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Protein

Probable insulin-like peptide 5

Gene

Ilp5

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • insulin receptor binding Source: UniProtKB

GO - Biological processi

  • female mating behavior Source: FlyBase
  • insulin receptor signaling pathway Source: UniProtKB
  • locomotory behavior Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • regulation of insulin receptor signaling pathway Source: GO_Central
  • sleep Source: FlyBase

Enzyme and pathway databases

SignaLinkiQ7KUD5.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable insulin-like peptide 5
Short name:
dILP5
Alternative name(s):
Insulin-related peptide 5
Cleaved into the following 2 chains:
Gene namesi
Name:Ilp5Imported
Synonyms:HDC09365Imported
ORF Names:CG33273
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0044048. Ilp5.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: FlyBase

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001620123 – 108Probable insulin-like peptide 5Sequence analysisAdd BLAST86
PeptideiPRO_000001620223 – 50Probable insulin-like peptide 5 B chainSequence analysisAdd BLAST28
PropeptideiPRO_000001620353 – 81Connecting peptideSequence analysisAdd BLAST29
PeptideiPRO_000001620484 – 108Probable insulin-like peptide 5 A chainSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 93Interchain (between B and A chains)By similarity
Disulfide bondi41 ↔ 106Interchain (between B and A chains)By similarity
Disulfide bondi92 ↔ 97By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ7KUD5.
PRIDEiQ7KUD5.

Expressioni

Tissue specificityi

Expressed at a high level in seven cells of each larval brain hemisphere that may correspond to neurosecretory cells. Expressed at a moderate level in the larval gut.1 Publication

Developmental stagei

Expressed in the larva but not in the embryo.1 Publication

Gene expression databases

BgeeiFBgn0044048.
GenevisibleiQ7KUD5. DM.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.By similarity

GO - Molecular functioni

  • insulin receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi7227.FBpp0076100.

Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi30 – 40Combined sources11
Helixi88 – 92Combined sources5
Helixi99 – 104Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WFUX-ray1.85A87-108[»]
B24-47[»]
2WFVX-ray1.85A84-108[»]
B24-46[»]
ProteinModelPortaliQ7KUD5.
SMRiQ7KUD5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7KUD5.

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KB5Y. Eukaryota.
ENOG4110NKZ. LUCA.
InParanoidiQ7KUD5.
KOiK04526.
OrthoDBiEOG091G0RIK.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
PfamiView protein in Pfam
PF00049. Insulin. 1 hit.
PRINTSiPR00276. INSULINFAMLY.
SMARTiView protein in SMART
SM00078. IlGF. 1 hit.
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiView protein in PROSITE
PS00262. INSULIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7KUD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFRSVIPVL LFLIPLLLSA QAANSLRACG PALMDMLRVA CPNGFNSMFA
60 70 80 90 100
KRGTLGLFDY EDHLADLDSS ESHHMNSLSS IRRDFRGVVD SCCRKSCSFS

TLRAYCDS
Length:108
Mass (Da):11,972
Last modified:March 29, 2005 - v2
Checksum:i897675835FF76552
GO

Sequence cautioni

The sequence AAS65048 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAS65048.1. Different initiation.
BK002023 Genomic DNA. Translation: DAA02868.1.
RefSeqiNP_996037.1. NM_206315.2.
UniGeneiDm.27905.

Genome annotation databases

GeneIDi2768992.
KEGGidme:Dmel_CG33273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAS65048.1. Different initiation.
BK002023 Genomic DNA. Translation: DAA02868.1.
RefSeqiNP_996037.1. NM_206315.2.
UniGeneiDm.27905.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WFUX-ray1.85A87-108[»]
B24-47[»]
2WFVX-ray1.85A84-108[»]
B24-46[»]
ProteinModelPortaliQ7KUD5.
SMRiQ7KUD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0076100.

Proteomic databases

PaxDbiQ7KUD5.
PRIDEiQ7KUD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2768992.
KEGGidme:Dmel_CG33273.

Organism-specific databases

CTDi2768992.
FlyBaseiFBgn0044048. Ilp5.

Phylogenomic databases

eggNOGiENOG410KB5Y. Eukaryota.
ENOG4110NKZ. LUCA.
InParanoidiQ7KUD5.
KOiK04526.
OrthoDBiEOG091G0RIK.

Enzyme and pathway databases

SignaLinkiQ7KUD5.

Miscellaneous databases

EvolutionaryTraceiQ7KUD5.
GenomeRNAii2768992.
PROiPR:Q7KUD5.

Gene expression databases

BgeeiFBgn0044048.
GenevisibleiQ7KUD5. DM.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
PfamiView protein in Pfam
PF00049. Insulin. 1 hit.
PRINTSiPR00276. INSULINFAMLY.
SMARTiView protein in SMART
SM00078. IlGF. 1 hit.
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiView protein in PROSITE
PS00262. INSULIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiINSL5_DROME
AccessioniPrimary (citable) accession number: Q7KUD5
Secondary accession number(s): Q6ILJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: April 12, 2017
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.