SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7K755

- GLT11_CAEEL

UniProt

Q7K755 - GLT11_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Putative polypeptide N-acetylgalactosaminyltransferase 11

Gene
gly-11, Y75B8A.9
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor By similarity.

Catalytic activityi

UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.

Cofactori

Manganese By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei199 – 1991Substrate By similarity
Metal bindingi255 – 2551Manganese By similarity
Binding sitei256 – 2561Substrate By similarity
Metal bindingi257 – 2571Manganese By similarity
Binding sitei360 – 3601Substrate By similarity
Metal bindingi388 – 3881Manganese By similarity
Binding sitei391 – 3911Substrate By similarity
Binding sitei396 – 3961Substrate By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. polypeptide N-acetylgalactosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Lectin, Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT27. Glycosyltransferase Family 27.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative polypeptide N-acetylgalactosaminyltransferase 11 (EC:2.4.1.41)
Short name:
pp-GaNTase 11
Alternative name(s):
Protein-UDP acetylgalactosaminyltransferase 11
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11
Gene namesi
Name:gly-11
ORF Names:Y75B8A.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiY75B8A.9a; CE23021; WBGene00001636; gly-11.
Y75B8A.9b; CE35810; WBGene00001636; gly-11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei12 – 2918Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini30 – 605576Lumenal Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 605605Putative polypeptide N-acetylgalactosaminyltransferase 11PRO_0000059154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi149 ↔ 383 By similarity
Glycosylationi205 – 2051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi374 ↔ 450 By similarity
Glycosylationi490 – 4901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi494 ↔ 515 By similarity
Disulfide bondi541 ↔ 553 By similarity
Disulfide bondi578 ↔ 594 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7K755.
PRIDEiQ7K755.

Interactioni

Protein-protein interaction databases

STRINGi6239.Y75B8A.9a.

Structurei

3D structure databases

ProteinModelPortaliQ7K755.
SMRiQ7K755. Positions 122-602.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini481 – 605125Ricin B-type lectinAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni158 – 271114Catalytic subdomain AAdd
BLAST
Regioni329 – 39163Catalytic subdomain BAdd
BLAST

Domaini

There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding By similarity.
The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity By similarity.

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239675.
GeneTreeiENSGT00740000115054.
HOGENOMiHOG000038227.
InParanoidiQ7K755.
OMAiANGTHCL.
OrthoDBiEOG7J9VP2.
PhylomeDBiQ7K755.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR027791. Galactosyl_T_C.
IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF02709. Glyco_transf_7C. 1 hit.
PF00535. Glycos_transf_2. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
SMARTiSM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF53448. SSF53448. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: Q7K755-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLLLWRRKTV GLICLFSILL TIYLYVSMYP EDNERVWNSG NADIQRKHEK    50
LNNGGQGRHD FDDDEGAEKD EEDAVEKQNI AAPPLPKSFT TFPDRSKEIE 100
IDTDLLGKIN GKAEDDLQVE GYKKYQFNGL LSDRIGSRRK IKDSRNARCS 150
SLTYSDSLPA ASIVVCYFNE SPSVLIRMVN SIFDRTKPEH LHEILLVDDS 200
SEWSNATDEA IKYREKHIIQ WEKVKFLKTD KNEGLIRAKI FGARRANGEV 250
LVFLDSHCEV NEEWLPPLLD QIKQNRRRVV CPIIDIIDAI TMKYVESPVC 300
TGGVNWAMTF KWDYPHRSYF EDPMNYVNPL KSPTMAGGLF AIDKEYFFEI 350
GSYDEGMDVW GAENVEISVR IWTCGGELLI MPCSRVGHIF RRQRPYGIKT 400
DSMGKNSVRL ARVWLDEYLE NFFEARPNYR TFTDYGDLTS RISLRRNLQC 450
KPFKWYLENI YPELLPDNTP NQLNNQILVA GKKYLIKMAN GTHCLSAENS 500
QGRIANGNRV EMRKCNHMER MQQWKYSSTN ELRPMGSSRM CLDSLRGISV 550
ILCHNQGAHQ MWQVSNAGKL YSRSVNKCAT GSNDVSALST LKFCSLANSF 600
QFVEL 605

Note: No experimental confirmation available.

Length:605
Mass (Da):69,597
Last modified:August 16, 2004 - v2
Checksum:iF84C132FA794C661
GO
Isoform b (identifier: Q7K755-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     436-436: G → V
     437-605: Missing.

Note: No experimental confirmation available.

Show »
Length:436
Mass (Da):50,453
Checksum:i16BC07CEE870C051
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei436 – 4361G → V in isoform b. VSP_011242
Alternative sequencei437 – 605169Missing in isoform b. VSP_011243Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL033514 Genomic DNA. Translation: CAA22098.1.
AL033514 Genomic DNA. Translation: CAE47472.1.
PIRiT27397.
RefSeqiNP_001022948.1. NM_001027777.3. [Q7K755-1]
NP_001022949.1. NM_001027778.3. [Q7K755-2]
UniGeneiCel.62.

Genome annotation databases

EnsemblMetazoaiY75B8A.9a; Y75B8A.9a; WBGene00001636. [Q7K755-1]
GeneIDi176647.
KEGGicel:CELE_Y75B8A.9.
UCSCiY75B8A.9a. c. elegans. [Q7K755-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL033514 Genomic DNA. Translation: CAA22098.1 .
AL033514 Genomic DNA. Translation: CAE47472.1 .
PIRi T27397.
RefSeqi NP_001022948.1. NM_001027777.3. [Q7K755-1 ]
NP_001022949.1. NM_001027778.3. [Q7K755-2 ]
UniGenei Cel.62.

3D structure databases

ProteinModelPortali Q7K755.
SMRi Q7K755. Positions 122-602.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.Y75B8A.9a.

Protein family/group databases

CAZyi GT27. Glycosyltransferase Family 27.

Proteomic databases

PaxDbi Q7K755.
PRIDEi Q7K755.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Y75B8A.9a ; Y75B8A.9a ; WBGene00001636 . [Q7K755-1 ]
GeneIDi 176647.
KEGGi cel:CELE_Y75B8A.9.
UCSCi Y75B8A.9a. c. elegans. [Q7K755-1 ]

Organism-specific databases

CTDi 176647.
WormBasei Y75B8A.9a ; CE23021 ; WBGene00001636 ; gly-11.
Y75B8A.9b ; CE35810 ; WBGene00001636 ; gly-11.

Phylogenomic databases

eggNOGi NOG239675.
GeneTreei ENSGT00740000115054.
HOGENOMi HOG000038227.
InParanoidi Q7K755.
OMAi ANGTHCL.
OrthoDBi EOG7J9VP2.
PhylomeDBi Q7K755.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

NextBioi 893444.
PROi Q7K755.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR027791. Galactosyl_T_C.
IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR000772. Ricin_B_lectin.
[Graphical view ]
Pfami PF02709. Glyco_transf_7C. 1 hit.
PF00535. Glycos_transf_2. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view ]
SMARTi SM00458. RICIN. 1 hit.
[Graphical view ]
SUPFAMi SSF50370. SSF50370. 1 hit.
SSF53448. SSF53448. 1 hit.
PROSITEi PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiGLT11_CAEEL
AccessioniPrimary (citable) accession number: Q7K755
Secondary accession number(s): Q9XW72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi