Unreviewed, UniProtKB/TrEMBL Q7KN56 (Q7KN56_DROME)

Names and origin

Protein names

Submitted name:
    LD23835p EMBL AAD27864.2

Gene names

Name:	BubR1 FlyBase FBgn0025458
Synonyms:	Bub1 EMBL AAD27864.2 FlyBase FBgn0025458

Organism

Drosophila melanogaster (Fruit fly) EMBL AAD27864.2

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1484 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily. RuleBase RU000305V3

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304V2 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase RuleBase RU000305V3 Transferase
Gene Ontology (GO)
Biological process	mitotic cell cycle spindle assembly checkpoint Inferred from direct assay. Source: FlyBase mitotic spindle organization Inferred from mutant phenotype. Source: FlyBase protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro regulation of exit from mitosis Inferred from genetic interaction. Source: FlyBase syncytial blastoderm mitotic cell cycle Inferred from mutant phenotype. Source: FlyBase
Cellular component	cytoplasm Inferred from direct assay. Source: FlyBase outer kinetochore of condensed chromosome Non-traceable author statement. Source: FlyBase
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAD27864.2

Sequences

	Sequence		Length	Mass (Da)
	Q7KN56-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 1B936D9686C7FDD1	FASTA	1,484	167,747
	10 20 30 40 50 60 SARSFCLTDT RQPKVSGHLL EENDMDFDNA KENIQPLASG RNVSLLQASL SQDSTHGQEL 70 80 90 100 110 120 LAQRKQMEEE VRTYKGADPL GAWYTFICWI EQSYPAGGSG SGLQTVLHQC LTKFEDDERY 130 140 150 160 170 180 RQDKRLIKLF IKFMEKQKDK IEFYQQMYNN GIGTMLADFY IAWAYSYDLS GNMRKADEIF 190 200 210 220 230 240 RLGLECRAEP LEDLKEAHHH FGYTVGQRML YSTGEEANAV NQELNERRLA LQSLHGRRQQ 250 260 270 280 290 300 ISNSITVGSI RTGAAVKSGL PGVVQVEPST TTSRRNVGRN VEVFNDENSE GNIPISNSET 310 320 330 340 350 360 EVKSSLRSII DSACSQENIK EPVAWNKANA KRHKHGKIFG SNASPDLGFD IHVDEQAMPP 370 380 390 400 410 420 ITNYERRLEQ PFRFPTNFVA KNRPQEPWVT PVTIEDEPNA SGLPCYNKCL LYPRPNIEFS 430 440 450 460 470 480 PEEYRAYSFL KHRNPQHPFI HRNDDWWGTG RVIRGIRCYP NFARYSKPQD LDELDKFWKP 490 500 510 520 530 540 PLVPGLQVVF DKIYNEVEQK EYQPEELLAA KWMEKRNVTV HGDFDMEETV CLPGNKMPRR 550 560 570 580 590 600 KSFFPSSFRK SIMPRRVSSV QEEDEKKEDE ATLIVKDIPS QVAPKIPESP CDQIDEPKIK 610 620 630 640 650 660 IFEDSGSPRD NFAVPAVPVP KIEIYEDSEE PQPTPKTRPF YDGDETCSTQ MFNMFIKSQA 670 680 690 700 710 720 VSTPKGTQKQ APSRQFGTVL KELPLPEEAA HSVESPVETR SPTLRKQLST ILETSEHGTQ 730 740 750 760 770 780 SLATSGTTTK STITSTSSPG SNAVSKLGSK IEENTPGQMR LQRVISAGVS AVLSEPEKPG 790 800 810 820 830 840 GDNFLRRELW EPNAPSVPML KSLRFQEDKT ETIPRPLACF QEDKTETLPQ MPIALPENSM 850 860 870 880 890 900 DHGSLGAENC FSAPQLPTLE DESDLCGLFG KTPPKTNIFG SPKRNFDPTS QLFKSTQGDR 910 920 930 940 950 960 RSFAVTGNKL EAAPSISNLQ DSFMCDLSFV PETQPEAVAK SGAIQKFDIF LDDTQPKLTK 970 980 990 1000 1010 1020 SKPVALMVSS FDLDCTLPET QQVAIKEPGT QQENIGHSHM IASFMKDCTE IGSCPSQMPA 1030 1040 1050 1060 1070 1080 SVVKTNISST SNKIKFSNDS MSESSRKAPV NENVGISKQP DEFFELNAAT EMFATNISMI 1090 1100 1110 1120 1130 1140 KNSTLLIPNA KVAEASELSI YYKTTPLTPK QSHRSWSQSD LETPPRENFV HPTSNGDQTV 1150 1160 1170 1180 1190 1200 LNETLADANK NPFNVELISS LLESIDFSMY IEKLPHCQLV GHVKRLHPNT HLEVHNEKFE 1210 1220 1230 1240 1250 1260 VSKMIGKGAY GSVYVGKHLK SGKKVALKQE RPTNYWEFYI CLEIHSRLTS EQMIPSYAHI 1270 1280 1290 1300 1310 1320 DYALVGNNSS VYISEFSDYG SLIGVCNKVK SVTNRNMDEY VVMHLSCQML DIVDHLHAMG 1330 1340 1350 1360 1370 1380 IIHADIKPDN FLLMKPICAD PNEVSLQLID FGVSIDMKLF PDNQTFNYVH HDDLFKCIEM 1390 1400 1410 1420 1430 1440 RTGRPWTYQL DLYGLVSVMH VLLFGRYMEV VQRSPSTIWM PKTNVPRYFQ RTMWENIFRT 1450 1460 1470 1480 LLNIRDCRTM PNLQQLRTQL KCALAEKEKY VAEAISKFNT ILQK

References

[1]

Tsang G., Brokstein P., Frise E., Harvey D., Evans-Holm M., Lewis S.E., Suh C., Rubin G.M. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAD27864.2.

[2]

Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. , Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAD27864.2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF132565 mRNA. Translation: AAD27864.2.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q7KN56.
Genome annotation databases
Ensembl	FBgn0025458. Drosophila melanogaster. [Contig view]
NMPDR	fig|7227.3.peg.3414.
Organism-specific databases
FlyBase	FBgn0025458. BubR1.
Phylogenomic databases
HOGENOM	Q7KN56.
Gene expression databases
ArrayExpress	Q7KN56.
Family and domain databases
InterPro	IPR015661. Bub1. IPR013212. Mad3_BUB1_I. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view]
PANTHER	PTHR14030. Bub1. 1 hit.
Pfam	PF08311. Mad3_BUB1_I. 1 hit. PF00069. Pkinase. 2 hits. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00777. Mad3_BUB1_I. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q7KN56_DROME

Accession

Primary (citable) accession number: Q7KN56

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)