Q7KES3 (Q7KES3_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Hephaestus EMBL AAL27010.1

Submitted name:
Hephaestus, isoform M EMBL ABW08817.1

Gene names

Name:	heph FlyBase FBgn0011224
ORF Names:	Dmel_CG31000 EMBL ABW08817.1

Organism

Drosophila melanogaster (Fruit fly) EMBL AAL27010.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	568 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	imaginal disc-derived wing margin morphogenesis Inferred from mutant phenotype. Source: FlyBase imaginal disc-derived wing vein morphogenesis Inferred from mutant phenotype. Source: FlyBase mRNA processing Inferred from electronic annotation. Source: InterPro negative regulation of oskar mRNA translation Inferred from mutant phenotype. Source: FlyBase oocyte microtubule cytoskeleton polarization Inferred from mutant phenotype. Source: FlyBase sperm individualization Inferred from mutant phenotype. Source: FlyBase
Cellular component	cytoplasm Inferred from direct assay. Source: FlyBase nucleus Inferred from electronic annotation. Source: InterPro ribonucleoprotein complex Inferred from direct assay. Source: FlyBase
Molecular function	mRNA 3'-UTR binding Inferred from direct assay. Source: FlyBase nucleotide binding Inferred from electronic annotation. Source: InterPro translation repressor activity, nucleic acid binding Inferred from mutant phenotype. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7KES3 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: F7E8EAD61852C6A8	FASTA	568	61,202
	10 20 30 40 50 60 MAPASDNNNQ DLATKKAKLE PGTVLAGGIA KASKVIHLRN IPNESGEADV IALGIPFGRV 70 80 90 100 110 120 TNVLVLKGKN QAFIEMADEI SATSMVSCYT VTPPQMRGRM VYVQFSNHRE LKTDQGHNNS 130 140 150 160 170 180 TAHSDYSVQS PASGSPLPLS AAANATSNNA NSSSDSNSAM GILQNTSAVN AGGNTNAAGG 190 200 210 220 230 240 PNTVLRVIVE SLMYPVSLDI LHQIFQRYGK VLKIVTFTKN NSFQALIQYP DANSAQHAKS 250 260 270 280 290 300 LLDGQNIYNG CCTLRIDNSK LTALNVKYNN DKSRDFTNPA LPPGEPGVDI MPTAGGLMNT 310 320 330 340 350 360 NDLLLIAARQ RPSLSGDKIV NGLGAPGVLP PFALGLGTPL TGGYNNALPN LAAFSLANSG 370 380 390 400 410 420 ALQTTAPAMR GYSNVLLVSN LNEEMVTPDA LFTLFGVYGD VQRVKILYNK KDSALIQMAE 430 440 450 460 470 480 PQQAYLAMSH LDKLRLWGKP IRVMASKHQA VQLPKEGQPD AGLTRDYSQN PLHRFKKPGS 490 500 510 520 530 540 KNYQNIYPPS ATLHLSNIPS SCSEDDIKEA FTSNSFEVKA FKFFPKDRKM ALLQLLSVEE 550 560 AVLALIKMHN HQLSESNHLR VSFSKSNI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[3]	"Hephaestus negatively regulates Notch activity in the larval wing disc." Dansereau D.A., Brook W.J. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Head EMBL AAL27010.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF436844 mRNA. Translation: AAL27010.1. AE014297 Genomic DNA. Translation: ABW08817.1.
RefSeq	NP_001097993.1. NM_001104523.2.
UniGene	Dm.19417.
3D structure databases
ProteinModelPortal	Q7KES3.
SMR	Q7KES3. Positions 25-115, 179-285, 373-568.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7KES3.
Proteomic databases
PRIDE	Q7KES3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0112865; FBpp0111778; FBgn0011224.
GeneID	48571.
KEGG	dme:Dmel_CG31000.
UCSC	CG31000-RM. d. melanogaster.
Organism-specific databases
CTD	9843.
FlyBase	FBgn0011224. heph.
Phylogenomic databases
GeneTree	EMGT00050000000537.
InParanoid	Q7KES3.
Gene expression databases
ArrayExpress	Q7KES3.
Bgee	Q7KES3.
Family and domain databases
InterPro	IPR006536. HnRNP-L_PTB. IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 4 hits.
KO	K14948.
Pfam	PF00076. RRM_1. 2 hits. [Graphical view]
SMART	SM00360. RRM. 4 hits. [Graphical view]
TIGRFAMs	TIGR01649. HnRNP-L_PTB. 1 hit.
PROSITE	PS50102. RRM. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	839481.

Entry information

Entry name

Q7KES3_DROME

Accession

Primary (citable) accession number: Q7KES3

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)