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Protein
Submitted name:

Drosha

Gene

drosha

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • double-stranded RNA binding Source: FlyBase
  • ribonuclease III activity Source: GO_Central

GO - Biological processi

  • cellular response to starvation Source: FlyBase
  • germarium-derived female germ-line cyst formation Source: FlyBase
  • germarium-derived oocyte fate determination Source: FlyBase
  • mushroom body development Source: FlyBase
  • pre-miRNA processing Source: GO_Central
  • primary miRNA processing Source: FlyBase
  • production of siRNA involved in RNA interference Source: GO_Central
  • RNA phosphodiester bond hydrolysis, endonucleolytic Source: GO_Central
  • rRNA catabolic process Source: InterPro
  • salivary gland histolysis Source: FlyBase

Keywordsi

Molecular functionHydrolaseImported, RNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
DroshaImported (EC:3.1.26.3Imported)
Submitted name:
LD20030pImported
Submitted name:
RibonucleaseImported
Gene namesi
Name:droshaImported
ORF Names:CG8730Imported, Dmel_CG8730Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0026722. drosha.

Subcellular locationi

GO - Cellular componenti

  • microprocessor complex Source: WormBase
  • nucleus Source: GO_Central

Expressioni

Gene expression databases

BgeeiFBgn0026722.

Interactioni

Protein-protein interaction databases

IntActiQ7KNF1. 3 interactors.
STRINGi7227.FBpp0087926.

Structurei

3D structure databases

SMRiQ7KNF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini743 – 923RNase IIIInterPro annotationAdd BLAST181
Domaini975 – 1098RNase IIIInterPro annotationAdd BLAST124
Domaini1125 – 1200DRBM (double-stranded RNA-binding)InterPro annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG1817. Eukaryota.
COG0571. LUCA.
KOiK03685.
OMAiLSRKVQH.
OrthoDBiEOG091G02A9.

Family and domain databases

CDDicd00593. RIBOc. 2 hits.
Gene3Di1.10.1520.10. 2 hits.
HAMAPiMF_00104. RNase_III. 1 hit.
InterProiView protein in InterPro
IPR014720. dsRBD_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
PfamiView protein in Pfam
PF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
PF00636. Ribonuclease_3. 1 hit.
SMARTiView protein in SMART
SM00358. DSRM. 1 hit.
SM00535. RIBOc. 2 hits.
SUPFAMiSSF69065. SSF69065. 3 hits.
PROSITEiView protein in PROSITE
PS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q7KNF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQPPLPPPP VQPAPPPPPP PPEEDLSPPG VGVPSHNYSS NESHSQSSKS
60 70 80 90 100
LDYVYPETPA PYASSVPSYD PYQQPPAYGY EGYAYNEQAQ KYGGQESHYQ
110 120 130 140 150
YQYPASGSSF LYESYKYPDR YPAYSSNYRP PSERQRYTSN SSSQGYHHYP
160 170 180 190 200
GYSSGRRYEQ RHDQEHRQIQ DSRYAHEPRH GHYAHRQAKG SQHGYYGSAA
210 220 230 240 250
RNQVSDDYSP RGHHERERNE TLEKTRAKPK VETERDRLLR QWCSNFCEKP
260 270 280 290 300
EDYVKKMNAL SEADAPVESW VRSSPAELYY ERTKSENEVR GRARLQKLCT
310 320 330 340 350
LFDEELLQRA KRVREKLPVY VPPPRKARRR VCKHKHKSEA CSSSSSSDDD
360 370 380 390 400
SDEDAFKIEQ DCCMEELSRK VQHPQRVHAD LWHNDAGEMN DGPLCRCSAK
410 420 430 440 450
SRRIGIRHGI YPGETGYKLC DPNSNNAGKL FHYRISISPP TNFLTKTPTI
460 470 480 490 500
IKHDEHEFLF EGFSLLSHVR LSDLPVCKVI RFNIEYTIEY EEEKMPENFT
510 520 530 540 550
IHELDIFFKY LFHELLELVD FNLMPNLPSG NVEESCPAFH FFPRFVRDLP
560 570 580 590 600
DNGKEVLAMV EVLRYLLDNS AQLVERQQLL HLNQISQSEW QNYVDFIKGM
610 620 630 640 650
LVTKPGYKPC SLRVDQLDRN NSDLPECVDR ETGISHPAIV HFGICHPQLS
660 670 680 690 700
YAGNPEYQKA WREYVKYRHL MANMSKPSFK DKRKLEEKEQ RLQEMRTQGR
710 720 730 740 750
MKRNITVAIS SEGFYRTGIM CDVVQHAMLI PVLTGHLRFH KSLDLLEESI
760 770 780 790 800
GYRFKNRYLL QLALTHPSYK ENYGTNPDHA RNSLTNCGIR QPEYGDRKIH
810 820 830 840 850
YMNTRKRGIN TLVSIMSRFG KEHETVSNIT HNERLEFLGD AVVEFLSSIH
860 870 880 890 900
LFFMFPELEE GGLATYRAAI VQNQHLALLA KKLQLEEFML YAHGSDLCHE
910 920 930 940 950
LELRHAMANC FEALMGALLL DGGIKVADEV FTDALFRQDE KLLSIWKNLP
960 970 980 990 1000
EHPLQEQEPL GDRSCIDSYR VLKELTKFED SIGIKFKHIR LLARAFTDRS
1010 1020 1030 1040 1050
IGFTHLTLGS NQRLEFLGDT VLQLICSEYL YRHFPEHHEG HLSLLRSSLV
1060 1070 1080 1090 1100
NNRTQAVVCD DLGMPKYAVY ANPKADLKTK DRADLLEAFL GALYVDKGLL
1110 1120 1130 1140 1150
YCEQFCHVCL FPRLQLFIMN QDWNDPKSKL QQCCLTLRTM DGGEPDIPYY
1160 1170 1180 1190 1200
KVVEASGPTN TRVYKVAVYF RSKRLATSSG SSIQQAEMNA AKQALENSRD
1210 1220 1230 1240 1250
LFPQLDHQKR VIAKSIKKQT GNELDNDSDR QHQEEKIKRP KYATPLQDES
1260 1270 1280 1290 1300
HLPKQYRMHE NISSDELPED EDFESTAPKS PTMPLRSNRS GSSSSSSSSD
1310 1320
SDGSTSSPKC KRRLKKCSSV SSKSSLG
Length:1,327
Mass (Da):152,817
Last modified:October 3, 2006 - v1
Checksum:i84AD3AABD676C9E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116572 mRNA. Translation: AAD31170.1.
AE013599 Genomic DNA. Translation: AAF59169.1.
BT023503 mRNA. Translation: AAY84903.1.
RefSeqiNP_477436.1. NM_058088.4.
UniGeneiDm.4482.

Genome annotation databases

EnsemblMetazoaiFBtr0088850; FBpp0087926; FBgn0026722.
GeneIDi35747.
KEGGidme:Dmel_CG8730.
UCSCiCG8730-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ7KNF1_DROME
AccessioniPrimary (citable) accession number: Q7KNF1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: August 30, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported