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Q7KVK3

- Q7KVK3_DROME

UniProt

Q7KVK3 - Q7KVK3_DROME

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Protein
Submitted name: Roundabout, isoform A
Gene
robo, CG13521, Dmel_CG13521
Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. heparin binding Source: FlyBase
  2. protein binding Source: FlyBase
  3. receptor activity Source: FlyBase
Complete GO annotation...

GO - Biological processi

  1. Roundabout signaling pathway Source: FlyBase
  2. axon guidance Source: FlyBase
  3. axon midline choice point recognition Source: FlyBase
  4. brain morphogenesis Source: FlyBase
  5. dendrite guidance Source: FlyBase
  6. dendrite morphogenesis Source: FlyBase
  7. embryonic heart tube development Source: FlyBase
  8. entrainment of circadian clock Source: FlyBase
  9. epithelial cell migration, open tracheal system Source: FlyBase
  10. gonad development Source: FlyBase
  11. locomotion involved in locomotory behavior Source: FlyBase
  12. motor neuron axon guidance Source: FlyBase
  13. muscle cell cellular homeostasis Source: FlyBase
  14. neuron recognition Source: FlyBase
  15. outflow tract morphogenesis Source: FlyBase
  16. photoreceptor cell axon guidance Source: FlyBase
  17. positive regulation of cell-cell adhesion Source: FlyBase
  18. regulation of dendrite development Source: FlyBase
  19. regulation of epithelial cell migration, open tracheal system Source: FlyBase
  20. salivary gland boundary specification Source: FlyBase
  21. startle response Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Roundabout, isoform AImported
Gene namesi
Name:roboImported
ORF Names:CG13521Imported, Dmel_CG13521Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0005631. robo.

Subcellular locationi

GO - Cellular componenti

  1. Slit-Robo signaling complex Source: FlyBase
  2. axon Source: FlyBase
  3. axonal growth cone Source: FlyBase
  4. dendrite Source: FlyBase
  5. integral component of plasma membrane Source: FlyBase
  6. neuronal cell body Source: FlyBase
  7. plasma membrane Source: FlyBase
  8. protein complex Source: FlyBase
  9. vesicle Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ7KVK3.

Expressioni

Gene expression databases

BgeeiQ7KVK3.

Interactioni

Protein-protein interaction databases

IntActiQ7KVK3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ7KVK3.
SMRiQ7KVK3. Positions 51-863.

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00720000108572.
InParanoidiQ7KVK3.

Family and domain databases

Gene3Di2.60.40.10. 8 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7KVK3-1 [UniParc]FASTAAdd to Basket

