ID   Q7K8X7_DROME            Unreviewed;       221 AA.
AC   Q7K8X7;
DT   03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2006, sequence version 1.
DT   24-JAN-2024, entry version 155.
DE   SubName: Full=Glutathione S transferase E9 {ECO:0000313|EMBL:AAF57693.1};
DE            EC=2.5.1.18 {ECO:0000313|EMBL:AAF57693.1, ECO:0000313|EMBL:CAD26833.1};
DE   SubName: Full=Putative glutathione S-transferase {ECO:0000313|EMBL:CAD26833.1};
GN   Name=GstE9 {ECO:0000313|EMBL:AAF57693.1,
GN   ECO:0000313|FlyBase:FBgn0063491};
GN   Synonyms=CT38753 {ECO:0000313|EMBL:AAF57693.1}, Dmel\CG17534
GN   {ECO:0000313|EMBL:AAF57693.1}, DmGSTE9 {ECO:0000313|EMBL:AAF57693.1},
GN   E9 {ECO:0000313|EMBL:AAF57693.1}, GST3-1
GN   {ECO:0000313|EMBL:CAD26833.1}, Gst3-1 {ECO:0000313|EMBL:AAF57693.1},
GN   GSTE9 {ECO:0000313|EMBL:AAF57693.1}, gste9
GN   {ECO:0000313|EMBL:AAF57693.1};
GN   ORFNames=CG17534 {ECO:0000313|EMBL:AAF57693.1,
GN   ECO:0000313|FlyBase:FBgn0063491}, Dmel_CG17534
GN   {ECO:0000313|EMBL:AAF57693.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:CAD26833.1};
RN   [1] {ECO:0000313|EMBL:CAD26833.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Canton S {ECO:0000313|EMBL:CAD26833.1};
RC   TISSUE=Appendages enriched in antennae {ECO:0000313|EMBL:CAD26833.1};
RA   Kim M.S.;
RT   "Analyse des Geruchsystems von Drosophila unter Verwendung der Enhancer-
RT   Trap-Technik.";
RL   Thesis (1996), Department of Fakultaet fuer Chemie,
RL   Ruhr-Universitaet-Bochum, Bochum, GERMANY.
RN   [2] {ECO:0000313|EMBL:AAF57693.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA   An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA   Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA   Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA   Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA   Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA   Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA   Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3] {ECO:0000313|EMBL:CAD26833.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Canton S {ECO:0000313|EMBL:CAD26833.1};
RC   TISSUE=Appendages enriched in antennae {ECO:0000313|EMBL:CAD26833.1};
RA   Wagner S.;
RT   "Drosophila melanogaster Glutathione-S-transferase gene cluster with
RT   expression in the olfactory organs.";
RL   (In) Elsner N., Kreutzberg G.W. (eds.);
RL   Goettingen Neurobiology Report 2001, Proceedings of the 4th Meeting of the
RL   German Neuroscience Society 2001, 28th Goettingen Neurobiology Conference,
RL   Volume II, pp.452-452, Georg Thieme Verlag, Stuttgart, New York (2001).
RN   [4] {ECO:0000313|EMBL:AAF57693.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT   euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [5] {ECO:0000313|EMBL:AAF57693.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [6] {ECO:0000313|EMBL:AAF57693.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA   Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin: a
RT   genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [7] {ECO:0000313|EMBL:AAF57693.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [8] {ECO:0000313|EMBL:CAD26833.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Canton S {ECO:0000313|EMBL:CAD26833.1};
RC   TISSUE=Appendages enriched in antennae {ECO:0000313|EMBL:CAD26833.1};
RA   Hovemann B.T.;
RL   Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:AAF57693.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [10] {ECO:0000313|EMBL:AAF57693.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA   Svirskas R., Rubin G.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:AAF57693.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [12] {ECO:0000313|EMBL:AAF57693.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
RN   [13] {ECO:0000313|EMBL:AAF57693.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26109357; DOI=.1534/g3.115.018929;
RG   FlyBase Consortium;
RA   Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E.,
RA   Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M.,
RA   Gelbart W.M., null;
RT   "Gene Model Annotations for Drosophila melanogaster: Impact of High-
RT   Throughput Data.";
RL   G3 (Bethesda) 5:1721-1736(2015).
