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Protein

Proliferating cell nuclear antigen

Gene

PF3D7_1226600

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, NucleotidyltransferaseImported, Transferase
Biological processDNA replicationUniRule annotation

Enzyme and pathway databases

ReactomeiR-PFA-110320. Translesion Synthesis by POLH.
R-PFA-174411. Polymerase switching on the C-strand of the telomere.
R-PFA-4615885. SUMOylation of DNA replication proteins.
R-PFA-5358565. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
R-PFA-69091. Polymerase switching.
R-PFA-69166. Removal of the Flap Intermediate.
R-PFA-69183. Processive synthesis on the lagging strand.

Names & Taxonomyi

Protein namesi
Recommended name:
Proliferating cell nuclear antigenUniRule annotation
Gene namesi
ORF Names:PF3D7_1226600Imported, PFL1285cImported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1226600.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

  • nucleus Source: GeneDB
  • PCNA complex Source: GeneDB

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 129PCNA_NInterPro annotationAdd BLAST129
Domaini133 – 243PCNA_CInterPro annotationAdd BLAST111

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000211098.
InParanoidiQ7KQJ9.
KOiK04802.
OMAiMDGSHVA.

Family and domain databases

HAMAPiMF_00317. DNApol_clamp_arch. 1 hit.
InterProiView protein in InterPro
IPR000730. Pr_cel_nuc_antig.
IPR022649. Pr_cel_nuc_antig_C.
IPR022659. Pr_cel_nuc_antig_CS.
IPR022648. Pr_cel_nuc_antig_N.
PANTHERiPTHR11352:SF0. PTHR11352:SF0. 1 hit.
PfamiView protein in Pfam
PF02747. PCNA_C. 1 hit.
PF00705. PCNA_N. 1 hit.
PRINTSiPR00339. PCNACYCLIN.
TIGRFAMsiTIGR00590. pcna. 1 hit.
PROSITEiView protein in PROSITE
PS01251. PCNA_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7KQJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFECRIDGQF FKKLFETLKD ICTEVNLECD ENGIKMQSMD CSHVSLVDLN
60 70 80 90 100
IVSDFFQHYR CDKNCVLGIS INFMLKILSV IKEKSTVFLF KEDNENDAVL
110 120 130 140 150
NIGIIDEEEQ SSADDSLEIQ VKLINAQKEH LEIPQSEYHC QCTMKSKKFQ
160 170 180 190 200
EFTKYLNSIG DNVSISMKKD AMILSTTGSD IKVTKQFTND MTDISITCTK
210 220 230 240 250
SVSQEFATRY LVMFSRASSL SDEVLISLSP HIPISIKFNF KQQLTDLQDP
260
SHLTFFLAPK IGDY
Length:264
Mass (Da):30,163
Last modified:July 5, 2004 - v1
Checksum:i6C5DF3EE6498CCF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014848 Genomic DNA. Translation: AAN36343.1.
LN999947 Genomic DNA. Translation: CZT99425.1.
RefSeqiXP_001350663.1. XM_001350627.1.

Genome annotation databases

EnsemblProtistsiCZT99425; CZT99425; PF3D7_1226600.
GeneDBiPF3D7_1226600.1:pep.
GeneIDi811309.
KEGGipfa:PFL1285c.

Similar proteinsi

Entry informationi

Entry nameiQ7KQJ9_PLAF7
AccessioniPrimary (citable) accession number: Q7KQJ9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported