Q7KYR7 (BT2A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Butyrophilin subfamily 2 member A1

Gene names

Name:	BTN2A1
Synonyms:	BT2.1, BTF1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	527 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Tissue specificity	Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney. Ref.2
Sequence similarities	Belongs to the immunoglobulin superfamily. BTN/MOG family. Contains 1 B30.2/SPRY domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Sequence caution	The sequence BAD93014.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAB71221.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipid metabolic process Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7KYR7-2)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7KYR7-1)

The sequence of this isoform differs from the canonical sequence as follows:
     247-262: CAVALPIIVVILMIPI → L
     482-527: VPVRPFFRLG...LHRVGTHQSL → GPDTSQSGDP...SFLLLTRLCF

Isoform 3 (identifier: Q7KYR7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q7KYR7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     328-334: VDVVLDP → ELQFFSN
     335-527: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q7KYR7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Isoform 6 (identifier: Q7KYR7-6)

The sequence of this isoform differs from the canonical sequence as follows:
     328-330: VDV → GPV
     331-527: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 527	499	Butyrophilin subfamily 2 member A1		PRO_0000014529
Regions
	Topological domain	29 – 248	220	Extracellular Potential
	Transmembrane	249 – 269	21	Helical; Potential
	Topological domain	270 – 527	258	Cytoplasmic Potential
	Domain	29 – 141	113	Ig-like V-type
	Domain	310 – 506	197	B30.2/SPRY
Amino acid modifications
	Glycosylation	46	1	N-linked (GlcNAc...) Potential
	Glycosylation	114	1	N-linked (GlcNAc...) Ref.8
	Glycosylation	120	1	N-linked (GlcNAc...) Ref.8
	Disulfide bond	51 ↔ 125		By similarity
Natural variations
	Alternative sequence	1 – 152	152	Missing in isoform 3.		VSP_012708
	Alternative sequence	1 – 61	61	Missing in isoform 5.		VSP_044249
	Alternative sequence	247 – 262	16	CAVAL…LMIPI → L in isoform 2.		VSP_035843
	Alternative sequence	328 – 334	7	VDVVLDP → ELQFFSN in isoform 4.		VSP_043165
	Alternative sequence	328 – 330	3	VDV → GPV in isoform 6.		VSP_045005
	Alternative sequence	331 – 527	197	Missing in isoform 6.		VSP_045006
	Alternative sequence	335 – 527	193	Missing in isoform 4.		VSP_043166
	Alternative sequence	482 – 527	46	VPVRP…THQSL → GPDTSQSGDPPEPIESIPWS HSHVDKPWSFQQPPHNTHLP AASFTPTTDLSPSFLLLTRL CF in isoform 2.		VSP_035844
	Natural variant	124	1	R → C. Corresponds to variant rs3734539 [ dbSNP | Ensembl ].		VAR_049825
	Natural variant	178	1	W → C. Corresponds to variant rs13195402 [ dbSNP | Ensembl ].		VAR_061303
	Natural variant	178	1	W → L. Corresponds to variant rs13195401 [ dbSNP | Ensembl ].		VAR_061304
	Natural variant	207	1	V → M. Corresponds to variant rs13195509 [ dbSNP | Ensembl ].		VAR_049826
	Natural variant	378	1	R → Q. Corresponds to variant rs3734542 [ dbSNP | Ensembl ].		VAR_049827
	Natural variant	451	1	G → A. Corresponds to variant rs3734543 [ dbSNP | Ensembl ].		VAR_049828
Experimental info
	Sequence conflict	29	1	Q → H in AAC02650. Ref.1
	Sequence conflict	29	1	Q → H in AAC02653. Ref.1
	Sequence conflict	119	1	E → G in AAC02650. Ref.1
	Sequence conflict	119	1	E → G in AAC02653. Ref.1
	Sequence conflict	144	1	G → ER in AAC02650. Ref.1
	Sequence conflict	144	1	G → ER in AAC02653. Ref.1
	Sequence conflict	208	1	I → V in CAD97989. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: 0EB0731062E02F6C	FASTA	527	59,633
	10 20 30 40 50 60 MESAAALHFS RPASLLLLLL SLCALVSAQF IVVGPTDPIL ATVGENTTLR CHLSPEKNAE 70 80 90 100 110 120 DMEVRWFRSQ FSPAVFVYKG GRERTEEQME EYRGRTTFVS KDISRGSVAL VIHNITAQEN 130 140 150 160 170 180 GTYRCYFQEG RSYDEAILHL VVAGLGSKPL ISMRGHEDGG IRLECISRGW YPKPLTVWRD 190 200 210 220 230 240 PYGGVAPALK EVSMPDADGL FMVTTAVIIR DKSVRNMSCS INNTLLGQKK ESVIFIPESF 250 260 270 280 290 300 MPSVSPCAVA LPIIVVILMI PIAVCIYWIN KLQKEKKILS GEKEFERETR EIALKELEKE 310 320 330 340 350 360 RVQKEEELQV KEKLQEELRW RRTFLHAVDV VLDPDTAHPD LFLSEDRRSV RRCPFRHLGE 370 380 390 400 410 420 SVPDNPERFD SQPCVLGRES FASGKHYWEV EVENVIEWTV GVCRDSVERK GEVLLIPQNG 430 440 450 460 470 480 FWTLEMHKGQ YRAVSSPDRI LPLKESLCRV GVFLDYEAGD VSFYNMRDRS HIYTCPRSAF 490 500 510 520 SVPVRPFFRL GCEDSPIFIC PALTGANGVT VPEEGLTLHR VGTHQSL
	Isoform 2 [UniParc]. Checksum: 22EAF9F31FA2343B	FASTA	528	60,004
	10 20 30 40 50 60 MESAAALHFS RPASLLLLLL SLCALVSAQF IVVGPTDPIL ATVGENTTLR CHLSPEKNAE 70 80 90 100 110 120 DMEVRWFRSQ FSPAVFVYKG GRERTEEQME EYRGRTTFVS KDISRGSVAL VIHNITAQEN 130 140 150 160 170 180 GTYRCYFQEG RSYDEAILHL VVAGLGSKPL ISMRGHEDGG IRLECISRGW YPKPLTVWRD 190 200 210 220 230 240 PYGGVAPALK EVSMPDADGL FMVTTAVIIR DKSVRNMSCS INNTLLGQKK ESVIFIPESF 250 260 270 280 290 300 MPSVSPLAVC IYWINKLQKE KKILSGEKEF ERETREIALK ELEKERVQKE EELQVKEKLQ 310 320 330 340 350 360 EELRWRRTFL HAVDVVLDPD TAHPDLFLSE DRRSVRRCPF RHLGESVPDN PERFDSQPCV 370 380 390 400 410 420 LGRESFASGK HYWEVEVENV IEWTVGVCRD SVERKGEVLL IPQNGFWTLE MHKGQYRAVS 430 440 450 460 470 480 SPDRILPLKE SLCRVGVFLD YEAGDVSFYN MRDRSHIYTC PRSAFSGPDT SQSGDPPEPI 490 500 510 520 ESIPWSHSHV DKPWSFQQPP HNTHLPAASF TPTTDLSPSF LLLTRLCF
	Isoform 3 [UniParc]. Checksum: FB6932C0E209A02B	FASTA	375	42,770
	10 20 30 40 50 60 MRGHEDGGIR LECISRGWYP KPLTVWRDPY GGVAPALKEV SMPDADGLFM VTTAVIIRDK 70 80 90 100 110 120 SVRNMSCSIN NTLLGQKKES VIFIPESFMP SVSPCAVALP IIVVILMIPI AVCIYWINKL 130 140 150 160 170 180 QKEKKILSGE KEFERETREI ALKELEKERV QKEEELQVKE KLQEELRWRR TFLHAVDVVL 190 200 210 220 230 240 DPDTAHPDLF LSEDRRSVRR CPFRHLGESV PDNPERFDSQ PCVLGRESFA SGKHYWEVEV 250 260 270 280 290 300 ENVIEWTVGV CRDSVERKGE VLLIPQNGFW TLEMHKGQYR AVSSPDRILP LKESLCRVGV 310 320 330 340 350 360 FLDYEAGDVS FYNMRDRSHI YTCPRSAFSV PVRPFFRLGC EDSPIFICPA LTGANGVTVP 370 EEGLTLHRVG THQSL
	Isoform 4 [UniParc]. Checksum: 3BF0FE990D1F8095	FASTA	334	37,853
	10 20 30 40 50 60 MESAAALHFS RPASLLLLLL SLCALVSAQF IVVGPTDPIL ATVGENTTLR CHLSPEKNAE 70 80 90 100 110 120 DMEVRWFRSQ FSPAVFVYKG GRERTEEQME EYRGRTTFVS KDISRGSVAL VIHNITAQEN 130 140 150 160 170 180 GTYRCYFQEG RSYDEAILHL VVAGLGSKPL ISMRGHEDGG IRLECISRGW YPKPLTVWRD 190 200 210 220 230 240 PYGGVAPALK EVSMPDADGL FMVTTAVIIR DKSVRNMSCS INNTLLGQKK ESVIFIPESF 250 260 270 280 290 300 MPSVSPCAVA LPIIVVILMI PIAVCIYWIN KLQKEKKILS GEKEFERETR EIALKELEKE 310 320 330 RVQKEEELQV KEKLQEELRW RRTFLHAELQ FFSN
	Isoform 5 [UniParc]. Checksum: 854139B0C8D0E3F4	FASTA	466	53,204
	10 20 30 40 50 60 MEVRWFRSQF SPAVFVYKGG RERTEEQMEE YRGRTTFVSK DISRGSVALV IHNITAQENG 70 80 90 100 110 120 TYRCYFQEGR SYDEAILHLV VAGLGSKPLI SMRGHEDGGI RLECISRGWY PKPLTVWRDP 130 140 150 160 170 180 YGGVAPALKE VSMPDADGLF MVTTAVIIRD KSVRNMSCSI NNTLLGQKKE SVIFIPESFM 190 200 210 220 230 240 PSVSPCAVAL PIIVVILMIP IAVCIYWINK LQKEKKILSG EKEFERETRE IALKELEKER 250 260 270 280 290 300 VQKEEELQVK EKLQEELRWR RTFLHAVDVV LDPDTAHPDL FLSEDRRSVR RCPFRHLGES 310 320 330 340 350 360 VPDNPERFDS QPCVLGRESF ASGKHYWEVE VENVIEWTVG VCRDSVERKG EVLLIPQNGF 370 380 390 400 410 420 WTLEMHKGQY RAVSSPDRIL PLKESLCRVG VFLDYEAGDV SFYNMRDRSH IYTCPRSAFS 430 440 450 460 VPVRPFFRLG CEDSPIFICP ALTGANGVTV PEEGLTLHRV GTHQSL
	Isoform 6 [UniParc]. Checksum: C91FC3F56606AF92	FASTA	330	37,240
	10 20 30 40 50 60 MESAAALHFS RPASLLLLLL SLCALVSAQF IVVGPTDPIL ATVGENTTLR CHLSPEKNAE 70 80 90 100 110 120 DMEVRWFRSQ FSPAVFVYKG GRERTEEQME EYRGRTTFVS KDISRGSVAL VIHNITAQEN 130 140 150 160 170 180 GTYRCYFQEG RSYDEAILHL VVAGLGSKPL ISMRGHEDGG IRLECISRGW YPKPLTVWRD 190 200 210 220 230 240 PYGGVAPALK EVSMPDADGL FMVTTAVIIR DKSVRNMSCS INNTLLGQKK ESVIFIPESF 250 260 270 280 290 300 MPSVSPCAVA LPIIVVILMI PIAVCIYWIN KLQKEKKILS GEKEFERETR EIALKELEKE 310 320 330 RVQKEEELQV KEKLQEELRW RRTFLHAGPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex." Tazi-Ahnini R., Henry J., Offer C., Bouissou-Bouchouata C., Mather I.H., Pontarotti P. Immunogenetics 47:55-63(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2).
[2]	"A 1.1-Mb transcript map of the hereditary hemochromatosis locus." Ruddy D.A., Kronmal G.S., Lee V.K., Mintier G.A., Quintana L., Domingo R. Jr., Meyer N.C., Irrinki A., McClelland E.E., Fullan A., Mapa F.A., Moore T., Thomas W., Loeb D.B., Harmon C., Tsuchihashi Z., Wolff R.K., Schatzman R.C., Feder J.N. Genome Res. 7:441-456(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Colon endothelium.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Placenta.
[5]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Brain.
[6]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Lymph.
