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Q7KVK3

- Q7KVK3_DROME

UniProt

Q7KVK3 - Q7KVK3_DROME

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Protein
Submitted name:

Roundabout, isoform A

Gene

robo

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. heparin binding Source: FlyBase
  2. receptor activity Source: FlyBase

GO - Biological processi

  1. axon guidance Source: FlyBase
  2. axon midline choice point recognition Source: FlyBase
  3. brain morphogenesis Source: FlyBase
  4. dendrite guidance Source: FlyBase
  5. dendrite morphogenesis Source: FlyBase
  6. embryonic heart tube development Source: FlyBase
  7. entrainment of circadian clock Source: FlyBase
  8. epithelial cell migration, open tracheal system Source: FlyBase
  9. gonad development Source: FlyBase
  10. locomotion involved in locomotory behavior Source: FlyBase
  11. motor neuron axon guidance Source: FlyBase
  12. muscle cell cellular homeostasis Source: FlyBase
  13. neuron recognition Source: FlyBase
  14. outflow tract morphogenesis Source: FlyBase
  15. photoreceptor cell axon guidance Source: FlyBase
  16. positive regulation of cell-cell adhesion Source: FlyBase
  17. regulation of dendrite development Source: FlyBase
  18. regulation of epithelial cell migration, open tracheal system Source: FlyBase
  19. Roundabout signaling pathway Source: FlyBase
  20. salivary gland boundary specification Source: FlyBase
  21. startle response Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Roundabout, isoform AImported
Gene namesi
Name:roboImported
ORF Names:CG13521Imported, Dmel_CG13521Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0005631. robo.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: FlyBase
  2. axonal growth cone Source: FlyBase
  3. dendrite Source: FlyBase
  4. integral component of plasma membrane Source: FlyBase
  5. neuronal cell body Source: FlyBase
  6. plasma membrane Source: FlyBase
  7. protein complex Source: FlyBase
  8. Slit-Robo signaling complex Source: FlyBase
  9. vesicle Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ7KVK3.

Expressioni

Gene expression databases

BgeeiQ7KVK3.
ExpressionAtlasiQ7KVK3. differential.

Interactioni

Protein-protein interaction databases

IntActiQ7KVK3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ7KVK3.
SMRiQ7KVK3. Positions 51-863.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118886.

