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Protein

Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

Gene

CG17896

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity).By similarity

Catalytic activityi

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH.
3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei303NucleophilePROSITE-ProRule annotationBy similarity1
Binding sitei403NADSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi195 – 199NADSequence analysis5
Nucleotide bindingi247 – 252NADSequence analysis6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-DME-70895 Branched-chain amino acid catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (EC:1.2.1.18, EC:1.2.1.27)
Short name:
MMSDH
Short name:
Malonate-semialdehyde dehydrogenase [acylating]
Gene namesi
ORF Names:CG17896
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0023537 CG17896

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000043373? – 520Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ7KW39
PRIDEiQ7KW39

Expressioni

Gene expression databases

BgeeiFBgn0023537
ExpressionAtlasiQ7KW39 baseline and differential
GenevisibleiQ7KW39 DM

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi57566, 2 interactors
IntActiQ7KW39, 2 interactors
STRINGi7227.FBpp0070087

Structurei

3D structure databases

ProteinModelPortaliQ7KW39
SMRiQ7KW39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Sequence analysis

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2449 Eukaryota
ENOG410XNP1 LUCA
GeneTreeiENSGT00910000144256
InParanoidiQ7KW39
KOiK00140
OMAiSQWKEED
OrthoDBiEOG091G06SO
PhylomeDBiQ7KW39

Family and domain databases

CDDicd07085 ALDH_F6_MMSDH, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR010061 MeMal-semiAld_DH
PANTHERiPTHR43866 PTHR43866, 1 hit
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01722 MMSDH, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B1 Publication (identifier: Q7KW39-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLVRLIGAE ARHLAKRSYS SAAPTTKLFI DGKFVESKTN EWIDVHDPAT
60 70 80 90 100
NQVVTRVPKA TQAEMQAALE SNKKAFRSWS NQSILTRQQV MFKLQALIKE
110 120 130 140 150
NMGELAKNIT KEQGKTLADA EGDVLRGLQV VEHCCSIPSL QMGETVANVA
160 170 180 190 200
RDMDTYSLVL PLGVTAGVAP FNFPAMIPLW MFPVAITTGN TMLLKPSERV
210 220 230 240 250
PGATMLLMEL LNEAGCPPGV VNVIHGQHDA VNFICDAPEI KAVSFVGSDQ
260 270 280 290 300
AGKYIYERAG KNGKRVQSNM GAKNHGIILG DANKENTLNQ LAGAAFGAAG
310 320 330 340 350
QRCMALSTAV FVGDAQAWIP DLVERAQKLK VNAGHVPGTD VGPVISAASR
360 370 380 390 400
QRINDLIESG VKEGAKLILD GRKITVPGYE DGYFVGPTIL SDVTPSMKCY
410 420 430 440 450
TEEIFGPVLV ILKADTLDDA IGIVNANPYG NGTAVFTTNG AAARKFVNEI
460 470 480 490 500
DAGQVGVNVP IPVPLPMFSF TGTRGSFRGD HHFYGKQGIK FYTQTKTVTQ
510 520
LWRKTDVTHT QAAVAMPTMK
Note: No experimental confirmation available.Curated
Length:520
Mass (Da):55,972
Last modified:July 5, 2004 - v1
Checksum:i12AC03D9B9C3E41D
GO
Isoform A1 Publication (identifier: Q7KW39-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-10: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:511
Mass (Da):55,033
Checksum:i304898AEFE153447
GO

Sequence cautioni

The sequence CAA15632 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0519192 – 10Missing in isoform A. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF45510.2
AE014298 Genomic DNA Translation: AAF45511.1
AL009147 Genomic DNA Translation: CAA15632.1 Sequence problems.
AL009147 Genomic DNA Translation: CAB41309.1
AY069284 mRNA Translation: AAL39429.2
PIRiT13418
RefSeqiNP_569845.2, NM_130489.3 [Q7KW39-1]
NP_726672.1, NM_166844.1 [Q7KW39-2]
UniGeneiDm.11239

Genome annotation databases

EnsemblMetazoaiFBtr0070092; FBpp0070087; FBgn0023537 [Q7KW39-1]
FBtr0070093; FBpp0070088; FBgn0023537 [Q7KW39-2]
GeneIDi30995
KEGGidme:Dmel_CG17896
UCSCiCG17896-RA d. melanogaster [Q7KW39-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMMSA_DROME
AccessioniPrimary (citable) accession number: Q7KW39
Secondary accession number(s): O46056, Q8T9I0, Q9V408
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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