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Protein
Submitted name:

Anaplastic lymphoma kinase, isoform A

Gene

Alk

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • activation of MAPKK activity Source: FlyBase
  • axon guidance Source: FlyBase
  • compound eye photoreceptor development Source: FlyBase
  • digestive tract development Source: FlyBase
  • mesoderm development Source: FlyBase
  • negative regulation of cell size Source: FlyBase
  • negative regulation of neuromuscular synaptic transmission Source: FlyBase
  • positive regulation of ERK1 and ERK2 cascade Source: FlyBase
  • positive regulation of MAPK cascade Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • regulation of growth Source: FlyBase
  • regulation of hemocyte differentiation Source: FlyBase
  • regulation of olfactory learning Source: FlyBase
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
  • visceral muscle development Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, ReceptorImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Anaplastic lymphoma kinase, isoform AImported
Submitted name:
Anaplastic lymphoma kinase, isoform BImported (EC:2.7.10.-Imported, EC:2.7.10.1Imported, EC:2.7.10.2Imported)
Submitted name:
Receptor protein tyrosine kinase ALK splice variant AImported
Gene namesi
Name:AlkImported
ORF Names:CG8250Imported, Dmel_CG8250Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0040505. Alk.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1104 – 112825HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • subsynaptic reticulum Source: FlyBase
  • type Ib terminal bouton Source: FlyBase
  • type Is terminal bouton Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 17011678Sequence analysisPRO_5007711102Add
BLAST

Expressioni

Gene expression databases

BgeeiFBgn0040505.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0304259.

Structurei

3D structure databases

SMRiQ7KJ08. Positions 1158-1497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini286 – 450165MAMInterPro annotationAdd
BLAST
Domaini503 – 691189MAMInterPro annotationAdd
BLAST
Domaini1193 – 1462270Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
ENOG410XPVX. LUCA.
GeneTreeiENSGT00760000118818.
KOiK05119.
OMAiNAIMLSK.
OrthoDBiEOG091G0150.
PhylomeDBiQ7KJ08.

Family and domain databases

CDDicd06263. MAM. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR002172. LDrepeatLR_classA_rpt.
IPR000998. MAM_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF00629. MAM. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00137. MAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50068. LDLRA_2. 1 hit.
PS50060. MAM_2. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7KJ08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLRQLVVV LAILSLLVDP SFAQRPLIMN HTFSSLPMSQ HPSFNSWPSA
60 70 80 90 100
SGGKQLRNGR LHEQPLPLPQ PTLPVATQYE DYEAAPPGSR RDNKRRLAQM
110 120 130 140 150
AQRPGSGNGG RRGMESLRKE LMNPSVGGPG GGISGGGSGY PSYSATSSIG
160 170 180 190 200
RIDGLGQGLG SADRYGALYD QLRQPSGMAA MTAGPLGGPY STRFPPLYAG
210 220 230 240 250
VDDQPKRSNR KNSISELYKL KKALNQADEP AGGVTHGNFE GDPQPSSADP
260 270 280 290 300
LQEIKDRIRD TSPNANTYAP HTDATPSSEY EYELGVKCNF ETPCSWTWGN
310 320 330 340 350
YSDGFQVITG TELSKRNLTG LLPGPAADSI DDANGHFLYA RVNPSSRPLN
360 370 380 390 400
LTSPEFSTTM EKCFLEVYMH QSDMSHGLSR VVVELLHTAE SSWVPAEILG
410 420 430 440 450
DNVRQWTRKV YRLGRVSRDF RIVFEVVPDL RVGQKGHVAL DNLRMVNCFP
460 470 480 490 500
EGTKSEKCST SQVKCTSSKV PVCIHLPRIC DITRDCDEAE DEQQSCDKIP
510 520 530 540 550
YGGRCDFEED WCGWRDSGKT TLTWSRHTGS SPTHDTGPDG DHTMQHLQNN
560 570 580 590 600
TSGYYMLVNM NQHMNNSEKN SIIGFASNAI MVSKTFNPPP SVHGNPDSPY
610 620 630 640 650
RNSCVVRFFI HQFGKNPGSI NLSVVEMKEK ENITTTLWWS TKNQGSDWMR
660 670 680 690 700
AEYVLPNITS KYYLQFEARM GMRIYSDVAV DDFSLSPECF GLNIPEDHLG
710 720 730 740 750
GYNYWDVRQN LKSPTYKDFE YTNYLELTTC DTRGMIGPSQ AQCEAAYREQ
760 770 780 790 800
NKTHVLREVH VVEDQSSYKG MQKWKVPHEG HYTIIAKGAS GGLGSGGVGS
810 820 830 840 850
SRGSVAVAIL ELHKNEELYF LVGQQGENAC IKSMGVLKEA GCGTDHDLDL
860 870 880 890 900
AQYSFRSKQD MVKNIYIENG AGGGGGGSYV FLLNQAKNEA VPLLVAGGGG
910 920 930 940 950
GLGIGQYIDE DFQHGQKAKP LQAPESGQIN GEPLNKKTAG PGGGWRAKED
960 970 980 990 1000
QALSPTYGAA LLQGGRGGHS CYVELADNGT SVHRHGQGGF GGGGGGCNTG
1010 1020 1030 1040 1050
GGGGGYAGGD VYLTESNGEG GSSYISPSRS LREISEIHAG ASSGPGAIII
1060 1070 1080 1090 1100
IPAIEGCGCD YRCVALDEFR SKVRCICPDG WSLKRDNHTA CEIREEAGKS
1110 1120 1130 1140 1150
SFQYLVSILM ISLAVLFICI AALIFMLYNR YQRKKQSKKR HKMLVEQDLQ
1160 1170 1180 1190 1200
LTRLRNNIDD SNLNNFNPNY GCDGILNGHI DVNSLPQVAR DSLQLVNALG
1210 1220 1230 1240 1250
KGAFGEVYMA LYRHRDGDAV EMGVAVKTLR EDPKREKEED FLKEAAIMAK
1260 1270 1280 1290 1300
FNHPNMVHLI GVCFDRQPYY IVLELLAGGD LQKFLRENRN TPERPSLLTM
1310 1320 1330 1340 1350
KDLLFCALDV AKGCRYMESK RFIHRDIAAR NCLLSSKGPG RVVKIADFGM
1360 1370 1380 1390 1400
SRDIYRSDYY RKGGKAMLPI KWMPPEAFLD GIFTSKTDVW SFGILLWEVF
1410 1420 1430 1440 1450
SLGRSPYPGQ HNTQVMELVV RGGRLGSPTE CPVSIYKVMA DCWNPTPEDR
1460 1470 1480 1490 1500
PTFITLLEHL TACTQDASIM NAPLPNILGP TASERDDTVI RPPNGEEFCL
1510 1520 1530 1540 1550
AVPDYLVPLP PGGSNNPSMA SGSGYVPELQ RQQMSSCTPP AVTSPAAPHP
1560 1570 1580 1590 1600
RPVENIAPTS GDCWETSFIL PNSKVEPPVV GSGHDVPLAG GEEAKLISLD
1610 1620 1630 1640 1650
TPQPTPTTIQ PPLSFASQLD GITLDPSALT KSLPNGNAKQ SYANVQVKNE
1660 1670 1680 1690 1700
AEAKVINGVV GNGTVMNGDV STGSGGADSP FTIQGYAERY KDNNNHSEIS

