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Protein

Inositol-1-monophosphatase

Gene

142335_at

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Myo-inositol phosphate + H2O = myo-inositol + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: myo-inositol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Inositol-3-phosphate synthase (Inos)
  2. Inositol-1-monophosphatase (152392_at), Putative inositol monophosphatase 3 (CG15743), Inositol-1-monophosphatase (CG17029), Inositol-1-monophosphatase (Dmel\CG17026), Inositol-1-monophosphatase, Inositol-1-monophosphatase (IMP), Inositol-1-monophosphatase (CG17028-RA), Inositol-1-monophosphatase (IMP), Inositol-1-monophosphatase (CG17028-RA), Inositol-1-monophosphatase, Inositol-1-monophosphatase (142335_at)
This subpathway is part of the pathway myo-inositol biosynthesis, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00823; UER00788.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-1-monophosphataseUniRule annotation (EC:3.1.3.25UniRule annotation)
Gene namesi
Name:142335_atImported
Synonyms:Dmel\CG9391Imported, IMPImported
ORF Names:CG9391Imported, Dmel_CG9391Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0037063. CG9391.

Subcellular locationi

Expressioni

Gene expression databases

BgeeiFBgn0037063.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0296988.

Family & Domainsi

Sequence similaritiesi

Belongs to the inositol monophosphatase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2951. Eukaryota.
COG0483. LUCA.
GeneTreeiENSGT00390000014699.
KOiK01092.
OMAiNNYAEFC.
OrthoDBiEOG091G0D21.

Family and domain databases

CDDicd01639. IMPase. 1 hit.
InterProiView protein in InterPro
IPR033942. IMPase.
IPR020583. Inositol_monoP_metal-BS.
IPR020552. Inositol_monoPase_Li-sen.
IPR000760. Inositol_monophosphatase-like.
IPR020550. Inositol_monophosphatase_CS.
PANTHERiPTHR20854. PTHR20854. 1 hit.
PfamiView protein in Pfam
PF00459. Inositol_P. 1 hit.
PRINTSiPR00377. IMPHPHTASES.
PR00378. LIIMPHPHTASE.
PROSITEiView protein in PROSITE
PS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7KTW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHNVDVEKC LEVASNLVSE AGRLIARNNE QRQDFVCKSN DIDLVTQTDK
60 70 80 90 100
DVEQLLMDGI RRHFPEHKFI GEEESSGAEG VKKLTDEPTW IIDPVDGTMN
110 120 130 140 150
FVHAFPHSCI SVGLKVNKVT ELGLVYNPIL EQRFTARRGH GAFYNGRRIH
160 170 180 190 200
VSGQKELGKA LVTSEFGTTR DEAKMKVVHE NFEKMAKKAH GLRVLGSAAL
210 220 230 240 250
NMSMVALGAA DANYEFGIHA WDVCAGDLIV REAGGVVIDP AGGEFDIMSR
260 270
RVLAAATPEL AQEISKVLTQ FNPLPRDD
Length:278
Mass (Da):30,626
Last modified:July 5, 2004 - v1
Checksum:iB5AEEC2445A72D99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF51693.3.
AY071022 mRNA. Translation: AAL48644.1.
AE014296 Genomic DNA. Translation: AAN12162.1.
RefSeqiNP_649294.1. NM_141037.5.
NP_730610.3. NM_168893.3.
UniGeneiDm.1030.

Genome annotation databases

EnsemblMetazoaiFBtr0078417; FBpp0078071; FBgn0037063.
FBtr0305708; FBpp0296988; FBgn0037063.
GeneIDi40346.
KEGGidme:Dmel_CG9391.
UCSCiCG9391-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ7KTW5_DROME
AccessioniPrimary (citable) accession number: Q7KTW5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported