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Protein

Probable insulin-like peptide 5

Gene

Ilp5

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • insulin receptor binding Source: UniProtKB

GO - Biological processi

  • female mating behavior Source: FlyBase
  • insulin receptor signaling pathway Source: UniProtKB
  • locomotory behavior Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • sleep Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ7KUD5.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable insulin-like peptide 5
Short name:
dILP5
Alternative name(s):
Insulin-related peptide 5
Cleaved into the following 2 chains:
Gene namesi
Name:Ilp5Imported
Synonyms:HDC09365Imported
ORF Names:CG33273
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0044048. Ilp5.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 10886Probable insulin-like peptide 5Sequence analysisPRO_0000016201Add
BLAST
Peptidei23 – 5028Probable insulin-like peptide 5 B chainSequence analysisPRO_0000016202Add
BLAST
Propeptidei53 – 8129Connecting peptideSequence analysisPRO_0000016203Add
BLAST
Peptidei84 – 10825Probable insulin-like peptide 5 A chainSequence analysisPRO_0000016204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 93Interchain (between B and A chains)By similarity
Disulfide bondi41 ↔ 106Interchain (between B and A chains)By similarity
Disulfide bondi92 ↔ 97By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ7KUD5.

Expressioni

Tissue specificityi

Expressed at a high level in seven cells of each larval brain hemisphere that may correspond to neurosecretory cells. Expressed at a moderate level in the larval gut.1 Publication

Developmental stagei

Expressed in the larva but not in the embryo.1 Publication

Gene expression databases

BgeeiFBgn0044048.
ExpressionAtlasiQ7KUD5. differential.
GenevisibleiQ7KUD5. DM.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.By similarity

GO - Molecular functioni

  • insulin receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi7227.FBpp0076100.

Structurei

Secondary structure

1
108
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi30 – 4011Combined sources
Helixi88 – 925Combined sources
Helixi99 – 1046Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WFUX-ray1.85A87-108[»]
B24-47[»]
2WFVX-ray1.85A84-108[»]
B24-46[»]
ProteinModelPortaliQ7KUD5.
SMRiQ7KUD5. Positions 25-107.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7KUD5.

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KB5Y. Eukaryota.
ENOG4110NKZ. LUCA.
InParanoidiQ7KUD5.
KOiK04526.
OrthoDBiEOG091G0RIK.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7KUD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFRSVIPVL LFLIPLLLSA QAANSLRACG PALMDMLRVA CPNGFNSMFA
60 70 80 90 100
KRGTLGLFDY EDHLADLDSS ESHHMNSLSS IRRDFRGVVD SCCRKSCSFS

TLRAYCDS
Length:108
Mass (Da):11,972
Last modified:March 29, 2005 - v2
Checksum:i897675835FF76552
GO

Sequence cautioni

The sequence AAS65048 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAS65048.1. Different initiation.
BK002023 Genomic DNA. Translation: DAA02868.1.
RefSeqiNP_996037.1. NM_206315.2.
UniGeneiDm.27905.

Genome annotation databases

GeneIDi2768992.
KEGGidme:Dmel_CG33273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAS65048.1. Different initiation.
BK002023 Genomic DNA. Translation: DAA02868.1.
RefSeqiNP_996037.1. NM_206315.2.
UniGeneiDm.27905.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WFUX-ray1.85A87-108[»]
B24-47[»]
2WFVX-ray1.85A84-108[»]
B24-46[»]
ProteinModelPortaliQ7KUD5.
SMRiQ7KUD5. Positions 25-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0076100.

Proteomic databases

PaxDbiQ7KUD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2768992.
KEGGidme:Dmel_CG33273.

Organism-specific databases

CTDi2768992.
FlyBaseiFBgn0044048. Ilp5.

Phylogenomic databases

eggNOGiENOG410KB5Y. Eukaryota.
ENOG4110NKZ. LUCA.
InParanoidiQ7KUD5.
KOiK04526.
OrthoDBiEOG091G0RIK.

Enzyme and pathway databases

SignaLinkiQ7KUD5.

Miscellaneous databases

EvolutionaryTraceiQ7KUD5.
GenomeRNAii2768992.
PROiQ7KUD5.

Gene expression databases

BgeeiFBgn0044048.
ExpressionAtlasiQ7KUD5. differential.
GenevisibleiQ7KUD5. DM.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINSL5_DROME
AccessioniPrimary (citable) accession number: Q7KUD5
Secondary accession number(s): Q6ILJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: September 7, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.