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Q7KQL9 (ALF_PLAF7) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase

EC=4.1.2.13
Gene names
ORF Names:PF14_0425
OrganismPlasmodium falciparum (isolate 3D7) [Reference proteome]
Taxonomic identifier36329 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Traceable author statement PubMed 2190085. Source: GeneDB_Pfalciparum

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369Fructose-bisphosphate aldolase
PRO_0000233386

Sites

Active site1951Proton acceptor By similarity
Active site2371Schiff-base intermediate with dihydroxyacetone-P By similarity
Binding site621Substrate By similarity
Binding site1521Substrate By similarity
Site3691Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7KQL9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 2AE9CDED4F5C96A4

FASTA36940,105
        10         20         30         40         50         60 
MAHCTEYMNA PKKLPADVAE ELATTAQKLV QAGKGILAAD ESTQTIKKRF DNIKLENTIE 

        70         80         90        100        110        120 
NRASYRDLLF GTKGLGKFIS GAILFEETLF QKNEAGVPMV NLLHNENIIP GIKVDKGLVN 

       130        140        150        160        170        180 
IPCTDEEKST QGLDGLAERC KEYYKAGARF AKWRTVLVID TAKGKPTDLS IHETAWGLAR 

       190        200        210        220        230        240 
YASICQQNRL VPIVEPEILA DGPHSIEVCA VVTQKVLSCV FKALQENGVL LEGALLKPNM 

       250        260        270        280        290        300 
VTAGYECTAK TTTQDVGFLT VRTLRRTVPP ALPGVVFLSG GQSEEEASVN LNSINALGPH 

       310        320        330        340        350        360 
PWALTFSYGR ALQASVLNTW QGKKENVAKA REVLLQRAEA NSLATYGKYK GGAGGENAGA 


SLYEKKYVY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014187 Genomic DNA. Translation: AAN37038.1.
RefSeqXP_001348599.1. XM_001348563.2.

3D structure databases

ProteinModelPortalQ7KQL9.
SMRQ7KQL9. Positions 4-354.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid1207364. 4 interactions.
IntActQ7KQL9. 4 interactions.
STRING5833.PF14_0425-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsPF14_0425:mRNA; PF14_0425:pep; PF14_0425.
GeneID812007.
KEGGpfa:PF14_0425.

Organism-specific databases

EuPathDBPlasmoDB:PF3D7_1444800.

Phylogenomic databases

HOGENOMHOG000220876.
KOK01623.
OMAMLFRSDD.
PhylomeDBQ7KQL9.

Enzyme and pathway databases

UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERPTHR11627. PTHR11627. 1 hit.
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALF_PLAF7
AccessionPrimary (citable) accession number: Q7KQL9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways