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Q7KVK3 (Q7KVK3_DROME) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
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Names and origin

Protein namesSubmitted name:
Roundabout, isoform A EMBL AAF46887.1
Gene names
Name:robo
ORF Names:Dmel_CG13521 EMBL AAF46887.1
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›

Protein attributes

Sequence length1395 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   DomainRepeat SAAS SAAS013098
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRoundabout signaling pathway

Inferred from genetic interaction PubMed 10102267. Source: FlyBase

axon midline choice point recognition

Inferred from mutant phenotype PubMed 12040057PubMed 17049509PubMed 17121810. Source: FlyBase

brain morphogenesis

Inferred from genetic interaction PubMed 18713854. Source: FlyBase

dendrite guidance

Inferred from mutant phenotype PubMed 12592406. Source: FlyBase

embryonic heart tube development

Inferred from mutant phenotype PubMed 16360689PubMed 16888037. Source: FlyBase

entrainment of circadian clock

Inferred from direct assay PubMed 18215236. Source: FlyBase

epithelial cell migration, open tracheal system

Traceable author statement PubMed 14570584. Source: FlyBase

gonad development

Inferred from mutant phenotype PubMed 21377458. Source: FlyBase

locomotion involved in locomotory behavior

Inferred from mutant phenotype PubMed 18713854. Source: FlyBase

motor neuron axon guidance

Inferred from mutant phenotype PubMed 20808815. Source: FlyBase

muscle cell homeostasis

Inferred from genetic interaction PubMed 21256839. Source: FlyBase

outflow tract morphogenesis

Inferred from genetic interaction PubMed 18250318. Source: FlyBase

photoreceptor cell axon guidance

Inferred from mutant phenotype PubMed 21943192. Source: FlyBase

positive regulation of cell-cell adhesion

Inferred from mutant phenotype PubMed 16888037. Source: FlyBase

regulation of epithelial cell migration, open tracheal system

Inferred from mutant phenotype PubMed 12397103. Source: FlyBase

salivary gland boundary specification

Inferred from mutant phenotype PubMed 15950216. Source: FlyBase

startle response

Inferred from mutant phenotype PubMed 18713854. Source: FlyBase

   Cellular_componentSlit-Robo signaling complex

Inferred from direct assay PubMed 17062560. Source: FlyBase

axonal growth cone

Inferred from direct assay PubMed 10102267. Source: FlyBase

dendrite

Inferred from direct assay PubMed 12592406. Source: FlyBase

integral to plasma membrane

Inferred from sequence or structural similarity PubMed 9458045. Source: FlyBase

neuronal cell body

Inferred from direct assay PubMed 12592406. Source: FlyBase

protein complex

Inferred from physical interaction PubMed 19793885. Source: FlyBase

vesicle

Inferred from direct assay PubMed 12165468. Source: FlyBase

   Molecular_functionheparin binding

Inferred from direct assay PubMed 17062560PubMed 18359766. Source: FlyBase

receptor activity

Traceable author statement PubMed 12885551. Source: FlyBase

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q7KVK3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 25CED7DEB44F13F0

FASTA1,395151,760
        10         20         30         40         50         60 
MHPMHPENHA IARSTSTTNN PSRSRSSRMW LLPAWLLLVL VASNGLPAVR GQYQSPRIIE 

        70         80         90        100        110        120 
HPTDLVVKKN EPATLNCKVE GKPEPTIEWF KDGEPVSTNE KKSHRVQFKD GALFFYRTMQ 

       130        140        150        160        170        180 
GKKEQDGGEY WCVAKNRVGQ AVSRHASLQI AVLRDDFRVE PKDTRVAKGE TALLECGPPK 

       190        200        210        220        230        240 
GIPEPTLIWI KDGVPLDDLK AMSFGASSRV RIVDGGNLLI SNVEPIDEGN YKCIAQNLVG 

       250        260        270        280        290        300 
TRESSYAKLI VQVKPYFMKE PKDQVMLYGQ TATFHCSVGG DPPPKVLWKK EEGNIPVSRA 

       310        320        330        340        350        360 
RILHDEKSLE ISNITPTDEG TYVCEAHNNV GQISARASLI VHAPPNFTKR PSNKKVGLNG 

       370        380        390        400        410        420 
VVQLPCMASG NPPPSVFWTK EGVSTLMFPN SSHGRQHVAA DGTLQITDVR QEDEGYYVCS 

       430        440        450        460        470        480 
AFSVVDSSTV RVFLQVSSLD ERPPPIIQIG PANQTLPKGS VATLPCRATG NPSPRIKWFH 

       490        500        510        520        530        540 
DGHAVQAGNR YSIIQGSSLR VDDLQLSDSG TYTCTASGER GETSWAATLT VEKPGSTSLH 

       550        560        570        580        590        600 
RAADPSTYPA PPGTPKVLNV SRTSISLRWA KSQEKPGAVG PIIGYTVEYF SPDLQTGWIV 

       610        620        630        640        650        660 
AAQRVGDTQV TISGLTPGTS YVFLVRAENT QGISVPSGLS NTIKTIEADF DAASANDLSA 

       670        680        690        700        710        720 
ARTLLTGKSV ELIDASAINA SAVRLEWMLH VSADEKYVEG LRIHYKDASV PSAQYHSITV 

       730        740        750        760        770        780 
MDASAESFVV GNLKKYTKYE FFLTPFFETI EGQPSNSKTA LTYEDVPSAP PDNIQIGMYN 

       790        800        810        820        830        840 
QTAGWVRWTP PPSQHHNGNL YGYKIEVSAG NTMKVLANMT LNATTTSVLL NNLTTGAVYS 

       850        860        870        880        890        900 
VRLNSFTKAG DGPYSKPISL FMDPTHHVHP PRAHPSGTHD GRHEGQDLTY HNNGNIPPGD 

       910        920        930        940        950        960 
INPTTHKKTT DYLSGPWLMV LVCIVLLVLV ISAAISMVYF KRKHQMTKEL GHLSVVSDNE 

       970        980        990       1000       1010       1020 
ITALNINSKE SLWIDHHRGW RTADTDKDSG LSESKLLSHV NSSQSNYNNS DGGTDYAEVD 

      1030       1040       1050       1060       1070       1080 
TRNLTTFYNC RKSPDNPTPY ATTMIIGTSS SETCTKTTSI SADKDSGTHS PYSDAFAGQV 

      1090       1100       1110       1120       1130       1140 
PAVPVVKSNY LQYPVEPINW SEFLPPPPEH PPPSSTYGYA QGSPESSRKS SKSAGSGIST 

      1150       1160       1170       1180       1190       1200 
NQSILNASIH SSSSGGFSAW GVSPQYAVAC PPENVYSNPL SAVAGGTQNR YQITPTNQHP 

      1210       1220       1230       1240       1250       1260 
PQLPAYFATT GPGGAVPPNH LPFATQRHAA SEYQAGLNAA RCAQSRACNS CDALATPSPM 

      1270       1280       1290       1300       1310       1320 
QPPPPVPVPE GWYQPVHPNS HPMHPTSSNH QIYQCSSECS DHSRSSQSHK RQLQLEEHGS 

      1330       1340       1350       1360       1370       1380 
SAKQRGGHHR RRAPVVQPCM ESENENMLAE YEQRQYTSDC CNSSREGDTC SCSEGSCLYA 

      1390 
EAGEPAPRQM TAKNT

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE013599 Genomic DNA. Translation: AAF46887.1.
RefSeqNP_476899.1. NM_057551.3.
UniGeneDm.7485.

3D structure databases

ProteinModelPortalQ7KVK3.
SMRQ7KVK3. Positions 51-688, 752-855.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7KVK3.

Proteomic databases

PRIDEQ7KVK3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0071922; FBpp0071833; FBgn0005631.
GeneID37603.
KEGGdme:Dmel_CG13521.
UCSCCG13521-RA. d. melanogaster.

Organism-specific databases

CTD37603.
FlyBaseFBgn0005631. robo.

Phylogenomic databases

GeneTreeENSGT00680000099931.
InParanoidQ7KVK3.

Gene expression databases

ArrayExpressQ7KVK3.
BgeeQ7KVK3.

Family and domain databases

Gene3D2.60.40.10. 8 hits.
InterProIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
[Graphical view]
PfamPF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view]
SMARTSM00060. FN3. 3 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 3 hits.
PROSITEPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi37603.
NextBio804509.

Entry information

Entry nameQ7KVK3_DROME
AccessionPrimary (citable) accession number: Q7KVK3
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry info