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Q7K755

- GLT11_CAEEL

UniProt

Q7K755 - GLT11_CAEEL

Protein

Putative polypeptide N-acetylgalactosaminyltransferase 11

Gene

gly-11

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.By similarity

    Catalytic activityi

    UDP-N-acetyl-alpha-D-galactosamine + polypeptide = UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide.

    Cofactori

    Manganese.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei199 – 1991SubstrateBy similarity
    Metal bindingi255 – 2551ManganeseBy similarity
    Binding sitei256 – 2561SubstrateBy similarity
    Metal bindingi257 – 2571ManganeseBy similarity
    Binding sitei360 – 3601SubstrateBy similarity
    Metal bindingi388 – 3881ManganeseBy similarity
    Binding sitei391 – 3911SubstrateBy similarity
    Binding sitei396 – 3961SubstrateBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. polypeptide N-acetylgalactosaminyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Ligandi

    Lectin, Manganese, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT27. Glycosyltransferase Family 27.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative polypeptide N-acetylgalactosaminyltransferase 11 (EC:2.4.1.41)
    Short name:
    pp-GaNTase 11
    Alternative name(s):
    Protein-UDP acetylgalactosaminyltransferase 11
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11
    Gene namesi
    Name:gly-11
    ORF Names:Y75B8A.9
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiY75B8A.9a; CE23021; WBGene00001636; gly-11.
    Y75B8A.9b; CE35810; WBGene00001636; gly-11.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 605605Putative polypeptide N-acetylgalactosaminyltransferase 11PRO_0000059154Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi149 ↔ 383PROSITE-ProRule annotation
    Glycosylationi205 – 2051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi374 ↔ 450PROSITE-ProRule annotation
    Glycosylationi490 – 4901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi494 ↔ 515PROSITE-ProRule annotation
    Disulfide bondi541 ↔ 553PROSITE-ProRule annotation
    Disulfide bondi578 ↔ 594PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ7K755.
    PRIDEiQ7K755.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.Y75B8A.9a.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7K755.
    SMRiQ7K755. Positions 122-602.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini30 – 605576LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 2918Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini481 – 605125Ricin B-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni158 – 271114Catalytic subdomain AAdd
    BLAST
    Regioni329 – 39163Catalytic subdomain BAdd
    BLAST

    Domaini

    There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.By similarity
    The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.By similarity

    Sequence similaritiesi

    Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG239675.
    GeneTreeiENSGT00740000115054.
    HOGENOMiHOG000038227.
    InParanoidiQ7K755.
    OMAiANGTHCL.
    OrthoDBiEOG7J9VP2.
    PhylomeDBiQ7K755.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR027791. Galactosyl_T_C.
    IPR001173. Glyco_trans_2-like.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR000772. Ricin_B_lectin.
    [Graphical view]
    PfamiPF02709. Glyco_transf_7C. 1 hit.
    PF00535. Glycos_transf_2. 1 hit.
    PF00652. Ricin_B_lectin. 1 hit.
    [Graphical view]
    SMARTiSM00458. RICIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF50370. SSF50370. 1 hit.
    SSF53448. SSF53448. 1 hit.
    PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: Q7K755-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLLLWRRKTV GLICLFSILL TIYLYVSMYP EDNERVWNSG NADIQRKHEK    50
    LNNGGQGRHD FDDDEGAEKD EEDAVEKQNI AAPPLPKSFT TFPDRSKEIE 100
    IDTDLLGKIN GKAEDDLQVE GYKKYQFNGL LSDRIGSRRK IKDSRNARCS 150
    SLTYSDSLPA ASIVVCYFNE SPSVLIRMVN SIFDRTKPEH LHEILLVDDS 200
    SEWSNATDEA IKYREKHIIQ WEKVKFLKTD KNEGLIRAKI FGARRANGEV 250
    LVFLDSHCEV NEEWLPPLLD QIKQNRRRVV CPIIDIIDAI TMKYVESPVC 300
    TGGVNWAMTF KWDYPHRSYF EDPMNYVNPL KSPTMAGGLF AIDKEYFFEI 350
    GSYDEGMDVW GAENVEISVR IWTCGGELLI MPCSRVGHIF RRQRPYGIKT 400
    DSMGKNSVRL ARVWLDEYLE NFFEARPNYR TFTDYGDLTS RISLRRNLQC 450
    KPFKWYLENI YPELLPDNTP NQLNNQILVA GKKYLIKMAN GTHCLSAENS 500
    QGRIANGNRV EMRKCNHMER MQQWKYSSTN ELRPMGSSRM CLDSLRGISV 550
    ILCHNQGAHQ MWQVSNAGKL YSRSVNKCAT GSNDVSALST LKFCSLANSF 600
    QFVEL 605

