Homo sapiens. [Genome view] ENST00000395977; ENSP00000379301; ENSG00000133703; Homo sapiens. [Genome view] ENST00000397594; ENSP00000380722; ENSG00000174775; Homo sapiens. [Genome view] ENST00000397596; ENSP00000380723; ENSG00000174775; Homo sapiens. [Genome view] ENST00000406761; ENSP00000385392; ENSG00000133703; Homo sapiens. [Genome view] ENST00000417302; ENSP00000388246; ENSG00000174775; Homo sapiens. [Genome view] ENST00000451590; ENSP00000407586; ENSG00000174775; Homo sapiens. [Genome view]
Organism-specific databases
HGNC	HGNC:5173. HRAS. HGNC:6407. KRAS. HGNC:7989. NRAS.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q7KZ06.
Gene expression databases
ArrayExpress	Q7KZ06.
Bgee	Q7KZ06.
Family and domain databases
InterPro	IPR013753. Ras. IPR001806. Ras_GTPase. IPR015592. Ras_Ras_related. IPR020849. Ras_small_GTPase. [Graphical view]
PANTHER	PTHR11708:SF125. Ras_Ras_related. 1 hit.
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
PROSITE	PS51421. RAS. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

Q7KZ06_HUMAN

Accession

Primary (citable) accession number: Q7KZ06

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	February 9, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Names and origin · Protein attributes · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

Ontologies

Sequence annotation (Features)

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information