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Q7K755

- GLT11_CAEEL

UniProt

Q7K755 - GLT11_CAEEL

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Protein

Putative polypeptide N-acetylgalactosaminyltransferase 11

Gene

gly-11

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.By similarity

Catalytic activityi

UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.

Cofactori

Mn2+By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei199 – 1991SubstrateBy similarity
Metal bindingi255 – 2551ManganeseBy similarity
Binding sitei256 – 2561SubstrateBy similarity
Metal bindingi257 – 2571ManganeseBy similarity
Binding sitei360 – 3601SubstrateBy similarity
Metal bindingi388 – 3881ManganeseBy similarity
Binding sitei391 – 3911SubstrateBy similarity
Binding sitei396 – 3961SubstrateBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. polypeptide N-acetylgalactosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Lectin, Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT27. Glycosyltransferase Family 27.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative polypeptide N-acetylgalactosaminyltransferase 11 (EC:2.4.1.41)
Short name:
pp-GaNTase 11
Alternative name(s):
Protein-UDP acetylgalactosaminyltransferase 11
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11
Gene namesi
Name:gly-11
ORF Names:Y75B8A.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiY75B8A.9a; CE23021; WBGene00001636; gly-11.
Y75B8A.9b; CE35810; WBGene00001636; gly-11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei12 – 2918Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini30 – 605576LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 605605Putative polypeptide N-acetylgalactosaminyltransferase 11PRO_0000059154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi149 ↔ 383PROSITE-ProRule annotation
Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi374 ↔ 450PROSITE-ProRule annotation
Glycosylationi490 – 4901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi494 ↔ 515PROSITE-ProRule annotation
Disulfide bondi541 ↔ 553PROSITE-ProRule annotation
Disulfide bondi578 ↔ 594PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7K755.
PRIDEiQ7K755.

Interactioni

Protein-protein interaction databases

STRINGi6239.Y75B8A.9a.

Structurei

3D structure databases

ProteinModelPortaliQ7K755.
SMRiQ7K755. Positions 122-595.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini481 – 605125Ricin B-type lectinPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni158 – 271114Catalytic subdomain AAdd
BLAST
Regioni329 – 39163Catalytic subdomain BAdd
BLAST

Domaini

There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.By similarity
The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.By similarity

Sequence similaritiesi

Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG239675.
GeneTreeiENSGT00760000118828.
HOGENOMiHOG000038227.
InParanoidiQ7K755.
OMAiANGTHCL.
OrthoDBiEOG7J9VP2.
PhylomeDBiQ7K755.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR027791. Galactosyl_T_C.
IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF02709. Glyco_transf_7C. 1 hit.
PF00535. Glycos_transf_2. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
SMARTiSM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF53448. SSF53448. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: Q7K755-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLLWRRKTV GLICLFSILL TIYLYVSMYP EDNERVWNSG NADIQRKHEK
60 70 80 90 100
LNNGGQGRHD FDDDEGAEKD EEDAVEKQNI AAPPLPKSFT TFPDRSKEIE
110 120 130 140 150
IDTDLLGKIN GKAEDDLQVE GYKKYQFNGL LSDRIGSRRK IKDSRNARCS
160 170 180 190 200
SLTYSDSLPA ASIVVCYFNE SPSVLIRMVN SIFDRTKPEH LHEILLVDDS
210 220 230 240 250
SEWSNATDEA IKYREKHIIQ WEKVKFLKTD KNEGLIRAKI FGARRANGEV
260 270 280 290 300
LVFLDSHCEV NEEWLPPLLD QIKQNRRRVV CPIIDIIDAI TMKYVESPVC
310 320 330 340 350
TGGVNWAMTF KWDYPHRSYF EDPMNYVNPL KSPTMAGGLF AIDKEYFFEI
360 370 380 390 400
GSYDEGMDVW GAENVEISVR IWTCGGELLI MPCSRVGHIF RRQRPYGIKT
410 420 430 440 450
DSMGKNSVRL ARVWLDEYLE NFFEARPNYR TFTDYGDLTS RISLRRNLQC
460 470 480 490 500
KPFKWYLENI YPELLPDNTP NQLNNQILVA GKKYLIKMAN GTHCLSAENS
510 520 530 540 550
QGRIANGNRV EMRKCNHMER MQQWKYSSTN ELRPMGSSRM CLDSLRGISV
560 570 580 590 600
ILCHNQGAHQ MWQVSNAGKL YSRSVNKCAT GSNDVSALST LKFCSLANSF

QFVEL

Note: No experimental confirmation available.

Length:605
Mass (Da):69,597
Last modified:August 16, 2004 - v2
Checksum:iF84C132FA794C661
GO
Isoform b (identifier: Q7K755-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     436-436: G → V
     437-605: Missing.

Note: No experimental confirmation available.

Show »
Length:436
Mass (Da):50,453
Checksum:i16BC07CEE870C051
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei436 – 4361G → V in isoform b. CuratedVSP_011242
Alternative sequencei437 – 605169Missing in isoform b. CuratedVSP_011243Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL033514 Genomic DNA. Translation: CAA22098.1.
AL033514 Genomic DNA. Translation: CAE47472.1.
PIRiT27397.
RefSeqiNP_001022948.1. NM_001027777.3. [Q7K755-1]
NP_001022949.1. NM_001027778.3. [Q7K755-2]
UniGeneiCel.62.

Genome annotation databases

EnsemblMetazoaiY75B8A.9a; Y75B8A.9a; WBGene00001636. [Q7K755-1]
GeneIDi176647.
KEGGicel:CELE_Y75B8A.9.
UCSCiY75B8A.9a. c. elegans. [Q7K755-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL033514 Genomic DNA. Translation: CAA22098.1 .
AL033514 Genomic DNA. Translation: CAE47472.1 .
PIRi T27397.
RefSeqi NP_001022948.1. NM_001027777.3. [Q7K755-1 ]
NP_001022949.1. NM_001027778.3. [Q7K755-2 ]
UniGenei Cel.62.

3D structure databases

ProteinModelPortali Q7K755.
SMRi Q7K755. Positions 122-595.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.Y75B8A.9a.

Protein family/group databases

CAZyi GT27. Glycosyltransferase Family 27.

Proteomic databases

PaxDbi Q7K755.
PRIDEi Q7K755.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Y75B8A.9a ; Y75B8A.9a ; WBGene00001636 . [Q7K755-1 ]
GeneIDi 176647.
KEGGi cel:CELE_Y75B8A.9.
UCSCi Y75B8A.9a. c. elegans. [Q7K755-1 ]

Organism-specific databases

CTDi 176647.
WormBasei Y75B8A.9a ; CE23021 ; WBGene00001636 ; gly-11.
Y75B8A.9b ; CE35810 ; WBGene00001636 ; gly-11.

Phylogenomic databases

eggNOGi NOG239675.
GeneTreei ENSGT00760000118828.
HOGENOMi HOG000038227.
InParanoidi Q7K755.
OMAi ANGTHCL.
OrthoDBi EOG7J9VP2.
PhylomeDBi Q7K755.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

NextBioi 893444.
PROi Q7K755.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR027791. Galactosyl_T_C.
IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
IPR000772. Ricin_B_lectin.
[Graphical view ]
Pfami PF02709. Glyco_transf_7C. 1 hit.
PF00535. Glycos_transf_2. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view ]
SMARTi SM00458. RICIN. 1 hit.
[Graphical view ]
SUPFAMi SSF50370. SSF50370. 1 hit.
SSF53448. SSF53448. 1 hit.
PROSITEi PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiGLT11_CAEEL
AccessioniPrimary (citable) accession number: Q7K755
Secondary accession number(s): Q9XW72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 26, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3