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Q7KQL9

- ALF_PLAF7

UniProt

Q7KQL9 - ALF_PLAF7

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Protein
Fructose-bisphosphate aldolase
Gene
PF14_0425
Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621Substrate By similarity
Binding sitei152 – 1521Substrate By similarity
Active sitei195 – 1951Proton acceptor By similarity
Active sitei237 – 2371Schiff-base intermediate with dihydroxyacetone-P By similarity
Sitei369 – 3691Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate By similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. gluconeogenesis Source: GeneDB_Pfalciparum
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Gene namesi
ORF Names:PF14_0425
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1444800.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Fructose-bisphosphate aldolase
PRO_0000233386Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

BioGridi1207364. 4 interactions.
IntActiQ7KQL9. 4 interactions.
STRINGi5833.PF14_0425-1.

Structurei

3D structure databases

ProteinModelPortaliQ7KQL9.
SMRiQ7KQL9. Positions 4-354.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000220876.
KOiK01623.
OMAiMLFRSDD.
PhylomeDBiQ7KQL9.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7KQL9-1 [UniParc]FASTAAdd to Basket

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MAHCTEYMNA PKKLPADVAE ELATTAQKLV QAGKGILAAD ESTQTIKKRF    50
DNIKLENTIE NRASYRDLLF GTKGLGKFIS GAILFEETLF QKNEAGVPMV 100
NLLHNENIIP GIKVDKGLVN IPCTDEEKST QGLDGLAERC KEYYKAGARF 150
AKWRTVLVID TAKGKPTDLS IHETAWGLAR YASICQQNRL VPIVEPEILA 200
DGPHSIEVCA VVTQKVLSCV FKALQENGVL LEGALLKPNM VTAGYECTAK 250
TTTQDVGFLT VRTLRRTVPP ALPGVVFLSG GQSEEEASVN LNSINALGPH 300
PWALTFSYGR ALQASVLNTW QGKKENVAKA REVLLQRAEA NSLATYGKYK 350
GGAGGENAGA SLYEKKYVY 369
Length:369
Mass (Da):40,105
Last modified:July 5, 2004 - v1
Checksum:i2AE9CDED4F5C96A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014187 Genomic DNA. Translation: AAN37038.1.
RefSeqiXP_001348599.1. XM_001348563.2.

Genome annotation databases

EnsemblProtistsiPF14_0425:mRNA; PF14_0425:pep; PF14_0425.
GeneIDi812007.
KEGGipfa:PF14_0425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014187 Genomic DNA. Translation: AAN37038.1 .
RefSeqi XP_001348599.1. XM_001348563.2.

3D structure databases

ProteinModelPortali Q7KQL9.
SMRi Q7KQL9. Positions 4-354.
ModBasei Search...

Protein-protein interaction databases

BioGridi 1207364. 4 interactions.
IntActi Q7KQL9. 4 interactions.
STRINGi 5833.PF14_0425-1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi PF14_0425:mRNA ; PF14_0425:pep ; PF14_0425 .
GeneIDi 812007.
KEGGi pfa:PF14_0425.

Organism-specific databases

EuPathDBi PlasmoDB:PF3D7_1444800.

Phylogenomic databases

HOGENOMi HOG000220876.
KOi K01623.
OMAi MLFRSDD.
PhylomeDBi Q7KQL9.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view ]
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.

Entry informationi

Entry nameiALF_PLAF7
AccessioniPrimary (citable) accession number: Q7KQL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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