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Protein
Submitted name:

BcDNA.GH04962

Gene

GCS2alpha

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionGlycosidaseUniRule annotationImported, Hydrolase

Enzyme and pathway databases

ReactomeiR-DME-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-DME-901042. Calnexin/calreticulin cycle.

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.

Names & Taxonomyi

Protein namesi
Submitted name:
BcDNA.GH04962Imported
Submitted name:
Glucosidase 2 alpha subunit, isoform AImported
Submitted name:
Glucosidase 2 alpha subunit, isoform BImported
Submitted name:
Glucosidase 2 alpha subunit, isoform CImported (EC:3.2.1.-Imported)
Submitted name:
Glucosidase 2 alpha subunit, isoform DImported
Submitted name:
Glucosidase 2 alpha subunit, isoform EImported
Gene namesi
Name:GCS2alphaImported
Synonyms:BcDNA.GH04962Imported, BcDNA:GH04962Imported, clot#312Imported, Dmel\CG14476Imported
ORF Names:CG14476Imported, Dmel_CG14476Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0027588. GCS2alpha.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501097491721 – 924Sequence analysisAdd BLAST904

Expressioni

Gene expression databases

BgeeiFBgn0027588.

Interactioni

Protein-protein interaction databases

IntActiQ7KMM4. 8 interactors.
STRINGi7227.FBpp0070057.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini236 – 304Gal_mutarotas_2InterPro annotationAdd BLAST69

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1066. Eukaryota.
COG1501. LUCA.
GeneTreeiENSGT00760000119229.
KOiK05546.
OMAiTVHQPLW.
OrthoDBiEOG091G01CC.

Family and domain databases

InterProiView protein in InterPro
IPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 2 hits.

Sequencei

Sequence statusi: Complete.

Q7KMM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFALATVAI IWALFVLADG VDPGNFKTCE QSSFCRRSRK IQGSGSKYAL
60 70 80 90 100
IPGTLNTYAD SLTADLVNKE NHHQFAFKLE ALVGSTFRLQ IDEKQPLRPR
110 120 130 140 150
YRVEHALKGP TQAGRIRVQR ETDGEIVITS EKNKAVIHGD PFRIDFFEND
160 170 180 190 200
VLVVSVNAKN WLYFEHLRQK AQEPTSHPAE NENQQEQDAA VETPKAADTI
210 220 230 240 250
DDPGAWEENF KSHHDSKPYG PEAVALDFSF PAAKVLFGIP EHADSFILKS
260 270 280 290 300
TSGTDPYRLY NLDVFEYVVD SKMALYGSVP VIYGHGAQRT AGVYWQNAAE
310 320 330 340 350
TWVDIQTSET NVVSSLVNFV SGSQKTPPPA AHFMSESGIV DAFIMLGPKP
360 370 380 390 400
MDTFKQYAAL TGTHELPQLF ALAYHQSRWN YNDERDVTSV SAKFDEYNIP
410 420 430 440 450
MDTMWLDIEH TDGKRYFTWD KFKFPHPLAM IKNLTELGRH LVVIVDPHIK
460 470 480 490 500
RDNNYFFHRD CTDRGYYVKT REGNDYEGWC WPGAASYPDF FNPVVREYYA
510 520 530 540 550
SQYALDKFQT VTADVMLWND MNEPSVFNGP EITAPKDLIH YGNWEHRDVH
560 570 580 590 600
NLYGHMHLMG SFAGLQQRDP NQRPFILTRA HFAGSQRYAA IWTGDNFADW
610 620 630 640 650
SHLQHSVKMC LTEAVAGFSF CGADVGAFFG NPDTELLERW YQTGAFLPFF
660 670 680 690 700
RAHAHIDTKR REPWLFPERT RQVIQNAVIK RYSYLPLWYT AFYELELTGE
710 720 730 740 750
PVIRPLLAQY PLDKEAFGVD NQLLVQDRLL VRPVMQQGVS KVDVYFPAID
760 770 780 790 800
DKKNGDWWYD VDTYQRQERS GYVSVPVDDF KIPVWQRGGS IVPKKERQRR
810 820 830 840 850
ASTLMLHDPY TLIICLDRQG KASGSLYLDD EKSYAYRQGQ RIHVNYEFAH
860 870 880 890 900
DQLVNSFVGK PKYKTLAWIE RIVIAGLEKV PSSASITVNG VSQQLEVLHH
910 920
DNTVVVRKPG VKMDVDFAIK LNFA
Length:924
Mass (Da):105,731
Last modified:April 26, 2005 - v1
Checksum:i8EE23063677C4083
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145625 mRNA. Translation: AAD38600.1.
AE014298 Genomic DNA. Translation: AAF45432.1.
AE014298 Genomic DNA. Translation: AAG22460.1.
AE014298 Genomic DNA. Translation: AAN08995.1.
AE014298 Genomic DNA. Translation: AAN08996.1.
AE014298 Genomic DNA. Translation: AAN08997.1.
RefSeqiNP_652145.1. NM_143888.5.
NP_728434.1. NM_167757.3.
NP_728435.1. NM_167758.2.
NP_728436.1. NM_167759.2.
NP_728437.1. NM_167760.1.
UniGeneiDm.7659.

Genome annotation databases

EnsemblMetazoaiFBtr0070058; FBpp0070057; FBgn0027588.
FBtr0070059; FBpp0070058; FBgn0027588.
FBtr0070060; FBpp0070059; FBgn0027588.
FBtr0070061; FBpp0070060; FBgn0027588.
FBtr0070062; FBpp0070061; FBgn0027588.
GeneIDi49953.
KEGGidme:Dmel_CG14476.
UCSCiCG14476-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ7KMM4_DROME
AccessioniPrimary (citable) accession number: Q7KMM4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 27, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported