ID   Q7KLE5_DROME            Unreviewed;       602 AA.
AC   Q7KLE5;
DT   03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 161.
DE   SubName: Full=Amphiphysin {ECO:0000313|EMBL:AAD46684.1, ECO:0000313|EMBL:AAF58486.1};
DE   SubName: Full=LD19810p {ECO:0000313|EMBL:AAL28826.1};
GN   Name=Amph {ECO:0000313|EMBL:AAF58486.1,
GN   ECO:0000313|FlyBase:FBgn0027356};
GN   Synonyms=Amp {ECO:0000313|EMBL:AAF58486.1}, amph
GN   {ECO:0000313|EMBL:AAF58486.1}, DAMP {ECO:0000313|EMBL:AAF58486.1},
GN   Damp {ECO:0000313|EMBL:AAF58486.1}, dAmp
GN   {ECO:0000313|EMBL:AAF58486.1}, dAmph {ECO:0000313|EMBL:AAF58486.1},
GN   damph {ECO:0000313|EMBL:AAF58486.1}, Dmel\CG8604
GN   {ECO:0000313|EMBL:AAF58486.1};
GN   ORFNames=CG8604 {ECO:0000313|EMBL:AAF58486.1,
GN   ECO:0000313|FlyBase:FBgn0027356}, Dmel_CG8604
GN   {ECO:0000313|EMBL:AAF58486.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AAD46684.1};
RN   [1] {ECO:0000313|EMBL:CAB45188.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zhang Y.Q., Xue H., Broadie K.S.;
RT   "Dissecting the funtions of amphiphysin.";
RL   Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAD46684.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=10607911; DOI=10.1016/S0378-1119(99)00451-5;
RA   Razzaq A., Su Y., Mehren J.E., Mizuguchi K., Jackson A.P., Gay N.J.,
RA   O'Kane C.J.;
RT   "Characterisation of the gene for Drosophila amphiphysin.";
RL   Gene 241:167-174(2000).
RN   [3] {ECO:0000313|EMBL:AAF58486.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA   An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA   Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA   Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA   Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA   Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA   Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA   Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [4] {ECO:0000313|EMBL:AAL28826.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Berkeley {ECO:0000313|EMBL:AAL28826.1};
RA   Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA   Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M.,
RA   Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J.,
RA   Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E.,
RA   Rubin G.M., Celniker S.;
RL   Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:AAF58486.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT   euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [6] {ECO:0000313|EMBL:AAF58486.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [7] {ECO:0000313|EMBL:AAF58486.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA   Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin: a
RT   genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [8] {ECO:0000313|EMBL:AAF58486.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [9] {ECO:0007829|PDB:1URU}
RP   X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 1-244.
RX   PubMed=14645856; DOI=10.1126/science.1092586;
RA   Peter B.J., Kent H.M., Mills I.G., Vallis Y., Butler P.J., Evans P.R.,
RA   McMahon H.T.;
RT   "BAR domains as sensors of membrane curvature: the amphiphysin BAR
RT   structure.";
RL   Science 303:495-499(2004).
RN   [10] {ECO:0000313|EMBL:AAF58486.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [11] {ECO:0000313|EMBL:AAF58486.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA   Svirskas R., Rubin G.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:AAF58486.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [13] {ECO:0000313|EMBL:AAF58486.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
RN   [14] {ECO:0000313|EMBL:AAF58486.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26109357; DOI=.1534/g3.115.018929;
RG   FlyBase Consortium;
RA   Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E.,
RA   Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M.,
RA   Gelbart W.M., null;
RT   "Gene Model Annotations for Drosophila melanogaster: Impact of High-
RT   Throughput Data.";
RL   G3 (Bethesda) 5:1721-1736(2015).
RN   [15] {ECO:0000313|EMBL:AAF58486.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26109356; DOI=.1534/g3.115.018937;
RG   FlyBase Consortium;
RA   Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E.,
RA   Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M.,
RA   null;
RT   "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.";
RL   G3 (Bethesda) 5:1737-1749(2015).
RN   [16] {ECO:0000313|EMBL:AAF58486.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25589440;
RA   Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E.,
RA   Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M.,
RA   Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M.,
RA   de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M.,
RA   Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M.,
RA   Karpen G.H., Celniker S.E.;
RT   "The Release 6 reference sequence of the Drosophila melanogaster genome.";
RL   Genome Res. 25:445-458(2015).
RN   [17] {ECO:0000313|EMBL:AAF58486.1}
RP   NUCLEOTIDE SEQUENCE.
RG   FlyBase;
RL   Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|EMBL:AAF58486.1}
RP   NUCLEOTIDE SEQUENCE.
RG   Berkeley Drosophila Genome Project;
RA   Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA   Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C.,
RA   Rubin G.;
RT   "Drosophila melanogaster release 4 sequence.";
RL   Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AF171225; AAD46684.1; -; mRNA.
DR   EMBL; AE013599; AAF58486.1; -; Genomic_DNA.
DR   EMBL; AY061278; AAL28826.1; -; mRNA.
DR   EMBL; AJ242855; CAB45188.1; -; mRNA.
DR   RefSeq; NP_523717.1; NM_078993.3.
