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Protein

Butyrophilin subfamily 2 member A1

Gene

BTN2A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • lipid metabolic process Source: ProtInc
Complete GO annotation...

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Butyrophilin subfamily 2 member A1
Gene namesi
Name:BTN2A1
Synonyms:BT2.1, BTF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:1136. BTN2A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 248220ExtracellularSequence AnalysisAdd
BLAST
Transmembranei249 – 26921HelicalSequence AnalysisAdd
BLAST
Topological domaini270 – 527258CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25456.

Polymorphism and mutation databases

BioMutaiBTN2A1.
DMDMi215274180.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 527499Butyrophilin subfamily 2 member A1PRO_0000014529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi51 ↔ 125PROSITE-ProRule annotation
Glycosylationi114 – 1141N-linked (GlcNAc...)1 Publication
Glycosylationi120 – 1201N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ7KYR7.
PaxDbiQ7KYR7.
PRIDEiQ7KYR7.

PTM databases

PhosphoSiteiQ7KYR7.

Expressioni

Tissue specificityi

Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney.1 Publication

Gene expression databases

BgeeiQ7KYR7.
CleanExiHS_BTN2A1.
ExpressionAtlasiQ7KYR7. baseline and differential.
GenevisibleiQ7KYR7. HS.

Organism-specific databases

HPAiHPA019208.

Interactioni

Protein-protein interaction databases

BioGridi116295. 28 interactions.
IntActiQ7KYR7. 2 interactions.
STRINGi9606.ENSP00000312158.

Structurei

3D structure databases

ProteinModelPortaliQ7KYR7.
SMRiQ7KYR7. Positions 28-237, 287-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 141113Ig-like V-typeAdd
BLAST
Domaini310 – 506197B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253704.
GeneTreeiENSGT00760000118933.
HOGENOMiHOG000230860.
HOVERGENiHBG050747.
InParanoidiQ7KYR7.
KOiK06712.
OMAiEMRGHED.
PhylomeDBiQ7KYR7.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013162. CD80_C2-set.
IPR013320. ConA-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR006574. PRY.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00409. IG. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7KYR7-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESAAALHFS RPASLLLLLL SLCALVSAQF IVVGPTDPIL ATVGENTTLR
60 70 80 90 100
CHLSPEKNAE DMEVRWFRSQ FSPAVFVYKG GRERTEEQME EYRGRTTFVS
110 120 130 140 150
KDISRGSVAL VIHNITAQEN GTYRCYFQEG RSYDEAILHL VVAGLGSKPL
160 170 180 190 200
ISMRGHEDGG IRLECISRGW YPKPLTVWRD PYGGVAPALK EVSMPDADGL
210 220 230 240 250
FMVTTAVIIR DKSVRNMSCS INNTLLGQKK ESVIFIPESF MPSVSPCAVA
260 270 280 290 300
LPIIVVILMI PIAVCIYWIN KLQKEKKILS GEKEFERETR EIALKELEKE
310 320 330 340 350
RVQKEEELQV KEKLQEELRW RRTFLHAVDV VLDPDTAHPD LFLSEDRRSV
360 370 380 390 400
RRCPFRHLGE SVPDNPERFD SQPCVLGRES FASGKHYWEV EVENVIEWTV
410 420 430 440 450
GVCRDSVERK GEVLLIPQNG FWTLEMHKGQ YRAVSSPDRI LPLKESLCRV
460 470 480 490 500
GVFLDYEAGD VSFYNMRDRS HIYTCPRSAF SVPVRPFFRL GCEDSPIFIC
510 520
PALTGANGVT VPEEGLTLHR VGTHQSL
Length:527
Mass (Da):59,633
Last modified:November 25, 2008 - v3
Checksum:i0EB0731062E02F6C
GO
Isoform 2 (identifier: Q7KYR7-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-262: CAVALPIIVVILMIPI → L
     482-527: VPVRPFFRLG...LHRVGTHQSL → GPDTSQSGDP...SFLLLTRLCF

Show »
Length:528
Mass (Da):60,004
Checksum:i22EAF9F31FA2343B
GO
Isoform 3 (identifier: Q7KYR7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: Missing.

Note: No experimental confirmation available.
Show »
Length:375
Mass (Da):42,770
Checksum:iFB6932C0E209A02B
GO
Isoform 4 (identifier: Q7KYR7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     328-334: VDVVLDP → ELQFFSN
     335-527: Missing.

Note: No experimental confirmation available.
Show »
Length:334
Mass (Da):37,853
Checksum:i3BF0FE990D1F8095
GO
Isoform 5 (identifier: Q7KYR7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Show »
Length:466
Mass (Da):53,204
Checksum:i854139B0C8D0E3F4
GO
Isoform 6 (identifier: Q7KYR7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     328-330: VDV → GPV
     331-527: Missing.

Note: No experimental confirmation available.
Show »
Length:330
Mass (Da):37,240
Checksum:iC91FC3F56606AF92
GO

Sequence cautioni

The sequence BAD93014.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAB71221.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291Q → H in AAC02650 (PubMed:9382921).Curated
Sequence conflicti29 – 291Q → H in AAC02653 (PubMed:9382921).Curated
Sequence conflicti119 – 1191E → G in AAC02650 (PubMed:9382921).Curated
Sequence conflicti119 – 1191E → G in AAC02653 (PubMed:9382921).Curated
Sequence conflicti144 – 1441G → ER in AAC02650 (PubMed:9382921).Curated
Sequence conflicti144 – 1441G → ER in AAC02653 (PubMed:9382921).Curated
Sequence conflicti208 – 2081I → V in CAD97989 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241R → C.
Corresponds to variant rs3734539 [ dbSNP | Ensembl ].
VAR_049825
Natural varianti178 – 1781W → C.
Corresponds to variant rs13195402 [ dbSNP | Ensembl ].
VAR_061303
Natural varianti178 – 1781W → L.
Corresponds to variant rs13195401 [ dbSNP | Ensembl ].
VAR_061304
Natural varianti207 – 2071V → M.
Corresponds to variant rs13195509 [ dbSNP | Ensembl ].
VAR_049826
Natural varianti378 – 3781R → Q.
Corresponds to variant rs3734542 [ dbSNP | Ensembl ].
VAR_049827
Natural varianti451 – 4511G → A.
Corresponds to variant rs3734543 [ dbSNP | Ensembl ].
VAR_049828

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 152152Missing in isoform 3. 1 PublicationVSP_012708Add
BLAST
Alternative sequencei1 – 6161Missing in isoform 5. 1 PublicationVSP_044249Add
BLAST
Alternative sequencei247 – 26216CAVAL…LMIPI → L in isoform 2. 1 PublicationVSP_035843Add
BLAST
Alternative sequencei328 – 3347VDVVLDP → ELQFFSN in isoform 4. 1 PublicationVSP_043165
Alternative sequencei328 – 3303VDV → GPV in isoform 6. 1 PublicationVSP_045005
Alternative sequencei331 – 527197Missing in isoform 6. 1 PublicationVSP_045006Add
BLAST
Alternative sequencei335 – 527193Missing in isoform 4. 1 PublicationVSP_043166Add
BLAST
Alternative sequencei482 – 52746VPVRP…THQSL → GPDTSQSGDPPEPIESIPWS HSHVDKPWSFQQPPHNTHLP AASFTPTTDLSPSFLLLTRL CF in isoform 2. 1 PublicationVSP_035844Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90142 mRNA. Translation: AAC02650.1.
U97496, U97495 Genomic DNA. Translation: AAC02653.1.
U97497 Genomic DNA. Translation: AAC02654.1.
U90543 mRNA. Translation: AAB53421.1.
BX538050 mRNA. Translation: CAD97989.1.
AK297098 mRNA. Translation: BAG59611.1.
AB209777 mRNA. Translation: BAD93014.1. Different initiation.
AL050330, AL121936 Genomic DNA. Translation: CAB71221.2. Sequence problems.
BC016661 mRNA. Translation: AAH16661.1.
CCDSiCCDS4613.1. [Q7KYR7-2]
CCDS47390.1. [Q7KYR7-4]
CCDS56404.1. [Q7KYR7-6]
CCDS56405.1. [Q7KYR7-5]
RefSeqiNP_001184162.1. NM_001197233.2. [Q7KYR7-5]
NP_001184163.1. NM_001197234.2. [Q7KYR7-6]
NP_008980.1. NM_007049.4. [Q7KYR7-2]
NP_510961.1. NM_078476.3. [Q7KYR7-4]
UniGeneiHs.159028.

Genome annotation databases

EnsembliENST00000312541; ENSP00000312158; ENSG00000112763.
ENST00000429381; ENSP00000416945; ENSG00000112763. [Q7KYR7-4]
ENST00000469185; ENSP00000419043; ENSG00000112763. [Q7KYR7-6]
ENST00000541522; ENSP00000443909; ENSG00000112763. [Q7KYR7-5]
GeneIDi11120.
KEGGihsa:11120.
UCSCiuc003nib.2. human. [Q7KYR7-2]
uc003nic.2. human. [Q7KYR7-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90142 mRNA. Translation: AAC02650.1.
U97496, U97495 Genomic DNA. Translation: AAC02653.1.
U97497 Genomic DNA. Translation: AAC02654.1.
U90543 mRNA. Translation: AAB53421.1.
BX538050 mRNA. Translation: CAD97989.1.
AK297098 mRNA. Translation: BAG59611.1.
AB209777 mRNA. Translation: BAD93014.1. Different initiation.
AL050330, AL121936 Genomic DNA. Translation: CAB71221.2. Sequence problems.
BC016661 mRNA. Translation: AAH16661.1.
CCDSiCCDS4613.1. [Q7KYR7-2]
CCDS47390.1. [Q7KYR7-4]
CCDS56404.1. [Q7KYR7-6]
CCDS56405.1. [Q7KYR7-5]
RefSeqiNP_001184162.1. NM_001197233.2. [Q7KYR7-5]
NP_001184163.1. NM_001197234.2. [Q7KYR7-6]
NP_008980.1. NM_007049.4. [Q7KYR7-2]
NP_510961.1. NM_078476.3. [Q7KYR7-4]
UniGeneiHs.159028.

3D structure databases

ProteinModelPortaliQ7KYR7.
SMRiQ7KYR7. Positions 28-237, 287-501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116295. 28 interactions.
IntActiQ7KYR7. 2 interactions.
STRINGi9606.ENSP00000312158.

Protein family/group databases

MEROPSiI43.001.

PTM databases

PhosphoSiteiQ7KYR7.

Polymorphism and mutation databases

BioMutaiBTN2A1.
DMDMi215274180.

Proteomic databases

MaxQBiQ7KYR7.
PaxDbiQ7KYR7.
PRIDEiQ7KYR7.

Protocols and materials databases

DNASUi11120.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312541; ENSP00000312158; ENSG00000112763.
ENST00000429381; ENSP00000416945; ENSG00000112763. [Q7KYR7-4]
ENST00000469185; ENSP00000419043; ENSG00000112763. [Q7KYR7-6]
ENST00000541522; ENSP00000443909; ENSG00000112763. [Q7KYR7-5]
GeneIDi11120.
KEGGihsa:11120.
UCSCiuc003nib.2. human. [Q7KYR7-2]
uc003nic.2. human. [Q7KYR7-4]

Organism-specific databases

CTDi11120.
GeneCardsiGC06P026458.
H-InvDBHIX0005650.
HGNCiHGNC:1136. BTN2A1.
HPAiHPA019208.
MIMi613590. gene.
neXtProtiNX_Q7KYR7.
PharmGKBiPA25456.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG253704.
GeneTreeiENSGT00760000118933.
HOGENOMiHOG000230860.
HOVERGENiHBG050747.
InParanoidiQ7KYR7.
KOiK06712.
OMAiEMRGHED.
PhylomeDBiQ7KYR7.
TreeFamiTF331083.

Miscellaneous databases

ChiTaRSiBTN2A1. human.
GenomeRNAii11120.
NextBioi42264.
PROiQ7KYR7.
SOURCEiSearch...

Gene expression databases

BgeeiQ7KYR7.
CleanExiHS_BTN2A1.
ExpressionAtlasiQ7KYR7. baseline and differential.
GenevisibleiQ7KYR7. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013162. CD80_C2-set.
IPR013320. ConA-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR006574. PRY.
IPR003877. SPRY_dom.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00409. IG. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex."
    Tazi-Ahnini R., Henry J., Offer C., Bouissou-Bouchouata C., Mather I.H., Pontarotti P.
    Immunogenetics 47:55-63(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Colon endothelium.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Placenta.
  5. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
    Tissue: Brain.
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Lymph.
  8. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-114 AND ASN-120.
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiBT2A1_HUMAN
AccessioniPrimary (citable) accession number: Q7KYR7
Secondary accession number(s): B4DLP9
, E9PGR4, O00475, P78408, Q59EN4, Q7KYQ7, Q7Z386, Q96AV7, Q9NU62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 25, 2008
Last modified: July 22, 2015
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.