Unreviewed, UniProtKB/TrEMBL Q7KTX7 (Q7KTX7_DROME)

Names and origin

Protein names

Submitted name:
    FI05213p EMBL ACH95278.1
Submitted name:
    Parkin, isoform B EMBL AAN12154.1
    EC=2.1.1.-
    EC=6.3.2.19
    Parkin, isoform C EMBL AAN12155.1
    PARKIN EMBL AAM18800.2

Gene names

Name:	park EMBL AAN12154.1 FlyBase FBgn0041100
Synonyms:	park-RC EMBL ACH95278.1, parkin EMBL AAM18800.2
ORF Names:	Dmel_CG10523 EMBL AAN12154.1

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	482 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 IBR-type zinc finger. Spearmint SPM002867

Ontologies

Keywords
Ligand	Metal-binding Spearmint SPM002867 Zinc Spearmint SPM002867
Molecular function	Ligase Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mitochondrial fission Inferred from genetic interaction. Source: FlyBase negative regulation of JNK cascade Inferred from direct assay. Source: FlyBase protein autoubiquitination Inferred from direct assay. Source: FlyBase response to oxidative stress Inferred from mutant phenotype. Source: FlyBase
Molecular function	ubiquitin conjugating enzyme binding Inferred from physical interaction. Source: FlyBase ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7KTX7-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 4A89C695475B213D	FASTA	482	54,105
	10 20 30 40 50 60 MSFIFKFIAT FVRKMLELLQ FGGKTLTHTL SIYVKTNTGK TLTVNLEPQW DIKNVKELVA 70 80 90 100 110 120 PQLGLQPDDL KIIFAGKELS DATTIEQCDL GQQSVLHAIR LRPPVQRQKI QSATLEEEEP 130 140 150 160 170 180 SLSDEASKPL NETLLDLQLE SEERLNITDE ERVRAKAHFF VHCSQCDKLC NGKLRVRCAL 190 200 210 220 230 240 CKGGAFTVHR DPECWDDVLK SRRIPGHCES LEVACVDNAA GDPPFAEFFF KCAEHVSGGE 250 260 270 280 290 300 KDFAAPLNLI KNNIKNVPCL ACTDVSDTVL VFPCASQHVT CIDCFRHYCR SRLGERQFMP 310 320 330 340 350 360 HPDFGYTLPC PAGCEHSFIE EIHHFKLLTR EEYDRYQRFA TEEYVLQAGG VLCPQPGCGM 370 380 390 400 410 420 GLLVEPDCRK VTCQNGCGYV FCRNCLQGYH IGECLPEGTG ASATNSCEYT VDPNRAAEAR 430 440 450 460 470 480 WDEASNVTIK VSTKPCPKCR TPTERDGGCM HMVCTRAGCG FEWCWVCQTE WTRDCMGAHW FG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S. Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Charaterization of parkin in Drosophila melanogaster." Kang S.J., Ahn J., Bae Y., Lee E., Park K. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[5]	Bae Y., Kang S., Ahn J., Lee E., Park K. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[6]	"Genome Structure Analysis and Characterization of Parkin in Drosophila melanogaster." Bae Y., Kang S., Park K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY093423 mRNA. Translation: AAM18800.2. AF510072 Genomic DNA. Translation: AAM43930.1. AE014296 Genomic DNA. Translation: AAN12154.1. AE014296 Genomic DNA. Translation: AAN12155.1. BT044504 mRNA. Translation: ACH95278.1.
RefSeq	NP_730600.1. NP_730601.1.
UniGene	Dm.20129
3D structure databases
HSSP	HSSP built from PDB template 1AAR based on UniProtKB Q862M4.
ModBase	Search...
Proteomic databases
PRIDE	Q7KTX7.
Genome annotation databases
Ensembl	FBgn0041100. Drosophila melanogaster. [Contig view]
GeneID	40336.
KEGG	dme:Dmel_CG10523.
Organism-specific databases
FlyBase	FBgn0041100. park.
Phylogenomic databases
HOGENOM	Q7KTX7.
OMA	Q7KTX7. SAEFFFK.
Gene expression databases
ArrayExpress	Q7KTX7.
Family and domain databases
InterPro	IPR002052. N6_adenine_Mtase_CS. IPR003977. Parkin. IPR016010. Parkin_C. IPR000626. Ubiquitin. IPR019955. Ubiquitin_supergroup. IPR002867. Znf_C6HC. [Graphical view]
PANTHER	PTHR11685:SF2. Parkin. 1 hit.
Pfam	PF01485. IBR. 1 hit. PF00240. ubiquitin. 1 hit. [Graphical view]
PIRSF	PIRSF037880. Parkin. 1 hit.
PRINTS	PR01475. PARKIN.
SMART	SM00647. IBR. 2 hits. SM00213. UBQ. 1 hit. [Graphical view]
PROSITE	PS00092. N6_MTASE. 1 hit. Uncertain. PS50053. UBIQUITIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	818239.

Entry information

Entry name

Q7KTX7_DROME

Accession

Primary (citable) accession number: Q7KTX7

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)