    Note: No experimental confirmation available.

    Length:605
    Mass (Da):69,597
    Last modified:August 16, 2004 - v2
    Checksum:iF84C132FA794C661
    GO
    Isoform b (identifier: Q7K755-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         436-436: G → V
         437-605: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:436
    Mass (Da):50,453
    Checksum:i16BC07CEE870C051
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei436 – 4361G → V in isoform b. CuratedVSP_011242
    Alternative sequencei437 – 605169Missing in isoform b. CuratedVSP_011243Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL033514 Genomic DNA. Translation: CAA22098.1.
    AL033514 Genomic DNA. Translation: CAE47472.1.
    PIRiT27397.
    RefSeqiNP_001022948.1. NM_001027777.3. [Q7K755-1]
    NP_001022949.1. NM_001027778.3. [Q7K755-2]
    UniGeneiCel.62.

    Genome annotation databases

    EnsemblMetazoaiY75B8A.9a; Y75B8A.9a; WBGene00001636. [Q7K755-1]
    GeneIDi176647.
    KEGGicel:CELE_Y75B8A.9.
    UCSCiY75B8A.9a. c. elegans. [Q7K755-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL033514 Genomic DNA. Translation: CAA22098.1 .
    AL033514 Genomic DNA. Translation: CAE47472.1 .
    PIRi T27397.
    RefSeqi NP_001022948.1. NM_001027777.3. [Q7K755-1 ]
    NP_001022949.1. NM_001027778.3. [Q7K755-2 ]
    UniGenei Cel.62.

    3D structure databases

    ProteinModelPortali Q7K755.
    SMRi Q7K755. Positions 122-602.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.Y75B8A.9a.

    Protein family/group databases

    CAZyi GT27. Glycosyltransferase Family 27.

    Proteomic databases

    PaxDbi Q7K755.
    PRIDEi Q7K755.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y75B8A.9a ; Y75B8A.9a ; WBGene00001636 . [Q7K755-1 ]
    GeneIDi 176647.
    KEGGi cel:CELE_Y75B8A.9.
    UCSCi Y75B8A.9a. c. elegans. [Q7K755-1 ]

    Organism-specific databases

    CTDi 176647.
    WormBasei Y75B8A.9a ; CE23021 ; WBGene00001636 ; gly-11.
    Y75B8A.9b ; CE35810 ; WBGene00001636 ; gly-11.

    Phylogenomic databases

    eggNOGi NOG239675.
    GeneTreei ENSGT00740000115054.
    HOGENOMi HOG000038227.
    InParanoidi Q7K755.
    OMAi ANGTHCL.
    OrthoDBi EOG7J9VP2.
    PhylomeDBi Q7K755.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    NextBioi 893444.
    PROi Q7K755.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR027791. Galactosyl_T_C.
    IPR001173. Glyco_trans_2-like.
    IPR029044. Nucleotide-diphossugar_trans.
    IPR000772. Ricin_B_lectin.
    [Graphical view ]
    Pfami PF02709. Glyco_transf_7C. 1 hit.
    PF00535. Glycos_transf_2. 1 hit.
    PF00652. Ricin_B_lectin. 1 hit.
    [Graphical view ]
    SMARTi SM00458. RICIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50370. SSF50370. 1 hit.
    SSF53448. SSF53448. 1 hit.
    PROSITEi PS50231. RICIN_B_LECTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGLT11_CAEEL
    AccessioniPrimary (citable) accession number: Q7K755
    Secondary accession number(s): Q9XW72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3