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Protein

Structural maintenance of chromosomes protein

Gene

SMC2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • mitotic chromosome condensation Source: FlyBase
  • mitotic nuclear division Source: FlyBase
  • mitotic spindle organization Source: FlyBase
  • neurogenesis Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Enzyme and pathway databases

ReactomeiR-DME-2514853. Condensation of Prometaphase Chromosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes proteinUniRule annotation
Gene namesi
Name:SMC2Imported
ORF Names:CG10212Imported, Dmel_CG10212Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0027783. SMC2.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

  • chromatin Source: FlyBase
  • condensin complex Source: FlyBase
  • cytoplasm Source: FlyBase
  • microtubule associated complex Source: FlyBase
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7227.FBpp0086591.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini518 – 638121SMC_hingeInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili317 – 36549Sequence analysisAdd
BLAST
Coiled coili679 – 71335Sequence analysisAdd
BLAST
Coiled coili729 – 76335Sequence analysisAdd
BLAST
Coiled coili817 – 935119Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SMC family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0933. Eukaryota.
COG1196. LUCA.
GeneTreeiENSGT00550000074857.
KOiK06674.
OMAiCQNGKIP.
OrthoDBiEOG7SR4KV.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR027120. Smc2.
IPR010935. SMC_hinge.
[Graphical view]
PANTHERiPTHR18937:SF9. PTHR18937:SF9. 1 hit.
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7KK96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVKKLVLDG FKSYGRRTEI EGFDPEFTAI TGLNGSGKSN ILDSICFVLG
60 70 80 90 100
ISNLQNVRAS ALQDLVYKNG QAGITKATVT IVFDNTNPAQ CPQGYEKCRE
110 120 130 140 150
ISVTRQVVVG GKNKFLINGK LVQNKKVQDF FCSIQLNVNN PNFLIMQGKI
160 170 180 190 200
QQVLNMKPKE VLSMVEEAAG TSQYKTKRDA TKTLIEKKET KVRETKVLLD
210 220 230 240 250
EEVLPKLVKL RQERSAYQEY QKICRDIDFL IRIHISAKYL KQCETLKTVE
260 270 280 290 300
ANEHKIEDRI ANCKATHAKN LAEVESIENS VKEMQQQIDA EMGGSIKNLE
310 320 330 340 350
TQLSAKRALE ATATGSLKAA QGTIQQDEKK IRMASKNIED DERALAKKEA
360 370 380 390 400
DMAKVQGEFE SLKEADARDS KAYEDAQKKL EAVSQGLSTN ENGEASTLQE
410 420 430 440 450
QLIVAKEQFS EAQTTIKTSE IELRHTRGVL KQREGETQTN DAAYVKDKKL
460 470 480 490 500
HDQLVVEIKN LERQLQSLDY EGGHFEKLKQ RRNDLHMRKR DLKRELDRCN
510 520 530 540 550
ASRYDLQYQD PEPNFDRRKV RGLVGKLFQV KDMQNSMALV QTAGGSLYSY
560 570 580 590 600
VTDDDVTSKK ILQRGNLQRR VTLIPINKIQ SGSLNRNVVE YAQNKVGAEN
610 620 630 640 650
VQWAMSLIDY DRYYEPVMKF CFGGTLICKD LIVAKQISYD PRINCRSVTL
660 670 680 690 700
EGDVVDPHGT VSGGAAPKGA NVLEELHAIK QIEKEYREID SEIAQVEKQI
710 720 730 740 750
ASIENQALAF NKMKENLDLR QHELTMCENR LAQTTFQQNQ AEIEEMRERV
760 770 780 790 800
KTLEQQIIDS REKQKTSQAK IVDIEAKLAD AKGYRERELN AATNEIKVTK
810 820 830 840 850
QRAEKSRANW KKREQEFETL QLEITELQKS IETAKKQHQE MIDNLEKFKA
860 870 880 890 900
ELDALKVNSS SAASEVTELE QAIKEQKDKL RDQNKEMRNQ LVKKEKMLKE
910 920 930 940 950
NQEIELEVKK KENEQKKISS DAKEAKKRME ALEAKYPWIP EEKNCFGMKN
960 970 980 990 1000
TRYDYSKEDP HEAGNKLAKM QEKKDKMERT LNMNAIMVLD REEENFKETE
1010 1020 1030 1040 1050
RRRNIVAMDK EKIKKIIVKM DEEEQDQLNK AATEVNTNFS GIFSSLLPGA
1060 1070 1080 1090 1100
EAKLNPVHTN GCLTGLEIKV GFNGIWKESL GELSGGQKSL VALSLVLAML
1110 1120 1130 1140 1150
KFSPAPLYIL DEVDAALDMS HTQNIGSMLK QHFTNSQFLI VSLKDGLFNH
1160 1170
ANVLFRTLFE EGVSTITRQV SRQATTNKR
Length:1,179
Mass (Da):134,335
Last modified:October 3, 2006 - v1
Checksum:i12F8DE3ADF5E4121
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179287 mRNA. Translation: AAD52673.1.
AE013599 Genomic DNA. Translation: AAF58197.1.
RefSeqiNP_610995.1. NM_137151.4.
UniGeneiDm.2168.

Genome annotation databases

EnsemblMetazoaiFBtr0087461; FBpp0086591; FBgn0027783.
GeneIDi36653.
KEGGidme:Dmel_CG10212.
UCSCiCG10212-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179287 mRNA. Translation: AAD52673.1.
AE013599 Genomic DNA. Translation: AAF58197.1.
RefSeqiNP_610995.1. NM_137151.4.
UniGeneiDm.2168.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0086591.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087461; FBpp0086591; FBgn0027783.
GeneIDi36653.
KEGGidme:Dmel_CG10212.
UCSCiCG10212-RA. d. melanogaster.

Organism-specific databases

CTDi10592.
FlyBaseiFBgn0027783. SMC2.

Phylogenomic databases

eggNOGiKOG0933. Eukaryota.
COG1196. LUCA.
GeneTreeiENSGT00550000074857.
KOiK06674.
OMAiCQNGKIP.
OrthoDBiEOG7SR4KV.

Enzyme and pathway databases

ReactomeiR-DME-2514853. Condensation of Prometaphase Chromosomes.

Miscellaneous databases

GenomeRNAii36653.
NextBioi799708.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR027120. Smc2.
IPR010935. SMC_hinge.
[Graphical view]
PANTHERiPTHR18937:SF9. PTHR18937:SF9. 1 hit.
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DmSMC2."
    Cobbe N., Steffensen S., Sunkel C., Coehlo P.A., Heck M.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. FlyBase
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ7KK96_DROME
AccessioniPrimary (citable) accession number: Q7KK96
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: May 11, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.