« Hide

MHPMHPENHA IARSTSTTNN PSRSRSSRMW LLPAWLLLVL VASNGLPAVR     50
GQYQSPRIIE HPTDLVVKKN EPATLNCKVE GKPEPTIEWF KDGEPVSTNE 100
KKSHRVQFKD GALFFYRTMQ GKKEQDGGEY WCVAKNRVGQ AVSRHASLQI 150
AVLRDDFRVE PKDTRVAKGE TALLECGPPK GIPEPTLIWI KDGVPLDDLK 200
AMSFGASSRV RIVDGGNLLI SNVEPIDEGN YKCIAQNLVG TRESSYAKLI 250
VQVKPYFMKE PKDQVMLYGQ TATFHCSVGG DPPPKVLWKK EEGNIPVSRA 300
RILHDEKSLE ISNITPTDEG TYVCEAHNNV GQISARASLI VHAPPNFTKR 350
PSNKKVGLNG VVQLPCMASG NPPPSVFWTK EGVSTLMFPN SSHGRQHVAA 400
DGTLQITDVR QEDEGYYVCS AFSVVDSSTV RVFLQVSSLD ERPPPIIQIG 450
PANQTLPKGS VATLPCRATG NPSPRIKWFH DGHAVQAGNR YSIIQGSSLR 500
VDDLQLSDSG TYTCTASGER GETSWAATLT VEKPGSTSLH RAADPSTYPA 550
PPGTPKVLNV SRTSISLRWA KSQEKPGAVG PIIGYTVEYF SPDLQTGWIV 600
AAQRVGDTQV TISGLTPGTS YVFLVRAENT QGISVPSGLS NTIKTIEADF 650
DAASANDLSA ARTLLTGKSV ELIDASAINA SAVRLEWMLH VSADEKYVEG 700
LRIHYKDASV PSAQYHSITV MDASAESFVV GNLKKYTKYE FFLTPFFETI 750
EGQPSNSKTA LTYEDVPSAP PDNIQIGMYN QTAGWVRWTP PPSQHHNGNL 800
YGYKIEVSAG NTMKVLANMT LNATTTSVLL NNLTTGAVYS VRLNSFTKAG 850
DGPYSKPISL FMDPTHHVHP PRAHPSGTHD GRHEGQDLTY HNNGNIPPGD 900
INPTTHKKTT DYLSGPWLMV LVCIVLLVLV ISAAISMVYF KRKHQMTKEL 950
GHLSVVSDNE ITALNINSKE SLWIDHHRGW RTADTDKDSG LSESKLLSHV 1000
NSSQSNYNNS DGGTDYAEVD TRNLTTFYNC RKSPDNPTPY ATTMIIGTSS 1050
SETCTKTTSI SADKDSGTHS PYSDAFAGQV PAVPVVKSNY LQYPVEPINW 1100
SEFLPPPPEH PPPSSTYGYA QGSPESSRKS SKSAGSGIST NQSILNASIH 1150
SSSSGGFSAW GVSPQYAVAC PPENVYSNPL SAVAGGTQNR YQITPTNQHP 1200
PQLPAYFATT GPGGAVPPNH LPFATQRHAA SEYQAGLNAA RCAQSRACNS 1250
CDALATPSPM QPPPPVPVPE GWYQPVHPNS HPMHPTSSNH QIYQCSSECS 1300
DHSRSSQSHK RQLQLEEHGS SAKQRGGHHR RRAPVVQPCM ESENENMLAE 1350
YEQRQYTSDC CNSSREGDTC SCSEGSCLYA EAGEPAPRQM TAKNT 1395
Length:1,395
Mass (Da):151,760
Last modified:July 5, 2004 - v1
Checksum:i25CED7DEB44F13F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013599 Genomic DNA. Translation: AAF46887.1.
RefSeqiNP_476899.1. NM_057551.3.
UniGeneiDm.7485.

Genome annotation databases

EnsemblMetazoaiFBtr0071922; FBpp0071833; FBgn0005631.
GeneIDi37603.
KEGGidme:Dmel_CG13521.
UCSCiCG13521-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013599 Genomic DNA. Translation: AAF46887.1 .
RefSeqi NP_476899.1. NM_057551.3.
UniGenei Dm.7485.

3D structure databases

ProteinModelPortali Q7KVK3.
SMRi Q7KVK3. Positions 51-863.
ModBasei Search...

Protein-protein interaction databases

IntActi Q7KVK3. 1 interaction.

Proteomic databases

PRIDEi Q7KVK3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0071922 ; FBpp0071833 ; FBgn0005631 .
GeneIDi 37603.
KEGGi dme:Dmel_CG13521.
UCSCi CG13521-RA. d. melanogaster.

Organism-specific databases

CTDi 37603.
FlyBasei FBgn0005631. robo.

Phylogenomic databases

GeneTreei ENSGT00720000108572.
InParanoidi Q7KVK3.

Miscellaneous databases

GenomeRNAii 37603.
NextBioi 804509.

Gene expression databases

Bgeei Q7KVK3.

Family and domain databases

Gene3Di 2.60.40.10. 8 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view ]
SMARTi SM00060. FN3. 3 hits.
SM00408. IGc2. 5 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  7. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.

Entry informationi

Entry nameiQ7KVK3_DROME
AccessioniPrimary (citable) accession number: Q7KVK3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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