Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

Gene

CG17896

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity).By similarity

Catalytic activityi

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH.
3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei303NucleophilePROSITE-ProRule annotationBy similarity1
Binding sitei403NADSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi195 – 199NADSequence analysis5
Nucleotide bindingi247 – 252NADSequence analysis6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-DME-70895. Branched-chain amino acid catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (EC:1.2.1.18, EC:1.2.1.27)
Short name:
MMSDH
Short name:
Malonate-semialdehyde dehydrogenase [acylating]
Gene namesi
ORF Names:CG17896
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0023537. CG17896.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000043373? – 520Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ7KW39.
PRIDEiQ7KW39.

Expressioni

Gene expression databases

BgeeiFBgn0023537.
ExpressionAtlasiQ7KW39. baseline.
GenevisibleiQ7KW39. DM.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi57566. 2 interactors.
IntActiQ7KW39. 2 interactors.
MINTiMINT-743398.
STRINGi7227.FBpp0070087.

Structurei

3D structure databases

ProteinModelPortaliQ7KW39.
SMRiQ7KW39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Sequence analysis

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2449. Eukaryota.
ENOG410XNP1. LUCA.
GeneTreeiENSGT00850000132298.
InParanoidiQ7KW39.
KOiK00140.
OMAiSNVKPNM.
OrthoDBiEOG091G06SO.
PhylomeDBiQ7KW39.

Family and domain databases

CDDicd07085. ALDH_F6_MMSDH. 1 hit.
Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
[Graphical view]
PANTHERiPTHR11699:SF183. PTHR11699:SF183. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01722. MMSDH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B1 Publication (identifier: Q7KW39-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLVRLIGAE ARHLAKRSYS SAAPTTKLFI DGKFVESKTN EWIDVHDPAT
60 70 80 90 100
NQVVTRVPKA TQAEMQAALE SNKKAFRSWS NQSILTRQQV MFKLQALIKE
110 120 130 140 150
NMGELAKNIT KEQGKTLADA EGDVLRGLQV VEHCCSIPSL QMGETVANVA
160 170 180 190 200
RDMDTYSLVL PLGVTAGVAP FNFPAMIPLW MFPVAITTGN TMLLKPSERV
210 220 230 240 250
PGATMLLMEL LNEAGCPPGV VNVIHGQHDA VNFICDAPEI KAVSFVGSDQ
260 270 280 290 300
AGKYIYERAG KNGKRVQSNM GAKNHGIILG DANKENTLNQ LAGAAFGAAG
310 320 330 340 350
QRCMALSTAV FVGDAQAWIP DLVERAQKLK VNAGHVPGTD VGPVISAASR
360 370 380 390 400
QRINDLIESG VKEGAKLILD GRKITVPGYE DGYFVGPTIL SDVTPSMKCY
410 420 430 440 450
TEEIFGPVLV ILKADTLDDA IGIVNANPYG NGTAVFTTNG AAARKFVNEI
460 470 480 490 500
DAGQVGVNVP IPVPLPMFSF TGTRGSFRGD HHFYGKQGIK FYTQTKTVTQ
510 520
LWRKTDVTHT QAAVAMPTMK
Note: No experimental confirmation available.Curated
Length:520
Mass (Da):55,972
Last modified:July 5, 2004 - v1
Checksum:i12AC03D9B9C3E41D
GO
Isoform A1 Publication (identifier: Q7KW39-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-10: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:511
Mass (Da):55,033
Checksum:i304898AEFE153447
GO

Sequence cautioni

The sequence CAA15632 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0519192 – 10Missing in isoform A. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF45510.2.
AE014298 Genomic DNA. Translation: AAF45511.1.
AL009147 Genomic DNA. Translation: CAA15632.1. Sequence problems.
AL009147 Genomic DNA. Translation: CAB41309.1.
AY069284 mRNA. Translation: AAL39429.2.
PIRiT13418.
RefSeqiNP_569845.2. NM_130489.3. [Q7KW39-1]
NP_726672.1. NM_166844.1. [Q7KW39-2]
UniGeneiDm.11239.

Genome annotation databases

EnsemblMetazoaiFBtr0070092; FBpp0070087; FBgn0023537. [Q7KW39-1]
GeneIDi30995.
KEGGidme:Dmel_CG17896.
UCSCiCG17896-RA. d. melanogaster. [Q7KW39-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF45510.2.
AE014298 Genomic DNA. Translation: AAF45511.1.
AL009147 Genomic DNA. Translation: CAA15632.1. Sequence problems.
AL009147 Genomic DNA. Translation: CAB41309.1.
AY069284 mRNA. Translation: AAL39429.2.
PIRiT13418.
RefSeqiNP_569845.2. NM_130489.3. [Q7KW39-1]
NP_726672.1. NM_166844.1. [Q7KW39-2]
UniGeneiDm.11239.

3D structure databases

ProteinModelPortaliQ7KW39.
SMRiQ7KW39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi57566. 2 interactors.
IntActiQ7KW39. 2 interactors.
MINTiMINT-743398.
STRINGi7227.FBpp0070087.

Proteomic databases

PaxDbiQ7KW39.
PRIDEiQ7KW39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070092; FBpp0070087; FBgn0023537. [Q7KW39-1]
GeneIDi30995.
KEGGidme:Dmel_CG17896.
UCSCiCG17896-RA. d. melanogaster. [Q7KW39-1]

Organism-specific databases

FlyBaseiFBgn0023537. CG17896.

Phylogenomic databases

eggNOGiKOG2449. Eukaryota.
ENOG410XNP1. LUCA.
GeneTreeiENSGT00850000132298.
InParanoidiQ7KW39.
KOiK00140.
OMAiSNVKPNM.
OrthoDBiEOG091G06SO.
PhylomeDBiQ7KW39.

Enzyme and pathway databases

ReactomeiR-DME-70895. Branched-chain amino acid catabolism.

Miscellaneous databases

ChiTaRSiCG17896. fly.
GenomeRNAii30995.
PROiQ7KW39.

Gene expression databases

BgeeiFBgn0023537.
ExpressionAtlasiQ7KW39. baseline.
GenevisibleiQ7KW39. DM.

Family and domain databases

CDDicd07085. ALDH_F6_MMSDH. 1 hit.
Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
[Graphical view]
PANTHERiPTHR11699:SF183. PTHR11699:SF183. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01722. MMSDH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMMSA_DROME
AccessioniPrimary (citable) accession number: Q7KW39
Secondary accession number(s): O46056, Q8T9I0, Q9V408
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.