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Q7KTS4 (Q7KTS4_DROME) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. PIRNR PIRNR037913

Subcellular location

Nucleus By similarity PIRNR PIRNR037913.

Sequence similarities

Belongs to the histone deacetylase family. HD Type 1 subfamily. PIRNR PIRNR037913

Ontologies

Keywords
   Biological processTranscription
Transcription regulation PIRNR PIRNR037913
   Cellular componentNucleus PIRNR PIRNR037913
   Molecular functionChromatin regulator PIRNR PIRNR037913
Hydrolase SAAS SAAS023801 PIRNR PIRNR037913 EMBL AAF52023.1
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell growth

Inferred from mutant phenotype PubMed 22956542. Source: FlyBase

chromatin silencing

Inferred from mutant phenotype PubMed 18454196. Source: FlyBase

histone H4-K16 acetylation

Inferred from mutant phenotype PubMed 22956542. Source: FlyBase

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 18454196. Source: FlyBase

regulation of transcription, DNA-templated

Inferred from direct assay PubMed 16137856. Source: FlyBase

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 16137856. Source: FlyBase

nucleus

Inferred from direct assay PubMed 16137856. Source: FlyBase

   Molecular_functionNAD-dependent histone deacetylase activity (H3-K14 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K18 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H3-K9 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

NAD-dependent histone deacetylase activity (H4-K16 specific)

Inferred from electronic annotation. Source: UniProtKB-EC

histone deacetylase activity

Inferred from direct assay PubMed 11281647PubMed 16137856. Source: FlyBase

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q7KTS4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 7527C32A40C4BA41

FASTA43849,643
        10         20         30         40         50         60 
MTDRRVSYFY NADVGNFHYG AGHPMKPQRL AVTHSLVMNY GLHKKMKIYR PYKASAQDML 

        70         80         90        100        110        120 
RFHSDEYIAY LQQVTPQNIQ CNSVAYTKYL AHFSVGEDCP VFDGLFDFCA MYTGASLEGA 

       130        140        150        160        170        180 
QKLNHNHSDI CINWSGGLHH AKKFEASGFC YVNDIVIGIL ELLKYHPRVL YIDIDVHHGD 

       190        200        210        220        230        240 
GVQEAFYLTD RVMTASFHKY GNYFFPGTGD MYEIGAESGR YYSVNVPLKE GIDDQSYFQV 

       250        260        270        280        290        300 
FKPIISAIMD FYRPTAIVLQ CGADSLAGDR LGCFSLSTKG HGECVKFVKE LNVPTLVVGG 

       310        320        330        340        350        360 
GGYTLRNVAR CWTHETSLLV DQDIENDLPA TEYYDFFAPD FTLHPEINSR QDNANSKQYL 

       370        380        390        400        410        420 
ELIVKHVYEN LKMCQHSPSV QMVQTPPDVD LEELRSNREE ASDPDVRISV ADEDKLVDAK 

       430 
NEFYDGDQDQ DKPDSAES 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. expand/collapse author list , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Berkeley EMBL AAL28869.1.
[3]"Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence."
Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., Pacleb J.M., Park S. expand/collapse author list , Pfeiffer B.D., Richards S., Sodergren E.J., Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.
Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[4]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[5]"The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[6]"Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[7]"Combined evidence annotation of transposable elements in genome sequences."
Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[8]"Drosophila melanogaster release 4 sequence."
Berkeley Drosophila Genome Project
Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[9]Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[10]"The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
Smith C.D., Shu S., Mungall C.J., Karpen G.H.
Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[11]"Sequence finishing and mapping of Drosophila melanogaster heterochromatin."
Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., Dimitri P., Karpen G.H., Celniker S.E.
Science 316:1625-1628(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[12]FlyBase
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[13]"Sequence variations in dosage compensation genes and histone deacetylases in In(1)BM2(reinverted) of Drosophila melanogaster."
Guru P., Bhosale P., Kar A.
Dros. Info. Service 94:84-86(2011)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: In EMBL AFI26263.1.
[14]Guru P., Kar A.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: In EMBL AFI26263.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014297 Genomic DNA. Translation: AAF52023.1.
AY061321 mRNA. Translation: AAL28869.1.
JQ663528 Genomic DNA. Translation: AFI26263.1.
RefSeqNP_651978.2. NM_143721.3.
UniGeneDm.3642.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7227.FBpp0078414.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0078767; FBpp0078414; FBgn0025825.
GeneID44446.
KEGGdme:Dmel_CG2128.
UCSCCG2128-RA. d. melanogaster.

Organism-specific databases

CTD8841.
FlyBaseFBgn0025825. Hdac3.

Phylogenomic databases

eggNOGCOG0123.
GeneTreeENSGT00530000062889.
InParanoidQ7KTS4.
KOK11404.
OMARERAMGF.
OrthoDBEOG7DNNTW.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Other

GenomeRNAi44446.
NextBio837273.
PROQ7KTS4.

Entry information

Entry nameQ7KTS4_DROME
AccessionPrimary (citable) accession number: Q7KTS4
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)