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Protein
Submitted name:

Dorsal interacting protein 4

Gene

lwr

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-UniRule
  • heat shock protein binding Source: FlyBase
  • identical protein binding Source: IntAct
  • SUMO ligase activity Source: FlyBase
  • SUMO transferase activity Source: FlyBase
  • transcription factor binding Source: FlyBase
  • ubiquitin activating enzyme binding Source: FlyBase

GO - Biological processi

  • cellular protein modification process Source: FlyBase
  • cellular response to transforming growth factor beta stimulus Source: FlyBase
  • dorsal closure Source: FlyBase
  • female meiosis chromosome segregation Source: FlyBase
  • female meiotic nuclear division Source: FlyBase
  • germ cell migration Source: FlyBase
  • hemocyte proliferation Source: FlyBase
  • humoral immune response Source: FlyBase
  • mitotic G2 DNA damage checkpoint Source: FlyBase
  • negative regulation of hemocyte proliferation Source: FlyBase
  • negative regulation of lamellocyte differentiation Source: FlyBase
  • negative regulation of Toll signaling pathway Source: FlyBase
  • protein import into nucleus Source: FlyBase
  • protein sumoylation Source: FlyBase
  • spectrosome organization Source: FlyBase
  • zygotic specification of dorsal/ventral axis Source: FlyBase

Keywordsi

Biological processUbl conjugation pathwayUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-3108214. SUMOylation of DNA damage response and repair proteins.
R-DME-3232118. SUMOylation of transcription factors.
R-DME-4551638. SUMOylation of chromatin organization proteins.
R-DME-4570464. SUMOylation of RNA binding proteins.
R-DME-4615885. SUMOylation of DNA replication proteins.

Names & Taxonomyi

Protein namesi
Submitted name:
Dorsal interacting protein 4Imported
Submitted name:
GEO03784p1Imported
Submitted name:
GM08377pImported
Submitted name:
Lesswright, isoform AImported
Submitted name:
Lesswright, isoform BImported
Submitted name:
Lesswright, isoform CImported
Submitted name:
Lesswright, isoform DImported
Submitted name:
RE25737pImported
Submitted name:
Ubiquitin-conjugating enzyme 9Imported
Submitted name:
Ubiquitin-conjugating enzyme 9 homologImported
Gene namesi
Name:lwrImported
Synonyms:dip4Imported, Dmel\CG3018Imported, DmUbc9Imported, Dmubc9Imported, DUbc9Imported, dUBC9Imported, dUbc9Imported, FBgn0010602Imported, hblImported, i105Imported, i56Imported, IwrImported, l(2)01519Imported, l(2)02858Imported, l(2)05486Imported, l(2)05487Imported, LwrImported, semiImported, Ubc 9Imported, Ubc-9Imported, UBC9Imported, Ubc9Imported, ubc9Imported, UbcD9Imported
ORF Names:CG3018Imported, Dmel_CG3018Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0010602. lwr.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0010602.

Interactioni

GO - Molecular functioni

  • heat shock protein binding Source: FlyBase
  • identical protein binding Source: IntAct
  • transcription factor binding Source: FlyBase
  • ubiquitin activating enzyme binding Source: FlyBase

Protein-protein interaction databases

STRINGi7227.FBpp0301731.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 146UBIQUITIN_CONJUGAT_2InterPro annotationAdd BLAST140

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0424. Eukaryota.
COG5078. LUCA.
GeneTreeiENSGT00550000075088.
KOiK10577.
OMAiKCKFTPP.
OrthoDBiEOG091G0NAK.

Family and domain databases

CDDicd00195. UBCc. 1 hit.
Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR027230. Ubc9.
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
PANTHERiPTHR43927. PTHR43927. 1 hit.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7KNM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGIAITRLG EERKAWRKDH PFGFVARPAK NPDGTLNLMI WECAIPGKKS
60 70 80 90 100
TPWEGGLYKL RMIFKDDYPT SPPKCKFEPP LFHPNVYPSG TVCLSLLDEE
110 120 130 140 150
KDWRPAITIK QILLGIQDLL NEPNIKDPAQ AEAYTIYCQN RLEYEKRVRA

QARAMAATE
Length:159
Mass (Da):18,148
Last modified:October 17, 2006 - v1
Checksum:i86FE1870845CFEE3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei159Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030443 Genomic DNA. Translation: AAC38964.1.
AF030444 mRNA. Translation: AAC38965.1.
AF106664 Genomic DNA. Translation: AAD21970.1.
AF218861 mRNA. Translation: AAF31701.1.
AE014134 Genomic DNA. Translation: AAF51487.1.
AY060944 mRNA. Translation: AAL28492.1.
AY113433 mRNA. Translation: AAM29438.1.
AE014134 Genomic DNA. Translation: AAN10499.1.
AE014134 Genomic DNA. Translation: AGB92370.1.
AE014134 Genomic DNA. Translation: AGB92371.1.
KX531808 mRNA. Translation: ANY27618.1.
AB017606 mRNA. Translation: BAA34574.1.
AB017607 Genomic DNA. Translation: BAA34575.1.
PIRiJC5970.
RefSeqiNP_001259833.1. NM_001272904.1.
NP_001259834.1. NM_001272905.1.
NP_476978.1. NM_057630.4.
NP_722637.1. NM_164385.2.
UniGeneiDm.3336.

Genome annotation databases

EnsemblMetazoaiFBtr0078081; FBpp0077741; FBgn0010602.
FBtr0078082; FBpp0077742; FBgn0010602.
FBtr0310028; FBpp0301731; FBgn0010602.
FBtr0310029; FBpp0301732; FBgn0010602.
GeneIDi33226.
KEGGidme:Dmel_CG3018.

Similar proteinsi

Entry informationi

Entry nameiQ7KNM2_DROME
AccessioniPrimary (citable) accession number: Q7KNM2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 17, 2006
Last sequence update: October 17, 2006
Last modified: November 22, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported