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Protein
Submitted name:

26S proteasome regulatory complex subunit p39A

Gene

Rpn9

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BRENDAi3.4.25.1. 1994.
ReactomeiR-DME-1169091. Activation of NF-kappaB in B cells.
R-DME-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-DME-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DME-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DME-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DME-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DME-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DME-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DME-195253. Degradation of beta-catenin by the destruction complex.
R-DME-202424. Downstream TCR signaling.
R-DME-2871837. FCERI mediated NF-kB activation.
R-DME-350562. Regulation of ornithine decarboxylase (ODC).
R-DME-446652. Interleukin-1 signaling.
R-DME-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DME-4608870. Asymmetric localization of PCP proteins.
R-DME-4641257. Degradation of AXIN.
R-DME-4641258. Degradation of DVL.
R-DME-5358346. Hedgehog ligand biogenesis.
R-DME-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5610780. Degradation of GLI1 by the proteasome.
R-DME-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DME-5632684. Hedgehog 'on' state.
R-DME-5658442. Regulation of RAS by GAPs.
R-DME-5676590. NIK-->noncanonical NF-kB signaling.
R-DME-5689603. UCH proteinases.
R-DME-5689880. Ub-specific processing proteases.
R-DME-6798695. Neutrophil degranulation.
R-DME-68949. Orc1 removal from chromatin.
R-DME-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DME-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-DME-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DME-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DME-8941858. Regulation of RUNX3 expression and activity.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
26S proteasome regulatory complex subunit p39AImported
Submitted name:
LD17530pImported
Submitted name:
Regulatory particle non-ATPase 9, isoform AImported
Submitted name:
Regulatory particle non-ATPase 9, isoform BImported
Gene namesi
Name:Rpn9Imported
ORF Names:CG10230Imported, Dmel_CG10230Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0028691. Rpn9.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • nucleus Source: GO_Central
  • proteasome complex Source: FlyBase
  • proteasome regulatory particle Source: FlyBase
  • proteasome regulatory particle, lid subcomplex Source: FlyBase

Keywords - Cellular componenti

ProteasomeImported

Expressioni

Gene expression databases

BgeeiFBgn0028691.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Rpn8P262703EBI-151692,EBI-253612

Protein-protein interaction databases

IntActiQ7KMP8. 9 interactors.
STRINGi7227.FBpp0083860.

Structurei

3D structure databases

SMRiQ7KMP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 361PCIInterPro annotationAdd BLAST94

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili131 – 154Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2908. Eukaryota.
ENOG410XPG9. LUCA.
GeneTreeiENSGT00390000001802.
KOiK03039.
OMAiKFADKIN.
OrthoDBiEOG091G0977.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR000717. PCI_dom.
IPR011990. TPR-like_helical_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01399. PCI. 1 hit.
SMARTiView protein in SMART
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7KMP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPQPNVTA YLATQKKTTN KELAAEWTLI EELYNEKLWN ELTIKLVTFV
60 70 80 90 100
RHESLQDETA LLQLYQNFLS TFETKINPYG LIQILEVVVD NIGDKKEAIE
110 120 130 140 150
FLEKMKDKVK ICDEAVWYLQ VMQGNLYLSN LNDLNATKKI IEELRDVLEE
160 170 180 190 200
AGNVTPVHGK YYMLASQYYR RVGKHSDYYR CGLQFLGCSM DEYPRDQWAQ
210 220 230 240 250
QAFFLGLAAL LGDGVYNIGE LLAHPILESL KGTENEWLME LLKAFNTGDI
260 270 280 290 300
NKFNDMKKIW SKIPDLAAQE VKLRQKISLL CLMEMTFKRS AIERAISFTD
310 320 330 340 350
IAQETKLPAK EVELLIMKAL ALDLVRGEID QVAGVVNMSW VQPRVLNRSQ
360 370 380
IVGMASTLDT WMGAITNMEK LMENRAAEIL TN
Length:382
Mass (Da):43,767
Last modified:October 3, 2006 - v1
Checksum:i096A8AB66C505D95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145311 mRNA. Translation: AAF08392.1.
AE014297 Genomic DNA. Translation: AAF56173.1.
AE014297 Genomic DNA. Translation: AAF56174.1.
AY061232 mRNA. Translation: AAL28780.1.
RefSeqiNP_651177.1. NM_142920.3.
NP_732899.1. NM_170088.2.
UniGeneiDm.3423.

Genome annotation databases

EnsemblMetazoaiFBtr0084469; FBpp0083860; FBgn0028691.
FBtr0084470; FBpp0083861; FBgn0028691.
GeneIDi42802.
KEGGidme:Dmel_CG10230.
UCSCiCG10230-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145311 mRNA. Translation: AAF08392.1.
AE014297 Genomic DNA. Translation: AAF56173.1.
AE014297 Genomic DNA. Translation: AAF56174.1.
AY061232 mRNA. Translation: AAL28780.1.
RefSeqiNP_651177.1. NM_142920.3.
NP_732899.1. NM_170088.2.
UniGeneiDm.3423.

3D structure databases

SMRiQ7KMP8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7KMP8. 9 interactors.
STRINGi7227.FBpp0083860.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0084469; FBpp0083860; FBgn0028691.
FBtr0084470; FBpp0083861; FBgn0028691.
GeneIDi42802.
KEGGidme:Dmel_CG10230.
UCSCiCG10230-RA. d. melanogaster.

Organism-specific databases

CTDi42802.
FlyBaseiFBgn0028691. Rpn9.

Phylogenomic databases

eggNOGiKOG2908. Eukaryota.
ENOG410XPG9. LUCA.
GeneTreeiENSGT00390000001802.
KOiK03039.
OMAiKFADKIN.
OrthoDBiEOG091G0977.

Enzyme and pathway databases

BRENDAi3.4.25.1. 1994.
ReactomeiR-DME-1169091. Activation of NF-kappaB in B cells.
R-DME-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-DME-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DME-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DME-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-DME-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DME-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DME-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DME-195253. Degradation of beta-catenin by the destruction complex.
R-DME-202424. Downstream TCR signaling.
R-DME-2871837. FCERI mediated NF-kB activation.
R-DME-350562. Regulation of ornithine decarboxylase (ODC).
R-DME-446652. Interleukin-1 signaling.
R-DME-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DME-4608870. Asymmetric localization of PCP proteins.
R-DME-4641257. Degradation of AXIN.
R-DME-4641258. Degradation of DVL.
R-DME-5358346. Hedgehog ligand biogenesis.
R-DME-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5610780. Degradation of GLI1 by the proteasome.
R-DME-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DME-5632684. Hedgehog 'on' state.
R-DME-5658442. Regulation of RAS by GAPs.
R-DME-5676590. NIK-->noncanonical NF-kB signaling.
R-DME-5689603. UCH proteinases.
R-DME-5689880. Ub-specific processing proteases.
R-DME-6798695. Neutrophil degranulation.
R-DME-68949. Orc1 removal from chromatin.
R-DME-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DME-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-DME-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DME-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DME-8941858. Regulation of RUNX3 expression and activity.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii42802.

Gene expression databases

BgeeiFBgn0028691.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR000717. PCI_dom.
IPR011990. TPR-like_helical_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01399. PCI. 1 hit.
SMARTiView protein in SMART
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ7KMP8_DROME
AccessioniPrimary (citable) accession number: Q7KMP8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 7, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.