ID   Q7KYZ9_HUMAN            Unreviewed;       143 AA.
AC   Q7KYZ9;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 103.
DE   SubName: Full=Alpha 1c-adrenoceptor subtype protein {ECO:0000313|EMBL:AAD14205.1};
DE   Flags: Fragment;
GN   Name=alpha 1c-adrenoceptor subtype {ECO:0000313|EMBL:AAD14205.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAD14205.1};
RN   [1] {ECO:0000313|EMBL:AAD14205.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=7805763; DOI=10.1016/0922-4106(94)90064-7;
RA   Diehl N.L., Shreeve S.M.;
RT   "Identification of the alpha 1c-adrenoceptor in rabbit arteries and the
RT   human saphenous vein using the polymerase chain reaction.";
RL   Eur. J. Pharmacol. 268:393-398(1994).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; S76001; AAD14205.1; -; mRNA.
DR   AlphaFoldDB; Q7KYZ9; -.
DR   PeptideAtlas; Q7KYZ9; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004937; F:alpha1-adrenergic receptor activity; IEA:InterPro.
DR   GO; GO:0055117; P:regulation of cardiac muscle contraction; IEA:InterPro.
DR   GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR001004; ADRA1A_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24248:SF16; ALPHA-1A ADRENERGIC RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00557; ADRENRGCA1AR.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        72..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        109..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..125
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
FT   NON_TER         143
FT                   /evidence="ECO:0000313|EMBL:AAD14205.1"
SQ   SEQUENCE   143 AA;  16177 MW;  C3284E15C08E3AEE CRC64;
     VMYCRVYVVA KRESRGLKSG LKTDKSDSEQ VTLRIHRKNA PAGGSGMASA KTKTHFSVRL
     LKFSREKKAA KTLGIVVGCF VLCWLPFFLV MPIGSFFPDF KPSETVFKIV FWLGYLNSCI
     NPIIYPCSSQ EFKKAFQNVL RIQ
//