Q7KJ08 (Q7KJ08_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Alk EMBL AAF57973.1
EC=2.7.10.- EMBL AAF57973.1
EC=2.7.10.1 EMBL AAF57973.1

Submitted name:
Receptor protein tyrosine kinase ALK splice variant A EMBL AAF36990.1

Gene names

Name:	Alk EMBL AAF57973.1 FlyBase FBgn0040505
ORF Names:	CG8250 FlyBase FBgn0040505, Dmel_CG8250 EMBL AAF57973.1

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome] EMBL AAF36990.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	1701 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS002011
Sequence similarities	Contains 1 protein kinase domain. SAAS SAAS002011

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS002011 Nucleotide-binding
Molecular function	Kinase Receptor EMBL AAF36990.1 Transferase Tyrosine-protein kinase SAAS SAAS002011
PTM	Phosphoprotein SAAS SAAS002011
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of MAPKK activity Inferred from mutant phenotype PubMed 12855999. Source: FlyBase axon guidance Inferred from mutant phenotype PubMed 17350579. Source: FlyBase compound eye photoreceptor development Inferred from mutant phenotype PubMed 17350579. Source: FlyBase digestive tract development Inferred from mutant phenotype PubMed 12855999. Source: FlyBase mesoderm development Inferred from mutant phenotype PubMed 17350579. Source: FlyBase negative regulation of cell size Inferred from mutant phenotype PubMed 21949657. Source: FlyBase positive regulation of ERK1 and ERK2 cascade Inferred from mutant phenotype PubMed 21949657. Source: FlyBase regulation of growth Inferred from mutant phenotype PubMed 21949657. Source: FlyBase regulation of hemocyte differentiation Inferred from mutant phenotype PubMed 15381778. Source: FlyBase regulation of olfactory learning Inferred from mutant phenotype PubMed 21949657. Source: FlyBase transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro visceral muscle development Inferred from mutant phenotype PubMed 14523447. Source: FlyBase
Cellular_component	membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Non-traceable author statement PubMed 10908587. Source: FlyBase transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7KJ08 [UniParc]. Last modified October 3, 2006. Version 1. Checksum: DBE6E5E54320342D	FASTA	1,701	185,579
	10 20 30 40 50 60 MPQLRQLVVV LAILSLLVDP SFAQRPLIMN HTFSSLPMSQ HPSFNSWPSA SGGKQLRNGR 70 80 90 100 110 120 LHEQPLPLPQ PTLPVATQYE DYEAAPPGSR RDNKRRLAQM AQRPGSGNGG RRGMESLRKE 130 140 150 160 170 180 LMNPSVGGPG GGISGGGSGY PSYSATSSIG RIDGLGQGLG SADRYGALYD QLRQPSGMAA 190 200 210 220 230 240 MTAGPLGGPY STRFPPLYAG VDDQPKRSNR KNSISELYKL KKALNQADEP AGGVTHGNFE 250 260 270 280 290 300 GDPQPSSADP LQEIKDRIRD TSPNANTYAP HTDATPSSEY EYELGVKCNF ETPCSWTWGN 310 320 330 340 350 360 YSDGFQVITG TELSKRNLTG LLPGPAADSI DDANGHFLYA RVNPSSRPLN LTSPEFSTTM 370 380 390 400 410 420 EKCFLEVYMH QSDMSHGLSR VVVELLHTAE SSWVPAEILG DNVRQWTRKV YRLGRVSRDF 430 440 450 460 470 480 RIVFEVVPDL RVGQKGHVAL DNLRMVNCFP EGTKSEKCST SQVKCTSSKV PVCIHLPRIC 490 500 510 520 530 540 DITRDCDEAE DEQQSCDKIP YGGRCDFEED WCGWRDSGKT TLTWSRHTGS SPTHDTGPDG 550 560 570 580 590 600 DHTMQHLQNN TSGYYMLVNM NQHMNNSEKN SIIGFASNAI MVSKTFNPPP SVHGNPDSPY 610 620 630 640 650 660 RNSCVVRFFI HQFGKNPGSI NLSVVEMKEK ENITTTLWWS TKNQGSDWMR AEYVLPNITS 670 680 690 700 710 720 KYYLQFEARM GMRIYSDVAV DDFSLSPECF GLNIPEDHLG GYNYWDVRQN LKSPTYKDFE 730 740 750 760 770 780 YTNYLELTTC DTRGMIGPSQ AQCEAAYREQ NKTHVLREVH VVEDQSSYKG MQKWKVPHEG 790 800 810 820 830 840 HYTIIAKGAS GGLGSGGVGS SRGSVAVAIL ELHKNEELYF LVGQQGENAC IKSMGVLKEA 850 860 870 880 890 900 GCGTDHDLDL AQYSFRSKQD MVKNIYIENG AGGGGGGSYV FLLNQAKNEA VPLLVAGGGG 910 920 930 940 950 960 GLGIGQYIDE DFQHGQKAKP LQAPESGQIN GEPLNKKTAG PGGGWRAKED QALSPTYGAA 970 980 990 1000 1010 1020 LLQGGRGGHS CYVELADNGT SVHRHGQGGF GGGGGGCNTG GGGGGYAGGD VYLTESNGEG 1030 1040 1050 1060 1070 1080 GSSYISPSRS LREISEIHAG ASSGPGAIII IPAIEGCGCD YRCVALDEFR SKVRCICPDG 1090 1100 1110 1120 1130 1140 WSLKRDNHTA CEIREEAGKS SFQYLVSILM ISLAVLFICI AALIFMLYNR YQRKKQSKKR 1150 1160 1170 1180 1190 1200 HKMLVEQDLQ LTRLRNNIDD SNLNNFNPNY GCDGILNGHI DVNSLPQVAR DSLQLVNALG 1210 1220 1230 1240 1250 1260 KGAFGEVYMA LYRHRDGDAV EMGVAVKTLR