C
Length:1,701
Mass (Da):185,579
Last modified:October 3, 2006 - v1
Checksum:iDBE6E5E54320342D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236106 mRNA. Translation: AAF36990.1.
AE013599 Genomic DNA. Translation: AAF57973.1.
AE013599 Genomic DNA. Translation: AGB93559.1.
RefSeqiNP_001261027.1. NM_001274098.1.
NP_652600.1. NM_144343.3.
UniGeneiDm.3324.

Genome annotation databases

EnsemblMetazoaiFBtr0087118; FBpp0086264; FBgn0040505.
FBtr0331926; FBpp0304259; FBgn0040505.
GeneIDi53425.
KEGGidme:Dmel_CG8250.
UCSCiCG8250-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236106 mRNA. Translation: AAF36990.1.
AE013599 Genomic DNA. Translation: AAF57973.1.
AE013599 Genomic DNA. Translation: AGB93559.1.
RefSeqiNP_001261027.1. NM_001274098.1.
NP_652600.1. NM_144343.3.
UniGeneiDm.3324.

3D structure databases

SMRiQ7KJ08. Positions 1158-1497.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0304259.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087118; FBpp0086264; FBgn0040505.
FBtr0331926; FBpp0304259; FBgn0040505.
GeneIDi53425.
KEGGidme:Dmel_CG8250.
UCSCiCG8250-RA. d. melanogaster.

Organism-specific databases

CTDi238.
FlyBaseiFBgn0040505. Alk.

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
ENOG410XPVX. LUCA.
GeneTreeiENSGT00760000118818.
KOiK05119.
OMAiNAIMLSK.
OrthoDBiEOG091G0150.
PhylomeDBiQ7KJ08.

Miscellaneous databases

GenomeRNAii53425.

Gene expression databases

BgeeiFBgn0040505.

Family and domain databases

CDDicd06263. MAM. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR002172. LDrepeatLR_classA_rpt.
IPR000998. MAM_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF00629. MAM. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00137. MAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50068. LDLRA_2. 1 hit.
PS50060. MAM_2. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7KJ08_DROME
AccessioniPrimary (citable) accession number: Q7KJ08
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.