Family and domain databases

Gene3Di2.60.40.10. 8 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7KVK3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHPMHPENHA IARSTSTTNN PSRSRSSRMW LLPAWLLLVL VASNGLPAVR
60 70 80 90 100
GQYQSPRIIE HPTDLVVKKN EPATLNCKVE GKPEPTIEWF KDGEPVSTNE
110 120 130 140 150
KKSHRVQFKD GALFFYRTMQ GKKEQDGGEY WCVAKNRVGQ AVSRHASLQI
160 170 180 190 200
AVLRDDFRVE PKDTRVAKGE TALLECGPPK GIPEPTLIWI KDGVPLDDLK
210 220 230 240 250
AMSFGASSRV RIVDGGNLLI SNVEPIDEGN YKCIAQNLVG TRESSYAKLI
260 270 280 290 300
VQVKPYFMKE PKDQVMLYGQ TATFHCSVGG DPPPKVLWKK EEGNIPVSRA
310 320 330 340 350
RILHDEKSLE ISNITPTDEG TYVCEAHNNV GQISARASLI VHAPPNFTKR
360 370 380 390 400
PSNKKVGLNG VVQLPCMASG NPPPSVFWTK EGVSTLMFPN SSHGRQHVAA
410 420 430 440 450
DGTLQITDVR QEDEGYYVCS AFSVVDSSTV RVFLQVSSLD ERPPPIIQIG
460 470 480 490 500
PANQTLPKGS VATLPCRATG NPSPRIKWFH DGHAVQAGNR YSIIQGSSLR
510 520 530 540 550
VDDLQLSDSG TYTCTASGER GETSWAATLT VEKPGSTSLH RAADPSTYPA
560 570 580 590 600
PPGTPKVLNV SRTSISLRWA KSQEKPGAVG PIIGYTVEYF SPDLQTGWIV
610 620 630 640 650
AAQRVGDTQV TISGLTPGTS YVFLVRAENT QGISVPSGLS NTIKTIEADF
660 670 680 690 700
DAASANDLSA ARTLLTGKSV ELIDASAINA SAVRLEWMLH VSADEKYVEG
710 720 730 740 750
LRIHYKDASV PSAQYHSITV MDASAESFVV GNLKKYTKYE FFLTPFFETI
760 770 780 790 800
EGQPSNSKTA LTYEDVPSAP PDNIQIGMYN QTAGWVRWTP PPSQHHNGNL
810 820 830 840 850
YGYKIEVSAG NTMKVLANMT LNATTTSVLL NNLTTGAVYS VRLNSFTKAG
860 870 880 890 900
DGPYSKPISL FMDPTHHVHP PRAHPSGTHD GRHEGQDLTY HNNGNIPPGD
910 920 930 940 950
INPTTHKKTT DYLSGPWLMV LVCIVLLVLV ISAAISMVYF KRKHQMTKEL
960 970 980 990 1000
GHLSVVSDNE ITALNINSKE SLWIDHHRGW RTADTDKDSG LSESKLLSHV
1010 1020 1030 1040 1050
NSSQSNYNNS DGGTDYAEVD TRNLTTFYNC RKSPDNPTPY ATTMIIGTSS
1060 1070 1080 1090 1100
SETCTKTTSI SADKDSGTHS PYSDAFAGQV PAVPVVKSNY LQYPVEPINW
1110 1120 1130 1140 1150
SEFLPPPPEH PPPSSTYGYA QGSPESSRKS SKSAGSGIST NQSILNASIH
1160 1170 1180 1190 1200
SSSSGGFSAW GVSPQYAVAC PPENVYSNPL SAVAGGTQNR YQITPTNQHP
1210 1220 1230 1240 1250
PQLPAYFATT GPGGAVPPNH LPFATQRHAA SEYQAGLNAA RCAQSRACNS
1260 1270 1280 1290 1300
CDALATPSPM QPPPPVPVPE GWYQPVHPNS HPMHPTSSNH QIYQCSSECS
1310 1320 1330 1340 1350
DHSRSSQSHK RQLQLEEHGS SAKQRGGHHR RRAPVVQPCM ESENENMLAE
1360 1370 1380 1390
YEQRQYTSDC CNSSREGDTC SCSEGSCLYA EAGEPAPRQM TAKNT
Length:1,395
Mass (Da):151,760
Last modified:July 5, 2004 - v1
Checksum:i25CED7DEB44F13F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013599 Genomic DNA. Translation: AAF46887.1.
RefSeqiNP_476899.1. NM_057551.4.
NP_726224.3. NM_166543.2.

Genome annotation databases

EnsemblMetazoaiFBtr0071922; FBpp0071833; FBgn0005631.
GeneIDi37603.
KEGGidme:Dmel_CG13521.
UCSCiCG13521-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013599 Genomic DNA. Translation: AAF46887.1 .
RefSeqi NP_476899.1. NM_057551.4.
NP_726224.3. NM_166543.2.

3D structure databases

ProteinModelPortali Q7KVK3.
SMRi Q7KVK3. Positions 51-863.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q7KVK3. 1 interaction.

Proteomic databases

PRIDEi Q7KVK3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0071922 ; FBpp0071833 ; FBgn0005631 .
GeneIDi 37603.
KEGGi dme:Dmel_CG13521.
UCSCi CG13521-RA. d. melanogaster.

Organism-specific databases

CTDi 37603.
FlyBasei FBgn0005631. robo.

Phylogenomic databases

GeneTreei ENSGT00760000118886.

Miscellaneous databases

GenomeRNAii 37603.
NextBioi 804509.

Gene expression databases

Bgeei Q7KVK3.
ExpressionAtlasi Q7KVK3. differential.

Family and domain databases

Gene3Di 2.60.40.10. 8 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view ]
SMARTi SM00060. FN3. 3 hits.
SM00408. IGc2. 5 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.

Entry informationi

Entry nameiQ7KVK3_DROME
AccessioniPrimary (citable) accession number: Q7KVK3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3