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Q7KYZ9

- Q7KYZ9_HUMAN

UniProt

Q7KYZ9 - Q7KYZ9_HUMAN

Protein
Submitted name:

Alpha 1c-adrenoceptor subtype protein

Gene

alpha 1c-adrenoceptor subtype

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. alpha1-adrenergic receptor activity Source: Ensembl

    GO - Biological processi

    1. activation of phospholipase C activity Source: Ensembl
    2. adult heart development Source: Ensembl
    3. aging Source: Ensembl
    4. calcium ion transport into cytosol Source: Ensembl
    5. cell growth Source: Ensembl
    6. micturition Source: Ensembl
    7. negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure Source: Ensembl
    8. negative regulation of Rho protein signal transduction Source: Ensembl
    9. negative regulation of synaptic transmission, GABAergic Source: Ensembl
    10. norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: Ensembl
    11. organ growth Source: Ensembl
    12. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    13. pilomotor reflex Source: Ensembl
    14. positive regulation of action potential Source: Ensembl
    15. positive regulation of cardiac muscle contraction Source: Ensembl
    16. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    17. positive regulation of heart rate by epinephrine-norepinephrine Source: Ensembl
    18. positive regulation of protein kinase C signaling Source: Ensembl
    19. positive regulation of smooth muscle contraction Source: Ensembl
    20. positive regulation of systemic arterial blood pressure Source: Ensembl
    21. positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: Ensembl
    22. positive regulation of vasoconstriction Source: Ensembl
    23. response to drug Source: Ensembl
    24. response to hormone Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Alpha 1c-adrenoceptor subtype proteinImported
    Gene namesi
    Name:alpha 1c-adrenoceptor subtypeImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro
    2. T-tubule Source: Ensembl
    3. Z disc Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ7KYZ9.
    BgeeiQ7KYZ9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7KYZ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000239244.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001004. ADRA1A_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00557. ADRENRGCA1AR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q7KYZ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    VMYCRVYVVA KRESRGLKSG LKTDKSDSEQ VTLRIHRKNA PAGGSGMASA    50
    KTKTHFSVRL LKFSREKKAA KTLGIVVGCF VLCWLPFFLV MPIGSFFPDF 100
    KPSETVFKIV FWLGYLNSCI NPIIYPCSSQ EFKKAFQNVL RIQ 143
    Length:143
    Mass (Da):16,177
    Last modified:July 5, 2004 - v1
    Checksum:iC3284E15C08E3AEE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei143 – 1431Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S76001 mRNA. Translation: AAD14205.1.
    UniGeneiHs.709175.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S76001 mRNA. Translation: AAD14205.1 .
    UniGenei Hs.709175.

    3D structure databases

    ProteinModelPortali Q7KYZ9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    H-InvDB HIX0034243.

    Phylogenomic databases

    HOGENOMi HOG000239244.

    Gene expression databases

    ArrayExpressi Q7KYZ9.
    Bgeei Q7KYZ9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001004. ADRA1A_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00557. ADRENRGCA1AR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the alpha 1c-adrenoceptor in rabbit arteries and the human saphenous vein using the polymerase chain reaction."
      Diehl N.L., Shreeve S.M.
      Eur. J. Pharmacol. 268:393-398(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ7KYZ9_HUMAN
    AccessioniPrimary (citable) accession number: Q7KYZ9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.