DR   PDB; 1URU; X-ray; 2.60 A; A=1-244.
DR   PDBsum; 1URU; -.
DR   AlphaFoldDB; Q7KLE5; -.
DR   EMDB; EMD-3192; -.
DR   EMDB; EMD-3193; -.
DR   EMDB; EMD-3194; -.
DR   EMDB; EMD-3195; -.
DR   EMDB; EMD-3196; -.
DR   SMR; Q7KLE5; -.
DR   IntAct; Q7KLE5; 15.
DR   STRING; 7227.FBpp0086941; -.
DR   PaxDb; 7227-FBpp0086941; -.
DR   DNASU; 36383; -.
DR   EnsemblMetazoa; FBtr0087828; FBpp0086941; FBgn0027356.
DR   GeneID; 36383; -.
DR   UCSC; CG8604-RA; d. melanogaster.
DR   AGR; FB:FBgn0027356; -.
DR   CTD; 273; -.
DR   FlyBase; FBgn0027356; Amph.
DR   VEuPathDB; VectorBase:FBgn0027356; -.
DR   eggNOG; KOG3771; Eukaryota.
DR   GeneTree; ENSGT00950000182882; -.
DR   HOGENOM; CLU_017859_4_0_1; -.
DR   InParanoid; Q7KLE5; -.
DR   OMA; QSKSCEK; -.
DR   OrthoDB; 4243832at2759; -.
DR   Reactome; R-DME-6798695; Neutrophil degranulation.
DR   Reactome; R-DME-8856828; Clathrin-mediated endocytosis.
DR   BioGRID-ORCS; 36383; 0 hits in 3 CRISPR screens.
DR   ChiTaRS; Amph; fly.
DR   EvolutionaryTrace; Q7KLE5; -.
DR   GenomeRNAi; 36383; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   Bgee; FBgn0027356; Expressed in adult Malpighian tubule (Drosophila) and 41 other cell types or tissues.
DR   ExpressionAtlas; Q7KLE5; baseline and differential.
DR   GO; GO:0032154; C:cleavage furrow; IDA:FlyBase.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0043226; C:organelle; IEA:UniProt.
DR   GO; GO:0005886; C:plasma membrane; IDA:FlyBase.
DR   GO; GO:0045202; C:synapse; IDA:FlyBase.
DR   GO; GO:0005543; F:phospholipid binding; ISS:FlyBase.
DR   GO; GO:0006887; P:exocytosis; TAS:FlyBase.
DR   GO; GO:0008104; P:protein localization; IMP:FlyBase.
DR   GO; GO:0006937; P:regulation of muscle contraction; IMP:FlyBase.
DR   GO; GO:0042052; P:rhabdomere development; IMP:FlyBase.
DR   GO; GO:0045313; P:rhabdomere membrane biogenesis; IMP:FlyBase.
DR   CDD; cd07588; BAR_Amphiphysin; 1.
DR   CDD; cd11790; SH3_Amphiphysin; 1.
DR   DisProt; DP02272; -.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR003005; Amphiphysin.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR46514; AMPHIPHYSIN; 1.
DR   PANTHER; PTHR46514:SF3; ENDOPHILIN-A; 1.
DR   Pfam; PF03114; BAR; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR01251; AMPHIPHYSIN.
DR   SMART; SM00721; BAR; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS51021; BAR; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:1URU};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:Q7KLE5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          24..242
FT                   /note="BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51021"
FT   DOMAIN          538..602
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          241..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          478..501
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..314
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..367
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        393..409
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        417..432
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   602 AA;  65902 MW;  86D1D4CBAE1B8F31 CRC64;
     MTENKGIMLA KSVQKHAGRA KEKILQNLGK VDRTADEIFD DHLNNFNRQQ ASANRLQKEF
     NNYIRCVRAA QAASKTLMDS VCEIYEPQWS GYDALQAQTG ASESLWADFA HKLGDQVLIP
     LNTYTGQFPE MKKKVEKRNR KLIDYDGQRH SFQNLQANAN KRKDDVKLTK GREQLEEARR
     TYEILNTELH DELPALYDSR ILFLVTNLQT LFATEQVFHN ETAKIYSELE AIVDKLATES
     QRGSNTLRKQ TSNPIKTSSP VQSPVNKLNN ANINSNYQNQ ITTNGGSSLA NSPTSTSSSL
     QEPRFDSVSS TPEPRPESPA AALVSATPSS PVENGVTTKS LERPELSGLN ASAKATTTTQ
     TSPTEDKAVV SEAVKPSETE GAAVAASVTP APPATPAQIN GNNNEPSIVK EGGKQPKELP
     STTSNAEAAA EAAANNGNSI EEHKQKKLGN DTTVTATETV TVTQHSVTST DTDNIVTISD
     TNTDTDTKTS TGTSQKGRPV PVVNRHSVNN LNKNPFEDDD ERIYEVPADA NTADLPPGVL
     YRVKATYGYA KEDVDELSFE IGDLIRVIEY DDPEDQEEGW LMGQKEGTNE KGLFPANFTR
     PI
//