LD23835p - Drosophila melanogaster (Fruit fly)

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Q7KN56 (Q7KN56_DROME) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 61. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
LD23835p EMBL AAD27864.2

Gene names

Name:	BubR1 FlyBase FBgn0025458
Synonyms:	Bub1 EMBL AAD27864.2 FlyBase FBgn0025458

Organism

Drosophila melanogaster (Fruit fly) EMBL AAD27864.2

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1484 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily. RuleBase RU000305

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase RuleBase RU000305 Transferase
Gene Ontology (GO)
Biological process	mitotic cell cycle spindle assembly checkpoint Inferred from direct assay. Source: FlyBase mitotic spindle organization Inferred from mutant phenotype. Source: FlyBase regulation of exit from mitosis Inferred from mutant phenotype. Source: FlyBase regulation of mitotic prometaphase Inferred from mutant phenotype. Source: FlyBase regulation of mitotic sister chromatid separation Inferred from mutant phenotype. Source: FlyBase sister chromatid segregation Inferred from mutant phenotype. Source: FlyBase syncytial blastoderm mitotic cell cycle Inferred from mutant phenotype. Source: FlyBase
Cellular component	condensed chromosome outer kinetochore Non-traceable author statement. Source: FlyBase cytoplasm Inferred from direct assay. Source: FlyBase
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Experimental info

Non-terminal residue

EMBL AAD27864.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q7KN56 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 1B936D9686C7FDD1
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FASTA

1,484

167,747

        10         20         30         40         50         60 
SARSFCLTDT RQPKVSGHLL EENDMDFDNA KENIQPLASG RNVSLLQASL SQDSTHGQEL 

        70         80         90        100        110        120 
LAQRKQMEEE VRTYKGADPL GAWYTFICWI EQSYPAGGSG SGLQTVLHQC LTKFEDDERY 

       130        140        150        160        170        180 
RQDKRLIKLF IKFMEKQKDK IEFYQQMYNN GIGTMLADFY IAWAYSYDLS GNMRKADEIF 

       190        200        210        220        230        240 
RLGLECRAEP LEDLKEAHHH FGYTVGQRML YSTGEEANAV NQELNERRLA LQSLHGRRQQ 

       250        260        270        280        290        300 
ISNSITVGSI RTGAAVKSGL PGVVQVEPST TTSRRNVGRN VEVFNDENSE GNIPISNSET 

       310        320        330        340        350        360 
EVKSSLRSII DSACSQENIK EPVAWNKANA KRHKHGKIFG SNASPDLGFD IHVDEQAMPP 

       370        380        390        400        410        420 
ITNYERRLEQ PFRFPTNFVA KNRPQEPWVT PVTIEDEPNA SGLPCYNKCL LYPRPNIEFS 

       430        440        450        460        470        480 
PEEYRAYSFL KHRNPQHPFI HRNDDWWGTG RVIRGIRCYP NFARYSKPQD LDELDKFWKP 

       490        500        510        520        530        540 
PLVPGLQVVF DKIYNEVEQK EYQPEELLAA KWMEKRNVTV HGDFDMEETV CLPGNKMPRR 

       550        560        570        580        590        600 
KSFFPSSFRK SIMPRRVSSV QEEDEKKEDE ATLIVKDIPS QVAPKIPESP CDQIDEPKIK 

       610        620        630        640        650        660 
IFEDSGSPRD NFAVPAVPVP KIEIYEDSEE PQPTPKTRPF YDGDETCSTQ MFNMFIKSQA 

       670        680        690        700        710        720 
VSTPKGTQKQ APSRQFGTVL KELPLPEEAA HSVESPVETR SPTLRKQLST ILETSEHGTQ 

       730        740        750        760        770        780 
SLATSGTTTK STITSTSSPG SNAVSKLGSK IEENTPGQMR LQRVISAGVS AVLSEPEKPG 

       790        800        810        820        830        840 
GDNFLRRELW EPNAPSVPML KSLRFQEDKT ETIPRPLACF QEDKTETLPQ MPIALPENSM 

       850        860        870        880        890        900 
DHGSLGAENC FSAPQLPTLE DESDLCGLFG KTPPKTNIFG SPKRNFDPTS QLFKSTQGDR 

       910        920        930        940        950        960 
RSFAVTGNKL EAAPSISNLQ DSFMCDLSFV PETQPEAVAK SGAIQKFDIF LDDTQPKLTK 

       970        980        990       1000       1010       1020 
SKPVALMVSS FDLDCTLPET QQVAIKEPGT QQENIGHSHM IASFMKDCTE IGSCPSQMPA 

      1030       1040       1050       1060       1070       1080 
SVVKTNISST SNKIKFSNDS MSESSRKAPV NENVGISKQP DEFFELNAAT EMFATNISMI 

      1090       1100       1110       1120       1130       1140 
KNSTLLIPNA KVAEASELSI YYKTTPLTPK QSHRSWSQSD LETPPRENFV HPTSNGDQTV 

      1150       1160       1170       1180       1190       1200 
LNETLADANK NPFNVELISS LLESIDFSMY IEKLPHCQLV GHVKRLHPNT HLEVHNEKFE 

      1210       1220       1230       1240       1250       1260 
VSKMIGKGAY GSVYVGKHLK SGKKVALKQE RPTNYWEFYI CLEIHSRLTS EQMIPSYAHI 

      1270       1280       1290       1300       1310       1320 
DYALVGNNSS VYISEFSDYG SLIGVCNKVK SVTNRNMDEY VVMHLSCQML DIVDHLHAMG 

      1330       1340       1350       1360       1370       1380 
IIHADIKPDN FLLMKPICAD PNEVSLQLID FGVSIDMKLF PDNQTFNYVH HDDLFKCIEM 

      1390       1400       1410       1420       1430       1440 
RTGRPWTYQL DLYGLVSVMH VLLFGRYMEV VQRSPSTIWM PKTNVPRYFQ RTMWENIFRT 

      1450       1460       1470       1480 
LLNIRDCRTM PNLQQLRTQL KCALAEKEKY VAEAISKFNT ILQK

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References

[1]	Tsang G., Brokstein P., Frise E., Harvey D., Evans-Holm M., Lewis S.E., Suh C., Rubin G.M. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAD27864.2.
[2]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. Celniker S. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAD27864.2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF132565 mRNA. Translation: AAD27864.2.
3D structure databases
ProteinModelPortal	Q7KN56.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7KN56.
Proteomic databases
PRIDE	Q7KN56.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
NMPDR	fig\|7227.3.peg.3414.
Organism-specific databases
FlyBase	FBgn0025458. BubR1.
Phylogenomic databases
eggNOG	inNOG08346.
GeneTree	EMGT00050000001700.
InParanoid	Q7KN56.
Gene expression databases
ArrayExpress	Q7KN56.
Bgee	Q7KN56.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR013212. Mad3_BUB1_I. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR015661. Ser/Thr_kinase_Bub1. [Graphical view]
PANTHER	PTHR14030. Bub1. 1 hit.
Pfam	PF08311. Mad3_BUB1_I. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00777. Mad3_BUB1_I. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51489. BUB1_N. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q7KN56_DROME

Accession

Primary (citable) accession number: Q7KN56

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	November 16, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information