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Protein
Submitted name:

Apical membrane antigen 1

Gene

AMA1

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • host cell surface binding Source: GeneDB

GO - Biological processi

  • entry into host cell Source: GeneDB
  • pathogenesis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Apical membrane antigen 1Imported
Submitted name:
Apical membrane antigen 1, AMA1Imported
Gene namesi
Name:AMA1Imported
ORF Names:PF11_0344Imported, PF3D7_1133400Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1133400.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei547 – 56721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical complex Source: GeneDB
  • integral component of membrane Source: GeneDB
  • microneme Source: GeneDB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3559647.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 622598Sequence analysisPRO_5004287766Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi149 ↔ 302Combined sources
Disulfide bondi217 ↔ 247Combined sources
Disulfide bondi263 ↔ 275Combined sources
Disulfide bondi320 ↔ 418Combined sources
Disulfide bondi337 ↔ 409Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z40X-ray1.90A/E104-438[»]
2Q8AX-ray2.40A104-438[»]
2Q8BX-ray2.30A104-438[»]
2Z8VX-ray2.35A/B104-438[»]
2Z8WX-ray2.45A/B104-438[»]
3SRJX-ray2.15A/B97-442[»]
3ZWZX-ray2.10A104-438[»]
4R19X-ray1.80A/B104-438[»]
4R1BX-ray1.60A104-438[»]
4R1CX-ray2.00A/B104-438[»]
ProteinModelPortaliQ7KQK5.
SMRiQ7KQK5. Positions 96-545.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7KQK5.

Family & Domainsi

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOGENOMiHOG000065866.
InParanoidiQ7KQK5.
KOiK13845.

Family and domain databases

Gene3Di4.10.1010.10. 1 hit.
InterProiIPR003298. Apmem_Ag1.
IPR024056. Apmem_Ag1_domain.
[Graphical view]
PfamiPF02430. AMA-1. 1 hit.
[Graphical view]
PRINTSiPR01361. MEROZOITESA.
SMARTiSM00815. AMA-1. 1 hit.
[Graphical view]
SUPFAMiSSF82910. SSF82910. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7KQK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKLYCVLLL SAFEFTYMIN FGRGQNYWEH PYQNSDVYRP INEHREHPKE
60 70 80 90 100
YEYPLHQEHT YQQEDSGEDE NTLQHAYPID HEGAEPAPQE QNLFSSIEIV
110 120 130 140 150
ERSNYMGNPW TEYMAKYDIE EVHGSGIRVD LGEDAEVAGT QYRLPSGKCP
160 170 180 190 200
VFGKGIIIEN SNTTFLTPVA TGNQYLKDGG FAFPPTEPLM SPMTLDEMRH
210 220 230 240 250
FYKDNKYVKN LDELTLCSRH AGNMIPDNDK NSNYKYPAVY DDKDKKCHIL
260 270 280 290 300
YIAAQENNGP RYCNKDESKR NSMFCFRPAK DISFQNYTYL SKNVVDNWEK
310 320 330 340 350
VCPRKNLQNA KFGLWVDGNC EDIPHVNEFP AIDLFECNKL VFELSASDQP
360 370 380 390 400
KQYEQHLTDY EKIKEGFKNK NASMIKSAFL PTGAFKADRY KSHGKGYNWG
410 420 430 440 450
NYNTETQKCE IFNVKPTCLI NNSSYIATTA LSHPIEVENN FPCSLYKDEI
460 470 480 490 500
MKEIERESKR IKLNDNDDEG NKKIIAPRIF ISDDKDSLKC PCDPEMVSNS
510 520 530 540 550
TCRFFVCKCV ERRAEVTSNN EVVVKEEYKD EYADIPEHKP TYDKMKIIIA
560 570 580 590 600
SSAAVAVLAT ILMVYLYKRK GNAEKYDKMD EPQDYGKSNS RNDEMLDPEA
610 620
SFWGEEKRAS HTTPVLMEKP YY
Length:622
Mass (Da):72,042
Last modified:July 5, 2004 - v1
Checksum:i60FE442074C38E94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014186 Genomic DNA. Translation: AAN35928.1.
LN999945 Genomic DNA. Translation: CZT98996.1.
RefSeqiXP_001348015.1. XM_001347979.1.

Genome annotation databases

EnsemblProtistsiPF11_0344:mRNA; PF11_0344:pep; PF11_0344.
GeneDBiPF3D7_1133400.1:pep.
GeneIDi810891.
KEGGipfa:PF11_0344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014186 Genomic DNA. Translation: AAN35928.1.
LN999945 Genomic DNA. Translation: CZT98996.1.
RefSeqiXP_001348015.1. XM_001347979.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z40X-ray1.90A/E104-438[»]
2Q8AX-ray2.40A104-438[»]
2Q8BX-ray2.30A104-438[»]
2Z8VX-ray2.35A/B104-438[»]
2Z8WX-ray2.45A/B104-438[»]
3SRJX-ray2.15A/B97-442[»]
3ZWZX-ray2.10A104-438[»]
4R19X-ray1.80A/B104-438[»]
4R1BX-ray1.60A104-438[»]
4R1CX-ray2.00A/B104-438[»]
ProteinModelPortaliQ7KQK5.
SMRiQ7KQK5. Positions 96-545.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL3559647.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPF11_0344:mRNA; PF11_0344:pep; PF11_0344.
GeneDBiPF3D7_1133400.1:pep.
GeneIDi810891.
KEGGipfa:PF11_0344.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1133400.

Phylogenomic databases

HOGENOMiHOG000065866.
InParanoidiQ7KQK5.
KOiK13845.

Miscellaneous databases

EvolutionaryTraceiQ7KQK5.

Family and domain databases

Gene3Di4.10.1010.10. 1 hit.
InterProiIPR003298. Apmem_Ag1.
IPR024056. Apmem_Ag1_domain.
[Graphical view]
PfamiPF02430. AMA-1. 1 hit.
[Graphical view]
PRINTSiPR01361. MEROZOITESA.
SMARTiSM00815. AMA-1. 1 hit.
[Graphical view]
SUPFAMiSSF82910. SSF82910. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 3D7Imported and Isolate 3D7Imported.
  2. "Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket."
    Bai T., Becker M., Gupta A., Strike P., Murphy V.J., Anders R.F., Batchelor A.H.
    Proc. Natl. Acad. Sci. U.S.A. 102:12736-12741(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 104-438, DISULFIDE BONDS.
  3. "Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody."
    Coley A.M., Gupta A., Murphy V.J., Bai T., Kim H., Foley M., Anders R.F., Batchelor A.H.
    PLoS Pathog. 3:1308-1319(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 104-438, DISULFIDE BONDS.
  4. "Structure of an IgNAR-AMA1 complex: targeting a conserved hydrophobic cleft broadens malarial strain recognition."
    Henderson K.A., Streltsov V.A., Coley A.M., Dolezal O., Hudson P.J., Batchelor A.H., Gupta A., Bai T., Murphy V.J., Anders R.F., Foley M., Nuttall S.D.
    Structure 15:1452-1466(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 104-438, DISULFIDE BONDS.
  5. P. falciparum Genome Sequencing Consortium
    Aslett M., Brunk B., Gardner M., Berriman M.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 3D7Imported.
  6. Briggs B.G., Marchant A.D., Perkins A.J.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 3D7Imported.
  7. Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 104-438, DISULFIDE BONDS.
  8. Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 104-438, DISULFIDE BONDS.

Entry informationi

Entry nameiQ7KQK5_PLAF7
AccessioniPrimary (citable) accession number: Q7KQK5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.