Q7KRU8 (Q7KRU8_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Ferritin 1 heavy chain homologue, isoform A EMBL AAF57034.1
EC=1.-.-.- EMBL AAF57034.1

Submitted name:
Ferritin 1 heavy chain homologue, isoform B EMBL AAF57035.1
EC=1.-.-.- EMBL AAF57035.1
Submitted name:
Ferritin 1 heavy chain homologue, isoform C EMBL AAF57037.1
EC=1.-.-.- EMBL AAF57037.1
Submitted name:
Ferritin 1 heavy chain homologue, isoform D EMBL AAF57036.1
EC=1.-.-.- EMBL AAF57036.1
Submitted name:
Ferritin subunit 1 EMBL AAB70121.1
Submitted name:
LD25232p EMBL AAL27642.1

Gene names

Name:	Fer1HCH EMBL AAF57034.1 FlyBase FBgn0015222
Synonyms:	Fer1 EMBL AAB70121.1
ORF Names:	Dmel_CG2216 EMBL AAF57034.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 ferritin-like diiron domain. RuleBase RU003668

Ontologies

Keywords
Molecular function	Oxidoreductase EMBL AAF57034.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular iron ion homeostasis Inferred from direct assay. Source: FlyBase iron ion transport Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from direct assay. Source: FlyBase fusome Inferred from direct assay. Source: FlyBase intracellular ferritin complex Inferred from direct assay. Source: FlyBase microtubule associated complex Inferred from direct assay. Source: FlyBase
Molecular function	ferric iron binding Inferred from electronic annotation. Source: InterPro ferrous iron binding Inferred from direct assay. Source: FlyBase oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7KRU8 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 279ACA2AEF96630B	FASTA	205	23,146
	10 20 30 40 50 60 MVKLIASLLL LAVVAQAYGD FKCSLAVPEI TKDWVDMKDA CIKGMRNQIQ EEINASYQYL 70 80 90 100 110 120 AMGAYFSRDT VNRPGFAEHF FKAAKEEREH GSKLVEYLSM RGQLTEGVSD LINVPTVAKQ 130 140 150 160 170 180 EWTDGAAALS DALDLEIKVT KSIRKLIQTC ENKPYNHYHL VDYLTGVYLE EQLHGQRELA 190 200 GKLTTLKKMM DTNGELGEFL FDKTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Release 5.1 annotation of Drosophila melanogaster heterochromatin." Smith C.D., Shu S., Mungall C.J., Karpen G.H. Science 316:1586-1591(2007) [PubMed: 17569856] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Sequence finishing and mapping of Drosophila melanogaster heterochromatin." Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., Dimitri P., Karpen G.H., Celniker S.E. Science 316:1625-1628(2007) [PubMed: 17569867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Combined evidence annotation of transposable elements in genome sequences." Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D. PLoS Comput. Biol. 1:166-175(2005) [PubMed: 16110336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[5]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[6]	"Heterochromatic sequences in a Drosophila whole-genome shotgun assembly." Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H. Genome Biol. 3:RESEARCH0085.1-RESEARCH0085.16(2002) [PubMed: 12537574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[7]	"The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective." Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J.W., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E. Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed: 12537573] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[8]	"Isolation and properties of Drosophila melanogaster ferritin--molecular cloning of a cDNA that encodes one subunit, and localization of the gene on the third chromosome." Charlesworth A., Georgieva T., Gospodov I., Law J.H., Dunkov B.C., Ralcheva N., Barillas-Mury C., Ralchev K., Kafatos F.C. Eur. J. Biochem. 247:470-475(1997) [PubMed: 9266686] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Canton S EMBL AAB70121.1.
[9]	"Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence." Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., Pacleb J.M., Park S. , Pfeiffer B.D., Richards S., Sodergren E.J., Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M. Genome Biol. 3 (12), RESEARCH0079 (2002) Cited for: NUCLEOTIDE SEQUENCE.
[10]	Drosophila Heterochromatin Genome Project Smith C.D., Shu S., Mungall C.J., Karpen G.H. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[11]	FlyBase Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[12]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAL27642.1.
[13]	"Drosophila melanogaster release 4 sequence." Berkeley Drosophila Genome Project Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[14]	Celniker S., Carlson J., Kennedy C., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Karpen G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[15]	Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[16]	"Drosophila ferritin mRNA: Alternative RNA splicing regulates the presence of iron-responsive element." Lind M.I., Soderhall K., Ekengren S., Melefors O., Soederhaell K. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Canton S EMBL CAA75724.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U91524 mRNA. Translation: AAB70121.1. AE014297 Genomic DNA. Translation: AAF57034.1. AE014297 Genomic DNA. Translation: AAF57035.1. AE014297 Genomic DNA. Translation: AAF57036.1. AE014297 Genomic DNA. Translation: AAF57037.1. AY061831 mRNA. Translation: AAL27642.1. Y15629 mRNA. Translation: CAA75724.1.
RefSeq	NP_524873.1. NM_080134.2. NP_733358.1. NM_170479.1. NP_733359.1. NM_170480.1. NP_733360.1. NM_170481.1.
UniGene	Dm.1630.
3D structure databases
ProteinModelPortal	Q7KRU8.
SMR	Q7KRU8. Positions 22-205.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7KRU8. 5 interactions.
MINT	MINT-1328338.
STRING	Q7KRU8.
Proteomic databases
PRIDE	Q7KRU8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0085631; FBpp0084995; FBgn0015222. FBtr0085632; FBpp0084996; FBgn0015222. FBtr0085633; FBpp0084997; FBgn0015222. FBtr0085634; FBpp0084998; FBgn0015222.
GeneID	46415.
KEGG	dme:Dmel_CG2216.
UCSC	CG2216-RA. d. melanogaster.
Organism-specific databases
CTD	46415.
FlyBase	FBgn0015222. Fer1HCH.
Phylogenomic databases
GeneTree	EMGT00050000011982.
InParanoid	Q7KRU8.
OMA	TGVYLEE.
PhylomeDB	Q7KRU8.
Gene expression databases
ArrayExpress	Q7KRU8.
Bgee	Q7KRU8.
Family and domain databases
InterPro	IPR001519. Ferritin. IPR009040. Ferritin-like. IPR012347. Ferritin-rel. IPR009078. Ferritin/RR-like. IPR008331. Ferritin_DPS_dom. [Graphical view]
Gene3D	G3DSA:1.20.1260.10. Ferritin_rel. 1 hit.
KO	K00522.
PANTHER	PTHR11431. Ferritin_N. 1 hit.
Pfam	PF00210. Ferritin. 1 hit. [Graphical view]
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
PROSITE	PS50905. FERRITIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	838836.

Entry information

Entry name

Q7KRU8_DROME

Accession

Primary (citable) accession number: Q7KRU8

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)