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Protein

Probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Gene

pgs1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.By similarity

Catalytic activityi

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

Pathwayi: phosphatidylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (pgs1)
  2. no protein annotated in this organism
This subpathway is part of the pathway phosphatidylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol, the pathway phosphatidylglycerol biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei253PROSITE-ProRule annotation1
Active sitei255PROSITE-ProRule annotation1
Active sitei260PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi160 – 167ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00084; UER00503

Names & Taxonomyi

Protein namesi
Recommended name:
Probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC:2.7.8.5)
Alternative name(s):
Phosphatidylglycerophosphate synthase 1
Short name:
PGP synthase 1
Gene namesi
Name:pgs1
ORF Names:DDB_G0277037
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0277037 pgs1

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003422011 – 581Probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseAdd BLAST581

Proteomic databases

PaxDbiQ7KWX2
PRIDEiQ7KWX2

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0237934

Structurei

3D structure databases

ProteinModelPortaliQ7KWX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini248 – 274PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST27
Domaini487 – 520PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 26Poly-Gly4
Compositional biasi30 – 37Poly-Thr8
Compositional biasi44 – 105Ser-richAdd BLAST62

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3964 Eukaryota
COG1502 LUCA
InParanoidiQ7KWX2
KOiK00995
OMAiHLKGFVI
PhylomeDBiQ7KWX2

Family and domain databases

InterProiView protein in InterPro
IPR016270 PGS1
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PANTHERiPTHR12586 PTHR12586, 1 hit
PfamiView protein in Pfam
PF13091 PLDc_2, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 1 hit

Sequencei

Sequence statusi: Complete.

Q7KWX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKRALAPIV QPQRLFAALM VIGGGGRSAT TTTTTTTKAC GNGSSQSPPS
60 70 80 90 100
TPLLSSKSST ITSNKKSAIP SSHLYIPKKS TLDSRQIGNY SREYSTSSSS
110 120 130 140 150
SSKKSIFNDT YLNDLFWQLS SQGPAFEVNP NNIDFIQEPI DFYNHLIDGV
160 170 180 190 200
KRSKKRITMA SLYLGTSKQE IELVKEMKLA MERNKELKIH ILLDGLRGTR
210 220 230 240 250
IGLDKESSAT ILGELLSLYS DRVTISMYHT PDLNGILKKV LPPRINETIG
260 270 280 290 300
VQHIKTYIFD DDLLLSGANL SKDYFTNRQD RYVLIRSTST VSNYFNEIVE
310 320 330 340 350
IIGSLSLHVD KDNRNQLLLS SGSIDPVTQS NEFKNLAYTK LSTLLKSHSY
360 370 380 390 400
YPSNSNSNSS VDSPFDCNNI NNGETTWIFP TIQMGPFNIR QDEVVTSHIF
410 420 430 440 450
ESVPNDSKFF ITSPYFNLTE NYLNLILTGK PKLDIITCSP QANGFYGSKG
460 470 480 490 500
LSSAVPDCYA IIEKRFLQRV QDTDNGDRIS VQEYIRDKWT YHAKGLWIQV
510 520 530 540 550
KNQQHPSITL IGSPNFGSRS VEKDLEAQII LITQNKQLQQ KMENEKNYLW
560 570 580
TDTQNANLEL FEKRKVSLMV RFLVYIFGNY L
Length:581
Mass (Da):65,509
Last modified:July 5, 2004 - v1
Checksum:iE27C824B4B4C6542
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000019 Genomic DNA Translation: EAL69020.2
RefSeqiXP_642872.2, XM_637780.2

Genome annotation databases

EnsemblProtistsiEAL69020; EAL69020; DDB_G0277037
GeneIDi8620738
KEGGiddi:DDB_G0277037

Similar proteinsi

Entry informationi

Entry nameiPGPS1_DICDI
AccessioniPrimary (citable) accession number: Q7KWX2
Secondary accession number(s): Q550R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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