Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Amphiphysin

Gene

Amph

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • exocytosis Source: FlyBase
  • protein localization Source: FlyBase
  • regulation of muscle contraction Source: FlyBase
  • rhabdomere development Source: FlyBase
  • rhabdomere membrane biogenesis Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Submitted name:
AmphiphysinImported
Submitted name:
Amphiphysin, isoform AImported
Submitted name:
LD19810pImported
Gene namesi
Name:AmphImported
Synonyms:AmpImported
ORF Names:CG8604Imported, Dmel_CG8604Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0027356 Amph

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0027356

Interactioni

Protein-protein interaction databases

IntActiQ7KLE5 28 interactors.
STRINGi7227.FBpp0086941

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1URUX-ray2.60A1-244[»]
SMRiQ7KLE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 242BARInterPro annotationAdd BLAST219
Domaini538 – 602SH3InterPro annotationAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili168 – 192Sequence analysisAdd BLAST25

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3771 Eukaryota
ENOG410ZBW1 LUCA
GeneTreeiENSGT00390000017588
OrthoDBiEOG091G0JRY

Family and domain databases

Gene3Di1.20.1270.601 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR003005 Amphiphysin
IPR003017 Amphiphysin_1
IPR004148 BAR_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR44669 PTHR44669, 2 hits
PfamiView protein in Pfam
PF03114 BAR, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR01251 AMPHIPHYSIN
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q7KLE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTENKGIMLA KSVQKHAGRA KEKILQNLGK VDRTADEIFD DHLNNFNRQQ
60 70 80 90 100
ASANRLQKEF NNYIRCVRAA QAASKTLMDS VCEIYEPQWS GYDALQAQTG
110 120 130 140 150
ASESLWADFA HKLGDQVLIP LNTYTGQFPE MKKKVEKRNR KLIDYDGQRH
160 170 180 190 200
SFQNLQANAN KRKDDVKLTK GREQLEEARR TYEILNTELH DELPALYDSR
210 220 230 240 250
ILFLVTNLQT LFATEQVFHN ETAKIYSELE AIVDKLATES QRGSNTLRKQ
260 270 280 290 300
TSNPIKTSSP VQSPVNKLNN ANINSNYQNQ ITTNGGSSLA NSPTSTSSSL
310 320 330 340 350
QEPRFDSVSS TPEPRPESPA AALVSATPSS PVENGVTTKS LERPELSGLN
360 370 380 390 400
ASAKATTTTQ TSPTEDKAVV SEAVKPSETE GAAVAASVTP APPATPAQIN
410 420 430 440 450
GNNNEPSIVK EGGKQPKELP STTSNAEAAA EAAANNGNSI EEHKQKKLGN
460 470 480 490 500
DTTVTATETV TVTQHSVTST DTDNIVTISD TNTDTDTKTS TGTSQKGRPV
510 520 530 540 550
PVVNRHSVNN LNKNPFEDDD ERIYEVPADA NTADLPPGVL YRVKATYGYA
560 570 580 590 600
KEDVDELSFE IGDLIRVIEY DDPEDQEEGW LMGQKEGTNE KGLFPANFTR

PI
Length:602
Mass (Da):65,902
Last modified:October 3, 2006 - v1
Checksum:i86D1D4CBAE1B8F31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF171225 mRNA Translation: AAD46684.1
AE013599 Genomic DNA Translation: AAF58486.1
AY061278 mRNA Translation: AAL28826.1
AJ242855 mRNA Translation: CAB45188.1
RefSeqiNP_523717.1, NM_078993.3
UniGeneiDm.3121

Genome annotation databases

EnsemblMetazoaiFBtr0087828; FBpp0086941; FBgn0027356
GeneIDi36383
UCSCiCG8604-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ7KLE5_DROME
AccessioniPrimary (citable) accession number: Q7KLE5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported