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Q7KVK3

- Q7KVK3_DROME

UniProt

Q7KVK3 - Q7KVK3_DROME

Protein
Submitted name:

Roundabout, isoform A

Gene

robo

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. heparin binding Source: FlyBase
    2. protein binding Source: FlyBase
    3. receptor activity Source: FlyBase

    GO - Biological processi

    1. axon guidance Source: FlyBase
    2. axon midline choice point recognition Source: FlyBase
    3. brain morphogenesis Source: FlyBase
    4. dendrite guidance Source: FlyBase
    5. dendrite morphogenesis Source: FlyBase
    6. embryonic heart tube development Source: FlyBase
    7. entrainment of circadian clock Source: FlyBase
    8. epithelial cell migration, open tracheal system Source: FlyBase
    9. gonad development Source: FlyBase
    10. locomotion involved in locomotory behavior Source: FlyBase
    11. motor neuron axon guidance Source: FlyBase
    12. muscle cell cellular homeostasis Source: FlyBase
    13. neuron recognition Source: FlyBase
    14. outflow tract morphogenesis Source: FlyBase
    15. photoreceptor cell axon guidance Source: FlyBase
    16. positive regulation of cell-cell adhesion Source: FlyBase
    17. regulation of dendrite development Source: FlyBase
    18. regulation of epithelial cell migration, open tracheal system Source: FlyBase
    19. Roundabout signaling pathway Source: FlyBase
    20. salivary gland boundary specification Source: FlyBase
    21. startle response Source: FlyBase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Roundabout, isoform AImported
    Gene namesi
    Name:roboImported
    ORF Names:CG13521Imported, Dmel_CG13521Imported
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0005631. robo.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: FlyBase
    2. axonal growth cone Source: FlyBase
    3. dendrite Source: FlyBase
    4. integral component of plasma membrane Source: FlyBase
    5. neuronal cell body Source: FlyBase
    6. plasma membrane Source: FlyBase
    7. protein complex Source: FlyBase
    8. Slit-Robo signaling complex Source: FlyBase
    9. vesicle Source: FlyBase

    PTM / Processingi

    Proteomic databases

    PRIDEiQ7KVK3.

    Expressioni

    Gene expression databases

    BgeeiQ7KVK3.

    Interactioni

    Protein-protein interaction databases

    IntActiQ7KVK3. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7KVK3.
    SMRiQ7KVK3. Positions 51-688, 752-855.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    RepeatSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00720000108572.
    InParanoidiQ7KVK3.

