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Protein
Submitted name:

BcDNA.GH04962

Gene

GCS2alpha

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationImported, Hydrolase

Enzyme and pathway databases

ReactomeiR-DME-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-DME-901042. Calnexin/calreticulin cycle.

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.

Names & Taxonomyi

Protein namesi
Submitted name:
BcDNA.GH04962Imported
Submitted name:
Glucosidase 2 alpha subunit, isoform AImported
Submitted name:
Glucosidase 2 alpha subunit, isoform BImported
Submitted name:
Glucosidase 2 alpha subunit, isoform CImported
Submitted name:
Glucosidase 2 alpha subunit, isoform DImported
Submitted name:
Glucosidase 2 alpha subunit, isoform EImported (EC:3.2.1.20Imported)
Gene namesi
Name:GCS2alphaImported
Synonyms:BcDNA.GH04962Imported
ORF Names:CG14476Imported, Dmel_CG14476Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0027588. GCS2alpha.

Subcellular locationi

GO - Cellular componenti

  • endomembrane system Source: FlyBase
  • extracellular region Source: FlyBase
  • microtubule associated complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 924904Sequence analysisPRO_5007710931Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0070057.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini236 – 30469Gal_mutarotas_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 31 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1066. Eukaryota.
COG1501. LUCA.
GeneTreeiENSGT00760000119229.
KOiK05546.
OMAiFDEEREW.
OrthoDBiEOG7VQJDS.

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 2 hits.

Sequencei

Sequence statusi: Complete.

Q7KMM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFALATVAI IWALFVLADG VDPGNFKTCE QSSFCRRSRK IQGSGSKYAL
60 70 80 90 100
IPGTLNTYAD SLTADLVNKE NHHQFAFKLE ALVGSTFRLQ IDEKQPLRPR
110 120 130 140 150
YRVEHALKGP TQAGRIRVQR ETDGEIVITS EKNKAVIHGD PFRIDFFEND
160 170 180 190 200
VLVVSVNAKN WLYFEHLRQK AQEPTSHPAE NENQQEQDAA VETPKAADTI
210 220 230 240 250
DDPGAWEENF KSHHDSKPYG PEAVALDFSF PAAKVLFGIP EHADSFILKS
260 270 280 290 300
TSGTDPYRLY NLDVFEYVVD SKMALYGSVP VIYGHGAQRT AGVYWQNAAE
310 320 330 340 350
TWVDIQTSET NVVSSLVNFV SGSQKTPPPA AHFMSESGIV DAFIMLGPKP
360 370 380 390 400
MDTFKQYAAL TGTHELPQLF ALAYHQSRWN YNDERDVTSV SAKFDEYNIP
410 420 430 440 450
MDTMWLDIEH TDGKRYFTWD KFKFPHPLAM IKNLTELGRH LVVIVDPHIK
460 470 480 490 500
RDNNYFFHRD CTDRGYYVKT REGNDYEGWC WPGAASYPDF FNPVVREYYA
510 520 530 540 550
SQYALDKFQT VTADVMLWND MNEPSVFNGP EITAPKDLIH YGNWEHRDVH
560 570 580 590 600
NLYGHMHLMG SFAGLQQRDP NQRPFILTRA HFAGSQRYAA IWTGDNFADW
610 620 630 640 650
SHLQHSVKMC LTEAVAGFSF CGADVGAFFG NPDTELLERW YQTGAFLPFF
660 670 680 690 700
RAHAHIDTKR REPWLFPERT RQVIQNAVIK RYSYLPLWYT AFYELELTGE
710 720 730 740 750
PVIRPLLAQY PLDKEAFGVD NQLLVQDRLL VRPVMQQGVS KVDVYFPAID
760 770 780 790 800
DKKNGDWWYD VDTYQRQERS GYVSVPVDDF KIPVWQRGGS IVPKKERQRR
810 820 830 840 850
ASTLMLHDPY TLIICLDRQG KASGSLYLDD EKSYAYRQGQ RIHVNYEFAH
860 870 880 890 900
DQLVNSFVGK PKYKTLAWIE RIVIAGLEKV PSSASITVNG VSQQLEVLHH
910 920
DNTVVVRKPG VKMDVDFAIK LNFA
Length:924
Mass (Da):105,731
Last modified:April 26, 2005 - v1
Checksum:i8EE23063677C4083
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145625 mRNA. Translation: AAD38600.1.
AE014298 Genomic DNA. Translation: AAF45432.1.
AE014298 Genomic DNA. Translation: AAG22460.1.
AE014298 Genomic DNA. Translation: AAN08995.1.
AE014298 Genomic DNA. Translation: AAN08996.1.
AE014298 Genomic DNA. Translation: AAN08997.1.
RefSeqiNP_652145.1. NM_143888.5.
NP_728434.1. NM_167757.3.
NP_728435.1. NM_167758.2.
NP_728436.1. NM_167759.2.
NP_728437.1. NM_167760.1.
UniGeneiDm.7659.

Genome annotation databases

EnsemblMetazoaiFBtr0070058; FBpp0070057; FBgn0027588.
FBtr0070059; FBpp0070058; FBgn0027588.
FBtr0070060; FBpp0070059; FBgn0027588.
FBtr0070061; FBpp0070060; FBgn0027588.
FBtr0070062; FBpp0070061; FBgn0027588.
GeneIDi49953.
KEGGidme:Dmel_CG14476.
UCSCiCG14476-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145625 mRNA. Translation: AAD38600.1.
AE014298 Genomic DNA. Translation: AAF45432.1.
AE014298 Genomic DNA. Translation: AAG22460.1.
AE014298 Genomic DNA. Translation: AAN08995.1.
AE014298 Genomic DNA. Translation: AAN08996.1.
AE014298 Genomic DNA. Translation: AAN08997.1.
RefSeqiNP_652145.1. NM_143888.5.
NP_728434.1. NM_167757.3.
NP_728435.1. NM_167758.2.
NP_728436.1. NM_167759.2.
NP_728437.1. NM_167760.1.
UniGeneiDm.7659.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0070057.

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070058; FBpp0070057; FBgn0027588.
FBtr0070059; FBpp0070058; FBgn0027588.
FBtr0070060; FBpp0070059; FBgn0027588.
FBtr0070061; FBpp0070060; FBgn0027588.
FBtr0070062; FBpp0070061; FBgn0027588.
GeneIDi49953.
KEGGidme:Dmel_CG14476.
UCSCiCG14476-RA. d. melanogaster.

Organism-specific databases

CTDi49953.
FlyBaseiFBgn0027588. GCS2alpha.

Phylogenomic databases

eggNOGiKOG1066. Eukaryota.
COG1501. LUCA.
GeneTreeiENSGT00760000119229.
KOiK05546.
OMAiFDEEREW.
OrthoDBiEOG7VQJDS.

Enzyme and pathway databases

ReactomeiR-DME-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-DME-901042. Calnexin/calreticulin cycle.

Miscellaneous databases

ChiTaRSiCG14476. fly.
GenomeRNAii49953.

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  4. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. Millard Andrew
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ7KMM4_DROME
AccessioniPrimary (citable) accession number: Q7KMM4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.