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Protein

DNA polymerase

Gene

PF10_0165

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-PFA-69166. Removal of the Flap Intermediate.
R-PFA-69183. Processive synthesis on the lagging strand.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
ORF Names:PF10_0165Imported, PF3D7_1017000Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1017000.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

  • delta DNA polymerase complex Source: GeneDB

Keywords - Cellular componenti

NucleusUniRule annotation

Structurei

3D structure databases

SMRiQ7KQL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 471DNA_pol_B_exo1InterPro annotationAdd BLAST346
Domaini529 – 966DNA_pol_BInterPro annotationAdd BLAST438
Domaini1003 – 1073zf-C4polInterPro annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili158 – 178Sequence analysisAdd BLAST21
Coiled coili657 – 677Sequence analysisAdd BLAST21
Coiled coili1073 – 1093Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerUniRule annotation

Phylogenomic databases

HOGENOMiHOG000036616.
InParanoidiQ7KQL4.
KOiK02327.
OMAiCLVNYTE.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 1 hit.
InterProiView protein in InterPro
IPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom_sf.
IPR012337. RNaseH-like_sf.
IPR036397. RNaseH_sf.
IPR025687. Znf-C4pol.
PfamiView protein in Pfam
PF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
PF14260. zf-C4pol. 1 hit.
PRINTSiPR00106. DNAPOLB.
SMARTiView protein in SMART
SM00486. POLBc. 1 hit.
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiView protein in PROSITE
PS00116. DNA_POLYMERASE_B. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7KQL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELKTCPFT NVIPYGLLYD KLKKEKNNDV PENYVIEEFD KLLKNYERPN
60 70 80 90 100
VYDEIGNATF KNDEDLITFQ IDLDYTVENI FKNMIYNESG SNNSILNDIY
110 120 130 140 150
MPYRILLSKD KNYVSVPIIR IYSLRKDGCS VLINVHNFFP YFYVEKPDDF
160 170 180 190 200
DNEDLIKLEM LMNENLNLNS QYKIYEKKIL KIEIVKTESL MYFKKNGKKD
210 220 230 240 250
FLKITVLLPK MVPSLKKYFE GIVHVNNKSI GGIVYEANLP FILRYIIDHK
260 270 280 290 300
ITGSSWINCK KGHYYIRNKN KKISNCTFEI DISYEHVEPI TLENEYQQIP
310 320 330 340 350
KLRILSFDIE CIKLDGKGFP EAKNDPIIQI SSILYFQGEP IDNCTKFIFT
360 370 380 390 400
LLECASIPGS NVIWFNDEKT LLEAWNEFII RIDPDFLTGY NIINFDLPYI
410 420 430 440 450
LNRGTALNLK KLKFLGRIKN VASTVKDSSF SSKQFGTHET KEINIFGRIQ
460 470 480 490 500
FDVYDLIKRD YKLKSYTLNY VSFEFLKEQK EDVHYSIMND LQNESPESRK
510 520 530 540 550
RIATYCIKDG VLPLRLIDKL LFIYNYVEMA RVTGTPFVYL LTRGQQIKVT
560 570 580 590 600
SQLYRKCKEL NYVIPSTYMK VNTNEKYEGA TVLEPIKGYY IEPISTLDFA
610 620 630 640 650
SLYPSIMIAH NLCYSTLIKS NHEVSDLQND DITTIQGKNN LKFVKKNVKK
660 670 680 690 700
GILPLIVEEL IEARKKVKLL IKNEKNNITK MVLNGRQLAL KISANSVYGY
710 720 730 740 750
TGASSGGQLP CLEVAVSITT LGRSMIEKTK ERVESFYCKS NGYEHNSTVI
760 770 780 790 800
YGDTDSVMVK FGTNNIEEAM TLGKDAAERI SKEFLSPIKL EFEKVYCPYL
810 820 830 840 850
LLNKKRYAGL LYTNPNKHDK MDCKGIETVR RDFCILIQQM METVLNKLLI
860 870 880 890 900
EKNLNSAIEY TKSKIKELLT NNIDMSLLVV TKSLGKTDYE TRLPHVELAK
910 920 930 940 950
KLKQRDSATA PNVGDRVSYI IVKGVKGQAQ YERAEDPLYV LDNNLAIDYN
960 970 980 990 1000
HYLDAIKSPL SRIFEVIMQN SDSLFSGDHT RHKTILTSSQ TALSKFLKKS
1010 1020 1030 1040 1050
VRCIGCNSSI KKPPLCNHCK ENKEFSIYMQ KIKDFKNKQN EFFQLWTECQ
1060 1070 1080 1090
RCQGNLHVDV ICMNRDCPIF YRRAKIKKDI ANLQEQVTSL RMDW
Length:1,094
Mass (Da):126,884
Last modified:July 5, 2004 - v1
Checksum:i27DE7E1D652EDACE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014831 Genomic DNA. Translation: AAN35363.1.
LN999944 Genomic DNA. Translation: CZT98423.1.
RefSeqiXP_001347450.1. XM_001347414.1.

Genome annotation databases

EnsemblProtistsiCZT98423; CZT98423; PF3D7_1017000.
GeneDBiPF3D7_1017000.1:pep.
GeneIDi810323.
KEGGipfa:PF10_0165.

Similar proteinsi

Entry informationi

Entry nameiQ7KQL4_PLAF7
AccessioniPrimary (citable) accession number: Q7KQL4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: December 20, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported