Unreviewed, UniProtKB/TrEMBL Q7KNF1 (Q7KNF1_DROME)

Names and origin

Protein names

Submitted name:
    Drosha EMBL AAF59169.1
    EC=3.1.26.3
Submitted name:
    LD20030p EMBL AAY84903.1
    Ribonuclease EMBL AAD31170.1

Gene names

Name:	drosha EMBL AAD31170.1 FlyBase FBgn0026722
ORF Names:	CG8730 FlyBase FBgn0026722, Dmel_CG8730 EMBL AAF59169.1

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome] EMBL AAD31170.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1327 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	primary microRNA processing Inferred from mutant phenotype. Source: FlyBase
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	double-stranded RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease III activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7KNF1-1 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: 84AD3AABD676C9E8	FASTA	1,327	152,817
	10 20 30 40 50 60 MYQPPLPPPP VQPAPPPPPP PPEEDLSPPG VGVPSHNYSS NESHSQSSKS LDYVYPETPA 70 80 90 100 110 120 PYASSVPSYD PYQQPPAYGY EGYAYNEQAQ KYGGQESHYQ YQYPASGSSF LYESYKYPDR 130 140 150 160 170 180 YPAYSSNYRP PSERQRYTSN SSSQGYHHYP GYSSGRRYEQ RHDQEHRQIQ DSRYAHEPRH 190 200 210 220 230 240 GHYAHRQAKG SQHGYYGSAA RNQVSDDYSP RGHHERERNE TLEKTRAKPK VETERDRLLR 250 260 270 280 290 300 QWCSNFCEKP EDYVKKMNAL SEADAPVESW VRSSPAELYY ERTKSENEVR GRARLQKLCT 310 320 330 340 350 360 LFDEELLQRA KRVREKLPVY VPPPRKARRR VCKHKHKSEA CSSSSSSDDD SDEDAFKIEQ 370 380 390 400 410 420 DCCMEELSRK VQHPQRVHAD LWHNDAGEMN DGPLCRCSAK SRRIGIRHGI YPGETGYKLC 430 440 450 460 470 480 DPNSNNAGKL FHYRISISPP TNFLTKTPTI IKHDEHEFLF EGFSLLSHVR LSDLPVCKVI 490 500 510 520 530 540 RFNIEYTIEY EEEKMPENFT IHELDIFFKY LFHELLELVD FNLMPNLPSG NVEESCPAFH 550 560 570 580 590 600 FFPRFVRDLP DNGKEVLAMV EVLRYLLDNS AQLVERQQLL HLNQISQSEW QNYVDFIKGM 610 620 630 640 650 660 LVTKPGYKPC SLRVDQLDRN NSDLPECVDR ETGISHPAIV HFGICHPQLS YAGNPEYQKA 670 680 690 700 710 720 WREYVKYRHL MANMSKPSFK DKRKLEEKEQ RLQEMRTQGR MKRNITVAIS SEGFYRTGIM 730 740 750 760 770 780 CDVVQHAMLI PVLTGHLRFH KSLDLLEESI GYRFKNRYLL QLALTHPSYK ENYGTNPDHA 790 800 810 820 830 840 RNSLTNCGIR QPEYGDRKIH YMNTRKRGIN TLVSIMSRFG KEHETVSNIT HNERLEFLGD 850 860 870 880 890 900 AVVEFLSSIH LFFMFPELEE GGLATYRAAI VQNQHLALLA KKLQLEEFML YAHGSDLCHE 910 920 930 940 950 960 LELRHAMANC FEALMGALLL DGGIKVADEV FTDALFRQDE KLLSIWKNLP EHPLQEQEPL 970 980 990 1000 1010 1020 GDRSCIDSYR VLKELTKFED SIGIKFKHIR LLARAFTDRS IGFTHLTLGS NQRLEFLGDT 1030 1040 1050 1060 1070 1080 VLQLICSEYL YRHFPEHHEG HLSLLRSSLV NNRTQAVVCD DLGMPKYAVY ANPKADLKTK 1090 1100 1110 1120 1130 1140 DRADLLEAFL GALYVDKGLL YCEQFCHVCL FPRLQLFIMN QDWNDPKSKL QQCCLTLRTM 1150 1160 1170 1180 1190 1200 DGGEPDIPYY KVVEASGPTN TRVYKVAVYF RSKRLATSSG SSIQQAEMNA AKQALENSRD 1210 1220 1230 1240 1250 1260 LFPQLDHQKR VIAKSIKKQT GNELDNDSDR QHQEEKIKRP KYATPLQDES HLPKQYRMHE 1270 1280 1290 1300 1310 1320 NISSDELPED EDFESTAPKS PTMPLRSNRS GSSSSSSSSD SDGSTSSPKC KRRLKKCSSV SSKSSLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel type of RNase III family proteins in eukaryotes." Filippov V., Solovyev V., Filippova M., Gill S.S. Gene 245:213-221(2000) [PubMed: 10713462] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Filippov V.A., Filippova M.A., Gill S.S. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[5]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[6]	Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J., Park S., Wan K., Yu C., Celniker S. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAY84903.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF116572 mRNA. Translation: AAD31170.1. AE013599 Genomic DNA. Translation: AAF59169.1. BT023503 mRNA. Translation: AAY84903.1.
RefSeq	NP_477436.1.
UniGene	Dm.4482
3D structure databases
HSSP	HSSP built from PDB template 1JFZ based on UniProtKB O67082.
ModBase	Search...
Proteomic databases
PRIDE	Q7KNF1.
Genome annotation databases
Ensembl	FBgn0026722. Drosophila melanogaster. [Contig view]
GeneID	35747.
KEGG	dme:Dmel_CG8730.
Organism-specific databases
FlyBase	FBgn0026722. drosha.
Phylogenomic databases
OMA	Q7KNF1. HLRFHKS.
Gene expression databases
ArrayExpress	Q7KNF1.
Family and domain databases
InterPro	IPR001159. Ds-RNA_bd. IPR014720. dsRNA-bd-like. IPR000999. RNase_III. [Graphical view]
Gene3D	G3DSA:3.30.160.20. dsRNA-bd-like. 1 hit. G3DSA:1.10.1520.10. RNase_III. 2 hits.
Pfam	PF00035. dsrm. 1 hit. PF00636. Ribonuclease_3. 2 hits. [Graphical view]
SMART	SM00358. DSRM. 1 hit. SM00535. RIBOc. 2 hits. [Graphical view]
PROSITE	PS50137. DS_RBD. 1 hit. PS00517. RNASE_3_1. 1 hit. PS50142. RNASE_3_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	795024.

Entry information

Entry name

Q7KNF1_DROME

Accession

Primary (citable) accession number: Q7KNF1

Entry history

Integrated into UniProtKB/TrEMBL:	October 3, 2006
Last sequence update:	October 3, 2006
Last modified:	July 7, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)