Reviewed, UniProtKB/Swiss-Prot Q7KWX2 (PGPS1_DICDI)

Names and origin

Protein names

Recommended name:
    Probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
    EC=2.7.8.5
Alternative name(s):
    Phosphatidylglycerophosphate synthase 1
    Phosphatidylglycerophosphate synthase
      Short name=PGP synthase

Gene names

Name:	pgs1
ORF Names:	DDB_G0277037

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	581 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-II family. Contains 2 PLD phosphodiesterase domains.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Domain	Repeat Transit peptide
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 581	581	Probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase		PRO_0000342201
Regions
	Domain	248 – 274	27	PLD phosphodiesterase 1
	Domain	487 – 520	34	PLD phosphodiesterase 2
	Nucleotide binding	160 – 167	8	ATP Potential
	Compositional bias	23 – 26	4	Poly-Gly
	Compositional bias	30 – 37	8	Poly-Thr
	Compositional bias	44 – 105	62	Ser-rich
Sites
	Active site	253	1	Potential
	Active site	255	1	Potential
	Active site	260	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7KWX2-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: E27C824B4B4C6542	FASTA	581	65,509
	10 20 30 40 50 60 MIKRALAPIV QPQRLFAALM VIGGGGRSAT TTTTTTTKAC GNGSSQSPPS TPLLSSKSST 70 80 90 100 110 120 ITSNKKSAIP SSHLYIPKKS TLDSRQIGNY SREYSTSSSS SSKKSIFNDT YLNDLFWQLS 130 140 150 160 170 180 SQGPAFEVNP NNIDFIQEPI DFYNHLIDGV KRSKKRITMA SLYLGTSKQE IELVKEMKLA 190 200 210 220 230 240 MERNKELKIH ILLDGLRGTR IGLDKESSAT ILGELLSLYS DRVTISMYHT PDLNGILKKV 250 260 270 280 290 300 LPPRINETIG VQHIKTYIFD DDLLLSGANL SKDYFTNRQD RYVLIRSTST VSNYFNEIVE 310 320 330 340 350 360 IIGSLSLHVD KDNRNQLLLS SGSIDPVTQS NEFKNLAYTK LSTLLKSHSY YPSNSNSNSS 370 380 390 400 410 420 VDSPFDCNNI NNGETTWIFP TIQMGPFNIR QDEVVTSHIF ESVPNDSKFF ITSPYFNLTE 430 440 450 460 470 480 NYLNLILTGK PKLDIITCSP QANGFYGSKG LSSAVPDCYA IIEKRFLQRV QDTDNGDRIS 490 500 510 520 530 540 VQEYIRDKWT YHAKGLWIQV KNQQHPSITL IGSPNFGSRS VEKDLEAQII LITQNKQLQQ 550 560 570 580 KMENEKNYLW TDTQNANLEL FEKRKVSLMV RFLVYIFGNY L

References

[1]

"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC115581 Genomic DNA. Translation: AAS38671.1. AAFI02000019 Genomic DNA. Translation: EAL69020.2.
RefSeq	XP_642872.2.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3394023.
GenomeReviews	Gene locus pgs1 in contig CM000151_GR.
KEGG	ddi:DDB_0237934.
Organism-specific databases
dictyBase	DDB_G0277037. pgs1.
Family and domain databases
InterPro	IPR016270. PLipase-D_PtdSer-synthase-type. IPR001736. PLipase_D/transphosphatidylase. [Graphical view]
Pfam	PF00614. PLDc. 2 hits. [Graphical view]
PIRSF	PIRSF000850. Phospholipase_D_PSS. 1 hit.
SMART	SM00155. PLDc. 2 hits. [Graphical view]
PROSITE	PS50035. PLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGPS1_DICDI

Accession

Primary (citable) accession number: Q7KWX2
Secondary accession number(s): Q550R0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	July 5, 2004
Last modified:	October 13, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)