Q7KUN5 (Q7KUN5_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Decapping protein 2, isoform C EMBL AAS64991.1
EC=3.-.-.- EMBL AAS64991.1

Gene names

Name:	Dcp2 FlyBase FBgn0036534
ORF Names:	CG6169 FlyBase FBgn0036534, Dmel_CG6169 EMBL AAS64991.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	774 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Hydrolase EMBL AAS64991.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	deadenylation-dependent decapping of nuclear-transcribed mRNA Inferred from direct assay. Source: FlyBase gene silencing by miRNA Inferred from mutant phenotype. Source: FlyBase regulation of cytoplasmic mRNA processing body assembly Inferred from mutant phenotype. Source: FlyBase
Cellular component	cytoplasmic mRNA processing body Inferred from direct assay. Source: FlyBase
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro m7G(5')pppN diphosphatase activity Inferred from direct assay. Source: FlyBase manganese ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7KUN5 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 6684B72D62980A8C	FASTA	774	86,260
	10 20 30 40 50 60 MIAIKVNNLA LLASLTLQKV LNINNNNNQH SKNNNHSDNS NSKQHEQQKQ QQQPQRRNLD 70 80 90 100 110 120 IKSEYDVLNQ LLKTGAVFTA TPTAPIAIER RKQTQQQQRP YAQQAHQQQQ QKQRLNSSIS 130 140 150 160 170 180 STHSSTSTNS SYGSSSSEDA AGTSAPTGAG EVVTSAALTP RASTTKASSN KLPEKSKIPS 190 200 210 220 230 240 DILDDLASRF IINVPDMELN NLIRMCFQIE LAHWFYLDFF CAPESGEDGE TPKCVQRKLP 250 260 270 280 290 300 SVGIKQFAMQ LFQHIPFLNK HFGTVDQILD EWKNYKLSVP TYGAILVSED HNHCLLVQSY 310 320 330 340 350 360 FARNSWGFPK GKINENEDPA HCATREASRE YIGILKNIIV YEETGFDITD LIDANDYIEA 370 380 390 400 410 420 FINYQYTRLY VVRNIPMDTQ FAPRTRNEIK CCDWFRIDAL PVNKNDAISK AKLGKTSNSF 430 440 450 460 470 480 FMIMPFVKRL KKWVNDRKAG IEPRRRKFSG QQSPKAASPT NMNGNCKKDV TGVRNESQRQ 490 500 510 520 530 540 RHKSMGDLDG VKLNNLNGKG TVGTGAGSAA SASATAAINS MNICNSNGKR NKQNAAAGSN 550 560 570 580 590 600 QATPTTIATP MTSNGAVVGG TVSSKRQLFH SQSQNDAQQS ASNEKQIVSS FDLIRKEKQQ 610 620 630 640 650 660 QLKAAKAQKQ QQQQQQRSRT KSQSDKQYNP QQPVKILGQQ QPTTGMDLIA MLSAAAAAQK 670 680 690 700 710 720 TPNNEQQTQE KQQQQQRPRP ASVSLNLGAG SATGATTSAP DAQYMHRLQR MASGTNLRIL 730 740 750 760 770 KRAQSQQPQQ HHQQQLQLEQ QQQQQQQLGI DFTPNLNSWT NFSFTKNFIA NVFC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014296 Genomic DNA. Translation: AAS64991.1.
RefSeq	NP_996100.1. NM_206378.1.
UniGene	Dm.11490.
3D structure databases
ProteinModelPortal	Q7KUN5.
SMR	Q7KUN5. Positions 178-441.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7KUN5.
Proteomic databases
PRIDE	Q7KUN5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0075540; FBpp0075295; FBgn0036534.
GeneID	39722.
KEGG	dme:Dmel_CG6169.
NMPDR	fig|7227.3.peg.10002.
UCSC	CG6169-RC. d. melanogaster.
Organism-specific databases
CTD	167227.
FlyBase	FBgn0036534. Dcp2.
Phylogenomic databases
GeneTree	EMGT00050000001547.
InParanoid	Q7KUN5.
Gene expression databases
ArrayExpress	Q7KUN5.
Bgee	Q7KUN5.
Family and domain databases
InterPro	IPR007722. mRNA_decapping_BoxA. IPR000086. NUDIX_hydrolase_dom. IPR015797. NUDIX_hydrolase_dom-like. [Graphical view]
Gene3D	G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
KO	K12613.
Pfam	PF05026. DCP2. 1 hit. PF00293. NUDIX. 1 hit. [Graphical view]
SUPFAM	SSF55811. NUDIX_hydrolase. 1 hit.
PROSITE	PS51462. NUDIX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	815047.

Entry information

Entry name

Q7KUN5_DROME

Accession

Primary (citable) accession number: Q7KUN5

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)