Q7KSF4 (Q7KSF4_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cheerio, isoform G EMBL AAS65162.2

Gene names

Name:	cher FlyBase FBgn0014141
ORF Names:	Dmel_CG3937 EMBL AAS65162.2

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	2399 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Domain	Repeat SAAS SAAS001589
Ligand	Actin-binding SAAS SAAS001589
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	determination of adult lifespan Inferred from mutant phenotype. Source: FlyBase female germline ring canal formation, actin assembly Inferred from mutant phenotype. Source: FlyBase germarium-derived female germ-line cyst encapsulation Inferred from mutant phenotype. Source: FlyBase mitosis Inferred from mutant phenotype. Source: FlyBase negative regulation of lamellocyte differentiation Inferred from mutant phenotype. Source: FlyBase olfactory learning Inferred from mutant phenotype. Source: FlyBase protein localization Inferred from mutant phenotype. Source: FlyBase
Cellular component	female germline ring canal inner rim Inferred from direct assay. Source: FlyBase female germline ring canal outer rim Inferred from direct assay. Source: FlyBase
Molecular function	actin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7KSF4 [UniParc]. Last modified March 3, 2009. Version 2. Checksum: 4380F2886019811D	FASTA	2,399	259,142
	10 20 30 40 50 60 MEAERDLAED AQWKKIQQNT FTRWANEHLK TIDRSINNLE TDLSDGLRLI ALIEVLSQKR 70 80 90 100 110 120 MPKYNKRPTF RSQKLENVSV ALKFLQDEGI KIVNIDSSDI VDCKLKLILG LIWTLILHYS 130 140 150 160 170 180 ISMPMWDGED DKQLNGSGHT PKQRLLNWIH AKIPDLPINN FTNDWTTGKA VGALVDACAP 190 200 210 220 230 240 GLCPDWELWD PKDAVQNASE AMGLADDWLN VRQLIKPEEL VNPNVDEQSM MTYLSQYPNS 250 260 270 280 290 300 KLKTGAPLRP KTNPNRVRAY GPGIEPIGPV VGAPANFTVE TFSAGKGSVD VDIQGPNGEI 310 320 330 340 350 360 EKADVRFNND KNLTYTVSYI PKSEGSHKVA VKFSGRDIPK SPFPVKVEGH AGDASKVKVT 370 380 390 400 410 420 GPGIQPNGVT IKKPTFFDIL AKDAGRGVPE VIIIDPANHK TSVAAKVRQL ENDTWRCEYV 430 440 450 460 470 480 TALQGLHSVN VFYAGTPIPN SPFPVKVAPL SDARKVRASG RGLQATGVRV GDDADFKIYT 490 500 510 520 530 540 EGAGEGEPEV RVIGPGGMNQ NVMQSKVDGN TYECHYYPTK EGRYVIMVTF AGQEVAKSPF 550 560 570 580 590 600 EVKVGPKKES SIVAYGPGLS SGVIGYPAAF VVETNGETGA LGFTVAGPSQ AEIECHDNGD 610 620 630 640 650 660 GSALVKYHPT AVGEYAVHIL CDNEDIPKSP FIAQILPRTD FHPELVKASG PGLEKNGVTI 670 680 690 700 710 720 NQPTSFTVDP SKAGNAPLDV VVQDVFGTKL PVELKNNPDG TKKVTYTPTS GVPHTVEVNY 730 740 750 760 770 780 GGVSTPNSPH RVYVGVPVDA AKVQAFGPWL QPGVRPNAAT HFNVDAREAG DAELKVKIIH 790 800 810 820 830 840 EETKIEVPCR IIDNEDNTYS VEVIPPSKGA YTTTMTYGGQ RVPLGEKVVV EQTVDVSKIK 850 860 870 880 890 900 VDGLEPTAPL NSLQQFRIIT HGLPKADLAV TITSPSGNRI KAHIIPTAEG FLVNFTPTQL 910 920 930 940 950 960 GEYLLSICFG GTPITPRPFR LQCLTGSDSN KVQAFGPGLE RGIVGQPAEF MIDTRGAGQG 970 980 990 1000 1010 1020 GLGVTVEGPC EAAINCRDNG DGTCNVAYLP TEAGDYTVNI TFNERHITGS PFQPLIVPVP 1030 1040 1050 1060 1070 1080 NLKNTRVSGI GIQPHGVIMN AATDFMVDMS KVGSNIDSGK LSCAIFDPMG HVLPSKIVQG 1090 1100 1110 1120 1130 1140 PTDDIFRIMY TPFEAGRHTI ELMYDNIPVP GSPFVVNVKS GCDPARCKAY GPGLEKGLTN 1150 1160 1170 1180 1190 1200 QKNKFTVETK GAGNGGLSLA IEGPSEAKMT CTDNRDGSCD VDYLATDPGE YDITIRFADK 1210 1220 1230 1240 1250 1260 HIPGSPFRVL VEETVDPSKV KVYGPGIEHG QVRESVPTFF NVDVGEAGPG RIAVKLTNSE 1270 1280 1290 1300 1310 1320 GIPVDNLRVE DKGNCIYAVH YVPPKAGSVL TCQVKFSEVE VPCSPFVMTV FPKSEPTKVK 1330 1340 1350 1360 1370 1380 VKGVNEKKKT PASLPAEFEI DTKQAGQADI NVAIKNPKGK AMQPRLEEVS TGTYVVSFVP 1390 1400 1410 1420 1430 1440 DECGTYQCSI KYGDKEIEGS PFKLEAFPTG EAKKCKLVEQ APKIQTSGSQ SHLKVDAREA 1450 1460 1470 1480 1490 1500 GDGAVTCKIT NKAGSEIVDI DVIEKDGFFD ILYALNDPGD YDINVKFGGK DIPNGSFSIK 1510 1520 1530 1540 1550 1560 AVESIEQYSH SEYIEEHTTK VVQQTTQSEL VNGKSEITYR SVAFEKLPLP TTGGNVTAEV 1570 1580 1590 1600 1610 1620 RMPSGKVDKP VIQDNRDGTV SVKYDPREEG SHELVVKYNG EPVQGSPFKF HVDSITSGYV 1630 1640 1650 1660 1670 1680 TAYGPGLTHG VTGEPANFTI STKGASAGGL TMAVEGPSKA DINYHDNKDG TVSVQYLPTA 1690 1700 1710 1720 1730 1740 PGEYQVSVRF GDKHIKGSPY FAKITGEGRK RNQISVGSCS EVTMPGDITD DDLRALNASI 1750 1760 1770 1780 1790 1800 QAPSGLEEPC FLKRMPTGNI GISFTPREIG EHLVSVKRLG KHINNSPFKV TVCEREVGDA 1810 1820 1830 1840 1850 1860 KKVKVSGTGL KEGQTHADNI FSVDTRNAGF GGLSVSIEGP SKAEIQCTDK DDGTLNISYK 1870 1880 1890 1900 1910 1920 PTEPGYYIVN LKFADHHVEG SPFTVKVAGE GSNRKREKIQ RERDAVPITE IGSQCKLTFK 1930 1940 1950 1960 1970 1980 MPGITSFDLA ACVTSPSNVT EDAEIQEVED GLYAVHFVPK ELGVHTVSVR YSEMHIPGSP 1990 2000 2010 2020 2030 2040 FQFTVGPLRD SGSHLVKAGG SGLERGVVGE AAEFNVWTRE AGGGSLAISV EGPSKADIEF 2050 2060 2070 2080 2090 2100 KDRKDGSCDV SYKVTEPGEY RVGLKFNDRH IPDSPFKVYV SPDAGDAHKL EVQQFPQGNI 2110 2120 2130 2140 2150 2160 QADAPYQFMV RKNGAKGELD AKIVAPSGTD DDCFIQVIDG EMYSVRFYPR ENGIHAIHVK 2170 2180 2190 2200 2210 2220 FNGVHIPDSP FRIKVGKDVA DPAAVHASGN GLDEVKTGHK ADFIINTCNA GVGTLAVSID 2230 2240 2250 2260 2270 2280 GPSKVAMDCT EVEEGYKVRY TPLLPGEHYI TVKYNNMHIV GSPFKVNATG DKLADEGAQE 2290 2300 2310 2320 2330 2340 TSTVIVETVQ KVAKGGKNTG VHLPTFKSDA SKVVSKGMGL KKAYIGKQNQ FSISATDAGN 2350 2360 2370 2380 2390 NILYVGMYGP KGPCEEFHVK HAGHNNYNVQ YLVRDRGQYV LLIKWGEEHI PGSPFQIDV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014297 Genomic DNA. Translation: AAS65162.2.
RefSeq	NP_996224.2. NM_206502.3.
3D structure databases
ProteinModelPortal	Q7KSF4.
SMR	Q7KSF4. Positions 4-242, 1129-1207, 1614-1717, 1799-1891, 1981-2092.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7KSF4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0290014; FBpp0288453; FBgn0014141.
GeneID	42066.
KEGG	dme:Dmel_CG3937.
Organism-specific databases
CTD	42066.
FlyBase	FBgn0014141. cher.
Phylogenomic databases
InParanoid	Q7KSF4.
PhylomeDB	Q7KSF4.
Gene expression databases
ArrayExpress	Q7KSF4.
Bgee	Q7KSF4.
Family and domain databases
InterPro	IPR001589. Actinin_actin-bd_CS. IPR001715. CH-domain. IPR001298. Filamin. IPR017868. Filamin/ABP280_repeat-like. IPR013783. Ig-like_fold. IPR014756. Ig_E-set. [Graphical view]
Gene3D	G3DSA:1.10.418.10. Calponin-homology. 2 hits. G3DSA:2.60.40.10. Ig-like_fold. 22 hits.
KO	K04437.
Pfam	PF00307. CH. 2 hits. PF00630. Filamin. 21 hits. [Graphical view]
SMART	SM00033. CH. 2 hits. SM00557. IG_FLMN. 22 hits. [Graphical view]
SUPFAM	SSF47576. Calponin-homology. 1 hit. SSF81296. Ig_E-set. 22 hits.
PROSITE	PS00019. ACTININ_1. 1 hit. PS00020. ACTININ_2. 1 hit. PS50021. CH. 2 hits. PS50194. FILAMIN_REPEAT. 22 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	827008.

Entry information

Entry name

Q7KSF4_DROME

Accession

Primary (citable) accession number: Q7KSF4

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)