[8]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-114 AND ASN-120, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U90142 mRNA. Translation: AAC02650.1. U97496, U97495 Genomic DNA. Translation: AAC02653.1. U97497 Genomic DNA. Translation: AAC02654.1. U90543 mRNA. Translation: AAB53421.1. BX538050 mRNA. Translation: CAD97989.1. AK297098 mRNA. Translation: BAG59611.1. AB209777 mRNA. Translation: BAD93014.1. Different initiation. AL050330, AL121936 Genomic DNA. Translation: CAB71221.2. Sequence problems. BC016661 mRNA. Translation: AAH16661.1.
IPI	IPI00019862. IPI00215967. IPI00549701. IPI00641524. IPI00947432.
RefSeq	NP_001184162.1. NM_001197233.1. NP_001184163.1. NM_001197234.1. NP_008980.1. NM_007049.3. NP_510961.1. NM_078476.2.
UniGene	Hs.159028.
3D structure databases
ProteinModelPortal	Q7KYR7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7KYR7. 2 interactions.
STRING	9606.ENSP00000312158.
Protein family/group databases
MEROPS	I43.001.
PTM databases
PhosphoSite	Q7KYR7.
Polymorphism databases
DMDM	215274180.
Proteomic databases
PaxDb	Q7KYR7.
PRIDE	Q7KYR7.
Protocols and materials databases
DNASU	11120.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000312541; ENSP00000312158; ENSG00000112763. ENST00000429381; ENSP00000416945; ENSG00000112763. ENST00000469185; ENSP00000419043; ENSG00000112763. ENST00000541522; ENSP00000443909; ENSG00000112763.
GeneID	11120.
KEGG	hsa:11120.
UCSC	uc003nib.2. human.
Organism-specific databases
CTD	11120.
GeneCards	GC06P026458.
H-InvDB	HIX0005650.
HGNC	HGNC:1136. BTN2A1.
HPA	HPA019208.
MIM	613590. gene.
neXtProt	NX_Q7KYR7.
PharmGKB	PA25456.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG253704.
HOGENOM	HOG000230860.
HOVERGEN	HBG050747.
InParanoid	Q7KYR7.
KO	K06712.
Gene expression databases
ArrayExpress	Q7KYR7.
Bgee	Q7KYR7.
CleanEx	HS_BTN2A1.
Genevestigator	Q7KYR7.
GermOnline	ENSG00000112763. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR001870. B30.2/SPRY. IPR003879. Butyrophylin. IPR013162. CD80_C2-set. IPR008985. ConA-like_lec_gl_sf. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. IPR006574. PRY. IPR018355. SPla/RYanodine_receptor_subgr. IPR003877. SPRY_rcpt. [Graphical view]
Pfam	PF08205. C2-set_2. 1 hit. PF00622. SPRY. 1 hit. PF07686. V-set. 1 hit. [Graphical view]
PRINTS	PR01407. BUTYPHLNCDUF.
SMART	SM00409. IG. 1 hit. SM00589. PRY. 1 hit. SM00449. SPRY. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50188. B302_SPRY. 1 hit. PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	BTN2A1. human.
GenomeRNAi	11120.
NextBio	42264.
SOURCE	Search...

Entry information

Entry name

BT2A1_HUMAN

Accession

Primary (citable) accession number: Q7KYR7
Secondary accession number(s): B4DLP9 , E9PGR4, O00475, P78408, Q59EN4, Q7KYQ7, Q7Z386, Q96AV7, Q9NU62

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 94 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.