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Protein

Triosephosphate isomerase

Gene

TPI

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (PF3D7_1439900), Triosephosphate isomerase (PF3D7_0318800), Triosephosphate isomerase (TPI)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10SubstrateBy similarity1
Binding sitei12SubstrateBy similarity1
Active sitei95ElectrophileBy similarity1
Active sitei165Proton acceptorBy similarity1

GO - Molecular functioni

  • triose-phosphate isomerase activity Source: GeneDB

GO - Biological processi

  • fatty acid biosynthetic process Source: GeneDB
  • gluconeogenesis Source: GeneDB
  • glyceraldehyde-3-phosphate biosynthetic process Source: GO_Central
  • glycerol catabolic process Source: GO_Central
  • glycolytic process Source: GeneDB
  • pentose-phosphate shunt Source: GeneDB

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis, Pentose shunt

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomerase (EC:5.3.1.1)
Short name:
TIM
Alternative name(s):
Triose-phosphate isomerase
Gene namesi
Name:TPI
ORF Names:PF14_0378
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1439900.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002333871 – 248Triosephosphate isomeraseAdd BLAST248

PTM databases

SwissPalmiQ7KQM0.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7KQM0.
SMRiQ7KQM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.Curated

Phylogenomic databases

HOGENOMiHOG000226413.
InParanoidiQ7KQM0.
KOiK01803.
OMAiLCVGEGL.
PhylomeDBiQ7KQM0.

Family and domain databases

CDDicd00311. TIM. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR035990. TIM_sf.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiView protein in Pfam
PF00121. TIM. 1 hit.
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiView protein in PROSITE
PS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7KQM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKYFVAAN WKCNGTLESI KSLTNSFNNL DFDPSKLDVV VFPVSVHYDH
60 70 80 90 100
TRKLLQSKFS TGIQNVSKFG NGSYTGEVSA EIAKDLNIEY VIIGHFERRK
110 120 130 140 150
YFHETDEDVR EKLQASLKNN LKAVVCFGES LEQREQNKTI EVITKQVKAF
160 170 180 190 200
VDLIDNFDNV ILAYEPLWAI GTGKTATPEQ AQLVHKEIRK IVKDTCGEKQ
210 220 230 240
ANQIRILYGG SVNTENCSSL IQQEDIDGFL VGNASLKESF VDIIKSAM
Length:248
Mass (Da):27,935
Last modified:July 5, 2004 - v1
Checksum:iEFC8A4373EA9BED1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA. Translation: AAN36991.1.
RefSeqiXP_001348552.1. XM_001348516.2.

Genome annotation databases

GeneDBiPF3D7_1439900.1:pep.
GeneIDi811960.
KEGGipfa:PF14_0378.

Similar proteinsi

Entry informationi

Entry nameiTPIS_PLAF7
AccessioniPrimary (citable) accession number: Q7KQM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families