    Family and domain databases

    Gene3Di2.60.40.10. 8 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    PF07679. I-set. 5 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 3 hits.
    SM00408. IGc2. 5 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7KVK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHPMHPENHA IARSTSTTNN PSRSRSSRMW LLPAWLLLVL VASNGLPAVR     50
    GQYQSPRIIE HPTDLVVKKN EPATLNCKVE GKPEPTIEWF KDGEPVSTNE 100
    KKSHRVQFKD GALFFYRTMQ GKKEQDGGEY WCVAKNRVGQ AVSRHASLQI 150
    AVLRDDFRVE PKDTRVAKGE TALLECGPPK GIPEPTLIWI KDGVPLDDLK 200
    AMSFGASSRV RIVDGGNLLI SNVEPIDEGN YKCIAQNLVG TRESSYAKLI 250
    VQVKPYFMKE PKDQVMLYGQ TATFHCSVGG DPPPKVLWKK EEGNIPVSRA 300
    RILHDEKSLE ISNITPTDEG TYVCEAHNNV GQISARASLI VHAPPNFTKR 350
    PSNKKVGLNG VVQLPCMASG NPPPSVFWTK EGVSTLMFPN SSHGRQHVAA 400
    DGTLQITDVR QEDEGYYVCS AFSVVDSSTV RVFLQVSSLD ERPPPIIQIG 450
    PANQTLPKGS VATLPCRATG NPSPRIKWFH DGHAVQAGNR YSIIQGSSLR 500
    VDDLQLSDSG TYTCTASGER GETSWAATLT VEKPGSTSLH RAADPSTYPA 550
    PPGTPKVLNV SRTSISLRWA KSQEKPGAVG PIIGYTVEYF SPDLQTGWIV 600
    AAQRVGDTQV TISGLTPGTS YVFLVRAENT QGISVPSGLS NTIKTIEADF 650
    DAASANDLSA ARTLLTGKSV ELIDASAINA SAVRLEWMLH VSADEKYVEG 700
    LRIHYKDASV PSAQYHSITV MDASAESFVV GNLKKYTKYE FFLTPFFETI 750
    EGQPSNSKTA LTYEDVPSAP PDNIQIGMYN QTAGWVRWTP PPSQHHNGNL 800
    YGYKIEVSAG NTMKVLANMT LNATTTSVLL NNLTTGAVYS VRLNSFTKAG 850
    DGPYSKPISL FMDPTHHVHP PRAHPSGTHD GRHEGQDLTY HNNGNIPPGD 900
    INPTTHKKTT DYLSGPWLMV LVCIVLLVLV ISAAISMVYF KRKHQMTKEL 950
    GHLSVVSDNE ITALNINSKE SLWIDHHRGW RTADTDKDSG LSESKLLSHV 1000
    NSSQSNYNNS DGGTDYAEVD TRNLTTFYNC RKSPDNPTPY ATTMIIGTSS 1050
    SETCTKTTSI SADKDSGTHS PYSDAFAGQV PAVPVVKSNY LQYPVEPINW 1100
    SEFLPPPPEH PPPSSTYGYA QGSPESSRKS SKSAGSGIST NQSILNASIH 1150
    SSSSGGFSAW GVSPQYAVAC PPENVYSNPL SAVAGGTQNR YQITPTNQHP 1200
    PQLPAYFATT GPGGAVPPNH LPFATQRHAA SEYQAGLNAA RCAQSRACNS 1250
    CDALATPSPM QPPPPVPVPE GWYQPVHPNS HPMHPTSSNH QIYQCSSECS 1300
    DHSRSSQSHK RQLQLEEHGS SAKQRGGHHR RRAPVVQPCM ESENENMLAE 1350
    YEQRQYTSDC CNSSREGDTC SCSEGSCLYA EAGEPAPRQM TAKNT 1395
    Length:1,395
    Mass (Da):151,760
    Last modified:July 5, 2004 - v1
    Checksum:i25CED7DEB44F13F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013599 Genomic DNA. Translation: AAF46887.1.
    RefSeqiNP_476899.1. NM_057551.3.
    UniGeneiDm.7485.

    Genome annotation databases

    EnsemblMetazoaiFBtr0071922; FBpp0071833; FBgn0005631.
    GeneIDi37603.
    KEGGidme:Dmel_CG13521.
    UCSCiCG13521-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013599 Genomic DNA. Translation: AAF46887.1 .
    RefSeqi NP_476899.1. NM_057551.3.
    UniGenei Dm.7485.

    3D structure databases

    ProteinModelPortali Q7KVK3.
    SMRi Q7KVK3. Positions 51-688, 752-855.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q7KVK3. 1 interaction.

    Proteomic databases

    PRIDEi Q7KVK3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0071922 ; FBpp0071833 ; FBgn0005631 .
    GeneIDi 37603.
    KEGGi dme:Dmel_CG13521.
    UCSCi CG13521-RA. d. melanogaster.

    Organism-specific databases

    CTDi 37603.
    FlyBasei FBgn0005631. robo.

    Phylogenomic databases

    GeneTreei ENSGT00720000108572.
    InParanoidi Q7KVK3.

    Miscellaneous databases

    GenomeRNAii 37603.
    NextBioi 804509.

    Gene expression databases

    Bgeei Q7KVK3.

    Family and domain databases

    Gene3Di 2.60.40.10. 8 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    PF07679. I-set. 5 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 3 hits.
    SM00408. IGc2. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    3. Cited for: GENOME REANNOTATION.
      Strain: BerkeleyImported.
    4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
      Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
      Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
      Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
      Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    6. "Combined evidence annotation of transposable elements in genome sequences."
      Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
      PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    7. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
      Smith C.D., Shu S., Mungall C.J., Karpen G.H.
      Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.

    Entry informationi

    Entry nameiQ7KVK3_DROME
    AccessioniPrimary (citable) accession number: Q7KVK3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3