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Protein

Inositol-1-monophosphatase

Gene

142335_at

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Myo-inositol phosphate + H2O = myo-inositol + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: myo-inositol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Inositol-3-phosphate synthase (Inos)
  2. Inositol-1-monophosphatase (152392_at), Putative inositol monophosphatase 3 (CG15743), Inositol-1-monophosphatase (CG17029), Inositol-1-monophosphatase (Dmel\CG17026), Inositol-1-monophosphatase, Inositol-1-monophosphatase (IMP), Inositol-1-monophosphatase (CG17028-RA), Inositol-1-monophosphatase (IMP), Inositol-1-monophosphatase (CG17028-RA), Inositol-1-monophosphatase, Inositol-1-monophosphatase (142335_at)
This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-DME-1855183 Synthesis of IP2, IP, and Ins in the cytosol
UniPathwayiUPA00823; UER00788

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-1-monophosphataseUniRule annotation (EC:3.1.3.25UniRule annotation)
Gene namesi
Name:142335_atImported
Synonyms:Dmel\CG9391Imported, IMPImported
ORF Names:CG9391Imported, Dmel_CG9391Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0037063 CG9391

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiQ7KTW5

Expressioni

Gene expression databases

BgeeiFBgn0037063

Interactioni

Protein-protein interaction databases

IntActiQ7KTW5, 13 interactors
STRINGi7227.FBpp0296988

Structurei

3D structure databases

SMRiQ7KTW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the inositol monophosphatase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG2951 Eukaryota
COG0483 LUCA
GeneTreeiENSGT00390000014699
KOiK01092
OMAiNNYAEFC
OrthoDBiEOG091G0D21

Family and domain databases

CDDicd01639 IMPase, 1 hit
InterProiView protein in InterPro
IPR033942 IMPase
IPR020583 Inositol_monoP_metal-BS
IPR020552 Inositol_monoPase_Li-sen
IPR000760 Inositol_monophosphatase-like
IPR020550 Inositol_monophosphatase_CS
PfamiView protein in Pfam
PF00459 Inositol_P, 1 hit
PRINTSiPR00377 IMPHPHTASES
PR00378 LIIMPHPHTASE
PROSITEiView protein in PROSITE
PS00629 IMP_1, 1 hit
PS00630 IMP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7KTW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHNVDVEKC LEVASNLVSE AGRLIARNNE QRQDFVCKSN DIDLVTQTDK
60 70 80 90 100
DVEQLLMDGI RRHFPEHKFI GEEESSGAEG VKKLTDEPTW IIDPVDGTMN
110 120 130 140 150
FVHAFPHSCI SVGLKVNKVT ELGLVYNPIL EQRFTARRGH GAFYNGRRIH
160 170 180 190 200
VSGQKELGKA LVTSEFGTTR DEAKMKVVHE NFEKMAKKAH GLRVLGSAAL
210 220 230 240 250
NMSMVALGAA DANYEFGIHA WDVCAGDLIV REAGGVVIDP AGGEFDIMSR
260 270
RVLAAATPEL AQEISKVLTQ FNPLPRDD
Length:278
Mass (Da):30,626
Last modified:July 5, 2004 - v1
Checksum:iB5AEEC2445A72D99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF51693.3
AY071022 mRNA Translation: AAL48644.1
AE014296 Genomic DNA Translation: AAN12162.1
RefSeqiNP_649294.1, NM_141037.5
NP_730610.3, NM_168893.3
UniGeneiDm.1030

Genome annotation databases

EnsemblMetazoaiFBtr0078417; FBpp0078071; FBgn0037063
FBtr0305708; FBpp0296988; FBgn0037063
GeneIDi40346
KEGGidme:Dmel_CG9391
UCSCiCG9391-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ7KTW5_DROME
AccessioniPrimary (citable) accession number: Q7KTW5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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