Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

Gene

CG17896

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity).By similarity

Catalytic activityi

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH.
3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei303 – 3031NucleophilePROSITE-ProRule annotationBy similarity
Binding sitei403 – 4031NADSequence analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi195 – 1995NADSequence analysis
Nucleotide bindingi247 – 2526NADSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-DME-70895. Branched-chain amino acid catabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (EC:1.2.1.18, EC:1.2.1.27)
Short name:
MMSDH
Short name:
Malonate-semialdehyde dehydrogenase [acylating]
Gene namesi
ORF Names:CG17896
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0023537. CG17896.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 520Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrialPRO_0000043373
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ7KW39.
PRIDEiQ7KW39.

Expressioni

Gene expression databases

BgeeiQ7KW39.
ExpressionAtlasiQ7KW39. differential.
GenevisibleiQ7KW39. DM.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi57566. 2 interactions.
IntActiQ7KW39. 2 interactions.
MINTiMINT-743398.
STRINGi7227.FBpp0070087.

Structurei

3D structure databases

ProteinModelPortaliQ7KW39.
SMRiQ7KW39. Positions 20-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Sequence analysis

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2449. Eukaryota.
ENOG410XNP1. LUCA.
GeneTreeiENSGT00760000118999.
InParanoidiQ7KW39.
KOiK00140.
OMAiSNVKPNM.
OrthoDBiEOG7J70F8.
PhylomeDBiQ7KW39.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
[Graphical view]
PANTHERiPTHR11699:SF183. PTHR11699:SF183. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01722. MMSDH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B1 Publication (identifier: Q7KW39-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLVRLIGAE ARHLAKRSYS SAAPTTKLFI DGKFVESKTN EWIDVHDPAT
60 70 80 90 100
NQVVTRVPKA TQAEMQAALE SNKKAFRSWS NQSILTRQQV MFKLQALIKE
110 120 130 140 150
NMGELAKNIT KEQGKTLADA EGDVLRGLQV VEHCCSIPSL QMGETVANVA
160 170 180 190 200
RDMDTYSLVL PLGVTAGVAP FNFPAMIPLW MFPVAITTGN TMLLKPSERV
210 220 230 240 250
PGATMLLMEL LNEAGCPPGV VNVIHGQHDA VNFICDAPEI KAVSFVGSDQ
260 270 280 290 300
AGKYIYERAG KNGKRVQSNM GAKNHGIILG DANKENTLNQ LAGAAFGAAG
310 320 330 340 350
QRCMALSTAV FVGDAQAWIP DLVERAQKLK VNAGHVPGTD VGPVISAASR
360 370 380 390 400
QRINDLIESG VKEGAKLILD GRKITVPGYE DGYFVGPTIL SDVTPSMKCY
410 420 430 440 450
TEEIFGPVLV ILKADTLDDA IGIVNANPYG NGTAVFTTNG AAARKFVNEI
460 470 480 490 500
DAGQVGVNVP IPVPLPMFSF TGTRGSFRGD HHFYGKQGIK FYTQTKTVTQ
510 520
LWRKTDVTHT QAAVAMPTMK
Note: No experimental confirmation available.Curated
Length:520
Mass (Da):55,972
Last modified:July 5, 2004 - v1
Checksum:i12AC03D9B9C3E41D
GO
Isoform A1 Publication (identifier: Q7KW39-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-10: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:511
Mass (Da):55,033
Checksum:i304898AEFE153447
GO

Sequence cautioni

The sequence CAA15632.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 109Missing in isoform A. 1 PublicationVSP_051919

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF45510.2.
AE014298 Genomic DNA. Translation: AAF45511.1.
AL009147 Genomic DNA. Translation: CAA15632.1. Sequence problems.
AL009147 Genomic DNA. Translation: CAB41309.1.
AY069284 mRNA. Translation: AAL39429.2.
PIRiT13418.
RefSeqiNP_569845.2. NM_130489.3. [Q7KW39-1]
NP_726672.1. NM_166844.1. [Q7KW39-2]
UniGeneiDm.11239.

Genome annotation databases

EnsemblMetazoaiFBtr0070092; FBpp0070087; FBgn0023537. [Q7KW39-1]
GeneIDi30995.
KEGGidme:Dmel_CG17896.
UCSCiCG17896-RA. d. melanogaster. [Q7KW39-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF45510.2.
AE014298 Genomic DNA. Translation: AAF45511.1.
AL009147 Genomic DNA. Translation: CAA15632.1. Sequence problems.
AL009147 Genomic DNA. Translation: CAB41309.1.
AY069284 mRNA. Translation: AAL39429.2.
PIRiT13418.
RefSeqiNP_569845.2. NM_130489.3. [Q7KW39-1]
NP_726672.1. NM_166844.1. [Q7KW39-2]
UniGeneiDm.11239.

3D structure databases

ProteinModelPortaliQ7KW39.
SMRiQ7KW39. Positions 20-506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi57566. 2 interactions.
IntActiQ7KW39. 2 interactions.
MINTiMINT-743398.
STRINGi7227.FBpp0070087.

Proteomic databases

PaxDbiQ7KW39.
PRIDEiQ7KW39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070092; FBpp0070087; FBgn0023537. [Q7KW39-1]
GeneIDi30995.
KEGGidme:Dmel_CG17896.
UCSCiCG17896-RA. d. melanogaster. [Q7KW39-1]

Organism-specific databases

FlyBaseiFBgn0023537. CG17896.

Phylogenomic databases

eggNOGiKOG2449. Eukaryota.
ENOG410XNP1. LUCA.
GeneTreeiENSGT00760000118999.
InParanoidiQ7KW39.
KOiK00140.
OMAiSNVKPNM.
OrthoDBiEOG7J70F8.
PhylomeDBiQ7KW39.

Enzyme and pathway databases

ReactomeiR-DME-70895. Branched-chain amino acid catabolism.

Miscellaneous databases

ChiTaRSiCG17896. fly.
GenomeRNAii30995.
PROiQ7KW39.

Gene expression databases

BgeeiQ7KW39.
ExpressionAtlasiQ7KW39. differential.
GenevisibleiQ7KW39. DM.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
[Graphical view]
PANTHERiPTHR11699:SF183. PTHR11699:SF183. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01722. MMSDH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley1 Publication.
  2. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Oregon-R1 Publication.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 332-520.
    Strain: Berkeley.
    Tissue: Ovary.

Entry informationi

Entry nameiMMSA_DROME
AccessioniPrimary (citable) accession number: Q7KW39
Secondary accession number(s): O46056, Q8T9I0, Q9V408
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.