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Q7KLE5

- Q7KLE5_DROME

UniProt

Q7KLE5 - Q7KLE5_DROME

Protein
Submitted name:

Amphiphysin

Gene

Amph

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. exocytosis Source: FlyBase
    2. neurotransmitter secretion Source: FlyBase
    3. protein localization Source: FlyBase
    4. regulation of muscle contraction Source: FlyBase
    5. rhabdomere development Source: FlyBase
    6. rhabdomere membrane biogenesis Source: FlyBase
    7. synaptic vesicle endocytosis Source: FlyBase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    AmphiphysinImported
    Submitted name:
    LD19810pImported
    Gene namesi
    Name:AmphImported
    Synonyms:AmpImported
    ORF Names:CG8604Imported, Dmel_CG8604Imported
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0027356. Amph.

    Subcellular locationi

    GO - Cellular componenti

    1. cleavage furrow Source: FlyBase
    2. cytoplasm Source: InterPro
    3. plasma membrane Source: FlyBase
    4. synapse Source: FlyBase

    Interactioni

    Protein-protein interaction databases

    STRINGi7227.FBpp0086941.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1URUX-ray2.60A1-244[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ7KLE5.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SH3 domain.UniRule annotation

    Keywords - Domaini

    SH3 domainUniRule annotation

    Phylogenomic databases

    eggNOGiNOG264615.
    GeneTreeiENSGT00390000017588.
    InParanoidiQ7KLE5.
    KOiK12562.
    OMAiEIYEPQW.
    OrthoDBiEOG7KSX87.

    Family and domain databases

    Gene3Di1.20.1270.60. 1 hit.
    InterProiIPR027267. AH/BAR-dom.
    IPR003005. Amphiphysin.
    IPR004148. BAR_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF03114. BAR. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR01251. AMPHIPHYSIN.
    SMARTiSM00721. BAR. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS51021. BAR. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7KLE5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTENKGIMLA KSVQKHAGRA KEKILQNLGK VDRTADEIFD DHLNNFNRQQ    50
    ASANRLQKEF NNYIRCVRAA QAASKTLMDS VCEIYEPQWS GYDALQAQTG 100
    ASESLWADFA HKLGDQVLIP LNTYTGQFPE MKKKVEKRNR KLIDYDGQRH 150
    SFQNLQANAN KRKDDVKLTK GREQLEEARR TYEILNTELH DELPALYDSR 200
    ILFLVTNLQT LFATEQVFHN ETAKIYSELE AIVDKLATES QRGSNTLRKQ 250
    TSNPIKTSSP VQSPVNKLNN ANINSNYQNQ ITTNGGSSLA NSPTSTSSSL 300
    QEPRFDSVSS TPEPRPESPA AALVSATPSS PVENGVTTKS LERPELSGLN 350
    ASAKATTTTQ TSPTEDKAVV SEAVKPSETE GAAVAASVTP APPATPAQIN 400
    GNNNEPSIVK EGGKQPKELP STTSNAEAAA EAAANNGNSI EEHKQKKLGN 450
    DTTVTATETV TVTQHSVTST DTDNIVTISD TNTDTDTKTS TGTSQKGRPV 500
    PVVNRHSVNN LNKNPFEDDD ERIYEVPADA NTADLPPGVL YRVKATYGYA 550
    KEDVDELSFE IGDLIRVIEY DDPEDQEEGW LMGQKEGTNE KGLFPANFTR 600
    PI 602
    Length:602
    Mass (Da):65,902
    Last modified:October 3, 2006 - v1
    Checksum:i86D1D4CBAE1B8F31
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF171225 mRNA. Translation: AAD46684.1.
    AE013599 Genomic DNA. Translation: AAF58486.1.
    AY061278 mRNA. Translation: AAL28826.1.
    AJ242855 mRNA. Translation: CAB45188.1.
    RefSeqiNP_523717.1. NM_078993.3.
    UniGeneiDm.3121.

    Genome annotation databases

    EnsemblMetazoaiFBtr0087828; FBpp0086941; FBgn0027356.
    GeneIDi36383.
    KEGGidme:Dmel_CG8604.
    UCSCiCG8604-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF171225 mRNA. Translation: AAD46684.1 .
    AE013599 Genomic DNA. Translation: AAF58486.1 .
    AY061278 mRNA. Translation: AAL28826.1 .
    AJ242855 mRNA. Translation: CAB45188.1 .
    RefSeqi NP_523717.1. NM_078993.3.
    UniGenei Dm.3121.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1URU X-ray 2.60 A 1-244 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7227.FBpp0086941.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0087828 ; FBpp0086941 ; FBgn0027356 .
    GeneIDi 36383.
    KEGGi dme:Dmel_CG8604.
    UCSCi CG8604-RA. d. melanogaster.

    Organism-specific databases

    CTDi 273.
    FlyBasei FBgn0027356. Amph.

    Phylogenomic databases

    eggNOGi NOG264615.
    GeneTreei ENSGT00390000017588.
    InParanoidi Q7KLE5.
    KOi K12562.
    OMAi EIYEPQW.
    OrthoDBi EOG7KSX87.

    Miscellaneous databases

    ChiTaRSi Amph. drosophila.
    EvolutionaryTracei Q7KLE5.
    GenomeRNAii 36383.
    NextBioi 798246.
    PROi Q7KLE5.

    Family and domain databases

    Gene3Di 1.20.1270.60. 1 hit.
    InterProi IPR027267. AH/BAR-dom.
    IPR003005. Amphiphysin.
    IPR004148. BAR_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF03114. BAR. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01251. AMPHIPHYSIN.
    SMARTi SM00721. BAR. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS51021. BAR. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dissecting the funtions of amphiphysin."
      Zhang Y.Q., Xue H., Broadie K.S.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Characterisation of the gene for Drosophila amphiphysin."
      Razzaq A., Su Y., Mehren J.E., Mizuguchi K., Jackson A.P., Gay N.J., O'Kane C.J.
      Gene 241:167-174(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BerkeleyImported.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    6. Cited for: GENOME REANNOTATION.
      Strain: BerkeleyImported.
    7. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
      Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
      Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    8. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
      Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
      Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    9. "BAR domains as sensors of membrane curvature: the amphiphysin BAR structure."
      Peter B.J., Kent H.M., Mills I.G., Vallis Y., Butler P.J., Evans P.R., McMahon H.T.
      Science 303:495-499(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 1-244.
    10. "Combined evidence annotation of transposable elements in genome sequences."
      Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
      PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    11. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    12. "Drosophila melanogaster release 4 sequence."
      Berkeley Drosophila Genome Project
      Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    13. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
      Smith C.D., Shu S., Mungall C.J., Karpen G.H.
      Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    14. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    15. FlyBase
      Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ7KLE5_DROME
    AccessioniPrimary (citable) accession number: Q7KLE5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 3, 2006
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3