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Protein
Submitted name:

Alpha 1c-adrenoceptor subtype protein

Gene

alpha 1c-adrenoceptor subtype

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. alpha1-adrenergic receptor activity Source: Ensembl

GO - Biological processi

  1. activation of phospholipase C activity Source: Ensembl
  2. adult heart development Source: Ensembl
  3. aging Source: Ensembl
  4. calcium ion transport into cytosol Source: Ensembl
  5. cell growth Source: Ensembl
  6. micturition Source: Ensembl
  7. negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure Source: Ensembl
  8. negative regulation of Rho protein signal transduction Source: Ensembl
  9. norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: Ensembl
  10. organ growth Source: Ensembl
  11. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  12. pilomotor reflex Source: Ensembl
  13. positive regulation of action potential Source: Ensembl
  14. positive regulation of cardiac muscle contraction Source: Ensembl
  15. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  16. positive regulation of heart rate by epinephrine-norepinephrine Source: Ensembl
  17. positive regulation of protein kinase C signaling Source: Ensembl
  18. positive regulation of smooth muscle contraction Source: Ensembl
  19. positive regulation of synaptic transmission, GABAergic Source: Ensembl
  20. positive regulation of systemic arterial blood pressure Source: Ensembl
  21. positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: Ensembl
  22. positive regulation of vasoconstriction Source: Ensembl
  23. response to drug Source: Ensembl
  24. response to hormone Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha 1c-adrenoceptor subtype proteinImported
Gene namesi
Name:alpha 1c-adrenoceptor subtypeImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
  2. T-tubule Source: Ensembl
  3. Z disc Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ7KYZ9.
ExpressionAtlasiQ7KYZ9. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ7KYZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000239244.

Family and domain databases

InterProiIPR001004. ADRA1A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00557. ADRENRGCA1AR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q7KYZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VMYCRVYVVA KRESRGLKSG LKTDKSDSEQ VTLRIHRKNA PAGGSGMASA
60 70 80 90 100
KTKTHFSVRL LKFSREKKAA KTLGIVVGCF VLCWLPFFLV MPIGSFFPDF
110 120 130 140
KPSETVFKIV FWLGYLNSCI NPIIYPCSSQ EFKKAFQNVL RIQ
Length:143
Mass (Da):16,177
Last modified:July 4, 2004 - v1
Checksum:iC3284E15C08E3AEE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei143 – 1431Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76001 mRNA. Translation: AAD14205.1.
UniGeneiHs.709175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76001 mRNA. Translation: AAD14205.1.
UniGeneiHs.709175.

3D structure databases

ProteinModelPortaliQ7KYZ9.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ7KYZ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

H-InvDBHIX0034243.

Phylogenomic databases

HOGENOMiHOG000239244.

Gene expression databases

BgeeiQ7KYZ9.
ExpressionAtlasiQ7KYZ9. baseline and differential.

Family and domain databases

InterProiIPR001004. ADRA1A_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00557. ADRENRGCA1AR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of the alpha 1c-adrenoceptor in rabbit arteries and the human saphenous vein using the polymerase chain reaction."
    Diehl N.L., Shreeve S.M.
    Eur. J. Pharmacol. 268:393-398(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ7KYZ9_HUMAN
AccessioniPrimary (citable) accession number: Q7KYZ9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 4, 2004
Last sequence update: July 4, 2004
Last modified: January 6, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.