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Q7KYZ9

- Q7KYZ9_HUMAN

UniProt

Q7KYZ9 - Q7KYZ9_HUMAN

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Protein
Submitted name: Alpha 1c-adrenoceptor subtype protein
Gene
alpha 1c-adrenoceptor subtype
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. alpha1-adrenergic receptor activity Source: Ensembl

GO - Biological processi

  1. activation of phospholipase C activity Source: Ensembl
  2. adult heart development Source: Ensembl
  3. aging Source: Ensembl
  4. calcium ion transport into cytosol Source: Ensembl
  5. cell growth Source: Ensembl
  6. micturition Source: Ensembl
  7. negative regulation of Rho protein signal transduction Source: Ensembl
  8. negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure Source: Ensembl
  9. negative regulation of synaptic transmission, GABAergic Source: Ensembl
  10. norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: Ensembl
  11. organ growth Source: Ensembl
  12. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  13. pilomotor reflex Source: Ensembl
  14. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  15. positive regulation of action potential Source: Ensembl
  16. positive regulation of cardiac muscle contraction Source: Ensembl
  17. positive regulation of heart rate by epinephrine-norepinephrine Source: Ensembl
  18. positive regulation of protein kinase C signaling Source: Ensembl
  19. positive regulation of smooth muscle contraction Source: Ensembl
  20. positive regulation of systemic arterial blood pressure Source: Ensembl
  21. positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: Ensembl
  22. positive regulation of vasoconstriction Source: Ensembl
  23. response to drug Source: Ensembl
  24. response to hormone Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha 1c-adrenoceptor subtype proteinImported
Gene namesi
Name:alpha 1c-adrenoceptor subtypeImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. T-tubule Source: Ensembl
  2. Z disc Source: Ensembl
  3. integral component of membrane Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiQ7KYZ9.
BgeeiQ7KYZ9.

Structurei

3D structure databases

ProteinModelPortaliQ7KYZ9.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000239244.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001004. ADRA1A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00557. ADRENRGCA1AR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q7KYZ9-1 [UniParc]FASTAAdd to Basket

« Hide

VMYCRVYVVA KRESRGLKSG LKTDKSDSEQ VTLRIHRKNA PAGGSGMASA    50
KTKTHFSVRL LKFSREKKAA KTLGIVVGCF VLCWLPFFLV MPIGSFFPDF 100
KPSETVFKIV FWLGYLNSCI NPIIYPCSSQ EFKKAFQNVL RIQ 143
Length:143
Mass (Da):16,177
Last modified:July 5, 2004 - v1
Checksum:iC3284E15C08E3AEE
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei143 – 1431Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S76001 mRNA. Translation: AAD14205.1.
UniGeneiHs.709175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S76001 mRNA. Translation: AAD14205.1 .
UniGenei Hs.709175.

3D structure databases

ProteinModelPortali Q7KYZ9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

H-InvDB HIX0034243.

Phylogenomic databases

HOGENOMi HOG000239244.

Gene expression databases

ArrayExpressi Q7KYZ9.
Bgeei Q7KYZ9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001004. ADRA1A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00557. ADRENRGCA1AR.
PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of the alpha 1c-adrenoceptor in rabbit arteries and the human saphenous vein using the polymerase chain reaction."
    Diehl N.L., Shreeve S.M.
    Eur. J. Pharmacol. 268:393-398(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ7KYZ9_HUMAN
AccessioniPrimary (citable) accession number: Q7KYZ9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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