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Q7KQL9

- ALF_PLAF7

UniProt

Q7KQL9 - ALF_PLAF7

Protein

Fructose-bisphosphate aldolase

Gene

PF14_0425

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei62 – 621SubstrateBy similarity
    Binding sitei152 – 1521SubstrateBy similarity
    Active sitei195 – 1951Proton acceptorBy similarity
    Active sitei237 – 2371Schiff-base intermediate with dihydroxyacetone-PBy similarity
    Sitei369 – 3691Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: GeneDB_Pfalciparum

    GO - Biological processi

    1. glycolytic process Source: GeneDB_Pfalciparum

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase (EC:4.1.2.13)
    Gene namesi
    ORF Names:PF14_0425
    OrganismiPlasmodium falciparum (isolate 3D7)
    Taxonomic identifieri36329 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
    ProteomesiUP000001450: Chromosome 14

    Organism-specific databases

    EuPathDBiPlasmoDB:PF3D7_1444800.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: GeneDB_Pfalciparum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Fructose-bisphosphate aldolasePRO_0000233386Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    BioGridi1207364. 4 interactions.
    IntActiQ7KQL9. 4 interactions.
    STRINGi5833.PF14_0425-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7KQL9.
    SMRiQ7KQL9. Positions 4-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000220876.
    KOiK01623.
    OMAiMLFRSDD.
    PhylomeDBiQ7KQL9.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7KQL9-1 [UniParc]FASTAAdd to Basket

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    MAHCTEYMNA PKKLPADVAE ELATTAQKLV QAGKGILAAD ESTQTIKKRF    50
    DNIKLENTIE NRASYRDLLF GTKGLGKFIS GAILFEETLF QKNEAGVPMV 100
    NLLHNENIIP GIKVDKGLVN IPCTDEEKST QGLDGLAERC KEYYKAGARF 150
    AKWRTVLVID TAKGKPTDLS IHETAWGLAR YASICQQNRL VPIVEPEILA 200
    DGPHSIEVCA VVTQKVLSCV FKALQENGVL LEGALLKPNM VTAGYECTAK 250
    TTTQDVGFLT VRTLRRTVPP ALPGVVFLSG GQSEEEASVN LNSINALGPH 300
    PWALTFSYGR ALQASVLNTW QGKKENVAKA REVLLQRAEA NSLATYGKYK 350
    GGAGGENAGA SLYEKKYVY 369
    Length:369
    Mass (Da):40,105
    Last modified:July 5, 2004 - v1
    Checksum:i2AE9CDED4F5C96A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014187 Genomic DNA. Translation: AAN37038.1.
    RefSeqiXP_001348599.1. XM_001348563.2.

    Genome annotation databases

    EnsemblProtistsiPF14_0425:mRNA; PF14_0425:pep; PF14_0425.
    GeneIDi812007.
    KEGGipfa:PF14_0425.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014187 Genomic DNA. Translation: AAN37038.1 .
    RefSeqi XP_001348599.1. XM_001348563.2.

    3D structure databases

    ProteinModelPortali Q7KQL9.
    SMRi Q7KQL9. Positions 4-354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 1207364. 4 interactions.
    IntActi Q7KQL9. 4 interactions.
    STRINGi 5833.PF14_0425-1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi PF14_0425:mRNA ; PF14_0425:pep ; PF14_0425 .
    GeneIDi 812007.
    KEGGi pfa:PF14_0425.

    Organism-specific databases

    EuPathDBi PlasmoDB:PF3D7_1444800.

    Phylogenomic databases

    HOGENOMi HOG000220876.
    KOi K01623.
    OMAi MLFRSDD.
    PhylomeDBi Q7KQL9.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate 3D7.

    Entry informationi

    Entry nameiALF_PLAF7
    AccessioniPrimary (citable) accession number: Q7KQL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3