RN   [14] {ECO:0000313|EMBL:AAF57693.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26109356; DOI=.1534/g3.115.018937;
RG   FlyBase Consortium;
RA   Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E.,
RA   Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M.,
RA   null;
RT   "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.";
RL   G3 (Bethesda) 5:1737-1749(2015).
RN   [15] {ECO:0000313|EMBL:AAF57693.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=25589440;
RA   Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E.,
RA   Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M.,
RA   Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M.,
RA   de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M.,
RA   Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M.,
RA   Karpen G.H., Celniker S.E.;
RT   "The Release 6 reference sequence of the Drosophila melanogaster genome.";
RL   Genome Res. 25:445-458(2015).
RN   [16] {ECO:0000313|EMBL:AAF57693.1}
RP   NUCLEOTIDE SEQUENCE.
RG   FlyBase;
RL   Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|EMBL:AAF57693.1}
RP   NUCLEOTIDE SEQUENCE.
RG   Berkeley Drosophila Genome Project;
RA   Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA   Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C.,
RA   Rubin G.;
RT   "Drosophila melanogaster release 4 sequence.";
RL   Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AE013599; AAF57693.1; -; Genomic_DNA.
DR   EMBL; AJ437578; CAD26833.1; -; mRNA.
DR   RefSeq; NP_725784.1; NM_166279.3.
DR   AlphaFoldDB; Q7K8X7; -.
DR   SMR; Q7K8X7; -.
DR   IntAct; Q7K8X7; 1.
DR   STRING; 7227.FBpp0085858; -.
DR   PaxDb; 7227-FBpp0085858; -.
DR   DNASU; 246581; -.
DR   EnsemblMetazoa; FBtr0086677; FBpp0085858; FBgn0063491.
DR   GeneID; 246581; -.
DR   KEGG; dme:Dmel_CG17534; -.
DR   UCSC; CG17534-RA; d. melanogaster.
DR   AGR; FB:FBgn0063491; -.
DR   CTD; 246581; -.
DR   FlyBase; FBgn0063491; GstE9.
DR   VEuPathDB; VectorBase:FBgn0063491; -.
DR   eggNOG; KOG0867; Eukaryota.
DR   GeneTree; ENSGT00940000165422; -.
DR   HOGENOM; CLU_011226_2_1_1; -.
DR   InParanoid; Q7K8X7; -.
DR   OMA; RYPKLNG; -.
DR   OrthoDB; 2318861at2759; -.
DR   SABIO-RK; Q7K8X7; -.
DR   BioGRID-ORCS; 246581; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 246581; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   Bgee; FBgn0063491; Expressed in antenna and 20 other cell types or tissues.
DR   ExpressionAtlas; Q7K8X7; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISS:FlyBase.
DR   GO; GO:0004364; F:glutathione transferase activity; IDA:FlyBase.
DR   GO; GO:0006749; P:glutathione metabolic process; IDA:FlyBase.
DR   CDD; cd03177; GST_C_Delta_Epsilon; 1.
DR   CDD; cd03045; GST_N_Delta_Epsilon; 1.
DR   Gene3D; 1.20.1050.10; -; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR43969:SF4; FI01423P-RELATED; 1.
DR   PANTHER; PTHR43969; GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED; 1.
DR   Pfam; PF13410; GST_C_2; 1.
DR   Pfam; PF13417; GST_N_3; 1.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SFLD; SFLDG01153; Main.4:_Theta-like; 1.
DR   SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|PeptideAtlas:Q7K8X7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   Transferase {ECO:0000313|EMBL:CAD26833.1}.
FT   DOMAIN          2..83
FT                   /note="GST N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50404"
FT   DOMAIN          89..220
FT                   /note="GST C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50405"
SQ   SEQUENCE   221 AA;  24882 MW;  90E690755250D203 CRC64;
     MGKLVLYGVE ASPPVRACKL TLDALGLQYE YRLVNLLAGE HKTKEFSLKN PQHTVPVLED
     DGKFIWESHA ICAYLVRRYA KSDDLYPKDY FKRALVDQRL HFESGVLFQG CIRNIAIPLF
     YKNITEVPRS QIDAIYEAYD FLEAFIGNQA YLCGPVITIA DYSVVSSVSS LVGLAAIDAK
     RYPKLNGWLD RMAAQPNYQS LNGNGAQMLI DMFSSKITKI V
//