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Q7KQL9

- ALF_PLAF7

UniProt

Q7KQL9 - ALF_PLAF7

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Protein

Fructose-bisphosphate aldolase

Gene

PF14_0425

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621SubstrateBy similarity
Binding sitei152 – 1521SubstrateBy similarity
Active sitei195 – 1951Proton acceptorBy similarity
Active sitei237 – 2371Schiff-base intermediate with dihydroxyacetone-PBy similarity
Sitei369 – 3691Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: GeneDB_Pfalciparum

GO - Biological processi

  1. glycolytic process Source: GeneDB_Pfalciparum
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Gene namesi
ORF Names:PF14_0425
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1444800.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GeneDB_Pfalciparum
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Fructose-bisphosphate aldolasePRO_0000233386Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi1207364. 4 interactions.
IntActiQ7KQL9. 4 interactions.
STRINGi5833.PF14_0425-1.

Structurei

3D structure databases

ProteinModelPortaliQ7KQL9.
SMRiQ7KQL9. Positions 4-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000220876.
InParanoidiQ7KQL9.
KOiK01623.
OMAiMLFRSDD.
PhylomeDBiQ7KQL9.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7KQL9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHCTEYMNA PKKLPADVAE ELATTAQKLV QAGKGILAAD ESTQTIKKRF
60 70 80 90 100
DNIKLENTIE NRASYRDLLF GTKGLGKFIS GAILFEETLF QKNEAGVPMV
110 120 130 140 150
NLLHNENIIP GIKVDKGLVN IPCTDEEKST QGLDGLAERC KEYYKAGARF
160 170 180 190 200
AKWRTVLVID TAKGKPTDLS IHETAWGLAR YASICQQNRL VPIVEPEILA
210 220 230 240 250
DGPHSIEVCA VVTQKVLSCV FKALQENGVL LEGALLKPNM VTAGYECTAK
260 270 280 290 300
TTTQDVGFLT VRTLRRTVPP ALPGVVFLSG GQSEEEASVN LNSINALGPH
310 320 330 340 350
PWALTFSYGR ALQASVLNTW QGKKENVAKA REVLLQRAEA NSLATYGKYK
360
GGAGGENAGA SLYEKKYVY
Length:369
Mass (Da):40,105
Last modified:July 5, 2004 - v1
Checksum:i2AE9CDED4F5C96A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014187 Genomic DNA. Translation: AAN37038.1.
RefSeqiXP_001348599.1. XM_001348563.2.

Genome annotation databases

EnsemblProtistsiPF14_0425:mRNA; PF14_0425:pep; PF14_0425.
GeneIDi812007.
KEGGipfa:PF14_0425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014187 Genomic DNA. Translation: AAN37038.1 .
RefSeqi XP_001348599.1. XM_001348563.2.

3D structure databases

ProteinModelPortali Q7KQL9.
SMRi Q7KQL9. Positions 4-354.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1207364. 4 interactions.
IntActi Q7KQL9. 4 interactions.
STRINGi 5833.PF14_0425-1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi PF14_0425:mRNA ; PF14_0425:pep ; PF14_0425 .
GeneIDi 812007.
KEGGi pfa:PF14_0425.

Organism-specific databases

EuPathDBi PlasmoDB:PF3D7_1444800.

Phylogenomic databases

HOGENOMi HOG000220876.
InParanoidi Q7KQL9.
KOi K01623.
OMAi MLFRSDD.
PhylomeDBi Q7KQL9.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view ]
PANTHERi PTHR11627. PTHR11627. 1 hit.
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.

Entry informationi

Entry nameiALF_PLAF7
AccessioniPrimary (citable) accession number: Q7KQL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3