EDPKREKEED FLKEAAIMAK FNHPNMVHLI 1270 1280 1290 1300 1310 1320 GVCFDRQPYY IVLELLAGGD LQKFLRENRN TPERPSLLTM KDLLFCALDV AKGCRYMESK 1330 1340 1350 1360 1370 1380 RFIHRDIAAR NCLLSSKGPG RVVKIADFGM SRDIYRSDYY RKGGKAMLPI KWMPPEAFLD 1390 1400 1410 1420 1430 1440 GIFTSKTDVW SFGILLWEVF SLGRSPYPGQ HNTQVMELVV RGGRLGSPTE CPVSIYKVMA 1450 1460 1470 1480 1490 1500 DCWNPTPEDR PTFITLLEHL TACTQDASIM NAPLPNILGP TASERDDTVI RPPNGEEFCL 1510 1520 1530 1540 1550 1560 AVPDYLVPLP PGGSNNPSMA SGSGYVPELQ RQQMSSCTPP AVTSPAAPHP RPVENIAPTS 1570 1580 1590 1600 1610 1620 GDCWETSFIL PNSKVEPPVV GSGHDVPLAG GEEAKLISLD TPQPTPTTIQ PPLSFASQLD 1630 1640 1650 1660 1670 1680 GITLDPSALT KSLPNGNAKQ SYANVQVKNE AEAKVINGVV GNGTVMNGDV STGSGGADSP 1690 1700 FTIQGYAERY KDNNNHSEIS C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo." Loren C.E., Scully A., Grabbe C., Edeen P.T., Thomas J., McKeown M., Hunter T., Palmer R.H. Genes Cells 6:531-544(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence." Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., Pacleb J.M., Park S. , Pfeiffer B.D., Richards S., Sodergren E.J., Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M. Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083-RESEARCH0083(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[5]	"The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective." Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E. Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[6]	"Heterochromatic sequences in a Drosophila whole-genome shotgun assembly." Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H. Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[7]	"Combined evidence annotation of transposable elements in genome sequences." Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D. PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[8]	Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[9]	"Drosophila melanogaster release 4 sequence." Berkeley Drosophila Genome Project Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[10]	"The Release 5.1 annotation of Drosophila melanogaster heterochromatin." Smith C.D., Shu S., Mungall C.J., Karpen G.H. Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[11]	"Sequence finishing and mapping of Drosophila melanogaster heterochromatin." Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., Dimitri P., Karpen G.H., Celniker S.E. Science 316:1625-1628(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[12]	FlyBase Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF236106 mRNA. Translation: AAF36990.1. AE013599 Genomic DNA. Translation: AAF57973.1.
RefSeq	NP_001261027.1. NM_001274098.1. NP_652600.1. NM_144343.3.
UniGene	Dm.3324.
3D structure databases
SMR	Q7KJ08. Positions 454-498, 1148-1497.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7KJ08. 1 interaction.
STRING	7227.FBpp0086264.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0087118; FBpp0086264; FBgn0040505. FBtr0331926; FBpp0304259; FBgn0040505.
GeneID	53425.
KEGG	dme:Dmel_CG8250.
UCSC	CG8250-RA. d. melanogaster.
Organism-specific databases
CTD	238.
FlyBase	FBgn0040505. Alk.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00700000104172.
InParanoid	Q7KJ08.
KO	K05119.
OMA	MAKFNHP.
OrthoDB	EOG431ZCW.
Family and domain databases
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR011009. Kinase-like_dom. IPR002172. LDrepeatLR_classA_rpt. IPR000998. MAM_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR002011. Tyr_kinase_rcpt_2_CS. [Graphical view]
Pfam	PF00629. MAM. 2 hits. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
SMART	SM00192. LDLa. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 2 hits. SSF56112. Kinase_like. 1 hit.
PROSITE	PS50068. LDLRA_2. 1 hit. PS50060. MAM_2. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00239. RECEPTOR_TYR_KIN_II. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	53425.
NextBio	841104.

Entry information

Entry name

Q7KJ08_DROME

Accession

Primary (citable) accession number: Q7KJ08

Entry history

Integrated into UniProtKB/TrEMBL:	October 3, 2006
Last sequence update:	October 3, 2006
Last modified:	May 29, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)