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Q7KLE5

- Q7KLE5_DROME

UniProt

Q7KLE5 - Q7KLE5_DROME

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Protein
Submitted name:

Amphiphysin

Gene

Amph

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. exocytosis Source: FlyBase
  2. neurotransmitter secretion Source: FlyBase
  3. protein localization Source: FlyBase
  4. regulation of muscle contraction Source: FlyBase
  5. rhabdomere development Source: FlyBase
  6. rhabdomere membrane biogenesis Source: FlyBase
  7. synaptic vesicle endocytosis Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
AmphiphysinImported
Submitted name:
LD19810pImported
Gene namesi
Name:AmphImported
Synonyms:AmpImported
ORF Names:CG8604Imported, Dmel_CG8604Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0027356. Amph.

Subcellular locationi

GO - Cellular componenti

  1. cleavage furrow Source: FlyBase
  2. cytoplasm Source: InterPro
  3. plasma membrane Source: FlyBase
  4. synapse Source: FlyBase
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0086941.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1URUX-ray2.60A1-244[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7KLE5.

Family & Domainsi

Sequence similaritiesi

Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotation

Phylogenomic databases

eggNOGiNOG264615.
GeneTreeiENSGT00390000017588.
KOiK12562.
OMAiEIYEPQW.
OrthoDBiEOG7KSX87.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR003005. Amphiphysin.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR01251. AMPHIPHYSIN.
SMARTiSM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7KLE5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTENKGIMLA KSVQKHAGRA KEKILQNLGK VDRTADEIFD DHLNNFNRQQ
60 70 80 90 100
ASANRLQKEF NNYIRCVRAA QAASKTLMDS VCEIYEPQWS GYDALQAQTG
110 120 130 140 150
ASESLWADFA HKLGDQVLIP LNTYTGQFPE MKKKVEKRNR KLIDYDGQRH
160 170 180 190 200
SFQNLQANAN KRKDDVKLTK GREQLEEARR TYEILNTELH DELPALYDSR
210 220 230 240 250
ILFLVTNLQT LFATEQVFHN ETAKIYSELE AIVDKLATES QRGSNTLRKQ
260 270 280 290 300
TSNPIKTSSP VQSPVNKLNN ANINSNYQNQ ITTNGGSSLA NSPTSTSSSL
310 320 330 340 350
QEPRFDSVSS TPEPRPESPA AALVSATPSS PVENGVTTKS LERPELSGLN
360 370 380 390 400
ASAKATTTTQ TSPTEDKAVV SEAVKPSETE GAAVAASVTP APPATPAQIN
410 420 430 440 450
GNNNEPSIVK EGGKQPKELP STTSNAEAAA EAAANNGNSI EEHKQKKLGN
460 470 480 490 500
DTTVTATETV TVTQHSVTST DTDNIVTISD TNTDTDTKTS TGTSQKGRPV
510 520 530 540 550
PVVNRHSVNN LNKNPFEDDD ERIYEVPADA NTADLPPGVL YRVKATYGYA
560 570 580 590 600
KEDVDELSFE IGDLIRVIEY DDPEDQEEGW LMGQKEGTNE KGLFPANFTR

PI
Length:602
Mass (Da):65,902
Last modified:October 3, 2006 - v1
Checksum:i86D1D4CBAE1B8F31
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF171225 mRNA. Translation: AAD46684.1.
AE013599 Genomic DNA. Translation: AAF58486.1.
AY061278 mRNA. Translation: AAL28826.1.
AJ242855 mRNA. Translation: CAB45188.1.
RefSeqiNP_523717.1. NM_078993.3.
UniGeneiDm.3121.

Genome annotation databases

EnsemblMetazoaiFBtr0087828; FBpp0086941; FBgn0027356.
GeneIDi36383.
KEGGidme:Dmel_CG8604.
UCSCiCG8604-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF171225 mRNA. Translation: AAD46684.1 .
AE013599 Genomic DNA. Translation: AAF58486.1 .
AY061278 mRNA. Translation: AAL28826.1 .
AJ242855 mRNA. Translation: CAB45188.1 .
RefSeqi NP_523717.1. NM_078993.3.
UniGenei Dm.3121.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1URU X-ray 2.60 A 1-244 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7227.FBpp0086941.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0087828 ; FBpp0086941 ; FBgn0027356 .
GeneIDi 36383.
KEGGi dme:Dmel_CG8604.
UCSCi CG8604-RA. d. melanogaster.

Organism-specific databases

CTDi 273.
FlyBasei FBgn0027356. Amph.

Phylogenomic databases

eggNOGi NOG264615.
GeneTreei ENSGT00390000017588.
KOi K12562.
OMAi EIYEPQW.
OrthoDBi EOG7KSX87.

Miscellaneous databases

ChiTaRSi Amph. drosophila.
EvolutionaryTracei Q7KLE5.
GenomeRNAii 36383.
NextBioi 798246.
PROi Q7KLE5.

Family and domain databases

Gene3Di 1.20.1270.60. 1 hit.
InterProi IPR027267. AH/BAR-dom.
IPR003005. Amphiphysin.
IPR004148. BAR_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF03114. BAR. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR01251. AMPHIPHYSIN.
SMARTi SM00721. BAR. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS51021. BAR. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dissecting the funtions of amphiphysin."
    Zhang Y.Q., Xue H., Broadie K.S.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Characterisation of the gene for Drosophila amphiphysin."
    Razzaq A., Su Y., Mehren J.E., Mizuguchi K., Jackson A.P., Gay N.J., O'Kane C.J.
    Gene 241:167-174(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  7. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  9. "BAR domains as sensors of membrane curvature: the amphiphysin BAR structure."
    Peter B.J., Kent H.M., Mills I.G., Vallis Y., Butler P.J., Evans P.R., McMahon H.T.
    Science 303:495-499(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 1-244.
  10. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  13. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  14. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  15. FlyBase
    Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ7KLE5_DROME
AccessioniPrimary (citable) accession number: Q7KLE5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3